scholarly journals Efficacy of Creatine Supplementation Combined with Resistance Training on Muscle Strength and Muscle Mass in Older Females: A Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3757
Author(s):  
Ellem Eduarda Pinheiro dos Santos ◽  
Rodrigo Cappato de de Araújo ◽  
Darren G. Candow ◽  
Scott C. Forbes ◽  
Jaddy Antunes Guijo ◽  
...  

Sarcopenia refers to the age-related loss of muscle strength and muscle mass, which is associated with a reduced quality of life, particularly in older females. Resistance training (RT) is well established to be an effective intervention to counter indices of sarcopenia. Accumulating research indicates that the addition of creatine supplementation (Cr) to RT augments gains in muscle strength and muscle mass, compared to RT alone. However, some evidence indicates that sex differences may alter the effectiveness of Cr. Therefore, we systematically reviewed randomized controlled trials (RCTs) investigating the efficacy of Cr + RT on measures of upper- and lower-body strength and muscle mass in older females. A systematic literature search was performed in nine electronic databases. Ten RCTs (N = 211 participants) were included the review. Overall, Cr significantly increased measures of upper-body strength (7 studies, n = 142, p = 0.04), with no effect on lower-body strength or measures of muscle mass. Sub-analyses revealed that both upper-body (4 studies, n = 97, p = 0.05) and lower-body strength (4 studies, n = 100, p = 0.03) were increased by Cr, compared to placebo in studies ≥ 24 weeks in duration. In conclusion, older females supplementing with Cr experience significant gains in muscle strength, especially when RT lasts for at least 24 weeks in duration. However, given the level of evidence, future high-quality studies are needed to confirm these findings.

Kinesiology ◽  
2019 ◽  
Vol 51 (2) ◽  
pp. 238-245
Author(s):  
Hamid Arazi ◽  
Ehsan Eghbali

2D:4D ratio is determined by balance between androgens and estrogens. Low level estrogen reduces bone mineral density (BMD) and incurs negative changes to bone microarchitecture, increasing the risk of osteoporosis and, as a consequence, fracture risk in women. The purpose of this study was to investigate the relationship between 2D:4D, muscle strength and body composition to BMD in young women. One hundred twenty-seven young women (age range 24-36 years) voluntarily participated in this study. Lengths of the second (index) and fourth (ring) fingers, upper and lower body strength and body composition (body mass index, BMI; waist to hip ratio, WHR) and body fat percentage were estimated. Also, blood levels of calcium and 25-hydroxyvitamin D (25OHD) were evaluated and dual-energy X-ray absorptiometry device was used to measure BMD in the lumbar spine (LS) and femoral neck (FN). The results showed that digit ratios, upper body and lower body muscle strength, BMI and fat percentage had a positive relationship with LS and FN BMD (LS BMD: r=.47, r=.56, r=.46, r=.34, r=.28, p≤.001, respectively; FN BMD: r=.34, r=.49, r=.51, r=.45, r=.27, p≤.001, respectively). In addition, there was no significant relationship between WHR and BMD of LS and FN (p˃.05). Multiple linear regression analysis showed the upper body strength was a stronger determinant of LS BMD and the lower body strength was a stronger determinant of FN BMD. Based on the results, the researchers concluded that upper and lower body strength, 2D:4D ratios and BMI were important determinants of young women’s BMD. Also, it seemed that some of these factors may be able to help predicting the osteoporosis potential in young women


2020 ◽  
Vol 28 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Darryn S. Willoughby ◽  
Kaitlan N. Beretich ◽  
Marcus Chen ◽  
LesLee K. Funderburk

Elevated circulating C-terminal agrin fragment (CAF) is a marker of neuromuscular junction degradation and sarcopenia. This study sought to determine if resistance training (RT) impacted the serum levels of CAF in perimenopausal (PERI-M) and postmenopausal (POST-M) women. A total of 35 women, either PERI-M or POST-M, participated in 10 weeks of RT. Body composition, muscle strength, and serum estradiol and CAF were determined before and after the RT. The data were analyzed with two-way analysis of variance (p ≤ .05). Upper body and lower body strength was significantly increased, by 81% and 73% and 86% and 79% for the PERI-M and POST-M participants, respectively; however, there were no significant changes in body composition. Estradiol was significantly less for the POST-M participants at pretraining compared with the PERI-M participants. CAF moderately increased by 22% for the PERI-M participants in response to RT, whereas it significantly decreased by 49% for the POST-M participants. Ten weeks of RT reduced the circulating CAF in the POST-M women and might play a role in attenuating degenerative neuromuscular junction changes.


