scholarly journals Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems

Polymers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 2897
Author(s):  
Carmelo Corsaro ◽  
Giulia Neri ◽  
Angela Maria Mezzasalma ◽  
Enza Fazio
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Polymer Chains ◽  
Patient Treatment ◽  
Release Mechanism ◽  
Release Process ◽  
Precise Control ◽  
Biochemical Processes ◽  
Drug Selectivity

Traditional pharmacotherapy suffers from multiple drawbacks that hamper patient treatment such as antibiotic resistances or low drug selectivity and toxicity during systemic applications. Some functional hybrid nanomaterials are designed to handle the drug release process under remote-control. More attention has recently been paid to synthetic polyelectrolytes for their intrinsic properties which allow them to rearrange into compact structures, ideal to be used as drug carriers or probes influencing biochemical processes. The presence of Ag nanoparticles (NPs) in the Poly methyl acrylate (PMA) matrix leads to an enhancement of drug release efficiency, even using a low-power laser whose wavelength is far from the Ag Surface Plasmon Resonance (SPR) peak. Further, compared to the colloids, the nanofiber-based drug delivery system has shown shorter response time and more precise control over the release rate. The efficiency and timing of involved drug release mechanisms has been estimated by the Weibull distribution function, whose parameters indicate that the release mechanism of nanofibers obeys Fick’s first law while a non-Fickian character controlled by diffusion and relaxation of polymer chains occurs in the colloidal phase.

scholarly journals Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 551 ◽  
Author(s):  
Jie Zhao ◽  
Xiangqiang Pan ◽  
Jian Zhu ◽  
Xiulin Zhu
Keyword(s):  
Aqueous Solution ◽  
Drug Release ◽  
Fluorescence Emission ◽  
Polymer Gels ◽  
Drug Carriers ◽  
Radical Copolymerization ◽  
Polymer Chains ◽  
Release Process ◽  
Free Radical Copolymerization ◽  
Crosslinked Polymer

Stimuli-responsive functional gels have shown significant potential for application in biosensing and drug release systems. In this study, aggregation-induced emission luminogen (AIEgen)-functionalized, diselenide-crosslinked polymer gels were synthesized via free radical copolymerization. A series of polymer gels with different crosslink densities or tetraphenylethylene (TPE) contents were synthesized. The diselenide crosslinker in the gels could be fragmented in the presence of H2O2 or dithiothreitol (DTT) due to its redox-responsive property. Thus, the TPE-containing polymer chains were released into the aqueous solution. As a result, the aqueous solution exhibited enhanced fluorescence emission due to the strong hydrophobicity of TPE. The degradation of polymer gels and fluorescence enhancement in an aqueous solution under different H2O2 or DTT concentrations were studied. Furthermore, the polymer gels could be used as drug carriers, suggesting a visual drug release process under the action of external redox agents. The AIEgen-functionalized, diselenide-crosslinked polymer gels hold great potential in the biomedical area for biosensing and controlled drug delivery.

scholarly journals FABRICATION OF NANO CLAY INTERCALATED POLYMERIC MICROBEADS FOR CONTROLLED RELEASE OF CURCUMIN

2021 ◽  
pp. 206-215
Author(s):  
DHARMENDER PALLERLA ◽  
SUMAN BANOTH ◽  
SUNKARI JYOTHI
Keyword(s):  
Drug Release ◽  
In Vitro Release ◽  
Controlled Drug Release ◽  
Fickian Diffusion ◽  
Simulated Gastric Fluid ◽  
Release Mechanism ◽  
Release Studies ◽  
Swelling Studies ◽  
Vitro Release

Objective: The objective of this study was to formulate and evaluate the Curcumin (CUR) encapsulated sodium alginate (SA)/badam gum (BG)/kaolin (KA) microbeads for controlled drug release studies. Methods: The fabricated microbeads were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), and scanning electron microscopy (SEM). Dynamic swelling studies and in vitro release kinetics were performed in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 °C. Results: FTIR confirms the formation of microbeads. DSC studies confirm the polymorphism of CUR in drug loaded microbeads which indicate the molecular level dispersion of the drug in the microbeads. SEM studies confirmed the microbeads are spherical in shape with wrinkled and rough surfaces. XRD studies reveal the molecular dispersion of CUR and the presence of KA in the developed microbeads. In vitro release studies and swelling studies depend on the pH of test media, which might be suitable for intestinal drug delivery. The % of drug release values fit into the Korsmeyer-Peppas equation and n values are obtained in the range of 0.577-0.664, which indicates that the developed microbeads follow the non-Fickian diffusion drug release mechanism. Conclusion: The results concluded that the CUR encapsulated microbeads are potentially good carriers for controlled drug release studies.

