Multi-Wavelength Photobiomodulation Therapy Combined with Static Magnetic Field on Long-Term Pulmonary Complication after COVID-19: A Case Report

Introduction: Photobiomodulation therapy, alone (PBMT) or combined with a static magnetic field (PBMT-sMF), has been demonstrated to be effective in the regeneration of tissues, modulation of inflammatory processes, and improvement in functional capacity. However, the effects of PBMT-sMF on the pulmonary system and COVID-19 patients remain scarce. Therefore, in this case report, we demonstrated the use of PBMT-sMF for peripheral oxygen saturation, pulmonary function, massive lung damage, and fibrosis as a pulmonary complication after COVID-19. Case report: A 53-year-old Mexican man who presented with decreased peripheral oxygen saturation, massive lung damage, and fibrosis after COVID-19 received PBMT-sMF treatment once a day for 45 days. The treatment was irradiated at six sites in the lower thorax and upper abdominal cavity and two sites in the neck area. We observed that the patient was able to leave the oxygen support during the treatment, and increase his peripheral oxygen saturation. In addition, the patient showed improvements in pulmonary severity scores and radiological findings. Finally, the patient presented with normal respiratory mechanics parameters in the medium-term, indicating total pulmonary recovery. Conclusions: The use of PBMT-sMF may potentially lead to safe treatment of and recovery from pulmonary complications after COVID-19, with regard to the structural and functional aspects.

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Immediate effects of photobiomodulation therapy combined with static magnetic field on the subsequent performance: a preliminary randomized crossover triple-blinded placebo-controlled trial

Biomedical Optics Express ◽

10.1364/boe.442075 ◽

2021 ◽

Author(s):

Ivo Aleixo-Junior ◽

Ernesto Cesar Leal-Junior ◽

Heliodora Casalechi ◽

Adriane Vanin ◽

Paulo Roberto de Paiva ◽

...

Keyword(s):

Magnetic Field ◽

Static Magnetic Field ◽

Controlled Trial ◽

Photobiomodulation Therapy ◽

Subsequent Performance

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Effects of photobiomodulation therapy combined to static magnetic field in strength training and detraining in humans: protocol for a randomised placebo-controlled trial

BMJ Open ◽

10.1136/bmjopen-2019-030194 ◽

2019 ◽

Vol 9 (10) ◽

pp. e030194

Author(s):

Paulo Roberto Vicente de Paiva ◽

Heliodora Leão Casalechi ◽

Shaiane Silva Tomazoni ◽

Caroline dos Santos Monteiro Machado ◽

Adriane Aver Vanin ◽

...

Keyword(s):

Magnetic Field ◽

Strength Training ◽

Static Magnetic Field ◽

Light Emitting Diode ◽

Controlled Trial ◽

Photobiomodulation Therapy ◽

Low Level Laser Therapy ◽

Controlled Clinical Trial ◽

Scientific Publications ◽

Ergogenic Effects

IntroductionIn recent years, it has been demonstrated that photobiomodulation therapy (PBMT) using low-level laser therapy and/or light-emitting diode therapy combined to static magnetic field (sMF) has ergogenic effects, improving muscular performance and accelerating postexercise recovery. However, many aspects related to these effects and its clinical applicability remain unknown. Therefore, the aim of this project is to evaluate the ergogenic effects of PBMT/sMF in detraining after a strength-training protocol.Methods and analysisThe study will be a randomised, triple-blind, placebo-controlled clinical trial. Healthy male volunteers will be randomly distributed into four experimental groups: PBMT/sMF before training sessions + PBMT/sMF during detraining, PBMT/sMF before training sessions + placebo during detraining, placebo before training sessions + PBMT/sMF during detraining and placebo before training sessions + placebo during detraining. Strength-training sessions will be carried out over 12 weeks, and the detraining period will occur during the 4 weeks after. The muscular strength and the structural properties of quadriceps will be analysed.Ethics and disseminationThis study was approved by the Research Ethics Committee of Nove de Julho University. The results from this study will be disseminated through scientific publications in international peer-reviewed journals and presented at national and international scientific meetings.Trial registration numberNCT03858179.

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Does photobiomodulation therapy combined to static magnetic field (PBMT-sMF) promote ergogenic effects even when the exercised muscle group is not irradiated? A randomized, triple-blind, placebo-controlled trial

BMC Sports Science Medicine and Rehabilitation ◽

10.1186/s13102-020-00197-6 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Caroline dos Santos Monteiro Machado ◽

Heliodora Leão Casalechi ◽

Adriane Aver Vanin ◽

Jônatas Bezerra de Azevedo ◽

Paulo de Tarso Camillo de Carvalho ◽

...

