scholarly journals Symptom Burden and Factors Associated with Acute Respiratory Infections in the First Two Years of Life—Results from the LoewenKIDS Cohort

2022 ◽  
Vol 10 (1) ◽  
pp. 111
Author(s):  
Susan Langer ◽  
Johannes Horn ◽  
Cornelia Gottschick ◽  
Bianca Klee ◽  
Oliver Purschke ◽  
...  
Keyword(s):  
Exclusive Breastfeeding ◽  
Respiratory Infections ◽  
Average Duration ◽  
Symptom Burden ◽  
Birth Cohort Study ◽  
Acute Respiratory Infections ◽  
Factors Associated ◽  
Childhood Illnesses ◽  
Specific Symptoms ◽  
Insight Into

Acute respiratory infections (ARIs) are the most common childhood illnesses worldwide whereby the reported frequency varies widely, often depending on type of assessment. Symptom diaries are a powerful tool to counteract possible under-reporting, particularly of milder infections, and thus offer the possibility to assess the full burden of ARIs. The following analyses are based on symptom diaries from participants of the German birth cohort study LoewenKIDS. Primary analyses included frequencies of ARIs and specific symptoms. Factors, which might be associated with an increased number of ARIs, were identified using the Poisson regression. A subsample of two hundred eighty-eight participants were included. On average, 13.7 ARIs (SD: 5.2 median: 14.0 IQR: 10–17) were reported in the first two years of life with an average duration of 11 days per episode (SD: 5.8, median: 9.7, IQR: 7–14). The median age for the first ARI episode was 91 days (IQR: 57–128, mean: 107, SD: 84.5). Childcare attendance and having siblings were associated with an increased frequency of ARIs, while exclusive breastfeeding for the first three months was associated with less ARIs, compared to exclusive breastfeeding for a longer period. This study provides detailed insight into the symptom burden of ARIs in German infants.

scholarly journals Factors related with the incidence of acute respiratory infections in toddlers in Sleman, Yogyakarta, Indonesia: Evidence from the Sleman Health and Demographic Surveillance System

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257881
Author(s):  
Fathmawati Fathmawati ◽  
Saidah Rauf ◽  
Braghmandita Widya Indraswari
Keyword(s):  
Regression Analysis ◽  
Surveillance System ◽  
Respiratory Infections ◽  
Water Source ◽  
Demographic Surveillance System ◽  
Acute Respiratory Infections ◽  
Exclusion Criteria ◽  
Children Under Five ◽  
Under Five ◽  
Factors Associated

Various factors associated with Acute Respiratory Infections (ARI) in toddlers have been widely observed, but there are no studies using data from the Sleman Health and Demographic Surveillance System (HDSS). This study aimed to determine the factors associated with ARI in children under five in Sleman, Yogyakarta, Indonesia. This research was an observational analytic study with a cross-sectional design, using secondary data from the Sleman HDSS. Data of 463 children under five who met the inclusion and exclusion criteria were used in this study. Inclusion criteria were toddlers who have complete observed variable data. The variables observed were the characteristics of children under five, the attributes of the mother, the physical condition of the house, the use of mosquito coils, sanitation facilities, and sources of drinking water. The exclusion criteria were toddlers with pulmonary tuberculosis in the past year. Data analysis used chi-squared tests for bivariate analysis and multivariate logistic regression analysis. The results showed that working mothers had a greater risk of ARI under five children with OR 1.46 (95% CI = 1.01–2.11), and groundwater as a water source was a protective factor against the occurrence of ARI in toddlers with OR 0.46 (95% CI = 0.26–0.81). After a logistic regression analysis was performed, only the drinking water source variable had a statistically significant relationship with the incidence of ARI in children under five with OR = 0.47 (95% CI = 0.268–0.827). Research on the relationship between water quality and the incidence of ARI in children under five is needed to follow up on these findings.

