scholarly journals Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?

2021 ◽  
Vol 11 (11) ◽  
pp. 1078
Author(s):  
Chao-Wei Lee ◽  
Sey-En Lin ◽  
Ming-Chin Yu ◽  
Hao-Wei Kou ◽  
Cheng-Han Lee ◽  
...  
Keyword(s):  
Uric Acid ◽  
Large Scale ◽  
Neutrophil To Lymphocyte Ratio ◽  
Oncologic Outcomes ◽  
Cytokeratin 19 ◽  
P Value ◽  
Chang Gung Memorial Hospital ◽  
Lymphocyte Ratio ◽  
Ck19 Expression ◽  
Hospital Patients

Background: Cytokeratin 19-positive (CK19(+)) hepatocellular carcinomas (HCC) are generally associated with poor prognosis after hepatectomy. It is typically detected from postoperative immunochemistry. We have analyzed several clinically available biomarkers, in particular, neutrophil to lymphocyte ratio (NLR) and aim to develop a panel of biomarkers in identifying CK19 expression in (HCC) preoperatively. Methods: We retrospectively reviewed 36 HCC patients who underwent liver resections during January 2017 to March 2018 in Chang Gung Memorial Hospital. Patients were grouped based on the status of CK19 expression and their baseline characteristics, perioperative and oncologic outcomes were compared. Novel biomarkers including NLR, alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and uric acid were analyzed and correlated with CK19 expression. Results: NLR is highly associated with CK19 expression. NLR alone gave an AUROC of 0.728 (p-value = 0.043), higher than AFP, CEA or tumor size alone. NLR when combined with AFP, CEA and uric acid, gave an AUROC as high as 0.933 (p-value = 0.004). Conclusion: The current study demonstrated the predictive capability of NLR in combination with AFP, CEA and uric acid for CK19 expression in HCC patients preoperatively. Further prospective, large-scale studies are warranted to validate our findings.

Pengaruh Ekstrak Daun Moringa Oleifera terhadap Mean Platelet Volume dan Neutrophil-To-Lymphocyte Ratio pada Pasien Autoimun

2021 ◽  
Vol 6 (1) ◽  
pp. 355
Author(s):  
Nurhasan Agung Prabowo ◽  
Arief Nurudhin
Keyword(s):  
Rheumatoid Arthritis ◽  
Mean Platelet Volume ◽  
Moringa Oleifera ◽  
Neutrophil To Lymphocyte Ratio ◽  
P Value ◽  
Platelet Volume ◽  
Lymphocyte Ratio

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak MO terhadap MVP dan NLR pada pasien autoimun. Metode penelitian yang digunakan adalah eksperimental yang dilakukan pada 30 pasien autoimun yang terdiri dari 28 pasien lupus dan 2 pasien rheumatoid arthritis di Poliklinik Reumatologi RSUD Moewardi pada Januari-Juli 2020. Pasien dikelompokkan menjadi dua, yaitu kelompok perlakuan dan kontrol. Pasien kelompok perlakuan mendapat 2gram ekstrak MO per hari, sedangkan pada kelompok kontrol mendapat plasebo. Perlakuan dilakukan selama 4 minggu, Pemeriksaan MPV dan NLR menggunakan haemositometer. Analisis statistik dilakukan dengan menggunakan uji-T berpasangan dan uji-T independen. Nilai p dianggap signifikan ketika p <0,05. Hasil penelitian menunjukkan bahwa MO menurunkan MPV (delta MPV = 4.141; r = 0.656; p = 0.02) dan NLR (delta NLR = 4.1391; r 0.489; p-value = 0.04). dapat disimpulkan MO menurunkan MPV dan NLR pada pasien autoimun.

