scholarly journals Dendrimers and Dendritic Materials against Infectious Diseases

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 154
Author(s):  
Francisco Javier de La Mata ◽  
Paula Ortega ◽  
Sandra García-Gallego
Keyword(s):  
Infectious Diseases ◽  
Therapeutic Strategies

The COVID-19 pandemic showed more deeply the need of our society to provide new therapeutic strategies to fight infectious diseases, not only against currently known illnesses, where common antibiotics and drugs appear to be not fully effective, but also against new infectious threats that may arise [...]

scholarly journals Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

2021 ◽  
Vol 22 (23) ◽  
pp. 13009
Author(s):  
Xi-Dian Tang ◽  
Tian-Tian Ji ◽  
Jia-Rui Dong ◽  
Hao Feng ◽  
Feng-Qiang Chen ◽  
...  
Keyword(s):  
Immune System ◽  
Infectious Diseases ◽  
Targeted Therapies ◽  
Tissue Damage ◽  
Systemic Infection ◽  
Therapeutic Strategies ◽  
Targeted Treatment ◽  
Cytokine Storm ◽  
Pathophysiological Mechanisms ◽  
Circulating Cytokines

Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, “multi-omics” immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.

scholarly journals ERS international congress 2020: highlights from the “Clinical techniques, imaging and endoscopy” assembly

2021 ◽  
pp. 00118-2021
Author(s):  
Pia Iben Pietersen ◽  
Bibi Klap ◽  
Nicole Hersch ◽  
Christian B. Laursen ◽  
Simon Walsh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Infectious Diseases ◽  
Lung Disease ◽  
Therapeutic Strategies ◽  
European Respiratory Society ◽  
Scientific Discussion ◽  
Diagnostic Approaches ◽  
Selection Of

The European Respiratory Society (ERS) congress in the year 2020, a year dominated by the SARS-CoV-2 pandemic, was the first virtual congress that was ever planned with an innovative and interactive congress programme upfront. It was a large, novel platform for scientific discussion and presentations of cutting-edge innovative developments. This manuscript summarises a selection of the scientific highlights from the “Clinical techniques, imaging and endoscopy” Assembly 14. In addition to presentations on the important role of bronchoscopy, imaging and ultrasound techniques in the field of SARS-CoV-2 infection, novel diagnostic approaches and innovative therapeutic strategies in patients with lung cancer, interstitial lung disease, obstructive airway disorders and infectious diseases were also discussed.

Polymeric micelles and nanomedicines: Shaping the future of next generation therapeutic strategies for infectious diseases

2021 ◽  
pp. 102927
Author(s):  
María A. Toscanini ◽  
María J. Limeres ◽  
Agustín Videla Garrido ◽  
Maximiliano Cagel ◽  
Ezequiel Bernabeu ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Polymeric Micelles ◽  
Therapeutic Strategies ◽  
Next Generation ◽  
The Future

Preface: Positive interactions between anti-infection drugs and the immune response: an emerging paradigm

Parasitology ◽  
1992 ◽  
Vol 105 (S1) ◽  
pp. S1-S2
Author(s):  
M. J. Doenhoff ◽  
L. H. Chappell
Keyword(s):  
Immune Response ◽  
Drug Resistance ◽  
Infectious Diseases ◽  
Slow Rate ◽  
Therapeutic Strategies ◽  
Positive Interactions ◽  
The Third ◽  
Success Stories ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

SummaryIn the third and fourth decades of this century chemotherapy began to be established as one of the greatest success stories in medicine. Now unfortunately severe problems compromise the efficacy of drugs used to treat infectious diseases, two of the most serious handicaps being the rapidity with which target pathogens can develop drug-resistance and the slow rate at which replacement products are appearing on the market. Increased understanding of the ways in which existing drugs act may help both to prolong their usefulness and to generate novel therapeutic strategies.

