scholarly journals Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 238
Author(s):  
Chooi Ling Lim ◽  
Chandramathi S. Raju ◽  
Tooba Mahboob ◽  
Sunil Kayesth ◽  
Kamal K. Gupta ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Healthcare Professionals ◽  
Plant Medicine ◽  
Pathological Conditions ◽  
Current Review ◽  
Methodical Approach ◽  
Therapeutic Value ◽  
Ancient Times ◽  
Therapeutic Perspective ◽  
Improve Patient

Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side-effects compared to modern medicines. However, phytopharmaceuticals need a scientific and methodical approach to deliver their components and thereby improve patient compliance and treatment adherence. Dose reduction, improved bioavailability, receptor selective binding, and targeted delivery of phytopharmaceuticals can be likely achieved by molding them into specific nano-formulations. In recent decades, nanotechnology-based phytopharmaceuticals have emerged as potential therapeutic candidates for the treatment of various communicable and non-communicable diseases. Nanotechnology combined with phytopharmaceuticals broadens the therapeutic perspective and overcomes problems associated with plant medicine. The current review highlights the therapeutic application of various nano-phytopharmaceuticals in neurological, cardiovascular, pulmonary, and gastro-intestinal disorders. We conclude that nano-phytopharmaceuticals emerge as promising therapeutics for many pathological conditions with good compliance and higher acceptance.

Nanoparticulate Drug Delivery System

2021 ◽  
pp. 173-185
Author(s):  
Akshada Bakliwal ◽  
Swati Gokul Talele ◽  
Shweta Shaileshkumar Gedam ◽  
Vijay Sharadkumar Chudiwal ◽  
Swapnil Sharadkumar Jain
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Drug Delivery Systems ◽  
Herbal Medicines ◽  
Delivery Systems ◽  
Drug Bioavailability ◽  
Therapeutic Value ◽  
Ancient Times ◽  
Novel Drug ◽  
Improve Patient

The herbal medicines have been extensively used worldwide since ancient times and have been accepted by physicians and patients for their improved therapeutic value as they have less adverse effects in contrast with modern medicines. Phytotherapeutics requires a scientific approach to carry the components in a sustained manner to increase patient compliance and to reduce the frequency of administration. This can be accomplished by designing novel drug delivery systems (NDDS) for herbal constituents. NDDSs not only reduce the frequency of drug administration to improve patient compliance but also help to enhance the therapeutic value by dropping toxicity and enhancing the drug bioavailability. A nanotechnology is a new approach in which nano-sized drug delivery systems of herbal drugs have a prospective future for enhancing the therapeutic activity and conquer problems associated with plant medicines. Hence, the addition of the nanotechnology as an NDDS in traditional medication is essential for the treatment of more chronic diseases like cancer, diabetes, asthma, and others.

Conceptualizing Narrative Health and Medicine to Develop Cultural Competence to Improve Communication During the COVID-19 Pandemic

2021 ◽  
Vol 8 (1) ◽  
pp. 32-36
Author(s):  
Kent Willis ◽  
Colleen Marzilli
Keyword(s):  
Healthcare Professional ◽  
Cultural Competence ◽  
Severe Acute Respiratory Syndrome ◽  
Patient Care ◽  
Patient Outcomes ◽  
Healthcare Professionals ◽  
Important Concept ◽  
Healthcare Environment ◽  
Health Narrative ◽  
Improve Patient

Narrative health is a technique that healthcare professionals can use to connect with patients. The events of 2020, including the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have identified that patient care is largely dependent upon relationships within the healthcare environment. Relationships in the healthcare environment are established through a trusting exchange between the patient and provider, and one technique to develop this relationship and trust is through narrative health. Narrative health provides the exchange of information between patient and provider in a discussion-like manner, or narrative health. This strategy promotes cultural competence amongst the healthcare professional team and improves communication between the patient and provider. Narrative health is an important concept for healthcare professionals to understand, and narrative health should be a part of any healthcare professional’s toolbox, especially in vulnerable times like the COVID pandemic. The inclusion of narrative health in practice has the potential to improve patient outcomes and empower healthcare professionals and patients.