scholarly journals POLY(VINYLPYRROLIDONE)-CHITOSAN HYDROGELS AS MATRICES FOR CONTROLLED DRUG RELEASE

2021 ◽  
Vol 55 (1-2) ◽  
pp. 63-73
Author(s):  
ALINA MIRELA IPATE ◽  
DIANA SERBEZEANU ◽  
ALEXANDRA BARGAN ◽  
CORNELIU HAMCIUC ◽  
LACRAMIOARA OCHIUZ ◽  
...  
Keyword(s):  
Drug Release ◽  
Sorption Capacity ◽  
Freeze Drying ◽  
Controlled Drug Release ◽  
Water Vapor Sorption ◽  
Release Mechanism ◽  
Drying Methods ◽  
Oral Infections ◽  
Mixing Ratios ◽  
Chitosan Hydrogels

In this study, hydrogels based on poly(vinylpyrrolidone) and chitosan, derived from different mixing ratios of poly(vinylpyrrolidone)/chitosan, were synthesized by the freeze-drying technique with the aim of obtaining new systems that could be used to release tetracycline hydrochloride (TH). Freeze-drying methods were also used to prepare the hydrogels containing TH. The hydrogels were characterized using Fourier transform infrared spectroscopy and scanning electron microscopy, as well as in terms of dynamic water vapour sorption capacity. The poly(vinylpyrrolidone)/chitosan hydrogels were evaluated with regard to the release of TH. The release profiles of TH from the poly(vinylpyrrolidone)/chitosan hydrogels depended on the chitosan content. It could be seen that if the concentration of chitosan was too high, the release was delayed and not fully achieved, because the release of the drug was prevented by the crystalline areas of the chitosan. According to the release study, the drug release mechanism of the poly(vinylpyrrolidone)/chitosan hydrogels loaded with TH perfectly fitted the Higuchi and the Korsmeyer-Peppas models. The highest value of water vapor sorption capacity was obtained for the hydrogel with the poly(vinylpyrrolidone)/chitosan ratio of 50/50. PVP-CS loaded with 3 wt% TH may potentially be used for the controlled delivery of tetracycline to treat oral infections.

scholarly journals Synthesis and Characterization of Lyophilized Chitosan-Based Hydrogels Cross-Linked with Benzaldehyde for Controlled Drug Release

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Fouad Damiri ◽  
Yahya Bachra ◽  
Chaimaa Bounacir ◽  
Asmae Laaraibi ◽  
Mohammed Berrada
Keyword(s):  
Ascorbic Acid ◽  
Drug Release ◽  
Drug Loading ◽  
In Vitro Release ◽  
Controlled Drug Release ◽  
Tween 20 ◽  
Release Mechanism ◽  
Synthetic Process ◽  
Chitosan Salt

In this study, chitosan-based hydrogels were produced by incorporating three drugs with a different solubility into a polymer matrix. The lyophilized chitosan salt was prepared using an innovative and less-expensive synthetic process by the freeze-drying technique. Firstly, the three drugs (caffeine, ascorbic acid, and 5-fluorouracil (5-FU)) were selected as model drugs to test the in vitro release behavior of the hydrogel. The drugs were solubilized in chitosan salt, lyophilized, and cross-linked with benzaldehyde involving the formation of a Schiff base with (–C=N-) linkage to produce a physical hydrogel. Subsequently, the physicochemical properties of N-benzyl chitosan and lyophilized chitosan salt were evaluated by Fourier-transform infrared (FTIR) spectra, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The intrinsic viscosity of the conventional chitosan was determined by the Mark–Houwink–Sakurada equation. Moreover, the kinetics of hydrogel swelling and drug release were studied by the UV-visible method at physiological conditions (pH = 7.4 at 37°C). The results show that lyophilized N-benzyl chitosan had a maximum swelling ratio of 720 ± 2% by immersion in phosphate-buffered saline solutions (PBS) (pH = 7.4 at 37°C). In vitro drug releases were evaluated in PBS, and the obtained results show that the maximum drug release after 24 h was 42% for caffeine, 99% for 5-FU, and 94% for ascorbic acid. Then, to optimize the cumulative release of caffeine, Tween 20 was added and 98% as a release percentage was obtained. The drug-loading results were investigated with the Korsmeyer–Peppas kinetic model and applied to determine the drug release mechanism.

