scholarly journals The Pluripotent Activities of Caffeic Acid Phenethyl Ester

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1335
Author(s):  
Batoryna Olgierd ◽  
Żyła Kamila ◽  
Banyś Anna ◽  
Morawiec Emilia
Keyword(s):  
Wound Healing ◽  
Caffeic Acid ◽  
Honey Bee ◽  
Broad Spectrum ◽  
Caffeic Acid Phenethyl Ester ◽  
Biological Properties ◽  
Published Data ◽  
Compound A ◽  
Inflammatory Agent ◽  
Anti Cancer

Caffeic acid phenethyl ester (CAPE) is a strong antioxidant extracted from honey bee-hive propolis. The mentioned compound, a well-known NF-κB inhibitor, has been used in traditional medicine as a potent anti-inflammatory agent. CAPE has a broad spectrum of biological properties including anti-viral, anti-bacterial, anti-cancer, immunomodulatory, and wound-healing activities. This review characterizes published data about CAPE biological properties and potential therapeutic applications, that can be used in various diseases.

Effects of caffeic acid phenethyl ester on wound healing in calvarial defects

2014 ◽  
Vol 73 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Hakki Oguz Kazancioglu ◽  
Mehmet Cihan Bereket ◽  
Seref Ezirganli ◽  
Mehmet Serif Aydin ◽  
Sertac Aksakalli
Keyword(s):  
Wound Healing ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Calvarial Defects

scholarly journals Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3514 ◽  
Author(s):  
Anna Kleczka ◽  
Robert Kubina ◽  
Radosław Dzik ◽  
Krzysztof Jasik ◽  
Jerzy Stojko ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Biological Properties ◽  
New Drugs ◽  
Pcr Analysis ◽  
Ovarian Cancer Cells ◽  
Cell Nuclei ◽  
Anticancer Properties ◽  
Induced Apoptosis

Ovarian cancer has the worst prognosis among all gynecological cancers. Therefore, it seems reasonable to seek new drugs that may improve the effectiveness of treatment or mitigate the adverse effects of chemotherapy. Caffeic acid phenethyl ester (CAPE) has many beneficial biological properties. The aim of the study was to assess the anticancer properties of CAPE against serum ovarian carcinoma cells. The morphology of the cells was evaluated in H-E staining and in transmission electron microscopy. The cytotoxic and proapoptotic activity of CAPE was investigated by using the XTT-NR-SRB assay, qRT-PCR analysis of BAX/BCL2 expression, and by cytometric evaluation. CAPE causes constriction in OV7 cells, numerous granulomas were observed in the cytoplasm, the cell nuclei were pyknotic. Autophagosomal vacuoles could suggest the occurrence of aponecrosis. CAPE significantly decreased the lysosomal activity and the total synthesis of cellular proteins. CAPE exhibited, dose and time dependent, cytotoxic activity against OV7 serum ovarian cancer cells. In OV7 cells CAPE induced apoptosis via dysregulation of BAX/BCL2 balance, while activated proapoptotic BAX gene expression level was 10 times higher than BCL2.

scholarly journals Antimicrobial and Antibiofilm Activity against Streptococcus mutans of Individual and Mixtures of the Main Polyphenolic Compounds Found in Chilean Propolis

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Jorge Jesús Veloz ◽  
Marysol Alvear ◽  
Luis A. Salazar
Keyword(s):  
Caffeic Acid ◽  
Streptococcus Mutans ◽  
Caffeic Acid Phenethyl Ester ◽  
Biological Properties ◽  
Tooth Surface ◽  
Dilution Method ◽  
Antibiofilm Activity ◽  
Biofilm Thickness ◽  
Low Concentrations ◽  
Important Health

Dental caries is multifactorial disease and an important health problem worldwide. Streptococcus mutans is considered as a major cariogenic agent in oral cavity. This bacteria can synthetize soluble and insoluble glucans from sucrose by glucosyltransferases enzymes and generate stable biofilm on the tooth surface. Biological properties of Chilean propolis have been described and it includes antimicrobial, antifungal, and antibiofilm activities. The main goal of this study was to quantify the concentrations of main flavonoids presents in Chilean propolis and compare some biological properties such as antimicrobial and antibiofilm activity of individual compounds and the mixture of this compounds, against S. mutans cultures. Chilean propolis was studied and some polyphenols present in this extract were quantified by HPLC-DAD using commercial standards of apigenin, quercetin, pinocembrin, and caffeic acid phenethyl ester (CAPE). MIC for antimicrobial activity was determined by serial dilution method and biofilm thickness on S. mutans was quantified by confocal microscopy. Pinocembrin, apigenin, quercetin, and caffeic acid phenethyl ester (CAPE) are the most abundant compounds in Chilean propolis. These polyphenols have strong antimicrobial and antibiofilm potential at low concentrations. However, pinocembrin and apigenin have a greater contribution to this action. The effect of polyphenols on S. mutans is produced by a combination of mechanisms to decrease bacterial growth and affect biofilm proliferation due to changes in their architecture.

Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights

2021 ◽  
Vol 19 ◽  
Author(s):  
Namrata Pramod Kulkarni ◽  
Bhupesh Vaidya ◽  
Acharan Narula ◽  
Shyam Sunder Sharma
Keyword(s):  
Caffeic Acid ◽  
Neurological Disorders ◽  
Therapeutic Potential ◽  
Caffeic Acid Phenethyl Ester ◽  
Depression And Anxiety ◽  
Age Related ◽  
Anti Cancer ◽  
Therapeutic Molecules ◽  
Conifer Trees ◽  
Lateral Sclerosis

: Neurological disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD), stroke, amyotrophic lateral sclerosis, Huntington’s disease (HD), epilepsy, traumatic brain injury (TBI), depression and anxiety are responsible for thousands of deaths worldwide every year. With the increase in life expectancy, there has been a rise in the prevalence of these disorders. Age is one of the major risk factors for these neurological disorders and with the aged population is set to rise to 1.25 billion by 2050. There is a growing concern to look for new therapeutic molecules to treat age-related diseases. Caffeic acid phenethyl ester (CAPE) is a molecule obtained from a number of botanical sources such as the bark of conifer trees as well as propolis which is extracted from beehives. Though CAPE remains relatively unexplored in human trials, it possesses antioxidant, anti-inflammatory, antimitogenic and anti-cancer activities as shown by preclinical studies. Apart from this, it also exhibits tremendous potential for the treatment of neurological disorders through modulation of multiple molecular pathways and attenuation of behavioural deficits. In the present article, we have reviewed the therapeutic potential of CAPE and its mechanisms in the treatment of neurological disorders.

Effects of caffeic acid phenethyl ester on wound healing of nasal mucosa in the rat: an experimental study

2014 ◽  
Vol 35 (4) ◽  
pp. 482-486 ◽  
Author(s):  
Vefa Kınıs ◽  
Musa Ozbay ◽  
Mehmet Akdag ◽  
Ulas Alabalık ◽  
Aylin Gul ◽  
...  
Keyword(s):  
Experimental Study ◽  
Wound Healing ◽  
Caffeic Acid ◽  
Nasal Mucosa ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Antifungal Activity of the Phenolic Compounds Ellagic Acid (EA) and Caffeic Acid Phenethyl Ester (CAPE) against Drug-Resistant Candida auris

2021 ◽  
Vol 7 (9) ◽  
pp. 763
Author(s):  
Fernanda Cristina Possamai Rossatto ◽  
Nagendran Tharmalingam ◽  
Iliana E. Escobar ◽  
Pedro Alves d’Azevedo ◽  
Karine Rigon Zimmer ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Ellagic Acid ◽  
Galleria Mellonella ◽  
Treatment Options ◽  
Caffeic Acid Phenethyl Ester ◽  
Biological Properties ◽  
Current Treatment ◽  
Drug Resistant ◽  
Candida Auris ◽  
Fungal Cell

Candida auris is an emerging healthcare-associated fungal pathogen that has become a serious global health threat. Current treatment options are limited due to drug resistance. New therapeutic strategies are required to target this organism and its pathogenicity. Plant polyphenols are structurally diverse compounds that present a vast range of biological properties. In the present study, plant-derived molecules ellagic acid (EA) and caffeic acid phenethyl ester (CAPE) were investigated for their antifungal and antivirulence activities against Candida auris. We also tested against C. albicans. The minimum inhibitory concentration (MIC) for EA ranged from 0.125 to 0.25 µg/mL and for CAPE ranged from 1 to 64 µg/mL against drug-resistant C. auris strains. Killing kinetics determined that after 4 h treatment with CAPE, there was a complete reduction of viable C. auris cells compared to fluconazole. Both compounds might act by modifying the fungal cell wall. CAPE significantly reduced the biomass and the metabolic activity of C. auris biofilm and impaired C. auris adhesion to cultured human epithelial cells. Furthermore, both compounds prolonged the survival rate of Galleria mellonella infected by C. auris (p = 0.0088 for EA at 32 mg/kg and p = 0.0028 for CAPE at 4 mg/kg). In addition, EA at 4 μg/mL prolonged the survival of C. albicans-infected Caenorhabditis elegans (p < 0.0001). CAPE was not able to prolong the survival of C. albicans-infected C. elegans. These findings highlight the antifungal and antivirulence effects of EA and CAPE against C. auris, and warrant further investigation as novel antifungal agents against drug-resistant infections.

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