[PP.21.11] REFERENCE VALUES AND DISTRIBUTION OF THE NEUTROPHIL TO LYMPHOCYTE RATIO IN A LARGE-SCALE POPULATION

2016 ◽  
Vol 34 ◽  
pp. e247-e248 ◽  
Author(s):  
E. HUGUET ◽  
G. Maccallini ◽  
P. Pardini ◽  
M. Hidalgo ◽  
S. Obregon ◽  
...  
Keyword(s):  
Reference Values ◽  
Large Scale ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Scale Population

Impact of Elevated Serum Uric Acid Levels on Systemic Inflammation in Patients With Psoriasis

Angiology ◽  
2016 ◽  
Vol 68 (3) ◽  
pp. 266-270 ◽  
Author(s):  
Berna Solak ◽  
Bahar Sevimli Dikicier ◽  
Teoman Erdem
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Systemic Inflammation ◽  
Linear Regression Analysis ◽  
Fasting Blood Glucose ◽  
Elevated Serum ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Pasi Score ◽  
Wbc Count

Patients with psoriasis have increased systemic inflammation and serum uric acid (SUA) levels compared with the general population. However, the role of SUA in modulating inflammation in these patients is not known. We evaluated the associations of SUA with inflammation and psoriasis severity; 199 patients with psoriasis and 54 healthy volunteers were included in the study. Demographic features, Psoriasis Area and Severity Index (PASI) scores, and laboratory data including SUA, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were collected. Patients with psoriasis had higher fasting blood glucose, body mass index (BMI), CRP, SUA, white blood cell (WBC) count, neutrophil count, and NLR compared with controls. The PASI score positively correlated only with CRP ( r = .185, P = .012) and NLR ( r = .313, P < .001). The BMI, WBC count, PASI score, and CRP, but not SUA, appeared as independent associates of NLR in patients with psoriasis in linear regression analysis. Neutrophil to lymphocyte ratio and SUA were significantly increased in patients with psoriasis compared with controls. Neutrophil to lymphocyte ratio and CRP were independent predictors of PASI score, whereas SUA was not. Serum uric acid seemed not to modulate the inflammation seen in patients with psoriasis in our cohort.

scholarly journals Systemic Inflammatory Response Based on Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker in Bladder Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Hyung Suk Kim ◽  
Ja Hyeon Ku
Keyword(s):  
Inflammatory Response ◽  
Cancer Patients ◽  
Systemic Inflammatory Response ◽  
Neutrophil To Lymphocyte Ratio ◽  
Oncologic Outcomes ◽  
Survival Outcomes ◽  
Lymphocyte Ratio ◽  
The Past ◽  
Differential White Blood Cell

A growing body of evidence suggests that systemic inflammatory response (SIR) in the tumor microenvironment is closely related to poor oncologic outcomes in cancer patients. Over the past decade, several SIR-related hematological factors have been extensively investigated in an effort to risk-stratify cancer patients to improve treatment selection and to predict posttreatment survival outcomes in various types of cancers. In particular, one readily available marker of SIR is neutrophil-to-lymphocyte ratio (NLR), which can easily be measured on the basis of absolute neutrophils and absolute lymphocytes in a differential white blood cell count performed in the clinical setting. Many investigators have vigorously assessed NLR as a potential prognostic biomarker predicting pathological and survival outcomes in patients with urothelial carcinoma (UC) of the bladder. In this paper, we aim to present the prognostic role of NLR in patients with UC of the bladder through a thorough review of the literature.

scholarly journals Neutrophil-to-lymphocyte ratio is a prognostic factor for colon cancer: a propensity score analysis

2020 ◽  
Author(s):  
Junichi Mazaki ◽  
Kenji katsumata ◽  
Kenta Kasahara ◽  
Tomoya Tago ◽  
Takahiro Wada ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Factor ◽  
Propensity Score ◽  
Propensity Score Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Oncologic Outcomes ◽  
Lymphocyte Ratio ◽  
Score Analysis ◽  
Significant Difference

