scholarly journals Mucormycosis in CAPA, a Possible Fungal Super-Infection

2021 ◽  
Vol 7 (9) ◽  
pp. 708
Author(s):  
Paola Saltini ◽  
Emanuele Palomba ◽  
Valeria Castelli ◽  
Marco Fava ◽  
Laura Alagna ◽  
...  
Keyword(s):  
Pulmonary Infection ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Pulmonary Aspergillosis ◽  
First Case ◽  
Super Infection

The occurrence of pulmonary fungal superinfection due to Aspergillus spp. in patients with COVID-19 is a well-described complication associated with significant morbidity and mortality. This can be related to a directed effect of the virus and to the immunosuppressive role of the therapies administered for the disease. Here, we describe the first case of pulmonary infection due to Mucorales occurring in a patient with a concomitant diagnosis of COVID-19-associated pulmonary aspergillosis.

scholarly journals The Olsenella Uli Induced Pneumonia: A Case Report

2021 ◽  
Author(s):  
Yufen Yan ◽  
Hong Li ◽  
Shuai Li ◽  
Shuhui Liu ◽  
Nan Jia ◽  
...  
Keyword(s):  
Therapeutic Strategy ◽  
Pulmonary Infection ◽  
Mass Spectrometry Analysis ◽  
Causative Role ◽  
Positive Bacterium ◽  
Spectrometry Analysis ◽  
First Case ◽  
Infection Treatment ◽  
Third Generation Cephalosporins

Abstract Olsenella uli is a Gram-positive bacterium common in the oral cavity or gastrointestinal tract. Here we reported a first case of human pneumonia caused by the Olsenella uli. The identification of Olsenella uli was based on micromorphology, sequence analysis and mass spectrometry analysis of the bacteria recovered from sputum. Ceftazidime，one of the third generation cephalosporins was used for the anti-infection treatment of the patient. CT results showed a significant improvement of the pulmonary lesion and pleural effusion and recovery from pulmonary infection after 10 days. The mechanism underlying Olsenella uli induced pneumonia is unclear, our report suggests a causative role of gingival bacteria in pathogenesis of pneumonia, and the intervention by Ceftazidime may offer a therapeutic strategy for Olsenella uli infection.

Case of relapsing sulfasalazine-induced hypersensitivity syndrome upon re-exposure

2020 ◽  
Vol 13 (9) ◽  
pp. e235803 ◽  
Author(s):  
Jason Winward ◽  
Laurel Lyckholm ◽  
Samuel M Brown ◽  
Mohamad Mokadem
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Crohn’S Disease ◽  
Hypersensitivity Syndrome ◽  
Morbidity And Mortality ◽  
Significant Morbidity ◽  
Timely Initiation ◽  
Source Of Infection ◽  
First Case ◽  
Appropriate Treatment

Sulfasalazine-induced hypersensitivity syndrome (SIHS) is a serious systemic delayed adverse drug reaction that is associated with significant morbidity and mortality. Here, we report the first case, to our knowledge, of a patient with previously unidentified SIHS who developed a significantly more rapid and extreme recurrence on re-exposure to sulfasalazine. The patient is a 58-year-old woman with asymptomatic Crohn’s disease who, 10 days after initiating sulfasalazine, developed fevers, diffuse rash, pancytopenia, hypotension and hepatitis without a definitive source of infection. Sixteen days after her first hospitalisation, she was restarted on sulfasalazine and was readmitted within 10 hours with a similar but more serious presentation, requiring vasopressors. She did recover completely without any further recurrence to date, after definitively discontinuing sulfasalazine. This case demonstrates the importance of recognising SIHS early in patients to prevent re-exposure to sulfasalazine and to ensure timely initiation of appropriate treatment.

Weakness

2018 ◽  
pp. 94-100
Author(s):  
Aaron Farney
Keyword(s):  
Intracranial Pressure ◽  
Therapeutic Option ◽  
Critical Role ◽  
Large Vessel ◽  
Morbidity And Mortality ◽  
Large Vessel Occlusion ◽  
Significant Morbidity ◽  
Vessel Occlusion ◽  
The Unconscious

Acute ischemic strokes have significant morbidity and mortality, particularly when they involve a large vessel occlusion. This case reviews the prehospital presentation of a patient with a large vessel occlusion stroke, the critical role prehospital personnel have in recognizing a stroke, determining the most appropriate facility, and identifying the most appropriate transport modality. Approaches to managing the unconscious patient’s airway are discussed, with particular attention to the effects intubation may have on intracranial pressure. As large vessel occlusion ischemic strokes have a therapeutic option not previously available, the role of prehospital identification and destination determination is even more critical ,and this case reviews those considerations.

scholarly journals A “Crazy Paving” Pattern on CT Scan in a Patient Treated with Pembrolizumab

2019 ◽  
Vol 14 (3) ◽  
pp. 242-245
Author(s):  
Maurizio Marvisi ◽  
Sara Ramponi ◽  
Laura Balzarini ◽  
Chiara Mancini
Keyword(s):  
Ct Scan ◽  
Morbidity And Mortality ◽  
Great Promise ◽  
Significant Morbidity ◽  
Exertional Dyspnea ◽  
Standard Management ◽  
First Case ◽  
History Of ◽  
Contrast Ct