2019 ◽  
Vol 44 (11) ◽  
pp. 1246-1253 ◽  
Author(s):  
Patrick Bernat ◽  
Darren G. Candow ◽  
Karolina Gryzb ◽  
Sara Butchart ◽  
Brad J. Schoenfeld ◽  
...  

The purpose was to investigate the effects of high-velocity resistance training (HVRT) and creatine supplementation in untrained healthy aging males. Participants were randomized to supplement with creatine (0.1 g·kg−1·day−1 of creatine + 0.1 g·kg−1·day−1 of maltodextrin) or placebo (0.2 g·kg−1·day−1 of maltodextrin) during 8 weeks of HVRT. Prior to and following HVRT and supplementation, assessments were made for muscle strength, muscle thickness, peak torque, and physical performance. There was a significant increase over time for all measures of muscle strength (p < 0.001), muscle thickness (p < 0.001), and some measures of peak torque (knee flexion; 1.05 and 3.14 rad/s; p < 0.001) and physical performance (balance board time-to-completion; p = 0.017). There was a group × time interaction for leg press strength (p = 0.044) and total lower-body strength (leg press, knee flexion, knee extension combined; p = 0.039). The creatine group experienced greater gains in leg press and total lower-body strength compared with the placebo group, with no other differences. HVRT increases muscle strength, muscle thickness, and some measures of peak torque and physical performance in untrained healthy aging males. The addition of creatine supplementation to HVRT further augments the gains in leg press and total lower-body strength. Novelty High-velocity resistance training increases muscle mass and performance. Creatine supplementation increases lower-body muscle strength. High-velocity resistance training and creatine supplementation are safe interventions for aging adults.


Author(s):  
Raja Nurul Jannat Raja Hussain ◽  
Maisarah Shari

Strength and conditioning coaches frequently use traditional resistance training (TRT) to build strength. However, in recent years, whole-body electromyostimulation (WB-EMS) was used in elite athletes to increase muscle strength. This study aimed to assess the effect of two different types of training on muscular strength. Sixty female collegiate players (Age = 23.52±1.89 years, Height = 156.20±1.71cm; Mass = 53.21±3.17kg) participated in this study and were randomly assigned to three training groups. All groups trained as usual for eight weeks, except for the first group, which received additional TRT. The second group received additional electrical stimulation training, and the third group did not receive any additional training following the regular softball bat swing training. Muscular strength (upper and lower body) was assessed by a 3RM bench press and a 3RM squat test before and after the eight-week programme. The primary findings indicate that after eight weeks of training, upper body and lower body strength increased significantly in both the TRT and WB-EMS groups (p = 0.000 and p = 0.000, respectively) in comparison to the control group. However, the t value indicated that the TRT group improved both upper body strength (20.18) and lower body strength (29.18) more than the WB-EMS group (upper body = 6.18; lower body = 6.47). The findings demonstrate the efficacy of both training modalities for increasing muscular strength and suggest that TRT be prioritised over whole-body electrical stimulation training for increasing muscular strength in collegiate softball players.


2021 ◽  
Vol 51 (5) ◽  
pp. 991-1010
Author(s):  
Henrik Petré ◽  
Erik Hemmingsson ◽  
Hans Rosdahl ◽  
Niklas Psilander

Abstract Background The effect of concurrent training on the development of maximal strength is unclear, especially in individuals with different training statuses. Objective The aim of this systematic review and meta-analysis study was to compare the effect of concurrent resistance and endurance training with that of resistance training only on the development of maximal dynamic strength in untrained, moderately trained, and trained individuals. Methods On the basis of the predetermined criteria, 27 studies that compared effects between concurrent and resistance training only on lower-body 1-repetition maximum (1RM) strength were included. The effect size (ES), calculated as the standardised difference in mean, was extracted from each study, pooled, and analysed with a random-effects model. Results The 1RM for leg press and squat exercises was negatively affected by concurrent training in trained individuals (ES =  – 0.35, p < 0.01), but not in moderately trained ( – 0.20, p = 0.08) or untrained individuals (ES = 0.03, p = 0.87) as compared to resistance training only. A subgroup analysis revealed that the negative effect observed in trained individuals occurred only when resistance and endurance training were conducted within the same training session (ES same session =  – 0.66, p < 0.01 vs. ES different sessions =  – 0.10, p = 0.55). Conclusion This study demonstrated the novel and quantifiable effects of training status on lower-body strength development and shows that the addition of endurance training to a resistance training programme may have a negative impact on lower-body strength development in trained, but not in moderately trained or untrained individuals. This impairment seems to be more pronounced when training is performed within the same session than in different sessions. Trained individuals should therefore consider separating endurance from resistance training during periods where the development of dynamic maximal strength is prioritised.