The Measurement and Mathematical Analysis of 5-Fu Release from Magnetic Polymeric Nanocapsules, following the Application of Ultrasound

2018 ◽  
Vol 18 (3) ◽  
pp. 438-449 ◽  
Author(s):  
Ziaeddin Abed ◽  
Samideh Khoei ◽  
Behafarid Ghalandari ◽  
Jaber Beik ◽  
Ali Shakeri-Zadeh ◽  
...  
Keyword(s):  
Drug Release ◽  
Mathematical Analysis ◽  
Ultrasound Irradiation ◽  
Controlled Drug Release ◽  
Release Profile ◽  
Release Mechanism ◽  
Drug Release Profile ◽  
Ultrasound Intensity ◽  
Dialysis Bag

Objective: To study the effects of ultrasound irradiation on the release profile of 5-fluorouracil (5-Fu) loaded magnetic poly lactic co-glycolic acid (PLGA) nanocapsules. Also, the controlled drug-release behaviour of the nanocapsules was mathematically investigated. Methods: The nanocapsules were synthesized, dispersed in phosphate buffered saline (PBS), transferred to a dialysis bag, and finally, irradiated by various ultrasound parameters (1 or 3MHz; 0.3-1W/cm2; 5-10 minutes). The release profile of the irradiated nanocapsules was recorded for 14 days. To find the in vitro drug release mechanism in the absence and presence of various intensities of ultrasound, the obtained data were fitted in various kinetic models for drug release. Results: The results demonstrated that the ultrasound speeded up the rate of drug release from the nanocapsules. The mathematical analysis illustrated that when the ultrasound intensity is increased, the probability of controlled release behaviour of the nanocapsules is raised. We found that drug release from the irradiated nanocapsules follows an erosion-controlled mechanism with the decrease in the velocity of diffusion. Conclusion: In conclusion, to attain a controlled drug-delivery strategy in the area of cancer therapy, the drug release profile of the nano-carriers may be well-controlled by ultrasound.

scholarly journals Targeted, Monitored, and Controlled Chemotherapy: A Multimodal Nanotechnology-Based Approach against Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Ali Shakeri-Zadeh ◽  
Samideh Khoei ◽  
Sepideh Khoee ◽  
Ali Mohammad Sharifi ◽  
Mohammad-Bagher Shiran
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Polymeric Nanoparticles ◽  
Control Release ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Chemotherapeutic Agents ◽  
Drug Uptake ◽  
Cancerous Cell ◽  
Cancer Tumor

We review innovative methods for treatment of cancer tumor on the basis of nanotechnology and physics to target, monitor and control release of chemotherapeutic agents. Chemotherapy is one of the main methods of treatment for cancer and plays a vital role in clinical practice, but side effects of anticancer drugs are still critical problems. Magnetic nanoparticles can be applied as an effective drug carriers and contrast agents for magnetic resonance imaging (MRI). Since certain nanoparticles have magnetic properties, they can be trapped in tumor during blood circulation by an external magnetic field. Also, polymeric nanoparticles are great candidates to encapsulate anticancer drugs and to control the release profile of drugs in biologic media. We suggest the construction of drug-loaded polymer-coated magnetic (DPM) nanoplatform with the potential for being utilized in medical imaging as well as having controlled drug release properties. Nanoplatform distribution can be monitored by MRI and with clever combination of ultrasound physics and suggested DPM nanoplatform, it would be feasible to increase the rate of drug release (in situ) and drug uptake by cancerous cell. To optimize the level of drug uptake by cancerous cell, the selection of ultrasound frequency and intensity is essential. The development of suggested method could be a new approach against cancer tumor.