Abstract Background: A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of cancer-associated malnutrition such as the neutrophil-to-lymphocyte ratio (NLR) in cancer recurrence and death has been increasingly recognized. This study aimed to analyze long-term oncologic outcomes of Stage II-III colon cancer to examine the prognostic value of NLR using a propensity score analysis.Methods: A total of 442 patients with colon cancer underwent radical surgery between 2000 and 2014 at Tokyo Medical University Hospital. Long-term oncologic outcomes of these patients were evaluated according to NLR values. A cut-off NLR of 3.0 was used based on receiver operating characteristic curve analysis. A propensity score analysis according to tumor sidedness was also performed. Primary outcomes were overall survival (OS) and relapse-free survival (RFS). Results: Patients with lower NLR values (“lower NLR group”) were more likely to have lymph node metastasis compared to those with higher NLR values (“higher NLR group”) before case matching. After case matching, clinical outcomes were similar between the two groups. There were no significant difference in 5-year OS and 5-year RFS rates between the two groups before case matching based on propensity scores. After case matching, 5-year OS rates were 94.5% in the lower NLR group (n = 135) and 87.0% in the higher NLR group (n = 135), showing a significant difference (p = 0.042). Five-year RFS rates were 87.8% in the lower NLR group and 77.9% in the higher NLR group, also showing a significant difference (p = 0.032). Among patients with left-sided colon cancer, 5-year OS and 5-year RFS rates were 95.2% and 87.3% in the lower NLR group (n = 88), respectively, and 86.4% and 79.2% in the higher NLR group (n = 71), respectively, showing significant differences (p = 0.014 and p = 0.047, respectively).Conclusions: The NLR is an important prognostic factor for advanced colon cancer, especially for left-sided colon cancer.

Frequency of High Neutrophil and Lymphocyte Ratio (NLR) Among NSTEMI/USA patients

2021 ◽  
Vol 15 (8) ◽  
pp. 2031-2034
Author(s):  
Afaq Shamim ◽  
Aijaz Zeeshan Khan Chachar ◽  
Miqdad Haider ◽  
Mohsin Asif ◽  
Sajjad Ali ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Chronic Stable Angina ◽  
Case Series ◽  
Neutrophil To Lymphocyte Ratio ◽  
Total Leucocyte Count ◽  
P Value ◽  
Lymphocyte Ratio ◽  
Case Series Study ◽  
History Of ◽  
St Elevation

Background: Neutrophil to lymphocyte ratio (NLR) is comparatively a new prognostic marker used in patients with chronic stable angina (CSA). NLR can help in predicting short and long term moralities in NSTEMI patients. Aim: To evaluate the frequency of high neutrophil and lymphocyte ratio among NSTEMI/USA patients and to compare frequency of mortality in patients of NSTEMI/USA having high NLR with those without high NLR. Study design& duration: Descriptive, case series study from 25th November 2020 to 24th May 2021. Study settings: Department of Medicine and Cardiology, Fatima Memorial Hospital, Lahore. Methods: 185 patients having non ST elevation myocardial infarction (NSTEMI) and/or unstable angina (UA) having 30 to 70 years age and both males and females were included. Patients with sepsis having total Leucocyte count (TLC>11,000/<4000), history of surgery or on steroids in the past three months, history of hematological malignancy, late for fibrinolysis or those with contraindication to fibrinolysis were excluded were excluded. Demographic information (name, age, address, and education) was also noted. Results: Mean age of the participants was 57.99 ± 6.10 years while the age range was from 30 to 70 years. Most of patients 164 were included in the age group of 51 to 70 years. 110 (59.46%) patients were male and 75 (46.54%) of them were females. Frequency of neutrophil and lymphocyte ratio among NSTEMI/USA patients was found in 91 (49.19%) patients. My study has shown higher frequency of mortality in patients of NSTEMI/USA having high NLR 26 (28.57%) compared to normal NLR 06 (6.38%) with p value = 0.0001. Conclusion: Frequency of high neutrophil and lymphocyte ratio among NSTEMI/USA patients is very high with higher mortality in high Neutrophil-to-lymphocyte ratio group as compared to low NLR group. Keywords: Myocardial infarction, Non ST elevation, Neutrophil-to-lymphocyte ratio

scholarly journals Feasibility of The Use of Neutrophil To Lymphocyte Ratio (NLR) As An Adjunct To Cytology To Suggest Thyroid Malignancy: A Prospective Study

2021 ◽  
Author(s):  
Pawan Kumar Tiwari ◽  
Biju Varghese ◽  
Arunjeet KK ◽  
Pankaj P Rao ◽  
Dronacharya Routh
Keyword(s):  
Tertiary Care ◽  
High Sensitivity ◽  
Needle Aspiration ◽  
Neutrophil To Lymphocyte Ratio ◽  
P Value ◽  
Care Hospital ◽  
Thyroid Malignancy ◽  
Class Iii ◽  
Lymphocyte Ratio ◽  
Area Under Roc Curve

