2-(2-(4-Methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic Acid
A simple and efficient protocol for the synthesis of the previously unknown 2-(2-(4-methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic acid was elaborated. The suggested method is based on the telescoped multicomponent reaction of 8-hydroxyquinoline, 4-methylglyoxal, and Meldrum’s acid. The studied process includes the initial interaction of the starting compounds in MeCN followed by intramolecular cyclization to the target product in refluxing acetic acid. The advantage of this approach is the application of readily available starting materials, atom economy, and a simple work-up procedure. The structure of the synthesized furylacetic acid derivative was proven by 1H, 13C, 2D-NMR, IR spectroscopy, and high-resolution mass spectrometry.
2013 ◽
Vol 8
(9)
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pp. 1934578X1300800
2008 ◽
Vol 3
(2)
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pp. 1934578X0800300
2007 ◽
Vol 62
(1)
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pp. 132-134
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2012 ◽
Vol 7
(1)
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pp. 1934578X1200700
2020 ◽
2020 ◽
Vol 86
(8)
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pp. 23-31