scholarly journals Reduction-Responsive Molecularly Imprinted Poly(2-isopropenyl-2-oxazoline) for Controlled Release of Anticancer Agents

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 506 ◽  
Author(s):  
Michał Cegłowski ◽  
Valentin Victor Jerca ◽  
Florica Adriana Jerca ◽  
Richard Hoogenboom
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Anticancer Agents ◽  
Release Kinetics ◽  
Controlled Drug Release ◽  
Release Mechanism ◽  
Molecularly Imprinted ◽  
Responsive Materials ◽  
Future Work ◽  
Specific Trigger

Trigger-responsive materials are capable of controlled drug release in the presence of a specific trigger. Reduction induced drug release is especially interesting as the reductive stress is higher inside cells than in the bloodstream, providing a conceptual controlled release mechanism after cellular uptake. In this work, we report the synthesis of 5-fluorouracil (5-FU) molecularly imprinted polymers (MIPs) based on poly(2-isopropenyl-2-oxazoline) (PiPOx) using 3,3′-dithiodipropionic acid (DTDPA) as a reduction-responsive functional cross-linker. The disulfide bond of DTDPA can be cleaved by the addition of tris(2-carboxyethyl)phosphine (TCEP), leading to a reduction-induced 5-FU release. Adsorption isotherms and kinetics for 5-FU indicate that the adsorption kinetics process for imprinted and non-imprinted adsorbents follows two different kinetic models, thus suggesting that different mechanisms are responsible for adsorption. The release kinetics revealed that the addition of TCEP significantly influenced the release of 5-FU from PiPOx-MIP, whereas for non-imprinted PiPOx, no statistically relevant differences were observed. This work provides a conceptual basis for reduction-induced 5-FU release from molecularly imprinted PiPOx, which in future work may be further developed into MIP nanoparticles for the controlled release of therapeutic agents.

scholarly journals Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram

2019 ◽  
Vol 4 (4) ◽  
pp. 155-162
Author(s):  
Fatemeh Dalayi ◽  
Leila Hajiaghababaei ◽  
Alireza Badiei ◽  
Elham Boorboor Azimi ◽  
Mohammad Reza Ganjali ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Ph Value ◽  
Drug Carrier ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Nanoporous Silica ◽  
Release Process ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Methods: Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated. Results: The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF. Conclusion: The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.

scholarly journals THE EFFECTS OF MODIFIED CLAY ON CONTROLLED DRUG RELEASE SYSTEMS

STED JOURNAL ◽  
2019 ◽  
Vol 1 (2) ◽  
Author(s):  
Davut Lacin ◽  
Ayse Zehra Aroguz ◽  
Vesna Teoflović ◽  
Olga Govedarica ◽  
Jelena Pavličević ◽  
...  
Keyword(s):  
Drug Release ◽  
Active Substance ◽  
Release Kinetics ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Ammonium Bromide ◽  
Buffer Solutions ◽  
Cetyltrimethyl Ammonium ◽  
Specific Tissue ◽  
Kinetics Of

Recently, controlled drug release systems have been garnering a lot of attention, due to more targeted and effective approach for delivering drugs to a specific tissue. Because of a specific structure and natural abundance, clays are being added to those systems in order to increase its efficiency and minimize costs. In this study, controlled release kinetics of the drug active substance 5-Fluorouracil was studied, using halloysite clay/polymer drug carriers. For this purpose, the halloysite clay was initially modified with cetyltrimethyl ammonium bromide (CTAB). Drug carriers were prepared by adding modified halloysite clays in the mixtures of polyvinyl alcohol (PVA) and sodium alginate. Firstly, the swelling behaviour of the prepared substances was studied in buffer solutions at different pH. The drug release kinetics from the drug carriers, loaded with 5- Fluorouracil, was observed under a UV-spectrophotometer at 266 nm. Release profiles of the active substance were obtained by studying its release in buffer solutions at different pH. The results showed that the prepared drug carriers with modified halloysite clay were suitable for carrying and releasing of the 5-Fluorouracil.

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