Lower extremity osteoarthritis: optimising musculoskeletal health is a growing global concern: a narrative review

2018 ◽  
Vol 53 (13) ◽  
pp. 806-811 ◽  
Author(s):  
Richard D Leech ◽  
Jillian Eyles ◽  
Mark E Batt ◽  
David J Hunter
Keyword(s):  
Patient Outcomes ◽  
Key Management ◽  
Structural Changes ◽  
Healthcare Professionals ◽  
Disease Process ◽  
Evidence Based ◽  
Musculoskeletal Health ◽  
Proactive Approach ◽  
Global Concern ◽  
Improve Patient

The burden of non-communicable diseases, such as osteoarthritis (OA), continues to increase for individuals and society. Regrettably, in many instances, healthcare professionals fail to manage OA optimally. There is growing disparity between the strength of evidence supporting interventions for OA and the frequency of their use in practice. Physical activity and exercise, weight management and education are key management components supported by evidence yet lack appropriate implementation. Furthermore, a recognition that treatment earlier in the disease process may halt progression or reverse structural changes has not been translated into clinical practice. We have largely failed to put pathways and procedures in place that promote a proactive approach to facilitate better outcomes in OA. This paper aims to highlight areas of evidence-based practical management that could improve patient outcomes if used more effectively.

scholarly journals Safety Performance in Acute Medical Care: A Qualitative, Explorative Study on the Perspectives of Healthcare Professionals

Healthcare ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1543
Author(s):  
Lina Heier ◽  
Donia Riouchi ◽  
Judith Hammerschmidt ◽  
Nikoloz Gambashidze ◽  
Andreas Kocks ◽  
...  
Keyword(s):  
Patient Safety ◽  
Nursing Students ◽  
Healthcare Professionals ◽  
Improve Patient Safety ◽  
Safety Performance ◽  
Structured Interviews ◽  
Performance Skills ◽  
Work Environment Factors ◽  
Improve Patient

Healthcare professionals need specific safety performance skills in order to maintain and improve patient safety. The purpose of this study is to get a deeper understanding of healthcare professionals’ perspective in acute care on the topic of safety performance. This study was conducted using a qualitative approach. Healthcare professionals working in nursing were interviewed using semi-structured interviews. Using content analyzing, categories were identified which present aspects of safety performance; subcategories were developed deductively. A total of 23 healthcare professionals were interviewed, of which 15 were registered nurses, five were nursing students and three were pedagogical personnel. Nine (39.1%) were <30 years old, 17 (73.9%) were female, and 9 (39.1%) had a leadership function. Results highlight the importance of safety performance as a construct of occupational health rather than of patient safety, and the role of the organization, as well as the self-responsibility of healthcare professionals. Healthcare professionals should be more conscious of their role, have a deeper understanding of the interaction of individual, team, patient, organization and work environment factors.

scholarly journals Second life in healthcare education: Virtual environment's potential to improve patient safety

2011 ◽  
pp. 17-23
Keyword(s):  
Patient Safety ◽  
Virtual Environments ◽  
Virtual Environment ◽  
Medical Errors ◽  
Second Life ◽  
Healthcare Professionals ◽  
Improve Patient Safety ◽  
Healthcare Education ◽  
Healthcare Profession ◽  
Improve Patient

Research has shown that a large portion of healthcare cost is due to medical errors. There are many factors that cause medical errors but one major factor is linked to healthcare professionals who are not adequately trained with the appropriate skills. Virtual environments and simulations are being used to help improve training in many different areas, including the healthcare profession. This paper explores the usage of Second Life in healthcare education and its ability to improve patient safety. The conclusion is that much progress and development still needs to be made before Second Life will make a significant impact on improved patient safety through healthcare education. There is a need to make the virtual environment more realistic to adequately train healthcare professionals.

Clinical Applications of Ultrasonography in Neurocritically Ill Patients

2020 ◽  
pp. 088506662090579
Author(s):  
Andrés Fabricio Caballero-Lozada ◽  
Kapil Laxman Nanwani ◽  
Favio Pavón ◽  
Andrés Zorrilla-Vaca ◽  
Carolina Zorrilla-Vaca
Keyword(s):  
Doppler Ultrasound ◽  
Perfusion Pressure ◽  
Color Doppler ◽  
Color Doppler Ultrasound ◽  
Comprehensive Management ◽  
Pathological Conditions ◽  
Cerebrovascular Events ◽  
Ocular Ultrasound ◽  
Patient Prognosis ◽  
Improve Patient

Ultrasonography is part of the multimodal monitoring of the neurocritical patient. Through transcranial color Doppler ultrasound, carotid-color Doppler ultrasound, and ocular ultrasound it is possible to diagnose and monitor a multitude of pathological conditions, such as cerebrovascular events, vasospasm, Terson syndrome, carotid atheromatosis, and brain death. Furthermore, these techniques enable the monitoring of the intracranial pressure, the cerebral perfusion pressure, and the midline deviation, which allows us to understand the patient’s neurocritical pathology at their bedside, in a noninvasive way. Although none of these tools have yet been shown to improve patient prognosis, the dissemination of knowledge and management of neurovascular ultrasonography could significantly improve the comprehensive management of neurocritical patients.

