scholarly journals Application of Mathematical Models to Determine the Feasibility of Amorphous Drug Layering in Pan Coaters

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 149
Author(s):  
Michael Choi ◽  
Stuart C. Porter ◽  
Axel Meisen
Keyword(s):  
Mathematical Models ◽  
Water Solubility ◽  
Amorphous State ◽  
Spray Coating ◽  
Monitoring And Control ◽  
Drug Products ◽  
Amorphous Drug ◽  
High Level ◽  
The Cost ◽  
And Control

Oral solid dosage forms that contain APIs in the amorphous state have become commonplace because of many drug substances exhibiting poor water solubility, which negatively impacts their absorption in the human GI tract. While micronization, solvent spray-drying, and hot-melt extrusion can address solubility issues, spray coating of the APIs onto beads and tablets offers another option for producing amorphous drug products. High-level comparisons between bead and tablet coating technologies have the potential for simpler equipment and operation that can reduce the cost of development and manufacturing. However, spray coating directly onto tablets is not without challenges, especially with respect to meeting uniformity acceptance value (AV) criteria, comprising accuracy (mean) and precision (variance) objectives. The feasibility of meeting AV criteria is examined, based on mathematical models for accuracy and precision. The results indicate that the main difficulty in manufacturing satisfactory drug-layered tablets by spray coating is caused by the practical limitations of achieving the necessary coating precision. Despite this limitation, it is shown that AV criteria can be consistently met by appropriate materials monitoring and control as well as processing equipment setup, operation, and maintenance.

scholarly journals Multi-Blockchain-Based IoT Data Processing Techniques to Ensure the Integrity of IoT Data in AIoT Edge Computing Environments

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3515
Author(s):  
Sung-Ho Sim ◽  
Yoon-Su Jeong
Keyword(s):  
Low Cost ◽  
Third Party ◽  
Monitoring And Control ◽  
Constant Size ◽  
Computing Environments ◽  
Iot Devices ◽  
Cloud Servers ◽  
The Cost ◽  
Processing Techniques ◽  
And Control

As the development of IoT technologies has progressed rapidly recently, most IoT data are focused on monitoring and control to process IoT data, but the cost of collecting and linking various IoT data increases, requiring the ability to proactively integrate and analyze collected IoT data so that cloud servers (data centers) can process smartly. In this paper, we propose a blockchain-based IoT big data integrity verification technique to ensure the safety of the Third Party Auditor (TPA), which has a role in auditing the integrity of AIoT data. The proposed technique aims to minimize IoT information loss by multiple blockchain groupings of information and signature keys from IoT devices. The proposed technique allows IoT information to be effectively guaranteed the integrity of AIoT data by linking hash values designated as arbitrary, constant-size blocks with previous blocks in hierarchical chains. The proposed technique performs synchronization using location information between the central server and IoT devices to manage the cost of the integrity of IoT information at low cost. In order to easily control a large number of locations of IoT devices, we perform cross-distributed and blockchain linkage processing under constant rules to improve the load and throughput generated by IoT devices.

Система дистанційного моніторингу та керування кліматичними параметрами приміщень в процесі промислового виробництва

2020 ◽  
pp. 19-23
Author(s):  
Ігор Бережний ◽  
◽  
Адріан Наконечний ◽  
Keyword(s):  
Energy Efficiency ◽  
Comparative Analysis ◽  
Technological Process ◽  
Remote Monitoring ◽  
High Speed ◽  
Monitoring And Control ◽  
Remote Monitoring And Control ◽  
The Cost ◽  
And Control ◽  
Communication Lines

Based on the research and comparative analysis of existing systems, an algorithm for remote monitoring and control of the technological process using IoT technologies is proposed and developed. We consider a system with flexible algorithms, which combines different data protocols using Wi-Fi technology, which allows you to use this type of system in any industry safely with high speed, energy efficiency and without the cost of communication lines.

Agent Support for Design of Aircraft Parts

1998 ◽  
Author(s):  
Krishna N. Jha ◽  
Andrea Morris ◽  
Ed Mytych ◽  
Judith Spering
Keyword(s):  
Preliminary Design ◽  
Formal Representation ◽  
Web Based ◽  
Agent Based ◽  
Multi Agent ◽  
High Level ◽  
Legacy Applications ◽  
The Cost ◽  
And Control ◽  
Task Structures

Abstract Designing aircraft parts requires extensive coordination among multiple distributed design groups. Achieving such a coordination is time-consuming and expensive, but the cost of ignoring or minimizing it is much higher in terms of delayed and inferior quality products. We have built a multi-agent-based system to provide the desired coordination among the design groups, the legacy applications, and other resources during the preliminary design (PD) process. A variety of agents are used to model the various design and control functionalities. The agent-representation includes a formal representation of the task-structures. A web-based user-interface provides high-level interface to the users. The agents collaborate to achieve the design goals.