Early nasal microbiota and acute respiratory infections during the first years of life

Thorax ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 592-599 ◽  
Author(s):  
Laura Toivonen ◽  
Kohei Hasegawa ◽  
Matti Waris ◽  
Nadim J Ajami ◽  
Joseph F Petrosino ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Respiratory Infections ◽  
16S Rrna Gene Sequencing ◽  
Population Based ◽  
Birth Cohort Study ◽  
Rrna Gene ◽  
Acute Respiratory Infections ◽  
Rrna Gene Sequencing ◽  
Tract Infections ◽  
Nasal Microbiota

BackgroundEmerging evidence shows that airway microbiota may modulate local immune responses, thereby contributing to the susceptibility and severity of acute respiratory infections (ARIs). However, there are little data on the longitudinal relationships between airway microbiota and susceptibility to ARIs in children.ObjectiveWe aimed to investigate the association of early nasal microbiota and the subsequent risk of ARIs during the first years of life.MethodsIn this prospective population-based birth-cohort study in Finland, we followed 839 healthy infants for ARIs from birth to age 24 months. Nasal microbiota was tested using 16S rRNA gene sequencing at age 2 months. We applied an unsupervised clustering approach to identify early nasal microbiota profiles, and examined the association of profiles with the rate of ARIs during age 2–24 months.ResultsWe identified five nasal microbiota profiles dominated by Moraxella, Streptococcus, Dolosigranulum, Staphylococcus and Corynebacteriaceae, respectively. Incidence rate of ARIs was highest in children with an early Moraxella-dominant profile and lowest in those with a Corynebacteriaceae-dominant profile (738 vs 552/100 children years; unadjusted incidence rate ratio (IRR), 1.34; 95% CI 1.16 to 1.54; p < 0.001). After adjusting for nine potential confounders, the Moraxella-dominant profile-ARI association persisted (adjusted IRR (aIRR), 1.19; 95% CI 1.04 to 1.37; p = 0.01). Similarly, the incidence rate of lower respiratory tract infections (a subset of all ARIs) was significantly higher in children with an early Moraxella-dominant profile (aIRR, 2.79; 95% CI 1.04 to 8.09; p = 0.04).ConclusionMoraxella-dominant nasal microbiota profile in early infancy was associated with an increased rate of ARIs during the first 2 years of life.

scholarly journals The effect of exclusive breastfeeding on reducing acute respiratory infections in low birth weight infants

2012 ◽  
Vol 52 (4) ◽  
pp. 229 ◽  
Author(s):  
Karolina Trigemayanti Tallo ◽  
I Kompyang Gede Suandi ◽  
Setya Wandita
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Exclusive Breastfeeding ◽  
Lower Risk ◽  
Acute Respiratory Infection ◽  
Low Birthweight ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Low Birth Weight Infants ◽  
History Of

Background Infants who are breastfed receive natural protectionagainst certain infections. Despite the known benefits of exclusivebreastfeeding, many Indonesian mothers choose to supplementwith formula. There have been few Indonesian studies on theeffect of exclusive breastfeeding in reducing acute respiratoryinfections in low birth weight infants in their first four monthsof life.Objective To investigate the effect of exclusive breastfeeding inreducing the incidence of acute respiratory infections in low birthweight infants during their first four months of life.Methods We conducted a prospective cohort study on low birthweight babies in Sanglah Hospital, Denpasar. The total numberof subjects was 181. The incidence of acute respiratory infectionsduring the first 4 months of life and the duration of breast feedingwere assessed by questionnaires. Data was analyzed Mth Chisquare and logistic regression tests.Results Infants who were exclusively breastfed for 4 months hada lower risk of acute respiratory infection than those who were notexclusively breastfed (RR 0.07; 95% CI 0.03 to 0.14; P􀁄O.OOI).After adjustment for gestational age, parity, maternal nutritionalstatus, family size, smoke exposure, and history of atopy, infantswho were exclusively breastfed still had a lower risk for acuterespiratory infection than those who were not exclusively breastfed(RR 0.06; 95% CI 0.03 to 0.13; P 􀁄 0.001)Conclusion Exclusive breastfeeding reduced the risk of acuterespiratory infection in low birth weight infants in the first fourmonths after birth. [Paediatr Indones. 2012;52:229,32].

