scholarly journals Meta-Analysis of Differential miRNA Expression after Bariatric Surgery

2019 ◽  
Vol 8 (8) ◽  
pp. 1220 ◽  
Author(s):  
Gladys Langi ◽  
Lukasz Szczerbinski ◽  
Adam Kretowski
Keyword(s):  
Bariatric Surgery ◽  
Target Genes ◽  
Web Of Science ◽  
Kegg Pathway ◽  
Meta Analysis ◽  
Obese Patients ◽  
Pathway Database ◽  
Efficient Treatment ◽  
Kegg Pathway Database ◽  
Before And After

Bariatric surgery is an efficient treatment for weight loss in obese patients and for resolving obesity comorbidities. However, the mechanisms behind these outcomes are unclear. Recent studies have indicated significant alterations in the transcriptome after surgery, specifically in the differential expression of microRNAs. In order to summarize the recent findings, we conducted a systematic summary of studies comparing microRNA expression levels before and after surgery. We identified 17 animal model and human studies from four databases (Ovid, Scopus, Web of Science, and PubMed) to be enrolled in this meta-analysis. From these studies, we identified 14 miRNAs which had the same direction of modulation of their expression after surgery in at least two studies (downregulated: hsa-miR-93-5p, hsa-miR-106b-5p, hsa-let-7b-5p, hsa-let-7i-5p, hsa-miR-16-5p, hsa-miR-19b-3p, hsa-miR-92a-3p, hsa-miR-222-3p, hsa-miR-142-3p, hsa-miR-140-5p, hsa-miR-155-5p, rno-miR-320-3p; upregulated: hsa-miR-7-5p, hsa-miR-320c). Pathway analysis for these miRNAs was done using database resources (DIANA-TarBase and KEGG pathway database) and their predicted target genes were discussed in relation with obesity and its comorbidities. Discrepancies in study design, such as miRNA source, bariatric surgery type, time of observation after surgery, and miRNA profiling methods, were also discussed.

POSTOPERATIVE COMPLIANCE OF BARIATRIC SURGERY PATIENTS REGARDING THE ASSESSMENT OF SERUM LEPTIN LEVELS AND INSULIN RESISTANCE

2019 ◽  
Vol 49 (1/2019) ◽  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Serum Levels ◽  
Medical Laboratory ◽  
Leptin Resistance ◽  
Obese Patients ◽  
Laboratory Assessment ◽  
Serum Leptin ◽  
Before And After ◽  
Bariatric Patients

Background and aims: Overweight and obese patients who undergo bariatric surgery require a rigorous clinical and paraclinical assessment both before and after the surgery at 3, 6, and 12 months.The present study aims the assessment of serum leptin levels and insulin resistance status in compliant bariatric patients to scheduled medical laboratory assessment at 6 months after surgery. Material and Method: The study included 109 eligible patients selected for bariatric surgery, 48 of whom attended the scheduled visit at 6 months after the surgery. Laboratory assessing regarded the insulin resistance by determining before meal the serum levels of leptin, glucose and insulin, as well as HOMA 1 and HOMA 2 indexes. Results: Patients who underwent bariatric treatment experienced a significant decrease in insulin resistance status. A higher percentage in the preoperative group was recorded in women, feature which was also recorded in the postoperative group that attended the scheduled visit at 6 months after surgery. Age is also an important factor that significantly influences the behavioral adherence to postoperative visits. Conclusions: Insulin resistance status improved significantly in 6 months after bariatric surgery among the fully compliant patients. The percentage of attendance at scheduled visits is higher among women, and decreases with age. Keywords: obesity surgery, leptin resistance, insulin resistance, HOMA index, compliance

scholarly journals Changes in Lipid Profile of Obese Patients Following Contemporary Bariatric Surgery: A Meta-Analysis

2016 ◽  
Vol 129 (9) ◽  
pp. 952-959 ◽  
Author(s):  
Sean P. Heffron ◽  
Amar Parikh ◽  
Alexandar Volodarskiy ◽  
Christine Ren-Fielding ◽  
Arthur Schwartzbard ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Lipid Profile ◽  
Meta Analysis ◽  
Obese Patients

Correction: Prevalence of Barrett’s esophagus in obese patients undergoing pre-bariatric surgery evaluation: a systematic review and meta-analysis

Endoscopy ◽  
2020 ◽  
Vol 52 (07) ◽  
pp. C8-C8
Author(s):  
Bashar Qumseya ◽  
Sherif Gendy ◽  
Alexander Wallace ◽  
Dennis Yang ◽  
Davis Estores ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Meta Analysis ◽  
Obese Patients

scholarly journals The effect of methadone on depression among addicts: a systematic review and meta-analysis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Masoud Mohammadi ◽  
Mohsen Kazeminia ◽  
Nasrin Abdoli ◽  
Behnam Khaledipaveh ◽  
Shamarina Shohaimi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Treatment Plan ◽  
Meta Analysis ◽  
Intervention Group ◽  
Depression Score ◽  
Inclusion Criteria ◽  
The World ◽  
Before And After ◽  
The Mean

