scholarly journals 3D Printing of Temporary Prostheses for Controlled-Release of Drugs: Design, Physical Characterization and Preliminary Studies

2021 ◽  
Vol 14 (12) ◽  
pp. 1240
Author(s):  
Carlos Bueno-López ◽  
Carlos Tamarit-Martínez ◽  
Adrián M. Alambiaga-Caravaca ◽  
Cristina Balaguer-Fernández ◽  
Virginia Merino ◽  
...  
Keyword(s):  
Controlled Release ◽  
3D Printing ◽  
Morphological Changes ◽  
Release Kinetics ◽  
Cylindrical Structures ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Continue Research ◽  
3D Printed ◽  
Model Drug

In recent years, the use of 3D printing technologies in orthopedic surgery has markedly increased, as they offer the possibility of printing personalized prostheses. The work presented in this article is a preliminary study of a research project which aims to manufacture customized spacers containing antibiotics for use in joint replacement surgery. The objective of this work was to design and print different 3D constructs to evaluate the use of different materials, their properties after the process of 3D printing, such as resistance, and the release kinetics of drugs from the constructs. Different designs and different materials were analyzed to obtain a 3D construct with suitable properties. Our design takes advantage of the micropores created between the layers of the 3D printed filaments to release the contained drug. Using polylactic acid (PLA) we were able to print cylindrical structures with interconnected micropores and a hollow chamber capable of releasing methylene blue, which was selected as a model drug. The final PLA 3D construct was printed with a 10% infill. The physical and technological characteristics, morphological changes at body temperature and interaction with water were considered to be acceptable. The PLA 3D printed constructs were found to have sufficient strength to withstand a force of 500 kg. The results obtained allow to continue research in this project, with the aim of manufacturing prostheses containing a reservoir of antibiotics or other drugs in their interior for their subsequent controlled release.

Controlled Release of Bi-Layered Malvidin Tablets Using 3D Printing Techniques

2021 ◽  
pp. 70-78
Author(s):  
Tejinder Kaur ◽  
Suruchi Singh
Keyword(s):  
Controlled Release ◽  
3D Printing ◽  
Fruits And Vegetables ◽  
Physical And Mechanical Properties ◽  
3D Printer ◽  
Anti Cancer ◽  
Printing Cost ◽  
3D Printed ◽  
Cost Efficient ◽  
3D Printing Technique

Malvidin belongs to the class of anthocyanidin, a pigment compound present in fruits and vegetables like the colored berries, flowers, and vegetables which have pigments on it and it is available commercially as malvidin chloride. Malvidin is known to possess many medicinal characteristics like anti-microbial, anti-diabetic, anti-inflammatory, anti-obesity, and anti-cancer. In this research paper, a 3D printing technique is used which evolves a 3D printer based on desktop that extrudes tablets comprising the active drug which here is malvidin our main ingredient and the other excipients which are used as binders and disintegrants. Methods which are adapted here for the formulation of 3D printed tablet make the tablets appropriate for immediate and sustained release with its definite physical and mechanical properties like hardness, friability, and weight. Tablets that are extruded by the 3D printer are controlled release bi-layer tablets. Due to involvement of 3D printer, printing cost for the bi-layered tablets found very low that makes our method as cost efficient.

Controlled Release of Bone Growth Factors from Injectable, Biodegradable Polymer Scaffolds for Bone Tissue Engineering

2000 ◽  
Vol 662 ◽  
Author(s):  
Elizabeth L. Hedberg ◽  
Antonios G. Mikos
Keyword(s):  
Growth Factors ◽  
Controlled Release ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Release Kinetics ◽  
Salt Content ◽  
Burst Effect ◽  
Plga Microparticles ◽  
Model Drug

AbstractThe objective of this research is to fabricate injectable, polymeric composites that will act as scaffolds for bone ingrowth as well as carriers for the controlled release of bone growth factors. To that end, the injectable polyester poly(propylene fumarate) (PPF) was loaded with poly(DLlactic-co-glycolic acid) (PLGA) microparticles carrying the model drug FITC-dextran. This preparation was then crosslinked with N-vinyl pyrrolidinone in the presence of benzoyl peroxide as initiator and sodium chloride (NaCl) as leachable porogen. The encapsulation of growth factors in microparticles is necessary to minimize their denaturation during scaffold crosslinking. PLGA microparticles (0.04 g microparticles/g PPF) were incorporated into PPF composites having variable NaCl weight percents (50 and 70 wt% NaCl) and the effect on FITC-dextran release kinetics was determined in vitro for cylinders of diameter 6.5 mm and height 13.0 mm. The FITC-dextran loaded microparticles alone exhibited a large initial burst effect, while the composite materials displayed a smaller burst effect and a longer linear region of release. At day 3, 54.6±2.1%, 5.1±0.9%, and 12.5±0.3% of loaded FITC-dextran was released into pH 7.4 phosphate buffered saline from the microparticles, the 50 wt% NaCl, and the 70 wt% NaCl composites, respectively. By day 28, 90.9±6.9%, 12.7±1.7%, and 34.4±0.4% of loaded FITC-dextran was released. Our results demonstrate that PLGA microparticles can be incorporated into PPF composites and that the release kinetics of FITC-dextran can be systematically manipulated through alteration of the composite initial salt content.

