scholarly journals Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 437
Author(s):  
Ming-Jen Cheng ◽  
Ming-Der Wu ◽  
Chao-Lin Chang ◽  
Hsun-Shuo Chang ◽  
Chiou-Fung Chyu ◽  
...  

Five new dimer compounds, namely Taiwaniacryptodimers A‒E (1–5), were isolated from the methanol extract of the roots of Taiwania cryptomerioides. Their structures were established by mean of spectroscopic analysis and comparison of NMR data with those of known analogues. Their antifungal activities were also evaluated. Our results indicated that metabolites 1, 2, 4, and 5 displayed moderate antifungal activities against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae.

2019 ◽  
Vol 2 (1) ◽  
pp. 1-2
Author(s):  
Ayah Rebhi Hilles ◽  
Syed Mahmood ◽  
Mohd Arifin Kaderi ◽  
Ridzwan Hashim ◽  
Tara Jalal ◽  
...  

Discovery and development of new drugs from marine and freshwater animal remain one of the most challenging areas in recent marine sciences field. Thus, the object of current study to examine the antifungal activity of Asian swamp eel (Monopterus albus) skin mucus. Eel skin mucus aqueous and methanol extracts were prepared with different extract concentrations from 0.49 to 1000 μg/mL against fungus pathogens i.e. Aspergillus niger and Microsporum gypseum. The antifungal assay conducted using well diffusion method. The results showed a dose dependent decrease the fungal growth, at 100µl/well, the inhibition zone of methanol extract against M. gypseum (25.7±0.75) mm, while the aqueous one was (23.3±0.16) mm Whereas eel skin mucus methanol and aqueous extracts showed lower inhibition zone against Aspergillus niger at the same concentration which was (11.1±0.59) mm and (9.0±0.15) mm respectively. The methanol extract showed the highest inhibitory activity against M. gypseum because M. gypseum infect the upper layers of the skin and eel skin mucus protect eels from infections. The results were statistically significant with p < 0.001. In conclusion, the present study carried out to reveal the antifungal activities of eel skin mucus which might be use as a source of antifungal agent.


2021 ◽  
pp. 5-8
Author(s):  
V. Nandagopalan ◽  
D. Kavitha

Calanthe masuca (D.Done) Lindl is a potential medicinal plant of terrestrial orchids. Tribal peoples were used the plants for therapeutic purpose. The present study was to evaluate the phytochemical analysis and Antimicrobial Activity of Calanthe masuca in leaf extracts. Preliminary phytochemical analysis revealed that the presence of bioactive substance in leaf extract was found that Alkaloids, Flavanoids, Phenol, Tannins, Saponins, Steroids, Terpenoids, Carboxcylic acid, Glycoside and Mucilage. Antimicrobial activity by Agar well diffusion method again six pathogenic microbes such as Staphylococcus aureus, Bacillus subtilis, E.coli and Pseudomonas aeruginosa in bacteria, Aspergillus niger and Candida albicans in fungi by using different solvent such as Aqueous, Methanol and Petroleum ether. It was observered that Methanol extract showed highest activity against the pathogen such as S.aureus (13.5 mm), B.subtilis (12.4 mm), E.coli (12.5 mm) and P.aeruginosa (13.0 mm) and then followed by the Aqueous extract and low activity showed in petroleum ether extract. The methanol extract showed signicant Antifungal activity against Aspergillus niger (14.0mm) and Candida albicans (13.0 mm) with higher concentration and Petroleum ether extract showed lower activity in fungi. The capacity of the crude concentrates of Calanthe masuca to suppress the development of microorganism which means that it has a wide range of antimicrobial potential utilized for various cures.


2021 ◽  
Vol 7 (21) ◽  
pp. 183-189
Author(s):  
Thu Hương Trương Thị ◽  
Hoài Vân Trần Thị ◽  
Thùy Dương Trần Thị ◽  
Mai Chu Quỳnh ◽  
Nguyệt Nguyễn Thị

Các cặn chiết ethanol tổng, n-hexane, ethyl acetate và 2 hợp chất 5-hydroxy-6,7-dimetoxyflavanon và 3β-hydroxy-urs-12-en-28-oic phân lập được từ loài Ké hoa đào (Urena lobata) thể hiện hoạt tính kháng tốt đối với 2 chủng vi khuẩn Gram (–) (Escherichia coli và Pseudomonas aeruginosa), 2 chủng Gram (+) (Bacillus subtillis và Staphylococcus aureus), 02 chủng nấm sợi (Aspergillus niger và Fusarium oxysporum), 2 chủng nấm men (Candida albicans và Saccharomyces cerevisiae) với đường kính vòng kháng khuẩn từ 8 đến 28 mm.


Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2178 ◽  
Author(s):  
Chi-I Chang ◽  
Cheng-Chi Chen ◽  
Chiy-Rong Chen ◽  
Ming-Der Wu ◽  
Ming-Jen Cheng ◽  
...  

Three new dimeric abietane-type diterpenoids, abieta-6,8,11,13-tetraen-12-yl 12-hydroxyabieta-8,11,13-trien-7α-yl peroxide (1), abieta-6,8,11,13-tetraen-12-yl 12-hydroxyabieta-8,11,13-trien-7β-yl peroxide (2), and 12-hydroxyabieta-8,11,13-trien-7β-yl 7-oxoabieta-5,8,11,13-tetraen-12-yl peroxide (3), together with four known abietane-type diterpenoids (4–7) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. At a concentration of 50 μM, compounds 1, 2, and 3 showed 26.2%, 23.6%, and 35.7% inhibition towards xanthine oxidase enzyme, respectively. In addition, compound 3 also showed 24.9% inhibition toward angiotensin-converting enzyme (ACE).


