scholarly journals Treatment with Micafungin in a Preterm Neonate with an Invasive Candida parapsilosis Infection after a Severe Terlipressin-Induced Skin Necrosis

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 890
Author(s):  
Domenico Umberto De Rose ◽  
Fiammetta Piersigilli ◽  
Bianca Maria Goffredo ◽  
Olivier Danhaive ◽  
Andrea Dotta ◽  
...  
Keyword(s):  
Skin Necrosis ◽  
Candida Parapsilosis ◽  
Preterm Neonate ◽  
Clinical History ◽  
Skin Lesions ◽  
Preterm Neonates ◽  
High Dose ◽  
Skin Grafts ◽  
Extremely Preterm ◽  
History Of

Candida parapsilosis infections are increasingly reported in preterm neonates, but the optimal treatment remains uncertain. We report the clinical history of an extremely preterm neonate, who developed a devastating skin necrosis due to terlipressin administration, with subsequent superinfection by Candida parapsilosis. The infant underwent multiple curettages and skin grafts to resolve skin lesions and was treated with systemic micafungin administration at a high dose (8 mg/kg/day), with resolution of the fungal infection.

scholarly journals Sarcoidosis presenting as facial and scalp ulceration with secondary bacterial infection of the skin

2019 ◽  
Vol 12 (11) ◽  
pp. e231769
Author(s):  
Georgi Fram ◽  
Smita Kohli ◽  
Angela Jiang ◽  
Scott Kaatz
Keyword(s):  
Skin Lesions ◽  
Cardiac Monitoring ◽  
High Dose ◽  
Severe Dehydration ◽  
Intravenous Antibiotics ◽  
History Of ◽  
Facial Wounds ◽  
Antibiotic Coverage ◽  
Dose Prednisone

A 67-year-old man with a medical history of multiorgan sarcoidosis was admitted to the hospital with skin ulceration and a superimposed polymicrobial infection that had failed outpatient management. The patient’s outpatient regimen included doxycycline, ciprofloxacin and moderate-dose prednisone therapy for a coinfection with Pseudomonas aeruginosa and methicillin-susceptible Staphylococcus aureus. The patient presented after a syncopal episode initially thought to be due to severe dehydration. Owing to concern for cardiac sarcoidosis as well as worsening skin lesions, he was admitted to the hospital for cardiac monitoring and intravenous antibiotics. On admission, we broadened antibiotic coverage and initiated high-dose steroids at 1 mg/kg/day of prednisone. He was discharged on intravenous antibiotics and a slow steroid taper 3 days later. At the patient’s 1-month and 5-month follow-up clinic visits, he demonstrated remarkable improvement of his scalp and facial wounds.

scholarly journals Blindness in a Woman With Human Immunodeficiency Virus Infection and Syphilis

1995 ◽  
Vol 3 (5) ◽  
pp. 198-201
Author(s):  
Michael Luchi ◽  
Curtis Beauregard ◽  
Kevin Ault ◽  
Daniel Hinthorn
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Hiv Infection ◽  
Skin Lesions ◽  
High Dose ◽  
Progressive Loss ◽  
Immunodeficiency Virus ◽  
History Of ◽  
Hands And Feet

Background: A concomitant infection with human immunodeficiency virus (HIV) may alter the natural history of other infections. Several reports indicate that syphilis may behave more aggressively when HIV infection is present.Case: A woman presented with a rash involving her hands and feet and progressive loss of the vision in her right eye. Her serologic tests for syphilis and HIV infection were positive. A diagnosis of neurosyphilis was confirmed by an analysis of cerebrospinal fluid (CSF). She was treated with high-dose intravenous (IV) penicillin. Her skin lesions resolved, but her vision did not improve.Conclusion: The incidence of HIV infection among women is rising. A patient with HIV and syphilis may develop neurosyphilis in a much shorter time than a patient without HIV infection.

