scholarly journals Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 360
Author(s):  
Ricardo Usategui-Martín ◽  
Daniel-Antonio De Luis-Román ◽  
José María Fernández-Gómez ◽  
Marta Ruiz-Mambrilla ◽  
José-Luis Pérez-Castrillón
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Vdr Gene ◽  
Genotypic Distribution ◽  
Vdr Gene Polymorphisms ◽  
Genetic And Environmental Factors ◽  
The Relationship

The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic review and meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI, TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship between the response to vitamin D supplementation and the genotypic distribution of these polymorphisms. We included eight studies that enrolled 1038 subjects. The results showed no significant association with the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt) of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a better response to vitamin D supplementation (p = 0.02 and p < 0.001). In conclusion, the TaqI and FokI polymorphisms could play a role in the modulation of the response to vitamin D supplementation, as they are associated with a better response to supplementation.

scholarly journals The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1567
Author(s):  
Irene Moridi ◽  
Alice Chen ◽  
Oded Tal ◽  
Reshef Tal
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Ovarian Reserve ◽  
Potential Benefit ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Human Reproduction ◽  
Female Reproduction ◽  
The Relationship

Accumulating evidence from animal and human studies indicates a role for vitamin D in female reproductive physiology, and numerous clinical studies have suggested its potential benefit for various aspects of human reproduction. Anti-Müllerian hormone (AMH) is an ovarian biomarker that plays an important role in folliculogenesis. It is the most sensitive ovarian reserve marker and is widely used clinically in reproductive medicine. While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting. Currently, there is considerable debate in the field whether vitamin D has the capacity to influence ovarian reserve, as indicated by the AMH level. The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH. In total, 18 observational studies and 6 interventional studies were included in this systematic review. Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH. However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman’s ovulatory status. Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) −0.53, 95% CI −0.91 to −0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003). In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.

scholarly journals Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

2020 ◽  
Author(s):  
Masoud Hassanzadeh Makoui ◽  
Saeed Aslani ◽  
Payam Mohammadi ◽  
Bahman Razi ◽  
danyal imani
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms

Abstract Objective The association between the vitamin D receptor ( VDR ) gene polymorphisms and the risk of Type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to July 2019 were identified by comprehensive systematic database search in web of science, Scopus, and PubMed. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup analysis stratified by ethnicity was also conducted.Results A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI genes polymorphism and T1DM in African and American populations, respectively.Conclusions This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

Vitamin D receptor (VDR) gene polymorphism and risk of rheumatoid arthritis (RA): systematic review and meta-analysis

2020 ◽  
Vol 39 (12) ◽  
pp. 3555-3569 ◽  
Author(s):  
Zahra Bagheri-Hosseinabadi ◽  
Danyal Imani ◽  
Hassan Yousefi ◽  
Mitra Abbasifard
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Vitamin D ◽  
Gene Polymorphism ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Vdr Gene ◽  
Vdr Gene Polymorphism

scholarly journals Association of select vitamin D receptor gene polymorphisms with the risk of tobacco-related cancers – a meta-analysis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Lukasz Laczmanski ◽  
Izabela Laczmanska ◽  
Felicja Lwow
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Receptor Gene ◽  
P Value ◽  
Vdr Gene ◽  
Taqi Polymorphism ◽  
Vdr Gene Polymorphisms

Abstract The observed increase in morbidity and mortality due to tobacco-related cancers, especially those in the respiratory system and esophagus, is becoming a public health challenge. Smoking cigarettes is one of the main risk factors predisposing individuals to many types of cancers. The aim of this study was to determine the role of select vitamin D receptor (VDR) gene polymorphisms as risk factors in tobacco-related cancers. The MEDLINE and ResearchGate databases were used to search for articles up to June 2017, and 12 articles including 26 studies concerning FokI, ApaI, TaqI and BsmI polymorphisms and lung, neck, head, esophageal and oral cancers were chosen. In total, 5 113 cases and 5 657 controls were included in the pooled analysis. We found a significant relationship between tobacco-related cancers and the occurrence of the “t” allele in the TaqI polymorphism of VDR. The occurrence of the “t” allele reduced the risk of tobacco-related cancers by 17% (OR = 0.83, 0.72–0.96 95% CI, p-value = 0.0114). Our analysis revealed that there is a correlation between the TaqI polymorphism of VDR and the risk of tobacco-related cancers.

