scholarly journals Araguspongine C Induces Autophagic Death in Breast Cancer Cells through Suppression of c-Met and HER2 Receptor Tyrosine Kinase Signaling

Marine Drugs ◽  
2015 ◽  
Vol 13 (1) ◽  
pp. 288-311 ◽  
Author(s):  
Mohamed Akl ◽  
Nehad Ayoub ◽  
Hassan Ebrahim ◽  
Mohamed Mohyeldin ◽  
Khaled Orabi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Receptor Tyrosine Kinase ◽  
Breast Cancer Cells ◽  
Kinase Signaling ◽  
Her2 Receptor ◽  
Tyrosine Kinase Signaling

scholarly journals ER-positive breast cancer cells are poised for RET-mediated endocrine resistance

2017 ◽  
Author(s):  
Sachi Horibata ◽  
Edward J. Rice ◽  
Hui Zheng ◽  
Lynne J. Anguish ◽  
Scott A. Coonrod ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Endocrine Resistance ◽  
Breast Cancers ◽  
Kinase Signaling ◽  
Tyrosine Kinase Signaling ◽  
Kinase Signaling Pathway

AbstractThe RET tyrosine kinase signaling pathway is involved in the development of endocrine resistant ER+ breast cancer. However, the expression of the RET receptor itself has not been directly linked to clinical cases of resistance, suggesting that additional factors are involved. We show that both ER+ endocrine resistant and sensitive breast cancers have functional RET tyrosine kinase signaling pathway, but that endocrine sensitive breast cancer cells lack RET ligands that are necessary to drive endocrine resistance. Transcription of one RET ligand, GDNF, is necessary and sufficient to confer resistance in the ER+ MCF-7 cell line. In patients, RET ligand expression predicts responsiveness to endocrine therapies and correlates with survival. Collectively, our findings show that ER+ tumor cells are “poised” for RET mediated endocrine resistance, expressing all components of the RET signaling pathway, but endocrine sensitive cells lack high expression of RET ligands that are necessary to initiate the resistance phenotype.

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