High-dose calcium reduces early-onset hyperkalemia in extremely preterm neonates

2012 ◽  
Vol 54 (6) ◽  
pp. 918-922 ◽  
Author(s):  
Masahiro Enomoto ◽  
Hirotaka Minami ◽  
Tsutomu Takano ◽  
Yoshinori Katayama ◽  
Yong Kye Lee
Keyword(s):  
Early Onset ◽  
Preterm Neonates ◽  
High Dose ◽  
Extremely Preterm

scholarly journals Lymphomatoid Papulosis in a Case of Atypical Secondary Syphilis

2019 ◽  
Vol 14 (4) ◽  
pp. e32-e33
Author(s):  
Xin (Peter) Mu ◽  
Ian Mazzetti
Keyword(s):  
Clinical History ◽  
Skin Lesions ◽  
Secondary Syphilis ◽  
Low Grade ◽  
Cutaneous Lesions ◽  
Syphilis Infection ◽  
Lymphomatoid Papulosis ◽  
History Of ◽  
Skin Biopsies ◽  
Syphilis Serology

AbstractLymphomatoid papulosis is an indolent cutaneous lymphoproliferative disorder that presents as recurrent self-resolving papulonodular skin lesions. Currently, there are no known causes for lymphomatoid papulosis and definitive diagnosis is only made histologically. A 64-year-old man presented with a 6-week history of bilateral leg pains, low-grade fevers, and a widespread eruption of painless erythematic papules. Despite testing positive for syphilis serology, he lacked the typical clinical history for classic syphilis and therefore, skin biopsies were performed to confirm the diagnosis. Unexpectedly, the skin biopsies revealed lymphomatoid papulosis which resolved with antibiotic treatments for syphilis. Considering the synchronous resolution of the patient’s syphilis infection and his cutaneous lesions, this is the first report of findings to suggest syphilis as a possible cause for lymphomatoid papulosis. Clinicians should appreciate the possibility of alternative diagnosis for cutaneous presentations in settings of confirmed syphilis infections. RESUMELa papulose lympho-matoïde est un trouble lymphoprolifératif cutané indolent qui se présente sous la forme de lésions cutanées papulonodulaires auto-résolutives récurrentes. Actuellement, il n’y a pas de causes connues de la papulose lymphomatoïde et le diagnostic définitif n’est posé que sur le plan histologique. Un homme de 64 ans a présenté une histoire de 6 semaines de douleurs bilatérales aux jambes, de fièvres de bas grade et d’éruptions généralisées de papules érythémateuses indolores. Malgré un test sérologique positif pour la syphilis, il n’avait pas les antécédents cliniques typiques de la syphilis classique et des biopsies cutanées ont donc été effectuées pour confirmer le diagnostic. De façon inattendue, les biopsies cutanées ont révélé une papulose lymphomatoïde qui s’est résorbée grâce à des traitements antibiotiques contre la syphilis. Compte tenu de la résolution synchrone de l’infection syphilitique du patient et de ses lésions cutanées, il s’agit du premier rapport de résultats suggérant que la syphilis est une cause possible de papulose lymphomatoïde. Les cliniciens devraient apprécier la possibilité d’un diagnostic alternatif pour les présentations cutanées dans les contextes d’infections syphilitiques confirmées.

scholarly journals Airway Challenges in a Preterm Neonate with Undiagnosed Complete Tracheal Rings Posted for Surgery

2021 ◽  
Author(s):  
Pratika Pradeep Bhokare ◽  
Sayli Rajendra Kulkarni
Keyword(s):  
Difficult Airway ◽  
Preterm Neonate ◽  
Airflow Obstruction ◽  
Failure To Thrive ◽  
Abdominal Distension ◽  
Exploratory Laparotomy ◽  
Supraglottic Airway ◽  
Preterm Neonates ◽  
History Of ◽  
Airway Anomalies

Preterm neonates are defined as those born before 37 weeks. The anatomical features of preterm neonates vary from that of an adult, such that they have a large tongue, an anterior funnel shaped larynx, angled vocal cords and an omega shaped epiglottis. Their physiological development also differ as they have a greater risk for apnoea of prematurity, airflow obstruction, bronchopulmonary dysplasia, low functional residual capacity and decreased transient oxygen tension. Congenital airway anomalies have a prevalence rate of 0.2-1 in 10,000 live births. Congenital Tracheal Stenosis (CTS) caused by complete tracheal rings is one of the rarest forms of all the airway anomalies that occur, which is characterised by presence of complete ‘O’ shaped cartilaginous rings of trachea devoid of a membranous part. The case discussed in the article is that of a day 26 preterm neonate with increasing abdominal distension and failure to thrive. The neonate was posted for an urgent exploratory laparotomy for abdominal decompression and ileostomy. Patient was kept on Continuous Positive Airway Pressure (CPAP) support for four days immediately after birth; however, intubation was never attempted nor required. With a history of respiratory depression and lack of history of previous intubation, difficult airway cart was kept ready prior to surgery. Supraglottic Airway (SGA) devices were at the core of airway rescue in this case of undiagnosed CTS. This case report shows how and why a preparation for difficult airway in preterm neonates is a necessity. It will provide as a guide if a similar case is encountered by the anaesthetist.