Controlled Release of Resveratrol and Lignan by Matrix Tableting

2013 ◽  
Vol 746 ◽  
pp. 330-336
Author(s):  
Mont Kumpugdee-Vollrath ◽  
Mario Helmis
Keyword(s):  
Controlled Release ◽  
Release Kinetics ◽  
Research Work ◽  
Magnesium Stearate ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Water Soluble Drug ◽  
The Matrix ◽  
Best Fitting ◽  
Model Drug

The aim of this research work was to develop the controlled release of two model drugs i.e. water insoluble drug - resveratrol and water soluble drug - lignan by matrix tableting with an eccentric tablet machine. For this purpose different kinds of polymers i.e. Metolose 90 SH-4000® (HMPC), Fetocel RT-N-100® (EC) and Eudragit RLPO® (polymethacrylate) were used. The matrix tablets containing 2 %wt of a model drug which were mixed with 5, 10, 20, 30 and 50 %wt of the polymers mentioned above. In addition, a glidant composed of 1 %wt talc and 1 %wt magnesium stearate as well as a filler Ludipress® were processed. Different physical properties of the powder mixtures (e.g. flowability) and of the tablets (e.g. hardness, uniformity of mass or drug content, drug release, etc.) were determined. Most of the tablets met the physical requirements. If the polymer content got higher the release was slower, which can be confirmed by the lower values of k. The release kinetics were described by three typical mathematic models i.e. biphasic, Noyes-Whitney and KorsmeyerPeppas. The best fitting results were ordered as follows: biphasic > Noyes-Witney > KorsmeyerPeppas.

scholarly journals Ordered mesoporous silicates as matrices for controlled release of drugs

2010 ◽  
Vol 60 (4) ◽  
pp. 373-385 ◽  
Author(s):  
Tina Ukmar ◽  
Odon Planinšek
Keyword(s):  
Controlled Release ◽  
Uv Light ◽  
Release Kinetics ◽  
Stimuli Responsive ◽  
Mesoporous Silicates ◽  
Ordered Mesoporous ◽  
Poorly Soluble ◽  
Model Drug ◽  
Kinetics Of

Ordered mesoporous silicates as matrices for controlled release of drugs Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established in vitro.

scholarly journals 3D Printing of Tunable Zero-Order Release Printlets

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1769 ◽  
Author(s):  
Fabrizio Fina ◽  
Alvaro Goyanes ◽  
Martin Rowland ◽  
Simon Gaisford ◽  
Abdul W. Basit
Keyword(s):  
3D Printing ◽  
Release Kinetics ◽  
Drug Loading ◽  
Zero Order ◽  
Prolonged Release ◽  
Fused Deposition ◽  
Order Release ◽  
Zero Order Release ◽  
3D Printed ◽  
Release Profiles

Zero-order release formulations are designed to release a drug at a constant rate over a prolonged time, thus reducing systemic side effects and improving patience adherence to the therapy. Such formulations are traditionally complex to manufacture, requiring multiple steps. In this work, fused deposition modeling (FDM) 3D printing was explored to prepare on-demand printlets (3D printed tablets). The design includes a prolonged release core surrounded by an insoluble shell able to provide zero-order release profiles. The effect of drug loading (10, 25, and 40% w/w paracetamol) on the mechanical and physical properties of the hot melt extruded filaments and 3D printed formulations was evaluated. Two different shell 3D designs (6 mm and 8 mm diameter apertures) together with three different core infills (100, 50, and 25%) were prepared. The formulations showed a range of zero-order release profiles spanning 16 to 48 h. The work has shown that with simple formulation design modifications, it is possible to print extended release formulations with tunable, zero-order release kinetics. Moreover, by using different infill percentages, the dose contained in the printlet can be infinitely adjusted, providing an additive manufacturing route for personalizing medicines to a patient.

scholarly journals Rapid controlled release by photo-irradiation using morphological changes in micelles formed by amphiphilic lophine dimers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masaaki Akamatsu ◽  
Kazuki Kobayashi ◽  
Hiroki Iwase ◽  
Yoshifumi Sakaguchi ◽  
Risa Tanaka ◽  
...  
Keyword(s):  
Controlled Release ◽  
Morphological Changes ◽  
Molecular Assembly ◽  
Active Components ◽  
Molecular Assemblies ◽  
On Demand ◽  
Photoresponsive Surfactants ◽  
Rapid Control ◽  
Ultraviolet Light Irradiation ◽  
Model Drug

