scholarly journals Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A-E

Marine Drugs ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. 519
Author(s):  
Tarik A. Mohamed ◽  
Abdelsamed I. Elshamy ◽  
Asmaa M. Abdel-Tawab ◽  
Mona M. AbdelMohsen ◽  
Shinji Ohta ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Soft Coral ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Coral Genus ◽  
Cytotoxic Compound ◽  
Oral Cavity Carcinoma ◽  
Ic50 Values ◽  
Enzymatic Machinery

The soft coral genus Sarcophyton contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A-E (1–5) were purified and characterized from an ethyl acetate extract of the red sea soft coral, Sarcophyton convolutum. Compounds were assemblies according to spectroscopic methods including FTIR, 1D- and 2D-NMR as well as HRMS. Metabolite cytotoxicity was tested against lung adenocarcinoma, cervical cancer, and oral-cavity carcinoma (A549, HeLa and HSC-2, respectively). The most cytotoxic compound, (4) was observed to be active against cell lines A549 and HSC-2 with IC50 values of 49.70 and 53.17 μM, respectively.

scholarly journals Fusarins G–L with Inhibition of NO in RAW264.7 from Marine-Derived Fungus Fusarium solani 7227

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 305
Author(s):  
Guangyuan Luo ◽  
Li Zheng ◽  
Qilin Wu ◽  
Senhua Chen ◽  
Jing Li ◽  
...  
Keyword(s):  
Fusarium Solani ◽  
2D Nmr ◽  
Inflammatory Activity ◽  
Raw264.7 Cells ◽  
Spectroscopic Methods ◽  
X Ray ◽  
X Ray Crystallography ◽  
Structure Activity ◽  
Ic50 Values ◽  
New Compounds

Six new fusarin derivatives, fusarins G–L (1–6), together with five known compounds (5–11) were isolated from the marine-derived fungus Fusarium solani 7227. The structures of the new compounds were elucidated by means of comprehensive spectroscopic methods (1D and 2D NMR, HRESIMS, ECD, and ORC) and X-ray crystallography. Compounds 5–11 exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide, with IC50 values ranging from 3.6 to 32.2 μM. The structure–activity relationships of the fusarins are discussed herein.

scholarly journals CONTRIBUTE TO STUDY ON CHEMICAL CONSTITUENTS OF URENA LOBATA (L.) OF VIETNAM

2019 ◽  
Vol 57 (2) ◽  
pp. 162
Author(s):  
Quan Minh Pham ◽  
Hoai Van Thi Tran ◽  
Lam Tien Do ◽  
Phuong Lan Doan ◽  
Inh Thi Cam ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Spectroscopic Methods ◽  
Tree Roots ◽  
Chemical Structures ◽  
Phytochemical Investigation ◽  
First Time

Urena lobata L. is used in Vietnamese traditional medicine for the treatment of several diseases. Tree roots are used to treat rheumatism, dysentery, poor digestion, flu, tonsils, malaria, asthma, goiter. Flowers are used to treat chickenpox, fever, and mental disorders. Branches, leaves or whole trees used to treat injuries bruises, rheumatism, mastitis, bites. Phytochemical investigation of the n-hexan and ethyl acetate extract of Urena lobata L. led to the isolation of β-sitosterol (1), β-sitosterol-3-O-β-D-glucopyranoside (2), a-acetylamino-phenylpropyl a-benzoylamino-phenylpropanoate (3), quercetin (4), and trans-tiliroside (5). Their chemical structures were determined by spectroscopic methods including MS, 1D, 2D NMR and comparing with those reported in previous papers. Two compounds 3, 5 were isolated for the first time from Urena lobata plant.

scholarly journals A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL Anthelia sp.

