scholarly journals Does Methylphenidate Work in Children and Adolescents with Attention Deficit Hyperactivity Disorder?

2021 ◽  
Vol 13 (3) ◽  
pp. 434-443
Author(s):  
Johanne Pereira Ribeiro ◽  
Emma Jasmine Arthur ◽  
Christian Gluud ◽  
Erik Simonsen ◽  
Ole Jakob Storebø
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Clinical Trials ◽  
Children And Adolescents ◽  
Systematic Reviews ◽  
Attention Deficit ◽  
Cochrane Review ◽  
Field Method ◽  
Randomised Clinical Trials ◽  
Hyperactivity Disorder ◽  
Meta Analyses

Objective: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder diagnosed in increasing proportions of children and adolescents. The psychostimulant methylphenidate has been considered the first-line pharmacological treatment for children and adolescents with ADHD for more than 60 years. Considering recent publications on methylphenidate for ADHD, we here give an overview of its effects in children and adolescents with ADHD, elicited by a well-disputed Cochrane review and narratively synthesise the evidence in the field. Method: We searched for systematic reviews and meta-analyses that investigated methylphenidate as an intervention for children and adolescence with ADHD compared with placebo or no treatment. We assessed the quality of the evidence using AMSTAR II. Results: We found 24 eligible systematic reviews and meta-analyses of which 11 were rated as high- quality evidence according to AMSTAR II. The evidence claiming that methylphenidate is beneficial in treating children and adolescents with ADHD was of very low certainty. The underreporting of adverse events in randomised clinical trials may impede an adequate depiction of the balance between benefits and harms. Conclusions: It appears that there is uncertain evidence on group-level to support the claim that methylphenidate is beneficial in treating children and adolescents with ADHD. Future randomised clinical trials and systematic reviews should include individual participant data, which would allow us to assess intervention effects across modifiers, like age, sex, ADHD subtypes, comorbidities, and dose.

scholarly journals Interventions Based on Mind–Body Therapies for the Improvement of Attention-Deficit/Hyperactivity Disorder Symptoms in Youth: A Systematic Review

Medicina ◽  
2019 ◽  
Vol 55 (7) ◽  
pp. 325 ◽  
Author(s):  
Yaira Barranco-Ruiz ◽  
Bingen Esturo Etxabe ◽  
Robinson Ramírez-Vélez ◽  
Emilio Villa-González
Keyword(s):  
Systematic Review ◽  
Attention Deficit Hyperactivity Disorder ◽  
Children And Adolescents ◽  
Attention Deficit ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
Different Populations ◽  
Meta Analyses ◽  
Positive Effect ◽  
Quality Tool

Background and objectives: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children and adolescents. Mind–body therapies (MBTs) seem to be effective for improving health in different populations; however, whether a positive effect occurs in children and adolescents with ADHD is still controversial. The main aim of this systematic review was to analyse the interventions based on MBT aimed to improve the main ADHD symptoms in children and adolescents. Materials and Methods: A systematic review was conducted following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines to identify MBT studies on children and adolescents (4–18 years) with a clinical diagnosis of ADHD. Study quality was evaluated by the NIH quality tool (U.S. National Institute of Health). Results: There were positive results in eleven out of twelve included studies regarding the effect of the MBT interventions on ADHD symptoms. With respect to ADHD symptoms, we observed differences across studies. In relation to the studies’ quality, eleven studies were rated “poor” and one was rated as “fair”. Conclusions: MBTs, such as yoga or mindfulness, could be positive strategies to mitigate ADHD symptoms in children and adolescents. However, further research with high-quality designs, with randomization, greater sample sizes, and more intensive supervised practice programs are needed.

scholarly journals Autistic spectrum disorder symptoms in children and adolescents with attention-deficit/hyperactivity disorder: a meta-analytical review

2019 ◽  
Vol 50 (13) ◽  
pp. 2240-2253 ◽  
Author(s):  
Jack Hollingdale ◽  
Emma Woodhouse ◽  
Susan Young ◽  
Adie Fridman ◽  
Will Mandy
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Children And Adolescents ◽  
Attention Deficit ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Clinical Samples ◽  
Hyperactivity Disorder ◽  
Significant Difference ◽  
Analytical Review ◽  
Meta Analyses

AbstractBackgroundResearch identifies highly variable prevalence estimates for autism spectrum disorder (ASD) in children and adolescents with attention deficit hyperactivity disorder (ADHD), particularly between community and clinical samples, warranting quantitative meta-analyses to investigate the true prevalence of ASD in children and adolescents with ADHD.MethodsStudies were identified through a systematic literature search of PsycINFO, MEDLINE and Web of Science through January 2018. Twenty-two publications met inclusion criteria (total N = 61 985). Two random effects meta-analyses were conducted: (1) to identify the proportion of children and adolescents with ADHD that met criteria for ASD; and (2) to compare the severity of dimensionally-measured ASD symptomology in children and adolescents with and without ADHD.ResultsThe overall pooled effect for children and adolescents with ADHD who met threshold for ASD was 21%. There was no significant difference between community samples (19%) and clinical samples (24%) or between US studies v. those from other countries. Children and adolescents with ADHD had substantially more dimensionally-measured ASD traits compared with those who did not have ADHD (d = 1.23).ConclusionThe findings provide further evidence that ADHD and ASD are associated in nature. Clinical and research implications are discussed.

scholarly journals A review of Cochrane reviews on pharmacological treatment for attention deficit hyperactivity disorder

2021 ◽  
Vol 15 (4) ◽  
pp. 421-427
Author(s):  
Giovanna Marcílio Santos ◽  
Elaine Marcílio Santos ◽  
Gustavo Duarte Mendes ◽  
Yara Dadalti Fragoso ◽  
Mariani Rafaela Souza ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Adverse Events ◽  
Children And Adolescents ◽  
Systematic Reviews ◽  
Attention Deficit ◽  
Randomized Clinical Trials ◽  
Placebo Treatment ◽  
Hyperactivity Disorder ◽  
Positive Effects ◽  
Cochrane Reviews

ABSTRACT. Attention deficit hyperactivity disorder (ADHD) is one of the most frequent childhood psychiatric problems. Objective: The objective of this study was to identify, synthesize the results, and critically evaluate all Cochrane systematic reviews (SRs) on the pharmacological interventions for children and adolescents (up to age 18) diagnosed with ADHD. Methods: The search was performed in the Cochrane Database of Systematic Reviews (via Wiley) in July 2020. Results: The search strategy resulted in four SRs of high methodological quality, analyzing 51 randomized clinical trials (9,013 participants). Compared to placebo, treatment with tricyclic antidepressants (TCAs) (desipramine), amphetamine, and methylphenidate showed improvement in symptoms such as difficulty concentrating, impulsivity, and hyperactivity in the short term (up to 6 months). There was an increase in the occurrence of adverse events, such as reduced appetite, difficulty sleeping, and abdominal pain. Insufficient evidence was found to support the effects of supplementation with polyunsaturated fatty acids. Conclusions: The use of TCAs, amphetamine, and methylphenidate in children and adolescents with ADHD seems to present positive effects and higher rates of minor adverse events when compared to placebo.

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