scholarly journals Polymorphisms of the Vitamin D Receptor Gene in Crohn Disease

2021 ◽  
Author(s):  
Bhettina Vieira Lopes ◽  
Vitor Linhares Ribeiro ◽  
Larissa de Oliveira Rosa Marques ◽  
Liliane Emilly dos Santos Sousa ◽  
Jacqueline Andréia Bernardes Leão-Cordeiro ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Crohn Disease ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Vdr Gene ◽  
Control Subjects ◽  
Inflammatory Conditions ◽  
Vdr Gene Polymorphisms

Abstract Introduction Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions of the gastrointestinal tract. Studies have shown that polymorphisms of the vitamin D receptor (VDR) gene may help elucidate the pathogenesis of CD. Objectives To analyze the role of VDR gene polymorphisms (ApaI, BsmI, FokI, and TaqI) in the development of CD. Methods The present study is a systematic review with meta-analysis. a total of 50 articles in English and Portuguese published from 2000 to 2020 were selected from 3 databases. The relationship between CD and the VDR gene was addressed in 16 articles. Results The TaqI polymorphism was analyzed in 3,689 patients and 4,645 control subjects (odds ratio [OR] = 0.948; 95% confidence interval [95%CI] = 0.851–1.056; p = 0.3467). The ApaI polymorphism was studied in 3,406 patients and 4,415 control subjects (OR = 1,033; 95%CI = 0.854–1.250; p = 0.7356). For FokI polymorphism, there were 2,998 patients and 4,146 control subjects (OR = 0.965; 95%CI = 0.734–1.267; p = 0.7958). Lastly, the BsmI polymorphism was analyzed in 2,981 patients and 4,477 control subjects (OR = 1,272; 95%CI = 0.748–2.161; p = 0.3743). Conclusion These four VDR gene polymorphisms were not associated with CD. Therefore, further studies with larger samples are required to corroborate or rectify the conclusions from the present meta-analysis.

Vitamin D receptor gene polymorphisms and osteoarthritis: a meta-analysis

Rheumatology ◽  
2020 ◽  
Author(s):  
Hui-Min Li ◽  
Yi Liu ◽  
Ren-Jie Zhang ◽  
Jing-Yu Ding ◽  
Cai-Liang Shen
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Recessive Model ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms ◽  
Apai Polymorphism ◽  
Meta Analyses

Abstract Objective To investigate the association of vitamin D receptor (VDR) gene polymorphisms with OA susceptibility. Methods Meta-analyses were performed using allelic contrast, contrast of homozygotes, and recessive and dominant models to clarify the association between OA and VDR ApaI, BsmI, TaqI and FokI polymorphisms. Odds ratio (OR) and the corresponding 95% CI were obtained, and subgroup analyses were performed based on the ethnicity and OA sites. Results A total of 18 studies with 2983 OA patients and 4177 controls were included in this meta-analysis. There were statistically significant associations in the spine between OA susceptibility and the VDR BsmI (B vs b: OR = 1.25, 95% CI: 1.03, 1.53, P = 0.026; BB vs bb: OR = 1.56, 95% CI: 1.02, 2.37, P = 0.038) and TaqI (T vs t: OR = 0.73, 95% CI: 0.54, 0.99, P = 0.044; TT vs Tt + tt: OR = 0.63, 95% CI: 0.42, 0.95, P = 0.028) polymorphisms, but not for the other polymorphisms. A statistically significant association was found between the VDR FokI polymorphism and OA susceptibility in the knee in the recessive model contrast (FF vs Ff + ff: OR = 0.63, 95% CI: 0.42, 0.95, P = 0.028), but this result was only pooled from one study. However, no significant associations were found between the VDR ApaI polymorphism and OA. Besides, ethnic stratification also indicated that there was no significant association between VDR gene polymorphism and OA in Caucasians or Asians. Conclusion Our meta-analysis suggests that the VDR BsmI and TaqI polymorphisms are associated with OA susceptibility in the spine. However, the VDR ApaI polymorphism is not a significant genetic risk factor for OA.

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