Background: Programmed cell death protein 1 (PD-1) and its ligand, PD-L1, have shown great promise in clinical practice and have been incorporated into standard management of NSCLC. Pneumonitis is a serious autoimmune toxicity associated with the use of anti-PD-1/PD-L1 antibodies, resulting in significant morbidity and mortality. Methods: We described the case of a 73-year-old woman with no history of smoking developing exertional dyspnea four months after taking Pembrolizumab. Results: High resolution contrast CT scan (HRCT) presented a unilateral “crazy paving” pattern, and bronchoalveolar lavage (BAL) an important lymphocytosis (20% of total cell count). The patient reached clinical stability after the administration of systemic steroids (2mg\Kg\die) and was discharged with long term oxygen therap Discussion: Pulmonary toxicity is frequent when using PD-1 inhibitors, resulting in significant morbidity and mortality, often leading to the discontinuation of therapy. Clinical presentation is usually protean and HRCT pattern is nonspecific. This is the first case presenting a “crazy paving” pattern associated with BAL lymphocytosis. Conclusion: Oncologists, pulmonologists, radiologists and general practitioners have to consider PD-1 and PD-L1 inhibitor pneumonitis as a potentially disabling and fatal event.

scholarly journals Empyema due to a highly transmissible Pseudomonas aeruginosa strain in an adult cystic fibrosis patient

2010 ◽  
Vol 59 (5) ◽  
pp. 614-616 ◽  
Author(s):  
Kamlesh Mohan ◽  
Vinay Lakshman ◽  
Joanne L. Fothergill ◽  
Martin J. Ledson ◽  
Craig Winstanley ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Respiratory Failure ◽  
Cystic Fibrosis Patient ◽  
Pulmonary Infection ◽  
Pleural Empyema ◽  
Morbidity And Mortality ◽  
Epidemic Strain ◽  
First Case ◽  
Progressive Respiratory Failure

Chronic pulmonary infection with Pseudomonas aeruginosa occurs in up to 85 % of individuals with cystic fibrosis (CF) by the time they reach adulthood, and is the major cause of morbidity and mortality: nearly all patients die from progressive respiratory failure due to repeated pulmonary exacerbations. However, despite the predilection of this organism for the lungs of CF people, infection of the pleura is much less common and is not well described in the CF population. We describe what is believed to be the first case of pleural empyema due to a particularly pathogenic transmissible strain of P. aeruginosa (the Liverpool epidemic strain) in an adult CF patient.

scholarly journals Depression among health care students in the time of COVID-19: the mediating role of resilience in the hopelessness–depression relationship

2021 ◽  
pp. 008124632199445
Author(s):  
Tammy-lee Pretorius
Keyword(s):  
Health Care ◽  
Traumatic Event ◽  
National Level ◽  
Depression Scale ◽  
Health Care Students ◽  
Mediating Role ◽  
First Case ◽  
Hopelessness Depression ◽  
The World

COVID-19 spread rapidly across the world, and by March 2020, the first case of COVID-19 was identified in South Africa. Lockdown-related measures such as restricted movement and isolation were implemented to contain the virus. Combined with these measures, factors such as economic decline, job losses, and food shortages can cause numerous mental health sequelae such as depression. Feelings of hopelessness and helplessness as well as cases of suicide have been reported around the world due to the pandemic and the associated feelings of anxiety and depression. The aims of this study were to investigate levels of hopelessness and depression in a sample of health care students. A random sample of students ( N = 174) enrolled in a health sciences programme at the University of the Western Cape completed the Beck Hopelessness Scale, the Center for Epidemiological Studies Depression Scale, and a three-item Resilience Scale. The results revealed high levels of hopelessness and depression compared to previously reported normative data for these scales. In addition, the indirect effects of hopelessness on depression were significant, demonstrating the mediating role of resilience in the hopelessness–depression relationship. These results highlight a call for universities to take proactive measures in providing students with free and easily accessible resources to help them cope and manage stress during a traumatic event. More importantly, at a national level, preventive measures should be implemented to strengthen resilience in young adults.

scholarly journals Genetic and epigenetic mechanisms in the development of congenital heart diseases

2021 ◽  
Vol 4 (2) ◽  
pp. e000196
Author(s):  
Yue Wu ◽  
Xiaosi Jin ◽  
Yuhao Zhang ◽  
Jing Zheng ◽  
Rulai Yang
Keyword(s):  
Congenital Heart ◽  
Heart Diseases ◽  
Gene Mutations ◽  
Morbidity And Mortality ◽  
Molecular Medicine ◽  
Epigenetic Mechanisms ◽  
Epigenetic Factors ◽  
Near Future

Congenital heart disease (CHD) is the most common of congenital cardiovascular malformations associated with birth defects, and it results in significant morbidity and mortality worldwide. The classification of CHD is still elusive owing to the complex pathogenesis of CHD. Advances in molecular medicine have revealed the genetic basis of some heart anomalies. Genes associated with CHD might be modulated by various epigenetic factors. Thus, the genetic and epigenetic factors are gradually accepted as important triggers in the pathogenesis of CHD. However, few literatures have comprehensively elaborated the genetic and epigenetic mechanisms of CHD. This review focuses on the etiology of CHD from genetics and epigenetics to discuss the role of these factors in the development of CHD. The interactions between genetic and epigenetic in the pathogenesis of CHD are also elaborated. Chromosome abnormalities and gene mutations in genetics, and DNA methylations, histone modifications and on-coding RNAs in epigenetics are summarized in detail. We hope the summative knowledge of these etiologies may be useful for improved diagnosis and further elucidation of CHD so that morbidity and mortality of children with CHD can be reduced in the near future.

scholarly journals The role of hepaticojejunostomy leaks after pancreatoduodenectomy in the increase of morbidity and mortality

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S289
Author(s):  
O. Usenko ◽  
M. Nichitaylo ◽  
V. Kopchak ◽  
P. Ogorodnik ◽  
O. Lytvyn ◽  
...  
Keyword(s):  
Morbidity And Mortality
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