Application of a Neural Manufacturing Concept to Process Modeling, Monitoring and Control

1995 ◽  
Vol 387 ◽  
Author(s):  
Chi Yung Fu ◽  
Loren Petrich ◽  
Benjamin Law
Keyword(s):  
Neural Networks ◽  
Artificial Neural Networks ◽  
Process Modeling ◽  
Lawrence Livermore National Laboratory ◽  
National Laboratory ◽  
Monitoring And Control ◽  
Artificial Neural ◽  
The Cost ◽  
And Control ◽  
Capital Intensive

AbstractThe cost of a fabrication line, such as one in a semiconductor house, has increased dramatically over the years, and it is possibly already past the point that some new start-up company can have sufficient capital to build a new fabrication line. Such capital-intensive manufacturing needs better utilization of resources and management of equipment to maximize its productivity. In order to maximize the return from such a capital-intensive manufacturing line, we need to work on the following: 1) increasing the yield, 2) enhancing the flexibility of the fabrication line, 3) improving quality, and finally 4) minimizing the down time of the processing equipment. Because of the significant advances now made in the fields of artificial neural networks, fuzzy logic, machine learning and genetic algorithms, we advocate the use of these new tools in manufacturing. We term the applications to manufacturing of these and other such tools that mimic human intelligence neural manufacturing. This paper describes the effort at the Lawrence Livermore National Laboratory (LLNL) [1] to use artificial neural networks to address certain semiconductor process modeling, monitoring and control questions.

Research and Development of Monitoring and Control Platform in Active Magnetic Bearing

2017 ◽  
Author(s):  
Yan Xunshi ◽  
Zhou Yan ◽  
Zhao Jingjing ◽  
Sun Zhe ◽  
Shi Zhengang
Keyword(s):  
Magnetic Bearing ◽  
Active Magnetic Bearing ◽  
Data Sampling ◽  
Monitoring And Control ◽  
Monitoring And Control System ◽  
Display Module ◽  
Processing Module ◽  
Previous Design ◽  
The Cost ◽  
And Control

In order to cut cost and simplify redevelopment, the paper proposes a new design for monitoring and control system in active magnetic bearing. Data sampling and processing module is separated with data display module. Singlechip processor is used to sample data from the DSP controller, and processes the data into the needed form. A touch-screen only for display takes on the processed data to customers. The design makes the systems easy to develop and shrink the cost to one tenth of previous design.

Developments in Pipeline Instrumentation

1987 ◽  
Vol 20 (1) ◽  
pp. 7-17 ◽  
Author(s):  
R A Furness
Keyword(s):  
Large Scale ◽  
Future Trends ◽  
Monitoring And Control ◽  
The Past ◽  
Control Equipment ◽  
Pipeline Monitoring ◽  
The Many ◽  
The Cost ◽  
New Generation ◽  
And Control

Pipelines are an integral part of the world's economy and literally billions of pounds worth of fluids are moved each year in pipelines of varying lengths and diameters. As the cost of some of these fluids and the price of moving them has increased, so the need to measure the flows more accurately and control and operate the line more effectively has arisen. Instrumentation and control equipment has developed steadily in the past decade but not as fast as the computers and microprocessors that are now a part of most large scale pipeline systems. It is the interfacing of the new generation of digital and sometimes ‘intelligent’ instrumentation with smaller and more powerful computers that has led to a quiet but rapid revolution in pipeline monitoring and control. This paper looks at the more significant developments from the many that have appeared in the past few years and attempts to project future trends in the industry for the next decade.

scholarly journals Digital radio based train control for safety assurance of maglev transportation

2016 ◽  
Vol 2 (3) ◽  
pp. 145-154
Author(s):  
V V Shmatchenko ◽  
P A Plekhanov
Keyword(s):  
Magnetic Levitation ◽  
Radio Channel ◽  
Practical Importance ◽  
Monitoring And Control ◽  
Digital Radio ◽  
Analysis And Synthesis ◽  
Control Automation ◽  
High Level ◽  
And Control ◽  
Working Out

Introduction. The Control System of Maglev Vehicles (further - CSMV) has key value for development maglev. Purpose. In article management by safe movement of maglev vehicles with use of digital radio channel are considered, the international experience is analysed and conclusions for Russian practice are drawn. Methodology. The following methods were used: system approach, analysis and synthesis, generalization. Results. CSMV should consider physical possibilities of magnetic levitation, factors and the restrictions influencing these possibilities, including - the factors connected with safety. CSMV should possess complex of functions allowing effectively, full and safely to realise possibility of magnetic levitation in conditions of specified factors and restrictions. Practical importance. The basic practical results, which can be received by working out CSMV, are: - creation CSMV with high level of control automation and consequently effective and safe; - working out within CSMV typical design decisions, applicable for adaptation to monitoring and control of problems various systems and maglev vehicles; - creation of preconditions of design and perfection of all complex of regulatory framework, conformity which provides safety of maglev infrastructure and vehicles; - reception of interaction experience of the Customer, the research and design organisations, the industry enterprises, the assembly and maintaining organisations at stages of life cycle of CSMV, as key subsystem of maglev. Conclusion. The main appointment of CSMV - creation and constant provide of conditions for safe and effective functioning and development of this new type of transport.