2017 ◽  
Vol 15 (1) ◽  
pp. 29
Author(s):  
Vega Julia Putri Adi ◽  
Usman Usman

Candida Albicans and Aspergillus Niger are some of the infectious fungi. Empirically bark, flower, root and mangrove leaves Rhizophora mucronata can be a hepatitis drug. This study aims to determine the antifungal potential of methanol extract of Rhizophora mucronata leaves to Candida Albicans and Aspergillus Niger fungus. Chemical test results that have been done previously are alkaloids, Flavanoid , triterpenoids, saponins, tannins and hydroquinone phenols. The antifungal test was performed by agar diffusion method on Potatos Dextrose Agar (PDA) medium and paper disc.Paper disc soaked in methanolic extract of Rhizophora mucronatapada leaf concentration 1000 ppm, 800 ppm, 600 ppm, 400 ppm and 200 ppm. The positive control solution used ketokenazole drug and negative control using aquades with incubation period of  3 x 24 hours. The results did not prove that Rhizophora mucronata leaf methanol extract was effective to inhibit antifungal activity against Candida Albicans and Aspergillus Niger fungi.


2019 ◽  
Vol 14 (1) ◽  
pp. 1934578X1901400
Author(s):  
Chi-I Chang ◽  
Jih-Jung Cheng ◽  
Chin Hsu ◽  
Cheng-Chi Chen ◽  
Wei-Yi Cheng ◽  
...  

Two new abietane-type diterpenoids, 15-hydroxy-12- O-methylsugiol (1) and 2a-hydroxy-12- O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM


2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Chi-Pien Chen ◽  
Ai-Yu Shen

In this study, an attempt was made to elucidate the combined effect of thymol analogues with propolis on fungi that are involved in human diseases. Antifungal activity of thymol analogues was examined by the agar dilution method, using antibiotic medium-3-enriched with 0.2% dextrose. The activity of thymol analogues against Penicillium rastrickii appeared to be more marked than against Candida albicans and Saccharomyces cerevisiae. Various thymol analogues and propolis, when tested alone, did not exhibit significant inhibitory activity. However, in the presence of sub-inhibitory concentrations of propolis, the relative antifungal potency of the thymol analogues was greatly enhanced. Natural thymol was found to be superior to the synthetic thymol analogues. In particular, the MIC of thymol was considerably reduced (191-fold) against Candida albicans by combination with propolis. This study highlights the potential of the combination of either thymol or synthetic thymol analogues with propolis to inhibit fungi.


2008 ◽  
Vol 6 (4) ◽  
pp. 562-568 ◽  
Author(s):  
Dominique Duguay ◽  
Matthew Zamora ◽  
Johanna Blacquiere ◽  
Francis Appoh ◽  
Christopher Vogels ◽  
...  

AbstractThe addition of formylphenylboronic acid derivatives to thiourea and ethyl acetoacetate proceeds in the presence of an additional Lewis acid catalyst to give the corresponding 3,4-dihydropyrimidin-2(1H)-(thio)ones (Biginelli products) in moderate yield. Compounds were tested for antifungal activity against pure cultures of Aspergillus niger, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae but, unfortunately, none showed any appreciable activity.


2008 ◽  
Vol 32 (3) ◽  
pp. 875-881 ◽  
Author(s):  
Lúcia Péret-Almeida ◽  
Cristina da Cunha Naghetini ◽  
Elzíria de Aguiar Nunan ◽  
Roberto Gonçalves Junqueira ◽  
Maria Beatriz Abreu Glória

Este trabalho teve como objetivo avaliar a atividade antimicrobiana da cúrcuma em pó, da curcumina disponível no comércio, dos pigmentos curcuminóides purificados e dos óleos essenciais da cúrcuma. As amostras foram analisadas quanto aos teores de pigmentos curcuminóides por cromatografia líquida de alta eficiência. O óleo essencial foi também analisado quanto à densidade, índice de refração e perfil das substâncias voláteis por cromatografia gasosa e detector de ionização de chamas. A atividade antimicrobiana in vitro foi determinada pelo método de difusão em ágar com discos de papel estéreis, impregnados com os extratos, sendo os diâmetros dos halos de inibição medidos com paquímetro. Os extratos etanólicos da cúrcuma, da curcumina comercial, e dos pigmentos curcumina e desmetoxicurcumina não inibiram o crescimento de Staphylococcus aureus, Bacillus subtilis, Salmonella choleraesuis, Escherichia coli, Aspergillus niger, Saccharomyces cerevisiae, e Candida albicans. Apenas o extrato etanólico da bisdesmetoxicurcumina apresentou atividade antimicrobiana em relação ao B. subtilis. O óleo essencial da cúrcuma apresentou atividade antimicrobiana para o B. subtilis, S. choleraesuis, E. coli, A. niger e S. cerevisiae, sendo que essa atividade aumentou em função do aumento da concentração. Os halos de inibição, obtidos com o óleo essencial, foram significativos, quando comparados aos respectivos antibióticos tradicionais, cloranfenicol e anfotericina, indicando ser o óleo essencial da cúrcuma um agente antimicrobiano em potencial.


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