Keyword(s):

Magnetic Field ◽

Static Magnetic Field ◽

Eccentric Exercise ◽

Local Group ◽

Controlled Trial ◽

Photobiomodulation Therapy ◽

Exercise Protocol ◽

Ergogenic Effects ◽

Non Local ◽

Musculoskeletal Performance

Abstract Background The direct application of photobiomodulation therapy (PBMT) using low-level laser therapy (LLLT) and light emitting diodes (LEDs) combined with a static magnetic field (sMF) (PBMT-sMF) to target tissues is shown to improve muscle performance and recovery. Studies have reported possible PBMT effects when a local distant to the target tissue is irradiated. Notably, the extent of these effects on musculoskeletal performance and the optimal site of irradiation remain unclear, although this information is clinically important since these aspects could directly affect the magnitude of the effect. Therefore, we investigated the effects of local and non-local PBMT-sMF irradiations on musculoskeletal performance and post-exercise recovery before an eccentric exercise protocol. Methods This randomized, triple-blind (participants, therapists and assessors), placebo-controlled trial included 30 healthy male volunteers randomly assigned to the placebo, local, and non-local groups. Active or placebo PBMT-sMF was applied to 6 sites of the quadriceps muscle of both legs. An eccentric exercise protocol was used to induce fatigue. The primary outcome was peak torque assessed by maximal voluntary contraction (MVC). The secondary outcomes were delayed onset muscle soreness (DOMS) measured by visual analogue scale (VAS), muscle injury assessed by serum creatine kinase activity (CK), and blood lactate levels. Evaluations were performed before the eccentric exercise protocol (baseline), as well as immediately after and 1, 24, 48, and 72 h upon protocol completion. Results Ten volunteers were randomized per group and analysed for all outcomes. Compared to the placebo and non-local groups, irradiation with PBMT-SMF led to statistically significant improvement (p < 0.05) with regard to all variables in the local group. The outcomes observed in the non-local group were similar to those in the placebo group with regard to all variables. The volunteers did not report any adverse effects. Conclusion Our results support the current evidence that local irradiation of all exercised muscles promotes ergogenic effects. PBMT-sMF improved performance and reduced muscle fatigue only when applied locally to muscles involved in physical activity. Trial registration NCT03695458. Registered October 04th 2018.

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The Dose Makes the Poison: A Case Report of Acquired Methemoglobinemia

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17061845 ◽

2020 ◽

Vol 17 (6) ◽

pp. 1845

Author(s):

Giulia Cannata ◽

Luciana Abate ◽

Chiara Scarabello ◽

Monica Rubini ◽

Alessandra Giacometti ◽

...

Keyword(s):

Case Report ◽

Oxygen Saturation ◽

Partial Pressure ◽

Venous Blood ◽

Nasal Cannula ◽

Partial Pressure Of Oxygen ◽

Blood Oxygen Saturation ◽

Peripheral Oxygen Saturation ◽

Methemoglobin Level ◽

Arterial Blood

Background: Methemoglobinemia (MET) should be suspected in cases where cyanosis is not associated with signs and symptoms of lung and/or heart disease, or in a cyanotic child exhibiting discrepancies in the partial pressure of oxygen in the arterial blood, the blood oxygen saturation, and the clinical assessment. Case presentation: A 10-month-old girl was taken to the Pediatric Emergency Department for the acute, sudden development of significant peroral cyanosis associated with gray pigmentation of the skin. The problem was evidenced approximately one hour after she ingested a homemade puree of mixed vegetables, mainly composed of potatoes and chards that had been prepared three days before and had been kept in the refrigerator since then. Physical examination revealed that the child was very pale, conscious, and without respiratory distress. Oxygen saturation of hemoglobin in the arterial blood (SpO2) was 94%. Respiratory, cardiovascular, and abdominal evaluations did not reveal any signs of disease. A venous blood sample showed chocolate-colored blood with a pH of 7.404, a partial pressure of CO2 (pCO2) of 40.6 mmHg, a partial pressure of oxygen (pO2) of 21.3 mmHg, a bicarbonate level of 24 mmol/L, and an oxygen saturation (SO2%) of 47.7%. CO-oximetry carried out simultaneously identified a methemoglobin level of 22%. MET was suspected, and oxygen via nasal cannula at a rate of 4 L/min was given with only a slight increase in oxygen saturation (96%). Slow intravenous injection of methylene blue 1 mg/kg over a period of 5 min was initiated. The peripheral oxygen saturation (SpO2) gradually improved to 100% over the next 20 min. Forty minutes later, venous blood gas analysis showed a methemoglobin level of 0.9% with a complete resolution of cyanosis; supplemental oxygen via nasal cannula was therefore discontinued. During the next 36 h, the patient remained hemodynamically stable with good oxygenation on room air. Conclusions: This case report shows that recognition of acquired MET in a child with sudden cyanosis onset requires a high index of suspicion. In daily activities, there is a need to pay particular attention when homemade vegetable soups for child alimentation are prepared. The consumption of vegetable soups must occur immediately after preparation. Storage in a refrigerator must last no more than 24 h and if longer storage is needed, vegetable soups should be frozen.