Abstract Background Opioids addiction and misuse are among the major problems in the world today. There have been several preliminary studies examining the effect of methadone on depression among addicts, however, these studies have reported inconsistent and even contradictory results. Therefore, the aim of the present study was to determine the effect of methadone on depression in addicts in Iran and around the world, using a meta-analysis approach. Methods This study was a systematic review and meta-analysis including articles published in the SID, MagIran, IranMedex, IranDoc, Cochrane, Embase, ScienceDirect, Scopus, PubMed and Web of Science databases were searched systematically to find articles published from 2006 to March 2019. Heterogeneity index was determined using the Cochran's test (Qc) and I2. Considering heterogeneity of studies, the random effects model was used to estimate the standardized difference of mean score for depression. Subsequently, the level of depression reduction in Iran and worldwide in the intervention group before and after the testwas measured. Results A total of 19 articles met the inclusion criteria, and were therefore selected for this systematic review and meta-analysis. The sample size of the intervention group in the selected studies was 1948. According to the meta-analysis results, the mean depression score in the intervention group was 26.4 ± 5.6 and 18.4 ± 2.6 before and after intervention respectively, indicating the reducing effect of methadone on depression, and this difference was statistically significant (P < 0.01). Conclusion The results of the present study show that methadone significantly reduces depression in addicts. Therefore, regular methadone use can be part of a drug treatment plan.

scholarly journals Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery

2018 ◽  
Vol 13 (3) ◽  
pp. 366-375 ◽  
Author(s):  
Jolanta A. Dardzińska ◽  
Łukasz Kaska ◽  
Monika Proczko-Stepaniak ◽  
Maria Szymańska-Gnacińska ◽  
Ewa Aleksandrowicz-Wrona ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Obese Patients ◽  
Desacyl Ghrelin ◽  
Different Types ◽  
Before And After

scholarly journals Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Hanfei Zhu ◽  
Ziqi Ren ◽  
Yan Zang ◽  
Hongxia Hua ◽  
Jinling Lu ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Interleukin 6 ◽  
Meta Analysis ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
Serum Levels ◽  
Risk Of Bias ◽  
Mean Difference ◽  
Vitamin B ◽  
Obese Patients

Vitamin deficiency, bacterial overgrowth, and gastrointestinal symptoms can be detected in obese patients after bariatric surgery that influences their quality of life (QoL) and weight. It is unclear if microecological preparations benefit obese patients following bariatric surgery. The aim of this study is to investigate the effects of microecological preparations on QoL, excess weight loss (EWL), and levels of vitamin B12 and inflammatory markers. We searched seven databases to identify reports published till December 1, 2019, and included randomized controlled trials investigating the effects of microecological preparations in obese adults undergoing bariatric surgery. The primary outcomes included QoL and EWL, while secondary outcomes comprised serum levels of vitamin B12, interleukin 6, TNF-α, and C-reactive protein (CRP). Study bias was analyzed using the Cochrane risk-of-bias tool. Statistical analyses were performed using Review Manager. The mean difference in outcomes was calculated using standardized mean difference (SMD) with a confidence interval (CI) of 95%. A majority of the studies showed a low or moderate risk of bias. Meta-analysis showed significantly higher levels of vitamin B12 in postoperative patients administered with microecological preparations (SMD = 0.52; 95% CI = 0.08–0.95; P=0.02). There were no significant differences in QoL (SMD = −0.14; 95% CI = −0.45–0.17; P=0.38), EWL (SMD = 0.45; 95% CI = −0.16–1.05; P=0.15), and levels of TNF-α (SMD = −0.29; 95% CI = −0.64–0.05; P=0.09), interleukin 6 (SMD = −0.1; 95% CI = −0.81–0.61; P=0.78]), and CRP (SMD = 0.02; 95% CI = −0.32–0.36; P=0.93). The trials examined indicated that microecological preparations had limited efficacy in improving QoL, EWL, and inflammatory response, but they stimulated the synthesis of vitamin B12. This may help in designing efficient microecological preparations to supplement bariatric surgery in obese individuals.

scholarly journals Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0163907 ◽  
Author(s):  
Kun Li ◽  
Jianan Zou ◽  
Zhibin Ye ◽  
Jianzhong Di ◽  
Xiaodong Han ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Renal Function ◽  
Meta Analysis ◽  
Obese Patients

scholarly journals Provision of nutritional support to those experiencing complications following bariatric surgery

2010 ◽  
Vol 69 (4) ◽  
pp. 536-542 ◽  
Author(s):  
Ella Segaran
Keyword(s):  
Bariatric Surgery ◽  
Energy Expenditure ◽  
Hospital Admissions ◽  
Nutrition Support ◽  
Considerable Proportion ◽  
Obese Patients ◽  
Free Living ◽  
Protein Requirements ◽  
Before And After ◽  
Oral Diet

This review details the practicalities of providing nutrition support to obese patients who experience complications following bariatric surgery and highlights some of the nutritional challenges encountered by this group of patients. Bariatric surgery to treat morbid obesity has significantly increased internationally over the past decade with hospital admissions rising annually. The gastric bypass is currently the most commonly performed procedure. The complication rate can be up to 16%, with a considerable proportion having nutritional implications. The treatment can involve avoidance of oral diet and nutrition support, i.e. enteral or parenteral nutrition. Opposition to nutrition support can be encountered. It is useful to clarify the aims of nutrition support, these being: the avoidance of overfeeding and its consequences, preservation of lean body mass and promotion of healing. Evidence suggests that hypoenergic nutrition is not harmful and may actually be beneficial. There is a lack of consensus regarding the optimum method to predict the nutritional requirements in the obese acutely unwell patient. The literature suggests that the predicted equations are fairly accurate compared to measured energy expenditure in free living obese patients before and after bariatric surgery. However, these findings cannot be directly applied to those obese patients experiencing complications of bariatric surgery, who will be acutely unwell exhibiting inflammatory response. It is therefore necessary to refer to the literature on energy expenditure in hospitalized obese patients, to help guide practice. More research examining the energy and protein requirements of obese patients needing nutrition support following bariatric surgery is urgently required.

Sign in / Sign up

Export Citation Format

Share Document