Emodin Decreases Hepatic Hypoxia-Inducible Factor-1α by Inhibiting its Biosynthesis

2016 ◽  
Vol 44 (05) ◽  
pp. 997-1008 ◽  
Author(s):  
Feifei Ma ◽  
Lijuan Hu ◽  
Ming Yu ◽  
Feng Wang
Keyword(s):  
Hepg2 Cells ◽  
Mammalian Cells ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1 ◽  
Hepatic Cells ◽  
Diet Induced Obesity ◽  
Pathological Conditions ◽  
Therapeutic Value ◽  
Normal Stability

Hypoxia-inducible factor-1 (HIF-1) is an [Formula: see text] dimeric transcription factor. Because HIF-1[Formula: see text] is instable with oxygen, HIF-1 is scarce in normal mammalian cells. However, HIF-1[Formula: see text] is expressed in pathological conditions such as cancer and obesity. Inhibiting HIF-1[Formula: see text] may be of therapeutic value for these pathologies. Here, we investigated whether emodin, derived from the herb of Rheum palmatum L, which is also known as Chinese rhubarb, and is native to China, regulates HIF-1[Formula: see text] expression. Male C57BL/6 mice without or with diet-induced obesity were treated with emodin for two weeks, while control mice were treated with vehicle. HIF-1[Formula: see text] expression was determined by Western blot. We found that emodin inhibited obesity-induced HIF-1[Formula: see text] expression in liver and skeletal muscle but did not regulate HIF-1[Formula: see text] expression in the kidneys or in intra-abdominal fat. In vitro, emodin inhibited HIF-1[Formula: see text] expression in human HepG2 hepatic cells and Y1 adrenocortical cells. Further, we investigated the mechanisms of HIF-1[Formula: see text] expression in emodin-treated HepG2 cells. First, we found that HIF-1[Formula: see text] had normal stability in the presence of emodin. Thus, emodin did not decrease HIF-1[Formula: see text] by stimulating its degradation. Importantly, emodin decreased the activity of the signaling pathways that led to HIF-1[Formula: see text] biosynthesis. Interestingly, emodin increased HIF-1[Formula: see text] mRNA in HepG2 cells. This may be a result of feedback in response to the emodin-induced decrease in the protein of HIF-1[Formula: see text]. In conclusion, emodin decreases hepatic HIF-1[Formula: see text] by inhibiting its biosynthesis.

scholarly journals IMMERSIVE TECHNOLOGIES IN HEALTHCARE TRAINING & EDUCATION: THREE PRINCIPLES FOR PROGRESS

2021 ◽  
Author(s):  
Centre for Immersive Technologies ◽  
Faisal Mushtaq
Keyword(s):  
Patient Outcomes ◽  
Healthcare Professionals ◽  
Open Science ◽  
Human Behaviour ◽  
Research Practices ◽  
Rigorous Evaluation ◽  
Industry Policy ◽  
Improve Patient ◽  
Healthcare Training ◽  
Immersive Technologies

THIS REPORT HIGHLIGHTS 3 PRINCIPLESTHROUGH WHICH PROGRESS IN THIS AREA CANBE ACCELERATED. THESE PRINCIPLES ARE:1. The design and development of immersive tools thatare driven by learning requirements, and informedby the science of human behaviour and cognition.2. Rigorous evaluation prior to, and during implementationof immersive technologies into the healthcare systemthrough open science and transparent research practices.3. Principles 1 and 2 are best achieved by fostering aculture of collaboration, inclusivity and solidarity betweendevelopers, educators, scientists, industry, policy makersand healthcare professionals to maximise uptake,accelerate learning and improve patient outcomes.

scholarly journals Validation of Digital Applications for Evaluation of Visual Parameters: A Narrative Review

Vision ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 58
Author(s):  
Kevin J. Mena-Guevara ◽  
David P. Piñero ◽  
Dolores de Fez
Keyword(s):  
Search Engine ◽  
Surgical Procedures ◽  
Scientific Evidence ◽  
Electronic Devices ◽  
Exclusion Criteria ◽  
Digital Device ◽  
Pathological Conditions ◽  
Current Review ◽  
Reference Manager ◽  
Bibliographic Search

The current review aimed to collect and critically analyze the scientific peer-reviewed literature that is available about the use of digital applications for evaluation of visual parameters in electronic devices (tablets and smartphones), confirming if there are studies calibrating and validating each of these applications. Three bibliographic search engines (using the search equation described in the paper) and the Mendeley reference manager search engine were used to complete the analysis. Only articles written in English and that are evaluating the use of tests in healthy patients to measure or characterize any visual function aspects using tablets or smartphones were included. Articles using electronic visual tests to assess the results of surgical procedures or are conducted in pathological conditions were excluded. A total of 19 articles meeting these inclusion and exclusion criteria were finally analyzed. One critical point of all these studies is that there was no mention of the characterization (spatial and/or colorimetrical) of screens and the stimuli used in most of them. Only two studies described some level of calibration of the digital device before the beginning of the study. Most revised articles described non-controlled comparatives studies (73.7%), reporting some level of scientific evidence on the validation of tools, although more consistent studies are needed.

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