2013 ◽  
Vol 13 (3) ◽  
pp. 216-220 ◽  
Author(s):  
Anggia Murni ◽  
Novriyandi Hanif ◽  
Junichi Tanaka
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Ethyl Acetate ◽  
Spectroscopic Data ◽  
Soft Coral ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Cancer Drug ◽  
Nmr Data ◽  
Anti Cancer

One new dolabellane (1) and two known diterpenoids stolonidiol (2) and clavinflol B (3) have been isolated from the ethyl acetate extract of the Indonesian soft coral Anthelia sp. A new compound 1 exhibited a moderate cytotoxicity against NBT-T2 cells at 10 µg/mL, while known compounds 2 and 3 showed cytotoxicity at 1 and 0.5 µg/mL, respectively. Structure of the new compound 1 was elucidated by interpretation of NMR spectroscopic data (1D and 2D NMR data) and mass spectrometry (ESIMS data) as well as comparison with those of related ones. This finding should be useful for anti cancer drug development of the promising dolabellane-types compound.

scholarly journals Four Flavan-3-ol Compounds From The Stembark of Chisocheton balansae C.DC. (MELIACEAE)

Molekul ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 9
Author(s):  
Unang Supratman ◽  
Mohamad Fajar ◽  
Supriatno Salam ◽  
Rani Maharani ◽  
Desi Harneti ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
13C Nmr ◽  
Chemical Structure ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Stem Bark ◽  
Spectroscopic Methods ◽  
Endemic Plants ◽  
North Sulawesi ◽  
First Time

Chisocheton balansae C.DC., is one of the Meliaceae family plants which is the endemic plants from Soputan Mountain, North Sulawesi, Indonesia. This study was aimed to determine the chemical structure of flavan-3-ol compounds from ethyl acetate extract of C. balansae C.DC stembark. Dried powder of C. balansae C.DC stem bark was extracted consecutively with n-hexane, ethyl acetate, and methanol solvents. Four flavan-3-ol compounds, named catechin (1), epicatechin (2), epigallocatechin-3-O-gallate (3), and epicatechin-3-O-gallate (4) were successfully isolated from ethyl acetate extract. The chemical structure of these isolates was determined by spectroscopic methods (1H-NMR, 13C-NMR, DEPT, and 2D-NMR) and comparison with previous reported spectral data. These compounds are first time reported from this plant.

scholarly journals New Cembranoids from the Soft Coral Sinularia arborea

2014 ◽  
Vol 9 (3) ◽  
pp. 1934578X1400900
Author(s):  
Li-Hsueh Wang ◽  
Kuan-Hua Chen ◽  
Chang-Feng Dai ◽  
Tsong-Long Hwang ◽  
Wei-Hsien Wang ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Soft Coral ◽  
Ethyl Acetate Extract ◽  
Inhibitory Effect ◽  
Human Neutrophils ◽  
Spectroscopic Methods

From the ethyl acetate extract of the soft coral Sinularia arborea, a new cembrane-type diterpenoid, arbolide C (1), along with (+)-sarcophytol T (2), an enantiomer of the known cembrane, sarcophytol T, were isolated. The structures of compounds 1 and 2 were established by spectroscopic methods and 1 was found to display an inhibitory effect on the release of elastase by human neutrophils.

scholarly journals 4-ETOKSI-3-METOKSIFENOL DAN METIL-3,4-DIHIDROKSIBENZOAT, DUA SENYAWA TURUNAN FENOLIK DARI EKSTRAK ETIL ASETAT KULIT UMBI GADUNG (Dioscorea hispida Dennst) DAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETIL ASETAT

2018 ◽  
Vol 3 (1) ◽  
pp. 71
Author(s):  
Nanik Siti Aminah ◽  
Alfinda Novi Kristanti ◽  
Qonitah Labibah ◽  
Ana Firdausyah ◽  
Yoshiaki Takaya
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
2D Nmr ◽  
Free Radical Scavenging ◽  
Spectroscopic Methods ◽  
Separation And Purification ◽  
Activity Assay ◽  
Vacuum Liquid Chromatography

Two phenolic compoundnamely 4-ethoxy-3-methoxyphenol and methyl-3,4-dihydroxybenzoic have been isolated fromDioscorea hispida Dennst. The isolation of phenolic compounds was done by maceration methods using methanol, followed by partition with n-hexane and ethyl acetate. The process of separation and purification used various chromatography techniques including vacuum liquid chromatography, column chromatography, and radial chromatography. The structure of isolated compounds were determined by spectroscopic methods including UV-Vis, IR, 1D and 2D NMR. The ethyl acetate extract was evaluated for DPPH free radical scavenging activity assay. The IC50of ethyl acetate extract was 415 ppm. The result of this assay indicated that ethyl acetate extract has a potential as an antioxidant.  Keywords: Dioscorea hispida Dennst, Dioscoreaceae, phenolic, 4-ethoxy-3-methoxyphenol, methyl-3,4-dihydroxybenzoic, and antioxidant