Preventive anti-inflammatory therapy during the acute respiratory infections in children with mild and moderate bronchial asthma

2020 ◽  
Vol 15 (6) ◽  
pp. 35-41
Author(s):  
V.A. Revyakina ◽  
◽  
I.A. Larkova ◽  
E.D. Kuvshinova ◽  
◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Respiratory Infections ◽  
Average Duration ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
External Respiration ◽  
Acute Respiratory Infections ◽  
Acute Period ◽  
Anti Inflammatory

Objective. To evaluate the efficacy and safety of using anti-inflammatory drugs based on ammonium glycyrrhizinate (AG) (Reglisam, CJSC “VIFITECH”, Russia) in children with BA in the acute period of ARI. Patients and methods. Under observation there were 42 children (from 6 to 10 years old) with a diagnosis of BA in the acute period of ARI (1–2 days from the beginning of clinical manifestations). Patients were randomized into the main group – 20 patients who were prescribed the drug ammonium glycyrrhizinate (Reglisam) in addition to symptomatic ARI therapy, and the control group – 22 children who were prescribed only symptomatic ARI therapy. The observation period was 14 days with 2 checkpoints (1st and 14th days), when the following parameters were evaluated: general clinical examination; asthma symptoms; PCR diagnostics of acute respiratory viral infection and influenza pathogens; external respiration and BA control test (C-ACT), administration of additional medications and development of adverse events. Results. There was a decrease in the average scores of daily and night symptoms of BA in the study group, both in dynamics and in comparison with the control group at visit 2 (p < 0.05). The average duration of ARI in the main group was 6.34 ± ± 1.15 days and was less than that in the control group of patients (10.95 ± 1.45 days) (p < 0.05). The average duration of the use of short-acting β2-agonists in the main group was 3.37 ± 1.05 days and was less in comparison with the control group (6.75 ± 1.6) (p < 0.05). On the 14th day of observation in the main group, the median of C-ACT parameters increased and corresponded to good control of BA, and the level of blood eosinophils decreased to normal values; in the control group, no such dynamics was found. In 78% of patients in the main group, on the 14th day of observation, the persistence of previously detected respiratory viruses and influenza was not determined, the proportion of such patients in the control group was more than 2 times less. Conclusion. The data obtained indicate the feasibility and effectiveness of the inclusion of the drug AG as a preventive therapy for children with asthma in the acute period of ARI to improve control over the course of the disease. Key words: bronchial asthma, children, therapy, ammonium glycyrrhizinate, acute respiratory infections

scholarly journals Acute respiratory infections in primary health care centres in northern Saudi Arabia

2000 ◽  
Vol 6 (5-6) ◽  
pp. 955-960
Author(s):  
A. H. El Gilany
Keyword(s):  
Saudi Arabia ◽  
Urban Areas ◽  
Respiratory Infections ◽  
Northern Region ◽  
Acute Respiratory Infections ◽  
National Programme ◽  
Factors Associated ◽  
Upper Respiratory Infections ◽  
Primary Health ◽  
Upper Respiratory

This study was carried out in the northern region of Saudi Arabia during 1419 AH [1998 AD]. A random sample of 1200 prescriptions was analysed to determine the magnitude of factors associated with acute respiratory infections [ARI]and their treatment. ARI were diagnosed in more than one-third of the prescriptions analysed, of which upper respiratory infections accounted for 65.8%, and pneumonia less than 1%. The prevalence of ARI was significantly higher in urban areas, among children, among males and during the colder seasons of the year. Antibiotics were prescribed for 87.8% of patients. This study reinforces the need to implement forthwith the Saudi national programme for diagnosis and treatment of ARI.

scholarly journals Vitamin D deficiency as a factor for immunity stimulation and lower risk of acute respiratory infections and COVID-19

2020 ◽  
Vol 26 (3) ◽  
pp. 295-303 ◽  
Author(s):  
T. L. Karonova ◽  
M. A. Vashukova ◽  
D. A. Gusev ◽  
K. A. Golovatuk ◽  
E. N. Grineva
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Therapeutic Agents ◽  
Acute Respiratory Infections ◽  
Factors Associated ◽  
Prophylactic Measures ◽  
Coronavirus Infection

During the COVID-19 pandemic, the efforts of many researchers around the world are aimed at finding preventive and prophylactic measures as well as therapeutic agents against SARS-CoV-2. Recent studies have showed that vitamin D deficiency could be one of many factors associated with the development and severity of acute respiratory infections, and vitamin D could be used for prevention and treatment of these patients. This review summarizes data about the role of vitamin D in the pathogenesis and prevention of respiratory viral infections, including new coronavirus infection as well as mechanisms for reducing the risk of infection with vitamin D therapy. Probably, this review will be of interest for endocrinologists and other specialists.

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