scholarly journals Automatic control of industrial peak loads

2009 ◽  
Vol 22 (3) ◽  
pp. 329-339
Author(s):  
Marija Kacarska ◽  
Vesna Arnautovski-Toseva ◽  
Sanja Veleva
Keyword(s):  
Automatic Control ◽  
Transfer Functions ◽  
Peak Load ◽  
Electrical Energy ◽  
Load Shedding ◽  
Monitoring And Control ◽  
Industrial Plants ◽  
Industrial Energy ◽  
The Cost ◽  
And Control

Automatic control of equipment is anticipated to represent the next logical step in the progression from passive monitoring toward plant wide automation. Automatic transfer functions, load-shedding and load sequencing are expected to find increasing application. In this paper a device named Peak Load for monitoring and control of power consumption in industrial plants is presented. It is a PLC based maxigraph developed upon the analysis of efficient and optimized use of the electrical energy and is planned to be used by medium and big industrial energy consumers with purpose to decrease the cost of their production. .

Enabling Cross-technology Communication from LoRa to ZigBee via Payload Encoding in Sub-1 GHz Bands

2022 ◽  
Vol 18 (1) ◽  
pp. 1-26
Author(s):  
Junyang Shi ◽  
Di Mu ◽  
Mo Sha
Keyword(s):  
Low Power ◽  
Mesh Networks ◽  
Area Network ◽  
Monitoring And Control ◽  
Wide Area Network ◽  
Wireless Monitoring ◽  
Wireless Mesh ◽  
Communication Approach ◽  
The Cost ◽  
And Control

Low-power wireless mesh networks (LPWMNs) have been widely used in wireless monitoring and control applications. Although LPWMNs work satisfactorily most of the time thanks to decades of research, they are often complex, inelastic to change, and difficult to manage once the networks are deployed. Moreover, the deliveries of control commands, especially those carrying urgent information such as emergency alarms, suffer long delay, since the messages must go through the hop-by-hop transport. Recent studies show that adding low-power wide-area network radios such as LoRa onto the LPWMN devices (e.g., ZigBee) effectively overcomes the limitation. However, users have shown a marked reluctance to embrace the new heterogeneous communication approach because of the cost of hardware modification. In this article, we introduce LoRaBee, a novel LoRa to ZigBee cross-technology communication (CTC) approach, which leverages the energy emission in the Sub-1 GHz bands as the carrier to deliver information. Although LoRa and ZigBee adopt distinct modulation techniques, LoRaBee sends information from LoRa to ZigBee by putting specific bytes in the payload of legitimate LoRa packets. The bytes are selected such that the corresponding LoRa chirps can be recognized by the ZigBee devices through sampling the received signal strength. Experimental results show that our LoRaBee provides reliable CTC communication from LoRa to ZigBee with the throughput of up to 281.61 bps in the Sub-1 GHz bands.

Study on the Construction of Intelligent Power Distribution Area of Rural Power Grid

2013 ◽  
Vol 846-847 ◽  
pp. 400-404
Author(s):  
Ya Jing Zhu ◽  
Hui Yu Tian ◽  
Ke Bi
Keyword(s):  
Rural Areas ◽  
Power Distribution ◽  
Integrated Management ◽  
Power Grid ◽  
Distribution Area ◽  
Monitoring And Control ◽  
Distribution Management ◽  
Power Load ◽  
High Level ◽  
And Control

In most of Chinas rural areas, the devices of power distribution area are low configured, simply designed and installed, and have few functions but lots of forms. Beyond, most of them only implement simple functions of power distribution and metering. They couldnt meet the needs of transformation of rural power grid. So its extremely urgent to reconstruct and build intelligent rural power distribution and realize the standardization of information model and the intelligent integrated management of power distribution area to improve the quality and reliability of power supply. In this paper, we analyzed the current development situation of Chinas rural area. Then from the aspect of solving the lagging intelligent level of rural power system, we do some research about developing a new intelligent integrated distribution box and distribution transformer terminal , then we propose the intelligent manage system of power distribution area to realize high intelligent level of power distribution management, high level monitoring and control and greatly improved manage efficiency. At the same time, we enhanced the serving strength for the customer and help to improved the entire intelligent power load , so we could supply high quality power to our customers.

Sign in / Sign up

Export Citation Format

Share Document