scholarly journals A Soft Resistive Sensor with a Semicircular Cross-Sectional Channel for Soft Cardiac Catheter Ablation

Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 4130
Author(s):  
Eric Rasmussen ◽  
Daniel Guo ◽  
Vybhav Murthy ◽  
Rachit Mishra ◽  
Cameron Riviere ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Liquid Metal ◽  
Force Feedback ◽  
Applied Force ◽  
Medical Community ◽  
Soft Robotics ◽  
Soft Sensors ◽  
Cross Sectional ◽  
Cardiac Catheter ◽  
Specific Loading

The field of soft robotics has attracted the interest of the medical community due to the ability of soft elastic materials to traverse the abnormal environment of the human body. However, sensing in soft robotics has been challenging due to the sensitivity of soft sensors to various loading conditions and the nonlinear signal responses that can arise under extreme loads. Ideally, soft sensors should provide a linear response under a specific loading condition and provide a different response for other loading directions. With these specifications in mind, our team created a soft elastomeric sensor designed to provide force feedback during cardiac catheter ablation surgery. Analytical and computational methods were explored to define a relationship between resistance and applied force for a semicircular, liquid metal filled channel in the soft elastomeric sensor. Pouillet’s Law is utilized to calculate the resistance based on the change in cross-sectional area resulting from various applied pressures. FEA simulations were created to simulate the deformation of the sensor under various loads. To confirm the validity of these simulations, the elastomer was modeled as a neo-Hookean material and the liquid metal was modeled as an incompressible fluid with negligible shear modulus under uniaxial compression. Results show a linearly proportional relationship between the resistance of the sensor and the application of a uniaxial force. Altering the direction of applied force results in a quadratic relationship between total resistance and the magnitude of force.

scholarly journals Conceptus Radiation Dose and Risk From Cardiac Catheter Ablation Procedures

Circulation ◽  
2001 ◽  
Vol 104 (8) ◽  
pp. 893-897 ◽  
Author(s):  
John Damilakis ◽  
Nicholas Theocharopoulos ◽  
Kostas Perisinakis ◽  
Emmanouel Manios ◽  
Panayiotis Dimitriou ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Radiation Dose ◽  
Cardiac Catheter

scholarly journals Evaluating Specivity, Sensitivity, Positive and Negative Predictive Values of CA125 for Diagnosing Ovarian Cancer

2021 ◽  
Vol 24 (2) ◽  
pp. 196-203
Author(s):  
Elahe Fini ◽  
◽  
Neda Nasirian ◽  
Bahram Hosein Beigy ◽  
◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Positive Predictive Value ◽  
Tumor Marker ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Screening Test ◽  
High Sensitivity ◽  
Medical Community ◽  
Cross Sectional ◽  
Predictive Values

Background and Aim: Ovarian cancer is among the most common cancers in women worldwide. CA125 is the most frequent biomarker used in the screening for ovarian cancer. CA125 has no high sensitivity and specificity as a screening test in the medical community; however, because of being simple and noninvasive, it is almost always requested for evaluation and ruling out cancer. It plays an important role in the treatment and post-treatment process, the prediction of prognosis, and the relapse of the disease. The present study aimed to determine the relationship between a high level of CA125 tumor marker and ovarian cancer by detecting spesivity, sensivity, positive and negative predictive values. Methods & Materials: In this cross-sectional study, all cases undergoing CA125 test in Velayat Hospital in 2017-1028 were evaluated for having ovarian cancer. In addition, the CA125 level was compared between healthy individuals and patients with ovarian cancer. Finally, the obtained data were analyzed using SPSS. Ethical Considerations: The present study was approved by the Qazvin University of Medical Sciences (Ethics Code: IR.QUMS.REC.1396.316). Results: In this study, 35.3% of the study participants received a definite diagnosis of ovarian cancer. Generally, CA125 values were negative in 41.8% and positive in.58.2% of the study subjects. The sensitivity of the test was measured as 80.1%, the specivity as 53.6%, the positive predictive value equaled 48.4%, and the negative predictive value was measured as 83%. There was a significant relationship between age and the presence of ovarian cancer, and serum CA125 levels. Conclusion: The present study suggested that age and the serum level of CA125 were statistically significant. Finally, CA125 levels were significantly related to ovarian cancer. It provided moderate specivity and specivity as well as low positive predictive value and high negative predictive value as a tumor marker; it is valuable for ruling out of tumor but not appropriate as a screening test.

scholarly journals Electroporation and its Relevance for Cardiac Catheter Ablation

2018 ◽  
Vol 4 (8) ◽  
pp. 977-986 ◽  
Author(s):  
Fred H.M. Wittkampf ◽  
René van Es ◽  
Kars Neven
Keyword(s):  
Catheter Ablation ◽  
Cardiac Catheter

Soft electrodes combining hydrogel and liquid metal

Soft Matter ◽  
2018 ◽  
Vol 14 (17) ◽  
pp. 3296-3303 ◽  
Author(s):  
Tim Shay ◽  
Orlin D. Velev ◽  
Michael D. Dickey
Keyword(s):  
Liquid Metal ◽  
Liquid Metals ◽  
Wearable Devices ◽  
Soft Robotics

Liquid metals interfaced with hydrogels create soft, deformable electrodes for emerging wearable devices and soft robotics. This paper quantifies and tunes the impedance of this interface for use in ECG electrodes.

scholarly journals Performance Optimization of Polymer Fibre Actuators for Soft Robotics

