scholarly journals Correlation between Hyperkalemia and the Duration of Several Hospitalizations in Patients with Chronic Kidney Disease

2022 ◽  
Vol 11 (1) ◽  
pp. 244
Author(s):  
Vincenzo Calabrese ◽  
Valeria Cernaro ◽  
Valeria Battaglia ◽  
Guido Gembillo ◽  
Elisa Longhitano ◽  
...  

(1) Background: This observational study aimed to verify the association between serum potassium levels and hospitalization days in patients with chronic kidney disease in a follow up of nine months. (2) Methods: Patients with chronic kidney disease were divided into group A (180 patients, potassium ≤ 5.1 mEq/L) and B (90 patients, potassium > 5.1 mEq/L). Student’s t-test, Mann–Whitney test, Pearson’s Chi-Square test, Pearson/Spearman’s correlation test and linear regression test were performed in the entire sample and in stage-G4/5 subsample. (3) Results: Groups A and B differed for estimated glomerular filtration rate (eGFR) (34.89 (IQR, 16.24–57.98) vs. 19.8 (IQR, 10.50–32.50) mL/min/1.73 m2; p < 0.0001), hemoglobin (11.64 ± 2.20 vs. 10.97 ± 2.19 g/dL, p = 0.048), sum of hospitalization days (8 (IQR, 6–10) vs. 11 (IQR, 7–15) days; p < 0.0001) and use of angiotensin II receptor blockers (40.2% vs. 53.3%; p = 0.010). Considering patients with eGFR 6–30 mL/min/1.73 m2, differences in the sum of hospitalization days were confirmed. Multivariable regression analysis showed that hyperkalemia is an independent risk factor of increased hospital length. In stage G4-G5, regression analysis showed that hyperkalemia is the only independent risk factor (β = 2.93, 95% confidence interval, 0.077–5.794, p = 0.044). (4) Conclusions: We observed significantly greater odds of increased length of hospital stay among patients with higher potassium, mostly in stages G4–G5 chronic kidney disease.

ESC CardioMed ◽  
2018 ◽  
pp. 2670-2673
Author(s):  
Susanna Price

Chronic kidney disease is a global health burden, with an estimated prevalence of 11–13%, with the majority of patients diagnosed as stage 3, and is an independent risk factor for cardiovascular disease. The incidence of acute kidney injury is increasing, and estimated to be present in one in five acute hospital admissions, and there is a bidirectional relationship between acute and chronic kidney disease. The relevance to the patient with cardiovascular disease relates to increased perioperative risk, as reduced kidney function is an independent risk factor for adverse postoperative cardiovascular outcomes including myocardial infarction, stroke, and progression of heart failure. Furthermore, patients undergoing cardiovascular investigations are at risk of developing acute kidney injury, in particular where iodinated contrast is administered. This chapter reviews the classification of renal disease and its impact on cardiovascular disease, as well as potential methods for reducing the development of contrast-induced acute kidney injury.


2020 ◽  
Vol 13 (3) ◽  
pp. 152-158
Author(s):  
Lauren Copeland ◽  
Keith Gillis

Measurement of urinary protein is an essential part of the evaluation of chronic kidney disease; it has both diagnostic and prognostic significance. Proteinuria is an independent risk factor for progression of renal disease, but is also independently associated with increased cardiovascular mortality. Despite its far-reaching implications, the definition, diagnosis and treatment of proteinuria can cause confusion in primary care. Early detection of proteinuria in the context of diabetes or otherwise is vital given the potential for intervention to reduce urinary protein losses and improve renal and cardiovascular outcomes. This article will focus on the definition, potential causes and management of proteinuria, including which individuals should be referred to secondary care.


2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Xin Du ◽  
Binbin Pan ◽  
Wenwen Li ◽  
Yonghua Zou ◽  
Xi Hua ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
San-Yuan Wu ◽  
Jui-Lung Shen ◽  
Kee-Ming Man ◽  
Yuan-Ju Lee ◽  
Huey-Yi Chen ◽  
...  

Pharmacological therapy for urolithiasis using medicinal plants has been increasingly adopted for the prevention of its recurrence. ADrosophila melanogastermodel developed for translational research of urolithiasis was applied to evaluate agents with potential antilithic effects and calcium oxalate (CaOx) formation. Potential antilithic herbs were prepared in a mixture of food in a diluted concentration of 5,000 from the original extract with 0.5% ethylene glycol (EG) as the lithogenic agent. The control group was fed with food only. After 3 weeks, flies (n≥150for each group) were killed using CO2narcotization, and the Malpighian tubules were dissected, removed, and processed for polarized light microscopy examination of the crystals. The crystal formation rate in the EG group was 100.0%. In the study, 16 tested herbal drugs reached the crystal formation rate of 0.0%, includingSalviae miltiorrhizae,Paeonia lactiflora, andCarthami flos.Scutellaria baicalensisenhanced CaOx crystal formation. Two herbal drugsCommiphora molmolandNatrii sulfascaused the death of all flies. Our rapid screening methods provided evidence that some medicinal plants have potential antilithic effects. These useful medicinal plants can be further studied using other animal or human models to verify their effects.Corrigendum to “An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease”


2010 ◽  
Vol 339 (6) ◽  
pp. 509-515 ◽  
Author(s):  
Hung-Yu Chang ◽  
Pei-Hsien Lee ◽  
Chen-Chou Lei ◽  
Yung-Chien Hsu ◽  
Hsun-Hao Chang ◽  
...  

2009 ◽  
Vol 338 (3) ◽  
pp. 185-189 ◽  
Author(s):  
Pei-Hsien Lee ◽  
Hung-Yu Chang ◽  
Yung-Chien Hsu ◽  
Chen-Chou Lei ◽  
Hsun-Hao Chang ◽  
...  

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