scholarly journals Hemidiaphragmatic paralysis related to extravasation of parenteral solution in very low birthweight neonates

2021 ◽  
Vol 14 (5) ◽  
pp. e242390
Author(s):  
Hai-Bo Huang ◽  
Qian-Shen Zhang ◽  
David G Tingay ◽  
Po-Yin Cheung
Keyword(s):  
Low Birthweight ◽  
Preterm Neonate ◽  
Spontaneous Recovery ◽  
Clinical Course ◽  
Venous Catheter ◽  
Preterm Neonates ◽  
Significant Morbidity ◽  
Very Low Birthweight ◽  
Central Venous ◽  
Extremely Preterm

Central venous catheter (CVC) placement is common in the care of very low birthweight (VLBW) preterm neonates. Although it is generally considered to be safe, CVC placement is associated with complications, including extravasation that may lead to significant morbidity and mortality. We report the clinical course of an extremely preterm neonate born at 27 weeks gestation, and another 5 VLBW preterm neonates reported in the literature with hemidiaphragmatic paralysis related to extravasation of parenteral solution from CVC placement. In VLBW preterm neonates, spontaneous recovery of diaphragmatic paralysis related to extravasation of parenteral solution is possible.

scholarly journals NCMP-19. SIDE EFFECTS FROM CHEMOTHERAPY VERSUS SYMPTOMS FROM COVID-19 INFECTION

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii126-ii127
Author(s):  
Senxi Du ◽  
Maya Hrachova ◽  
Xiao-Tang Kong
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Clinical History ◽  
Nausea And Vomiting ◽  
Medical Attention ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Ocular Lymphoma ◽  
Dose Methotrexate ◽  
History Of

Abstract INTRODUCTION Adverse effects from chemotherapy such as high dose methotrexate (HD-MTX) are seen during and after chemotherapy. During this coronavirus disease 2019 (COVID-19) pandemic period, COVID-19 infection symptoms following chemotherapy due to immune compromise could mimic chemotherapy associated side effects. Differentiation on time is needed for correct management. CASE REPORT A 50-year old male with clinical history of ocular lymphoma underwent HD-MTX therapy. Before admission, his routine COVID-19 test was negative. After receiving HD-MTX, he developed fatigue, nausea and vomiting. The symptoms resolved before discharge. Next day after discharge, he developed diarrhea, fatigue, subjective fever and feeling cold. His temperature was normal. His symptoms have been persistent for 4-5 days and have resolved gradually and spontaneously. Family members have had no symptoms. The patient denies COVID-19 contact history. The above symptoms were considered adverse effects from chemotherapy. The patient did not seek medical attention. Prior to admission for next cycle of HD-MTX, COVID-19 test was found positive. Chemotherapy was on hold. The patient started home quarantine. The patient has been doing well and practiced COVID-19 infection precaution at home. DISCUSSION The fatigue, nausea and vomiting during HD-MTX treatment are adverse effects from chemotherapy while the diarrhea, fatigue, subjective fever and chills developed after discharge are symptoms of COVID-19 infection. Our case highlights the importance of keeping in mind and differentiating between side effects from chemotherapy and symptoms of COVID-19 viral infection in cancer patients who receive chemotherapy.

scholarly journals Early High-Dose Caffeine Increases Seizure Burden in Extremely Preterm Neonates: A Preliminary Study

2016 ◽  
Vol 6 (3) ◽  
pp. 101-107 ◽  
Author(s):  
Zachary A. Vesoulis ◽  
Christopher McPherson ◽  
Jeffrey J. Neil ◽  
Amit M. Mathur ◽  
Terrie E. Inder
Keyword(s):  
Preterm Neonates ◽  
High Dose ◽  
Extremely Preterm ◽  
Preliminary Study
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