2020 ◽  
Vol 32 (3) ◽  
pp. 165-171
Author(s):  
Konstantinos D. Tambalis ◽  
Stamatis Mourtakos ◽  
Labros S. Sidossis

Purpose: To investigate the potential associations of maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) with physical fitness in children. Methods: A random sample of 5125 children and their mothers was evaluated. The mothers provided data contained in their medical booklets and pregnancy ultrasound records. The data from 5 physical fitness tests (eg, 20-m shuttle run, 30-m sprint, vertical jump, standing long jump, and small ball throw) were used to assess children’s cardiorespiratory fitness, speed, explosive power, and lower and upper body strength, respectively. Results: MppBMI was inversely associated with cardiorespiratory fitness (b = −0.02), lower body strength (b = −1.01), upper body strength (b = −0.07), and speed (b = 0.04). Also, GWG was unfavorably associated with cardiorespiratory fitness (b = −0.02), lower body strength (b = −1.12), upper body strength (b = −0.03), and speed (b = 0.03), after adjusting for sex, birth weight, and children’s BMI (all P values < .05). Children of mothers with an mppBMI ≥ 25 kg/m2 and excess GWG had almost 30% and 20% increased odds for low performances in physical fitness tests than those of mothers with an mppBMI < 25 kg/m2 and adequate GWG, respectively. Conclusions: Antenatal factors such as increased mppBMI and excess GWG could play an unfavorable role in the future health of the offspring.


2020 ◽  
Vol 9 (7) ◽  
pp. 2188 ◽  
Author(s):  
Andreas Mæchel Fritzen ◽  
Frank D. Thøgersen ◽  
Khaled Abdul Nasser Qadri ◽  
Thomas Krag ◽  
Marie-Louise Sveen ◽  
...  

Aging is related to an inevitable loss of muscle mass and strength. The mechanisms behind age-related loss of muscle tissue are not fully understood but may, among other things, be induced by age-related differences in myogenic regulatory factors. Resistance exercise training and deconditioning offers a model to investigate differences in myogenic regulatory factors that may be important for age-related loss of muscle mass and strength. Nine elderly (82 ± 7 years old) and nine young, healthy persons (22 ± 2 years old) participated in the study. Exercise consisted of six weeks of resistance training of the quadriceps muscle followed by eight weeks of deconditioning. Muscle biopsy samples before and after training and during the deconditioning period were analyzed for MyoD, myogenin, insulin-like growth-factor I receptor, activin receptor IIB, smad2, porin, and citrate synthase. Muscle strength improved with resistance training by 78% (95.0 ± 22.0 kg) in the elderly to a similar extent as in the young participants (83.5%; 178.2 ± 44.2 kg) and returned to baseline in both groups after eight weeks of deconditioning. No difference was seen in expression of muscle regulatory factors between elderly and young in response to exercise training and deconditioning. In conclusion, the capacity to gain muscle strength with resistance exercise training in elderly was not impaired, highlighting this as a potent tool to combat age-related loss of muscle function, possibly due to preserved regulation of myogenic factors in elderly compared with young muscle.


2015 ◽  
Vol 23 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Diane E. Adamo ◽  
Susan Ann Talley ◽  
Allon Goldberg

Age-related changes in physical abilities, such as strength and flexibility, contribute to functional losses. However, older individuals may be unaware of what specific physical abilities compromise independent functioning. Three groups of women, aged 60 to 69, 70 to 79, and 80 to 92 years, were administered the Senior Fitness Test (SFT) to determine age differences in physical abilities and risk for functional losses. The oldest group showed significant differences in lower body strength, aerobic endurance, and agility and dynamic balance when compared with the other groups who performed similarly. Across all groups, a faster rate of decline was found for lower body strength (50.6%) and dynamic balance and agility (45.7%) than upper body strength (21.3%) and aerobic endurance (33.6%). Criterion-referenced (CR) fitness standards suggested that 45% of the individuals were at risk for loss of independent functioning. This study highlights age-related differences in physical abilities and the risk for the loss of independence in later life.