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Effects of Photobiomodulation Therapy Combined with Static Magnetic Field in Severe COVID-19 Patients Requiring Intubation: A Pragmatic Randomized Placebo-Controlled Trial

Journal of Inflammation Research ◽

10.2147/jir.s318758 ◽

2021 ◽

Vol Volume 14 ◽

pp. 3569-3585

Author(s):

Thiago De Marchi ◽

Fabiano Frâncio ◽

João Vitor Ferlito ◽

Renata Weigert ◽

Cristiane de Oliveira ◽

...

Keyword(s):

Magnetic Field ◽

Static Magnetic Field ◽

Controlled Trial ◽

Photobiomodulation Therapy

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Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy

Case Reports in Pediatrics ◽

10.1155/2020/2853531 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Leah S. Heidenreich ◽

Jennifer L. Oliveira ◽

Peter J. Holmberg ◽

Vilmarie Rodriguez

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Case Report ◽

Oxygen Saturation ◽

Pulse Oximetry ◽

Congenital Heart ◽

Oxygen Affinity ◽

Low Oxygen ◽

Peripheral Oxygen Saturation ◽

Low Oxygen Affinity

Pulse oximetry is routinely used in the newborn nursery for clinical monitoring and to detect critical congenital heart disease. The differential diagnoses for reduced peripheral oxygen saturation in an infant include congenital heart disease, respiratory distress syndrome, transient tachypnea of the newborn, persistent pulmonary hypertension of the newborn, meconium aspiration syndrome, pneumonia, pneumothorax, and sepsis. The diagnostic evaluation for neonatal hypoxemia can be invasive and expensive. When this evaluation is unrevealing, other interventions may be tried without clear benefit to the patient, including, but not limited to, supplemental oxygen. Therefore, it is important to consider alternative, albeit rare, diagnoses, including hemoglobinopathies with abnormal oxygen binding properties. Mutations in the structure of alpha- and beta-globin chains can alter the affinity of hemoglobin for oxygen, and changes in oxygen affinity may result in changes in the oxygen saturation detected by pulse oximetry. These changes may or may not be of clinical significance. This case report describes Hemoglobin Sunshine Seth, a rare low-oxygen-affinity hemoglobin variant presenting as reduced peripheral oxygen saturation in an otherwise well-appearing infant male.

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Does photobiomodulation therapy combined to static magnetic field (PBMT-sMF) promote ergogenic effects even when the non-exercised leg is irradiated? A randomized, triple-blind, placebo-controlled trial.

10.21203/rs.2.19987/v1 ◽

2020 ◽

Author(s):

Caroline dos Santos Monteiro Machado ◽

Heliodora Leão Casalechi ◽

Adriane Aver Vanin ◽

Jônatas Bezerra de Azevedo ◽

Paulo de Tarso Camillo de Carvalho ◽

...

Keyword(s):

Magnetic Field ◽

Static Magnetic Field ◽

Statistical Significance ◽

Photobiomodulation Therapy ◽

Muscle Performance ◽

Current Evidence ◽

Controlled Study ◽

Exercise Protocol ◽

Ergogenic Effects ◽

Musculoskeletal Performance

Abstract Background The direct application of photobiomodulation therapy (PBMT) combined with a static magnetic field (sMF) (PBMT-sMF) to target tissues is shown to improve muscle performance and recovery. Studies have reported possible PBMT induced systemic effects. Notably, the extent of these effects on musculoskeletal performance and the optimal site of application remain unclear, although this information is clinically important because these factors directly affect the magnitude of the effect. We investigated the effects of PBMT-sMF on musculoskeletal performance and post-exercise recovery of muscles in exercised and non-exercised legs before the implementation of an exercise protocol.Methods This randomized, triple-blind placebo-controlled study included 30 healthy men randomly assigned to the placebo, exercised-leg, and non-exercised leg groups. Active or placebo PBMT-sMF was applied to 6 sites of the quadriceps muscle of both legs. An eccentric exercise protocol was used to induce fatigue. The following parameters were analyzed to evaluate exercise performance: peak torque assessed by maximal voluntary contraction (MVC), delayed muscle pain assessed by the visual analogue scale (VAS), muscle injury assessed by serum creatine kinase (CK), and fatigue assessed by serum lactate levels. Evaluations were performed before implementation of the eccentric (baseline) exercise protocol, as well as immediately after and 1, 24, 48, and 72 hours upon protocol completion. The Bonferroni post-hoc ANOVA test was used considering the level of statistical significance p <0.05.Results Compared to the placebo and systemic groups, irradiation with PBMT-SMF led to statistically significant improvement (p <0.05) with regard to all variables in the exercised-leg group. Results of irradiation in the non-exercised leg group were similar to those in the placebo group with regard to all variables.Conclusion Our results support the current evidence that irradiation of all exercised muscles produces ergogenic effects. PBMT-sMF improved performance and reduced muscle fatigue only when applied locally to muscles involved in physical activity.

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