scholarly journals Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2277
Author(s):  
Norbert Löwa ◽  
Dirk Gutkelch ◽  
Ernst-Albrecht Welge ◽  
Roland Welz ◽  
Florian Meier ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Process Monitoring ◽  
Magnetic Nanoparticle ◽  
Magnetic Particle ◽  
Nanoparticle Synthesis ◽  
Separation Processes ◽  
Magnetic Detector ◽  
Application Fields

Magnetic nanoparticles combine unique magnetic properties that can be used in a variety of biomedical applications for therapy and diagnostics. These applications place high demands on the magnetic properties of nanoparticles. Thus, research, development, and quality assurance of magnetic nanoparticles requires powerful analytical methods that are capable of detecting relevant structural and, above all, magnetic parameters. By directly coupling nanoparticle synthesis with magnetic detectors, relevant nanoparticle properties can be obtained and evaluated, and adjustments can be made to the manufacturing process in real time. This work presents a sensitive and fast magnetic detector for online characterization of magnetic nanoparticles during their continuous micromixer synthesis. The detector is based on the measurement of the nonlinear dynamic magnetic response of magnetic nanoparticles exposed to an oscillating excitation at a frequency of 25 kHz, a technique also known as magnetic particle spectroscopy. Our results underline the excellent suitability of the developed magnetic online detection for coupling with magnetic nanoparticle synthesis based on the micromixer approach. The proven practicability and reliability of the detector for process monitoring forms the basis for further application fields, e.g., as a monitoring tool for chromatographic separation processes.

Dynamic Magnetic Properties of Optimized Magnetic Nanoparticles for Magnetic Particle Imaging

2014 ◽  
Vol 50 (11) ◽  
pp. 1-4 ◽  
Author(s):  
Frank Ludwig ◽  
Christian Kuhlmann ◽  
Thilo Wawrzik ◽  
Jan Dieckhoff ◽  
Aidin Lak ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Magnetic Particle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging

scholarly journals A multi-purpose phantom kit for magnetic particle imaging

2021 ◽  
Vol 7 (2) ◽  
pp. 319-322
Author(s):  
Norbert Löwa ◽  
Rebecca Hoffmann ◽  
Dirk Gutkelch ◽  
Olaf Kosch ◽  
Silvio Dutz ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Spatial Distribution ◽  
Magnetic Nanoparticles ◽  
Magnetic Particle ◽  
Imaging Technique ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
Scenario Testing ◽  
Future Reference

Abstract Phantoms are essential tools for the development and characterization of Magnetic Particle Imaging (MPI), an imaging technique that can quantitatively map the spatial distribution of magnetic nanoparticles (MNP). The objective of this study was to develop and validate a modular MPI phantom kit with high versatility for platform-independent quality assurance and the assembling of defined geometries in MPI. It was shown that the developed MPI phantom kit can be used for both application scenario testing and quality assurance in MPI which provides the basis for future reference phantoms to directly compare existing scanners within the MPI community.

Magnetic particle spectroscopy characterization of the assemblies of magnetic nanoparticles

2015 ◽  
Author(s):  
Olga Mykhaylyk ◽  
Dietmar Eberbeck ◽  
Norbert Lowa ◽  
Isabella Almstatter ◽  
Christian Plank ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Particle

scholarly journals Design and validation of magnetic particle spectrometer for characterization of magnetic nanoparticle relaxation dynamics

AIP Advances ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. 056730 ◽  
Author(s):  
Nicolas Garraud ◽  
Rohan Dhavalikar ◽  
Lorena Maldonado-Camargo ◽  
David P. Arnold ◽  
Carlos Rinaldi
Keyword(s):  
Magnetic Nanoparticle ◽  
Magnetic Particle ◽  
Relaxation Dynamics

scholarly journals Development of an in-line magnetometer for flow chemistry and its demonstration for magnetic nanoparticle synthesis

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Maximilian O. Besenhard ◽  
Dai Jiang ◽  
Quentin A. Pankhurst ◽  
Paul Southern ◽  
Spyridon Damilos ◽  
...  
Keyword(s):  
Quality Control ◽  
Magnetic Nanoparticles ◽  
High Throughput ◽  
High Throughput Screening ◽  
Magnetic Nanoparticle ◽  
Nanoparticle Synthesis ◽  
Flow Chemistry ◽  
Continuous Quality ◽  
Highly Sensitive

A highly sensitive magnetometer for flow chemistry to characterise magnetic nanoparticles in solution, in situ and in real-time is presented. This facilitates continuous quality control and high-throughput screening of magnetic nanoparticle syntheses.

Preparation and Characterization of Fe3O4 Magnetic Nanoparticles Labeled with Technetium-99m Pertectnetate

2013 ◽  
Vol 459 ◽  
pp. 51-59 ◽  
Author(s):  
Chang Shu Tsai ◽  
Wei Chung Liu ◽  
Hong Yi Chen ◽  
Wei Chun Hsu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Magnetic Nanoparticle ◽  
Drug Carrier ◽  
Precipitation Method ◽  
Technetium 99M ◽  
Reducing Ability ◽  
Targeted Drug

In the aspect of biomedical diagnosis, magnetic nanoparticle can be used as drug carrier and MRI/ SPECT/ PET contrast agents. Magnetic fluid hyperthermia is one of the most important cancer therapies. Magnetic nanoparticles display their unique features as heating mediators for hyperthermia. In this study, Fe3O4magnetic nanoparticle was prepared by using chemical co-precipitation method. Tc-99m pertechnetate with Fe3O4magnetic nanoparticles is prepared by using magnet adsorption method. An attempt was also made to evaluate the application in the field of magnetic targeted drug delivery and radioactive targeted cancer treatment in the future. In this work, preparation and characterization of non-polymer and polymer (dextran) coated Fe3O4magnetic nanoparticles labeled with technetium-99m pertectnetate were evaluated and served as precursors study. The Tc-99m labeling efficiency of in-house Fe3O4magnetic nanoparticles (MNP) and commercial kit were ca.98.4 % and 85% (n=5), under the same conc. of 6mM, 0.1 ml of SnCl2·2H2O, respectively. The Tc-99m labeling efficiency of magnetic nanoparticles with its dextran-coated was ca. 58.2% (n=5) at the same conc. and volume of SnCl2·2H2O. The in-vitro stabilities of the 3 kinds of magnetite magnetic fluids were higher than 96.0% (n=5) during 2 hours. The reducing agent of SnCl2·2H2O plays a key role due to its reducing ability for Tc-99m pertechnetate. The optimal reaction time of SnCl2·2H2O with Tc-99m is better under 1 hour. In conclusion, the Fe3O4magnetic nanoparticle labeled with Tc-99m pertechnetate has shown good qualities for its labeling efficiency and stability. It may be feasible preliminary to utilize in the application of magnetic targeted drug delivery of bio-medicine.

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