2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Yuan Yang ◽  
Jia-hui Li ◽  
Nan-Jun Xu ◽  
Wei-Yi Yang ◽  
Jun Liu

Importance. Tai Chi exercise mostly involves muscle fitness with biological, biomechanical, and psychosomatic medicine in elderly rehabilitation. Increased incidents related to elderly muscle fitness deficiency tend to be an urgent public health issue. However, there is a controversy on the effects of Tai Chi exercise on muscle fitness, especially the lower body strength of the elderly. Objective. To determine whether lower body strength such as keen extension and flexion strength may be improved by Tai Chi exercise in older adults from the perspective of evidence-based medicine. Methods. Databases of PubMed, Embase, and Cochrane Library were searched up to July 1, 2021. Randomized clinical trials are adopted to compare Tai Chi exercise with sedentary behavior or other low intensity exercise in terms of influence on lower body strength rehabilitation, especially keen extension and flexion strength in people aged over 60. A meta-analysis was performed to discuss outcomes of lower body strength, knee muscle strength, and knee extension/flexion strength. Results. A total of 25 randomized trials involving 1995 participants fulfilled the inclusion criteria. (1) Tai Chi exercise significantly improved elderly lower body strength (−0.54, [−0.81, −0.28], p < 0.00001 , I2 = 74%), but there was no differential improvement in the strength of the knee joints (0.10, [−0.02, 0.23], p = 0.11 , I2 = 34%). (2) Elderly individual lower body strength declined with age, while this trend was suppressed by Tai Chi exercise (−0.35, [0.14, 0.56], p = 0.001 , I2 = 70%). (3) Although Tai Chi exercise did no significantly improve the large muscle group of knee joint extensor like quadriceps femoris (3.15, [−0.69, 6.99], p = 0.24 , I2 = 26%), it showed marked enhancement to the strength of deep small muscle group of knee joint flexor (10.25, [6.90, 13.61], p < 0.00001 , I2 = 0%). The heterogeneity might be caused by distinguished measurements of muscle strength. Therefore, Tai Chi exercise specifically enhanced some certain muscle strength of knee joints and improved muscle fitness rehabilitation as well as function activity for elderly. Conclusions. In this RCT meta-analysis, Tai Chi exercise has positive effects on lower body strength of elderly. Although no obvious improvement on the knee extensor is observed, it may be used as a rehabilitation treatment for training stable deep muscle groups to improve the knee flexion strength significantly.


Author(s):  
J R Hunter ◽  
A J Macquarrie ◽  
S C Sheridan

AbstractBackgroundParamedics are among the most frequently injured health professionals in Australia. A lack of physical capacity may contribute to injury risk in this occupational population.AimsThis study sought to describe and compare the physical fitness of male and female paramedics across age groups to ascertain differences in physical capacity.MethodsA group of regional Australian paramedics (n = 140; 78 males; mean ± SD 37.4 ± 9.9 years; body mass index 28.1 ± 4.9 kg/m2) underwent a fitness assessment. Measures included upper, lower and core-body muscular strength and flexibility. Outcomes were compared between genders and across age groups using two-way between-groups analysis of variance.ResultsMale paramedics had greater upper body strength (P < 0.05; push-ups) mean (95% CI): 22.6 (19.4–25.9) versus 18.7 (15.2–22.3); similar lower body strength (single-leg wall squat): 39.0 (32.6–45.3) s versus 36.7 (27.1–46.3) s; greater core strength (P < 0.05; prone plank hold): 87.9 (77.6–98.3) s versus 73.8 (63.7–83.8) s; similar upper body flexibility (back scratch): −4.0 (−6.7 to −1.3) cm versus −0.3 (−2.2 to 1.7) cm; and similar lower body flexibility (sit and reach): 20.4 (18.2–22.6) cm versus 26.1 (23.5–28.7) cm to female paramedics. Core, upper and lower body strength all decreased with age (P < 0.05).ConclusionsCore, upper and lower body strength and upper body flexibility were poorer for older compared to younger regional paramedics in New South Wales, Australia. Future research should investigate whether these outcomes are associated with occupational injury risk. This information would assist in the design of injury prevention interventions for paramedics such as tailored workplace exercise programs.


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