scholarly journals Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 56
Author(s):  
Achraf Noureddine ◽  
Michael L. Paffett ◽  
Stefan Franco ◽  
Alfonso E. Chan ◽  
Sandeep Pallikkuth ◽  
...  

This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell cycle is relevant to payload destination and dilution, and impacts delivery of therapeutic or diagnostic agents. Super-resolution stochastic optical reconstruction and sub-airy unit image acquisition, the latter combined with Huygens deconvolution microscopy, enable single nanoparticle and microtubule resolution. Combined structural and functional data provide enhanced details on biological processes, with an example of mitotic inheritance during cancer cell trivision.

Nanoscale ◽  
2018 ◽  
Vol 10 (45) ◽  
pp. 21041-21045 ◽  
Author(s):  
Xiao-Yu Zheng ◽  
Juan Pellico ◽  
Alexandr A. Khrapitchev ◽  
Nicola R. Sibson ◽  
Jason J. Davis

Integrating Dy-DOTA motifs into mesoporous silica nanoparticle scaffolds significantly amplifies the ultrahigh field T2 relaxivity via a Curie outer-sphere mechanism.


RSC Advances ◽  
2015 ◽  
Vol 5 (39) ◽  
pp. 30640-30646 ◽  
Author(s):  
Yue Yan ◽  
Jie Fu ◽  
Xin Liu ◽  
Tianfu Wang ◽  
Xiuyang Lu

An intracellular acidity-triggered doxorubicin release from “click chemistry” functionalized mesoporous silica nanoparticle was demonstrated.


Nanoscale ◽  
2018 ◽  
Vol 10 (19) ◽  
pp. 9141-9152 ◽  
Author(s):  
Xuyao Zhang ◽  
Jingyun Luan ◽  
Wei Chen ◽  
Jiajun Fan ◽  
Yanyang Nan ◽  
...  

Novel insights into mesoporous silica nanoparticle (MSN)-induced hepatotoxicity and the underlying mechanism, facilitating an increase of the biosafety of MSNs.


2016 ◽  
Vol 8 (12) ◽  
pp. 2561-2567 ◽  
Author(s):  
Shaping Huang ◽  
Liping Song ◽  
Zhidong Xiao ◽  
Yue Hu ◽  
Meiwen Peng ◽  
...  

In this paper, fluorescent graphene quantum dots (GQDs) grafted onto the surface of mesoporous silica nanoparticle (MSN) vehicles were prepared and characterized.


2018 ◽  
Vol 232 (9-11) ◽  
pp. 1733-1740 ◽  
Author(s):  
Yan Chen ◽  
Juan Wang ◽  
Jianhua Liu ◽  
Lehui Lu

Abstract The anticancer drug doxorubicin (DOX) is locked in the mesoporous silica nanoparticle by coating FeIII-TA polymer, and its burst release can be achieved under acidic environment, along with the decreased longitudinal relaxivity. This nanoplatform shows great potential to monitoring the drug delivery process and the fate of the nanocarrier.


2014 ◽  
Vol 781 ◽  
pp. 17-24 ◽  
Author(s):  
Pragnesh N. Dave ◽  
Lakha V. Chopda

In the early 1990s the discovery of the MCM-41 and the M41S family of mesoporous materials had open new era in the chemistry and biology. They have prominent application inbiotechnological, biomedical and heterogeneous catalysts. Mesoporous silica nanoparticles (MSNs) exhibit unique structural features like as their large surface areas, tunable pore sizes in nanometer and well-defined surface properties. MSN materials which are comprised of a honeycomb-like porous structure with hundreds of empty mesoporous channel that are able to encapsulate relatively large amounts of biomolecules. They are ideal candidate for constructing multifunctional materials that encapsulate a variety of functional nanostructured materials. Multifunctional MSN materials have become one of the most attractive areas in nanobiotechnology and nanomedicine for various disease diagnosis and therapy. Multifunctional MSN have been successfully developed as a multifunctional platform to deliver therapeutic and diagnostic agents. Multifunctional MSNs are a highly promising platform for intracellular controlled release of drugs. In this review we discuss the recent developments in design and fabrication of multifunctional mesoporous silica nanoparticles in as efficient drug delivery applications such as the site-specific delivery and intracellular controlled release of drugs.Abbreviations;APTES; 3-aminopropyl triethoxy sialne, ATP; Adenosine triphospahate, CD; cyclodextrinCPT; camptothecin, CS; Chitosan,CTAB; cyltrimethylammonium bromide,DNA; Deoxyribonucleic acid,DOX; doxorubicin,EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide,FD; fluorescein disodium,FSP;Fluroscent particle ,IBU;ibuprofen,MCM; mobil composition material, MPS; 3-trimethoxylsilyl propyl methacrylate, MS; mesoporous silica,MSN; mesoporous silica nanoparticle, MSNs; mesoporous silica nanoparticles,MSNP; mesoporous silica nanoparticle,NPS; nanoparticles;PFDTES;perfluorodecyltriethoxysilane, PAA; polyacrylic acid,PR;photo responsive,PMAA; polymethyl methacrylate,SBF; simulated body fluid,TEOS;tetraethyl orthosilicate,TUNA;Thio undecyl-tetraethyleneglycoestero-nitrobenzylethyldimethyl ammonium bromide.


2018 ◽  
Vol 42 (7) ◽  
pp. 5045-5051
Author(s):  
Nhat Tri Vo ◽  
Astam K. Patra ◽  
Dukjoon Kim

A hollow doughnut shaped mesoporous silica nanoparticle filler that significantly enhances the dimensional thermal stability without sacrificing the optical properties of poly(ether sulfone) films is reported.


2017 ◽  
Vol 5 (36) ◽  
pp. 7591-7597 ◽  
Author(s):  
Zigui Wang ◽  
Peng Wu ◽  
Zhilong He ◽  
Hongyan He ◽  
Weifeng Rong ◽  
...  

A mesoporous silica nanoparticle system with a lactose-mediated targeting effect was demonstrated to deliver a platinum(iv) prodrug for liver cancer therapy.


Author(s):  
Han Wu ◽  
Xin-Fei Xu ◽  
Jia-Qi Zhu ◽  
Ming-Da Wang ◽  
Chao Li ◽  
...  

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death worldwide, which lacks effective inhibition of progression and metastasis in the advanced clinical stage. Mesoporous silica nanoparticle (MSN)–based cytotoxic or immunoregulatory drug–loading strategies have attracted widespread attention in the recent years. As a representative of mesoporous biomaterials, MSNs have good biological characteristics and immune activation potential and can cooperate with adjuvants against HCC. This review summarizes the possible future development of the field from the perspective of tumor immunity and aims to stimulate the exploration of the immune mechanism of MSN-based therapy. Through this point of view, we hope to develop new clinical immune drugs that can be applied to HCC clinical management in the future.


2019 ◽  
Vol 7 (6) ◽  
pp. 2600-2610 ◽  
Author(s):  
Benny Ryplida ◽  
Gibaek Lee ◽  
Insik In ◽  
Sung Young Park

Here, we designed a pH-responsive Indocyanine Green (ICG)-loaded zwitterionic fluorescent carbon dot (CD)-encapsulating mesoporous silica nanoparticle (MSN) for pH-tunable image-guided photothermal therapy.


Sign in / Sign up

Export Citation Format

Share Document