Abstract Background: Inflammation is known to be associated with cancer development and progression. NLR is a simple and efficient marker of inflammation in numerous malignancies. Aim: The study aimed to investigate usefulness of neutrophil to lymphocyte ratio (NLR) as an adjunct to Fine needle aspiration cytology (FNAC) to suggest thyroid malignancy confirmed by histopathological report post operatively in Bethesda class III, IV & V.Methods: Prospective observational study at a tertiary care hospital over 2 years.Results: NLR in the benign group and malignant group were 1.75+0.23 and 2.19+0.29 (mean + SD) respectively (p-value <0.001). Area under ROC curve plotted was 0.823 (p-value <0.001), with recommended cut-off of 1.9. Relatively high sensitivity and specificity at 87.5 % and 82.5% implies excellent diagnostic accuracy.Conclusion: NLR with a value of 1.9 or higher is recommended as predictor of malignancy in thyroid nodule.

scholarly journals Neutrophil to Lymphocyte Ratio in Preeclampsia

2021 ◽  
pp. 115-118
Author(s):  
Alfian Prasetyo ◽  
Sheella Rima Bororing ◽  
Yuma Sukadarma
Keyword(s):  
Systematic Review ◽  
Diagnostic Criteria ◽  
Screening Tool ◽  
Neutrophil To Lymphocyte Ratio ◽  
Screening Tools ◽  
P Value ◽  
Lymphocyte Ratio

Abstract Objective: To determine the correlation between neutrophil to lymphocyte ratio and preeclampsia. To determine whether neutrophil to lymphocyte ratio can be used as a screening tool for preeclampsia.Methods: This study was conducted with a systematic review method. Articles that had been gathered and filtered were reviewed by QUADAS-2 tool. Guidelines from the American Congress of Obstetricians and Gynecologists (ACOG) and Pedoman Nasional Pelayanan Kedokteran were used as a diagnostic criteria for determining preeclampsiaResults: Studies conducted by Kirbas et al, Cakmak et al, Wang et al and Panwar et al stated that there is a correlation between neutrophil to lymphocyte ratio to preeclampsia (p-value < 0.05). Cut-off values are diverse between 3.5 - 5.6 with different sensitivity and specificity.Conclusion: This systematic review shows that there is a relationship between neutrophil to lymphocyte ratio and preeclampsia. Neutrophil to lymphocyte ratio can be used as screening tools for preeclampsia in the first trimester.Keywords: neutrophil to lymphocyte ratio, NLR, preeclampsia. Abstrak Tujuan: Mengetahui apakah terdapat hubungan antara rasio neutrofil terhadap limfosit dengan preeklampsia. Mengetahui apakah rasio neutrofil terhadap limfosit dapat dijadikan sebagai alat bantu skrining preeklampsia.Metode: Penelitian ini dilakukan dengan metode systematic review. Artikel yang disaring akan ditentukan kualitasnya menggunakan QUADAS-2. Kriteria diagnostik preeklampsia yang digunakan adalah American College of Obstetricians and Gynecologists (ACOG) untuk penelitian luar negeri dan Pedoman Nasional Pelayanan Kedokteran untuk penelitian dalam negeri.Hasil : Penelitian yang dilakukan oleh Kirbas et al, Cakmak et al, Wang et al, dan Panwar et al menyatakan bahwa terdapat hubungan antara rasio neutrofil terhadap limfosit dengan preeklampsia ( p-value < 0.05). Nilai cutoff dari rasio neutrofil terhadap preeklampsia beragam mulai dari 3.5 - 5.6 dengan sensitivitas dan spesifisitas yang berbeda-beda.Kesimpulan : Penelitian systematic review ini menunjukan bahwa rasio neutrofil terhadap limfosit memiliki hubungan dengan penyakit preeklampsia. Rasio neutrofil terhadap limfosit dapat dijadikan sebagai alat bantu skrining untuk preeklampsia pada trimester pertama.Kata kunci: rasio neutrofil terhadap Limfosit, NLR, preeklamsia.

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