AbstractPhoto-induced rapid control of molecular assemblies, such as micelles and vesicles, enables effective and on-demand release of drugs or active components, with applications such as drug delivery systems (DDS) and cosmetics. Thus far, no attempts to optimize the responsiveness of photoresponsive molecular assemblies have been published. We previously reported photoresponsive surfactants bearing a lophine dimer moiety that exhibit fast photochromism in confined spaces, such as inside a molecular assembly. However, rapid control of the micelle structures and solubilization capacity have not yet been demonstrated. In the present work, photo-induced morphological changes in micelles were monitored using in-situ small-angle neutron scattering (SANS) and UV/Vis absorption spectroscopy. An amphiphilic lophine dimer (3TEG-LPD) formed elliptical micelles. These were rapidly elongated by ultraviolet light irradiation, which could be reversed by dark treatment, both within 60 s. For a solution of 3TEG-LPD micelles solubilizing calcein as a model drug molecule, fluorescence and SANS measurements indicated rapid release of the incorporated calcein into the bulk solvent under UV irradiation. Building on these results, we investigated rapid controlled release via hierarchical chemical processes: photoisomerization, morphological changes in the micelles, and drug release. This rapid controlled release system allows for effective and on-demand DDS.

scholarly journals Three-Dimensional Printing and Medical Education: A Narrative Review of the Literature

2016 ◽  
Vol 6 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Michael Peppis Bartellas
Keyword(s):  
Medical Education ◽  
3D Printing ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Promising Tool ◽  
Base De Données ◽  
Teaching Anatomy ◽  
Il Y A ◽  
Continue Research ◽  
3D Printed

Objectives: Three-dimensional (3D) printing has emerged in the past decade as a promising tool for the world of medicine. The focus of this article is to review how 3D printed models have been used in medical education.Methods: PubMed was the article database used, and the search criteria included the terms 3D printing and education. The exclusion criteria filtered out articles that were older than ten years, were not in English, and did not target a human population. There were 90 discovered articles, and 38 appropriate articles were determined after reviewing titles and abstracts.Results: Three main themes emerged from this review: general medical education, surgical education, and patient education. The more specific findings can be further divided into: using 3D printed models for teaching anatomy and simulation training; and preop­erative planning, intraoperative guidance, and postoperative evaluation.Conclusions: The general consensus was that 3D haptic modelling was a useful tool for educating trainees, staff physicians, and pa­tients. The models helped in increasing participants’ understanding of anatomy and pathologies, and improving trainee skill set and confidence. There is much support to continue research in this area and to further develop ways in which 3D printing can help improve medical education.  Objectifs : L’impression tridimensionnelle (3D) s’annonce comme un outil prometteur pour le monde de la médecine. Le présent ar­ticle révisera comment les méthodes d’impression 3D ont été utilisées dans l’éducation médicale.Méthodes : La base de données utilisée pour les articles fut PubMed et les critères de recherche ont inclus les termes impression 3D et éducation. Les critères d’exclusion ont omis des articles qui dataient de plus de dix ans, qui n’étaient pas en anglais, et qui n’avaient pas comme cible la population humaine. Il y a 90 articles qui furent trouvés en tout et 38 de ces articles ont été jugés adéquats pour la révision.Résultats : Trois grands thèmes ont été ressortis lors de cette révision : éducation médicale générale, éducation chirurgicale, et éduca­tion des patients. De façon plus précise, les thèmes spécifiques suivants furent dégagés : l’utilisation d’impression de modèles 3D pour l’enseignement de l’anatomie et la formation par simulation, la préparation préopératoire, le guide intraopératoire, et l’évaluation postopératoire.Conclusion : Les modèles haptiques 3D étaient reconnus comme un outil efficace pour éduquer les stagiaires, les médecins, et les patients. Ces modèles ont aidé à augmenter la compréhension de l’anatomie et de la pathologie des participants et ont augmenté la confiance et les habiletés des stagiaires. Ces preuves démontrent l’importance de continuer la recherche dans ce domaine afin de développer davantage de façons d’optimiser l’éducation médicale à l’aide de l’impression tridimensionnelle.

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

A 3D-printed Microfluidic System for Automated and Near Real-time Quantitation of Biofilm-induced indole

2019 ◽  
Author(s):  
Giraso Kabandana ◽  
Curtis G. Jones ◽  
Sahra Khan Sharifi ◽  
Chengpeng Chen
Keyword(s):  
Real Time ◽  
Release Kinetics ◽  
Microfluidic System ◽  
3D Printed

We developed a novel microfluidic system that enables automated and near real-time quantitation of indole release kinetics from biofilms.

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