scholarly journals The Effects of One Anastomosis Gastric Bypass Surgery on the Gastrointestinal Tract

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 304
Author(s):  
Osnat Kaniel ◽  
Shiri Sherf-Dagan ◽  
Amir Szold ◽  
Peter Langer ◽  
Boris Khalfin ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Gastrointestinal Tract ◽  
Dietary Intake ◽  
Breath Test ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
One Anastomosis Gastric Bypass ◽  
Nutritional Deficiencies ◽  
Post Surgery ◽  
Glucose Breath Test

One anastomosis gastric bypass (OAGB) is an emerging bariatric procedure, yet data on its effect on the gastrointestinal tract are lacking. This study sought to evaluate the incidence of small-intestinal bacterial overgrowth (SIBO) following OAGB; explore its effect on nutritional, gastrointestinal, and weight outcomes; and assess post-OABG occurrence of pancreatic exocrine insufficiency (PEI) and altered gut microbiota composition. A prospective pilot cohort study of patients who underwent primary-OAGB surgery is here reported. The pre-surgical and 6-months-post-surgery measurements included anthropometrics, glucose breath-tests, biochemical tests, gastrointestinal symptoms, quality-of-life, dietary intake, and fecal sample collection. Thirty-two patients (50% females, 44.5 ± 12.3 years) participated in this study, and 29 attended the 6-month follow-up visit. The mean excess weight loss at 6 months post-OAGB was 67.8 ± 21.2%. The glucose breath-test was negative in all pre-surgery and positive in 37.0% at 6 months (p = 0.004). Positive glucose breath-test was associated with lower reported dietary intake and folate levels and higher vitamin A deficiency rates (p ≤ 0.036). Fecal elastase-1 test (FE1) was negative for all pre-surgery and positive in 26.1% at 6 months (p = 0.500). Both alpha and beta diversity decreased at 6 months post-surgery compared to pre-surgery (p ≤ 0.026). Relatively high incidences of SIBO and PEI were observed at 6 months post-OAGB, which may explain some gastrointestinal symptoms and nutritional deficiencies.

scholarly journals EARLY WEIGHT LOSS OUTCOMES AND GLUCOSE METABOLISM PARAMETERS AFTER BANDED VERSUS NON-BANDED ONE ANASTOMOSIS GASTRIC BYPASS: A PROSPECTIVE RANDOMIZED TRIAL

2019 ◽  
Vol 56 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Everton CAZZO ◽  
Felipe Gilberto VALERINI ◽  
Fábio Henrique Mendonça CHAIM ◽  
Pedro França da Costa SOARES ◽  
Almino Cardoso RAMOS ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Glucose Metabolism ◽  
Randomized Study ◽  
Standard Technique ◽  
One Anastomosis Gastric Bypass ◽  
Morbidly Obese ◽  
Model Assessment ◽  
Post Surgery ◽  
Early Weight Loss

ABSTRACT BACKGROUND: The influence of the placement of a band on the outcomes of one anastomosis gastric bypass (OAGB) has not been appropriately studied yet. OBJECTIVE: To compare early weight loss and glucose metabolism parameters following banded versus non-banded OAGB. METHODS: A prospective randomized study, which evaluated 20 morbidly obese individuals who underwent banded and non-banded OAGB and were followed-up for three months. Weight loss (percentage of excess weight loss - %EWL and percentage of body mass index loss - %BMIL) and glucose metabolism outcomes (glucose, insulin and homeostasis model assessment - HOMA) were compared. RESULTS: The banded group presented a significantly higher %EWL at one month (29.6±5.5% vs 17.2±3.4%; P<0.0001) and two months post-surgery (46±7% vs 34.2±9%; P=0.004544), as well as a significantly higher %BMIL at one month (9.7±1.1% vs 5.8±0.8%; P<0.0001), two months (15±1.4% vs 11.5±2.1; P=0.000248), and three months (18.8±1.8% vs 15.7±3.2%; P=0.016637). At three months, banded OAGB led to significant decreases of insulin (14.4±4.3 vs 7.6±1.9; P=0.00044) and HOMA (3.1±1.1 vs 1.5±0.4; P=0.00044), whereas non-banded OAGB also led to significant decreases of insulin (14.8±7.6 vs 7.8±3.1; P=0.006) and HOMA (3.2±1.9 vs 1.6±0.8; P=0.0041). The percent variation of HOMA did not significantly differ between banded and non-banded OAGB (P=0.62414); overall, the percent variation of HOMA was not correlated with %EWL (P=0.96988) or %BMIL (P=0.82299). CONCLUSION: Banded OAGB led to a higher early weight loss than the standard technique. Banded and non-banded OAGB led to improvements in insulin resistance regardless of weight loss.

Mo1928 - Does the Glucose Breath Test Correlate with Jejunal Microbes in Idiopathic small Intestinal Bacterial Overgrowth?

2018 ◽  
Vol 154 (6) ◽  
pp. S-854
Author(s):  
Richard W. McCallum ◽  
Antonio Mendoza-Ladd ◽  
Mingtao Zeng ◽  
Diana Diaz-Arévalo ◽  
Elisa Morales ◽  
...  
Keyword(s):  
Breath Test ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Intestinal Bacterial Overgrowth ◽  
Small Intestinal ◽  
Glucose Breath Test
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