α-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema tsavoense

Planta Medica ◽  
2020 ◽  
Vol 86 (11) ◽  
pp. 776-781 ◽  
Author(s):  
Thuc-Huy Duong ◽  
Tai-Xuan-Hoa Hang ◽  
Pierre Le Pogam ◽  
Thanh-Nha Tran ◽  
Dinh-Hung Mac ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
2D Nmr ◽  
Positive Control ◽  
Chemical Investigation ◽  
Spectroscopic Methods ◽  
Nmr Data ◽  
Ic50 Values

AbstractChemical investigation of the lichen Parmotrema tsavoense led to the isolation of 5 new depsidones, parmosidones F – J (1 – 5). These compounds were structurally elucidated using spectroscopic methods including HRESIMS and 2D NMR data. Compounds 1, 3, and 4 were evaluated for their inhibition of α-glucosidase. All exhibited potent α-glucosidase inhibitory activity with IC50 values ranging from 10.7 to 17.6 µM, which was much lower than that of the positive control acarbose (IC50 449 µM).

scholarly journals Stemphol Galactoside, a New Stemphol Derivative Isolated from the Tropical Endophytic Fungus Gaeumannomyces amomi

2010 ◽  
Vol 5 (4) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Juangjun Jumpathong ◽  
Muna Ali Abdalla ◽  
Saisamorn Lumyong ◽  
Hartmut Laatsch
Keyword(s):  
Carboxylic Acid ◽  
Ethyl Acetate ◽  
Endophytic Fungus ◽  
Kojic Acid ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Spectroscopic Methods

A new stemphol derivative, stemphol 1- O-β-D-galactopyranoside (1b), together with three known metabolites, stemphol (1a), indole-3-carboxylic acid, and kojic acid, has been isolated from the ethyl acetate extract of cultures of Gaeumannomyces amomi BCC4066, an endophytic fungus found on healthy parts of ginger ( Alpinia malaccensis; Thai name Kha-pa). The structure of 1b was established via spectroscopic methods, including 2D NMR measurements and GC/MS experiments.

scholarly journals Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

2021 ◽  
Vol 1 (1) ◽  
pp. 46-51
Author(s):  
Nunung Kurniasih ◽  
Asep Supriadin ◽  
Desi Harneti ◽  
Rizky Abdulah ◽  
Mohamad Nurul Azmi bin Mohamad Taib ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
2D Nmr ◽  
Cytotoxic Effects ◽  
Cytotoxicity Activity ◽  
Chemical Structures ◽  
Ergosterol Peroxide ◽  
Cervical Cancer Cells ◽  
Ic50 Values ◽  
Hela Cervical Cancer Cell

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.

scholarly journals Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031

Marine Drugs ◽  
2021 ◽  
Vol 19 (12) ◽  
pp. 701
Author(s):  
Jieyi Long ◽  
Yaqi Chen ◽  
Weihao Chen ◽  
Junfeng Wang ◽  
Xuefeng Zhou ◽  
...  
Keyword(s):  
Cyclic Peptides ◽  
Soft Coral ◽  
2D Nmr ◽  
X Ray Diffraction ◽  
X Ray ◽  
Cyclic Hexapeptide ◽  
Ic50 Value ◽  
Ic50 Values ◽  
Cyclic Hexapeptides ◽  
Aspergillus Sclerotiorum

Three novel cyclic hexapeptides, sclerotides C–E (1–3), and a new lipodepsipeptide, scopularide I (4), together with a known cyclic hexapeptide sclerotide A (5), were isolated from fermented rice cultures of a soft coral-derived fungus: Aspergillus sclerotiorum SCSIO 41031. The structures of the new peptides were determined by 1D and 2D NMR spectroscopic analysis, Marfey’s method, ESIMS/MS analysis, and single crystal X-ray diffraction analysis. Scopularide I (4) exhibited acetylcholinesterase inhibitory activity with an IC50 value of 15.6 μM, and weak cytotoxicity against the human nasopharyngeal carcinoma cell line HONE-EBV with IC50 values of 10.1 μM.

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