scholarly journals A Convenient Approach towards the Synthesis of ADMDP Type Iminosugars and Nojirimycin Derivatives from Sugar-Derived Lactams

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5459
Author(s):  
Piotr Szcześniak ◽  
Barbara Grzeszczyk ◽  
Bartłomiej Furman

An efficient method for the synthesis of nojirimycin- and pyrrolidine-based iminosugar derivatives has been developed. The strategy is based on the partial reduction in sugar-derived lactams by Schwartz’s reagent and tandem stereoselective nucleophilic addition of cyanide or a silyl enol ether dictated by Woerpel’s or diffusion control models, which affords amino-modified iminosugars, such as ADMDP or higher nojirimycin derivatives.

ChemInform ◽  
2003 ◽  
Vol 34 (3) ◽  
Author(s):  
Ming-Chung Yan ◽  
Zhijay Tu ◽  
Chunchi Lin ◽  
Ching-Fa Yao

2002 ◽  
Vol 43 (44) ◽  
pp. 7991-7994 ◽  
Author(s):  
Ming-Chung Yan ◽  
Zhijay Tu ◽  
Chunchi Lin ◽  
Ching-Fa Yao

2013 ◽  
Vol 42 (7) ◽  
pp. 691-693 ◽  
Author(s):  
Mitsuru Kitamura ◽  
Kento Murakami ◽  
Yuichiro Shiratake ◽  
Tatsuo Okauchi
Keyword(s):  

1989 ◽  
Vol 54 (11) ◽  
pp. 2605-2608 ◽  
Author(s):  
V. V. Zhdankin ◽  
M. Mullikin ◽  
Rik Tykwinski ◽  
Bruce Berglund ◽  
Ronald Caple ◽  
...  

2018 ◽  
Vol 24 (1) ◽  
pp. 23-26
Author(s):  
Zheng Li ◽  
Wenli Song ◽  
Jiaojiao He ◽  
Yan Du ◽  
Jingya Yang

Abstract An efficient method for the synthesis of the title compounds by reactions of divinyl ketones with thiourea is described. This protocol has the advantages of high yields, mild reaction conditions and simple work-up procedure.


Author(s):  
Ha Rim Lee ◽  
Seo Yun Kim ◽  
Min Ji Park ◽  
Yong Sun Park

A novel synthetic strategy for highly enantioenriched cis-3,5-disubstituted γ-lactones has been developed by the AgOTf-promoted nucleophilic substitution of α-bromoacetates with silyl enol ethers and subsequent reductive lactonization. The utility of...


2012 ◽  
pp. 1
Author(s):  
D. W. C. MacMillan ◽  
A. J. B. Watson
Keyword(s):  

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