scholarly journals Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer

2012 ◽  
Vol 7 (1) ◽  
Author(s):  
Wagner J Fávaro ◽  
Odilon S Nunes ◽  
Fabio RF Seiva ◽  
Iseu S Nunes ◽  
Lisa K Woolhiser ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Therapeutic Strategies ◽  
Toll Like Receptors

scholarly journals USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2

2020 ◽  
Vol 217 (5) ◽  
Author(s):  
Zeng Cai ◽  
Meng-Xin Zhang ◽  
Zhen Tang ◽  
Qiang Zhang ◽  
Jing Ye ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Viral Infection ◽  
Unknown Function ◽  
Nuclear Translocation ◽  
Therapeutic Strategies ◽  
Deubiquitinating Enzyme ◽  
Type I ◽  
Antiviral Responses ◽  
Type I Ifns ◽  
Increased Susceptibility

USP22 is a cytoplasmic and nuclear deubiquitinating enzyme, and the functions of cytoplasmic USP22 are unclear. Here, we discovered that cytoplasmic USP22 promoted nuclear translocation of IRF3 by deubiquitianting and stabilizing KPNA2 after viral infection. Viral infection induced USP22-IRF3 association in the cytoplasm in a KPNA2-depedent manner, and knockdown or knockout of USP22 or KPNA2 impaired IRF3 nuclear translocation and expression of downstream genes after viral infection. Consistently, Cre-ER Usp22fl/fl or Lyz2-Cre Usp22fl/fl mice produced decreased levels of type I IFNs after viral infection and exhibited increased susceptibility to lethal viral infection compared with the respective control littermates. Mechanistically, USP22 deubiquitinated and stabilized KPNA2 after viral infection to facilitate efficient nuclear translocation of IRF3. Reconstitution of KPNA2 into USP22 knockout cells restored virus-triggered nuclear translocation of IRF3 and cellular antiviral responses. These findings define a previously unknown function of cytoplasmic USP22 and establish a mechanistic link between USP22 and IRF3 nuclear translocation that expands potential therapeutic strategies for infectious diseases.

scholarly journals Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Yuki Murakami ◽  
Masato Hoshi ◽  
Yukio Imamura ◽  
Yuko Arioka ◽  
Yasuko Yamamoto ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Current Knowledge ◽  
Inflammatory Diseases ◽  
Therapeutic Strategies ◽  
Type I Interferons ◽  
Regulatory Function ◽  
Type I ◽  
Indoleamine 2,3 Dioxygenase ◽  
Tryptophan Metabolites

Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells. Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases. The pathophysiologic activity of L-tryptophan metabolites, kynurenines, is well recognized. Therefore, an understanding of the regulation of IDO1 and the subsequent biochemical reactions is essential for the design of therapeutic strategies in certain immune diseases. In this paper, current knowledge about the role of IDO1 and its metabolites during various infectious diseases is presented. Particularly, the regulation of type I interferons (IFNs) production via IDO1 in virus infection is discussed. This paper offers insights into new therapeutic strategies in the modulation of viral infection and several immune-related disorders.

Therapeutic strategies to target microbial protein–glycosaminoglycan interactions

2018 ◽  
Vol 46 (6) ◽  
pp. 1505-1515 ◽  
Author(s):  
Johannes Almer ◽  
Bernd Gesslbauer ◽  
Andreas J. Kungl
Keyword(s):  
Infectious Diseases ◽  
Drug Development ◽  
Heparan Sulfate ◽  
Chondroitin Sulfate ◽  
Therapeutic Strategies ◽  
Microbial Protein ◽  
Therapeutic Approaches ◽  
Microbial Invasion

Glycans are involved in a plethora of human pathologies including infectious diseases. Especially, glycosaminoglycans (GAGs), like heparan sulfate and chondroitin sulfate, have been found to be involved in different crucial stages of microbial invasion. Here, we review various therapeutic approaches, which target the interface of host GAGs and microbial proteins and discuss their limitations and challenges for drug development.

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