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 454 ◽  
Author(s):  
Ivan D. Rukhlenko ◽  
Syamak Farajikhah ◽  
Charles Lilley ◽  
Andre Georgis ◽  
Maryanne Large ◽  
...  
Keyword(s):  
Cross Sections ◽  
Performance Optimization ◽  
Analytical Calculation ◽  
Design Guidelines ◽  
Soft Robotics ◽  
Positive Pressure ◽  
Cross Sectional ◽  
Bending Angle ◽  
Pneumatic Actuators ◽  
Wide Range

Analytical modeling of soft pneumatic actuators constitutes a powerful tool for the systematic design and characterization of these key components of soft robotics. Here, we maximize the quasi-static bending angle of a soft pneumatic actuator by optimizing its cross-section for a fixed positive pressure inside it. We begin by formulating a general theoretical framework for the analytical calculation of the bending angle of pneumatic actuators with arbitrary cross-sections, which is then applied to an actuator made of a circular polymer tube and an asymmetric patch in the shape of a hollow-cylinder sector on its outer surface. It is shown that the maximal bending angle of this actuator can be achieved using a wide range of patches with different optimal dimensions and approximately the same cross-sectional area, which decreases with pressure. We also calculate the optimal dimensions of thin and small patches in thin pneumatic actuators. Our analytical results lead to clear design guidelines, which may prove useful for engineering and optimization of the key components of soft robotics with superior features.

P1450Deep vein thrombosis after right sided catheter ablation; more common then previously thought?

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
C Bruce ◽  
S Rogers ◽  
K Saraf ◽  
G Kirkwood ◽  
N Kirkland ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Femoral Vein ◽  
Accessory Pathway ◽  
Significant Proportion ◽  
Anticoagulation Therapy ◽  
Vena Cava ◽  
Iliac Vein ◽  
P Value ◽  
Cardiac Catheter ◽  
Vein Thrombosis

Abstract Funding Acknowledgements Bristol-Myers Squibb Background Right sided cardiac catheter ablation has become an indispensable tool to treat supraventricular cardiac dysrhythmias, with ablation of certain arrhythmias having cure rates over 90%. Due to this the frequency of these procedures is increasing annually and it is imperative we understand the incidence of all complication. One lesser studied complication is that of deep vein thrombosis (DVT), for which catheter ablation demonstrates all elements of Virchow"s triad.  As right sided ablations are carried out to treat troublesome palpitations, not to reduce mortality, it is important all risks are identified, especially those which are themselves potentially life threatening and can be modified. Purpose   To determine the incidence of DVT after right sided cardiac catheter ablation. Methods   We undertook a prospective multi-center study recruiting adult patients undergoing clinically indicated cardiac ablation for atrioventricular nodal re-entrant tachycardia and atrioventricular re-entrant tachycardia with right sided accessory pathway. Important exclusion criteria included patients on anticoagulation or antiplatelet therapy. Participants underwent bilateral compression venous duplex ultrasonography from the inferior vena cava to the popliteal vein to access for DVT at 24 hours and between 10 to 14 days post-procedure. The uncannulated contralateral leg acted as a control. Result   At interim analysis 71 participants had completed the study with average age 47 year (+/- 14), procedure duration 67 minutes, and with a female predominance. Seven patients developed acute DVT in either the femoral or internal iliac vein in the access leg. No thrombus was seen in the control leg. This gives an incidence of 10% (95% CI 4-19%) with p value of 0.023 on Chi-square testing. Conclusion We found a statistically significant proportion of patients undergoing right sided cardiac catheter ablation developed acute proximal DVT on ultrasound. All patients were treated with 3 to 6 months of anticoagulation therapy in accordance with NICE guidelines. These results suggest that DVT may occur at a high frequency then previously thought in this cohort and supports the consideration of peri-procedural prophylactic anticoagulation. Abstract Figure. Acute thrombus in the femoral vein

Gaps in patient-reported outcome measures in randomized clinical trials of cardiac catheter ablation: a systematic review

2020 ◽  
Vol 6 (4) ◽  
pp. 234-242
Author(s):  
Yang Chen ◽  
Myura Nagendran ◽  
Manuel Gomes ◽  
Peter V Wharton ◽  
Rosalind Raine ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Catheter Ablation ◽  
Outcome Measures ◽  
Comparative Effectiveness ◽  
Randomized Clinical Trials ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Cardiac Catheter ◽  
Patient Reported

Abstract The aim of this systematic review was to evaluate randomized clinical trials (RCTs) of cardiac catheter ablation (CCA) and to assess the prevalence, characteristics and reporting standards of clinically relevant patient-reported outcome measures (PROMs). Electronic database searches of Medline, Embase, CENTRAL, and the WHO Trial Registry were conducted in March 2019. The study protocol was registered on PROSPERO (CRD42019133086). Of 7125 records identified, 237 RCTs were included for analysis, representing 35 427 patients with a mean age of 59 years. Only 43 RCTs (18%) reported PROMs of which 27 included a generic PROM that measured health-related quality of life (HRQL) necessary to conduct comparative effectiveness research. There was notable under-representation of certain patient groups—only 31% were women and only 8% were of non-Caucasian ethnicity, in trials which reported such data. The reporting standard of PROMs was highly variable with 8–62% adherence against CONSORT PRO-specific items. In summary, PROMs play a crucial role in determining the clinical and cost-effectiveness of treatments which primarily offer symptomatic improvement, such as CCA. Their underuse significantly limits evaluation of the comparative effectiveness of treatments. Using CCA as an exemplar, there are additional issues of infrequent assessment, poor reporting and under-representation of many population groups. Greater use of PROMs, and specifically validated HRQL questionnaires, is paramount in giving patients a voice in studies, generating more meaningful comparisons between treatments and driving better patient-centred clinical and policy-level decision-making.

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