scholarly journals Eco-Friendly Separation of Antihyperlipidemic Combination Using UHPLC Particle-Packed and Monolithic Columns by Applying Green Analytical Chemistry Principles

Separations ◽  
2021 ◽  
Vol 8 (12) ◽  
pp. 246
Author(s):  
Naser F. Al-Tannak ◽  
Ahmed Hemdan
Keyword(s):  
Analytical Chemistry ◽  
Flow Rate ◽  
Monolithic Column ◽  
Internal Standard ◽  
Back Pressure ◽  
Pharmacokinetic Studies ◽  
Fenofibric Acid ◽  
Green Analytical Chemistry ◽  
Key Factor ◽  
Environmentally Safe

Efficient separation of pharmaceuticals and metabolites with the adequate resolution is a key factor in choosing the most suitable chromatographic method. For quality control, the analysis time is a key factor, especially in pharmacokinetic studies. High back pressure is considered as one of the most important factors in chromatography’s flow control, especially in UHPLC. The separation of the anti-hyperlipidemic mixtures was carried out using two columns: a column silica-based particle packed UHPLC and a monolithic column. The systematic suitability of the two columns was compared for the separation of Fenofibrate, its active metabolite, Fenofibric acid and Pravastatin using Atorvastatin as an internal standard. Separation on both columns was obtained using ethanol: buffer potassium dihydrogen orthophosphate pH = 3 (adjusted with orthophosphoric acid) (75:25 v/v) as mobile phase and flow rate 0.8 mL/min. The analytes’ peak detection was achieved by using a PDA detector at 287 nm, 214 nm, 236 nm, and 250 nm for Fenofibrate, Fenofibric acid, Pravastatin, and Atorvastatin, respectively. Reduction of back-pressure was achieved with the monolithic column, where the analytes could be completely separated in less than 1.5 min at a flow rate of 5 mL/min. The principles of Green Analytical Chemistry (GAC) were followed throughout the developed method using environmentally safe solvents.

Do we need Green Analytical Chemistry?

2016 ◽  
Vol 18 (4) ◽  
pp. 923-931 ◽  
Author(s):  
Mihkel Koel
Keyword(s):  
Analytical Chemistry ◽  
Cost Effective ◽  
Green Analytical Chemistry ◽  
Environmentally Safe

There is very strong opinion that Green Analytical Chemistry is needed beside so-called common Analytical Chemistry. However, the developments in Analytical Chemistry must lead to environmentally safe, economical and cost-effective methods on the whole.

scholarly journals Combining Normal/Reversed-Phase HPTLC with Univariate Calibration for the Piperine Quantification with Traditional and Ultrasound-Assisted Extracts of Various Food Spices of Piper nigrum L. under Green Analytical Chemistry Viewpoint

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 732
Author(s):  
Mohammed H. Alqarni ◽  
Prawez Alam ◽  
Ahmed I. Foudah ◽  
Magdy M. Muharram ◽  
Faiyaz Shakeel
Keyword(s):  
Analytical Chemistry ◽  
High Performance ◽  
Black Pepper ◽  
Reversed Phase ◽  
Normal Phase ◽  
Piper Nigrum ◽  
Green Analytical Chemistry ◽  
Pharmaceutical Samples ◽  
Analytical Technique ◽  
Ultrasound Assisted

Due to unavailability of sustainable analytical techniques for the quantitation of piperine (PPN) in food and pharmaceutical samples, there was a need to develop a rapid and sensitive sustainable analytical technique for the quantitation of PPN. Therefore, the current research presents a fast and highly sensitive normal/reversed-phase high-performance thin-layer chromatography (HPTLC) technique with classical univariate calibration for the quantitation of PPN in various food spices of black pepper with traditional (TE) and ultrasound-assisted extracts (UBE) of various food spices of Piper nigrum L. under green analytical chemistry viewpoint. The amount of PPN in TE of four different spices of black pepper—namely BPMH, BPLU, BPSH, and BPPA—was found to be 309.53, 304.97, 282.82, and 232.73 mg g−1, respectively using a sustainable normal-phase HPTLC technique. However, the amount of PPN in UBE of BPMH, BPLU, BPSH, and BPPA was recorded as 318.52, 314.60, 292.41, and 241.82 mg g−1, respectively using a sustainable normal phase HPTLC technique. The greenness of normal/reversed-phase HPTLC technique was predicted using AGREE metric approach. The eco-scale was found to be 0.90, suggested excellent greenness of normal/reversed-phase technique. UBE of PPN was also found to be superior over TE of PPN. Overall, the results of this research suggested that the proposed normal/reversed-phase densitometry technique could be effectively used for the quantitation of PPN in food and pharmaceutical samples.

SIMULTANEOUS ESTIMATION OF CURCUMIN AND GEFITINIB IN BULK AND TISSUE SAMPLES (PLASMA AND BRAIN HOMOGENATE) BY RP-HPLC: APPLICATION TO A DISTRIBUTION STUDY

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (07) ◽  
pp. 59-68
Author(s):  
H Mahajan ◽  
S Savale ◽  
P Nerkar ◽  
Keyword(s):  
Flow Rate ◽  
Mobile Phase ◽  
Internal Standard ◽  
Brain Homogenate ◽  
Reversed Phase ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Bulk Analysis ◽  
Experimental Conditions ◽  
Rp Hplc

The present study was aimed at developing a Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method for simultaneous determination of curcumin (CRM) and gefitinib (GFT) in bulk, plasma and brain homogenate. hydrochlorothiazide was used as an internal standard (IS). A new simple, rapid, selective, precise and accurate RP-HPLC method has been developed. The separation was achieved by using C-18 column (Qualisil BDS C18, 250 mm x 4.6 mm I.D.) coupled with a guard column of silica, mobile phase consisted of acetonitrile: water with 0.1% formic acid (30:70 v/v). The flow rate was 0.2 ml/min and the drug was detected using PDA detector at the wavelength of 242 nm. The experimental conditions, including the diluting solvent, mobile phase composition, column saturation and flow rate, were optimised to provide high-resolution and reproducible peaks. The method was developed and tested for linearity range of 10-60 μg/mL for bulk analysis and 200-800 ng/mL for plasma and brain homogenate. The developed method was validated as per ICH guidelines, in terms of linearity, application of the proposed method to bulk sample, recovery, precision, repeatability, ruggedness, sensitivity (LOD and LOQ) and robustness and stability study (short and long-term stabilities, freeze/thaw stability, post-preparative). The low value of % RSD showed that the method was precise within the acceptance limit of 2%. The developed method was successfully applied for the analysis of the drug in bulk as well as various marketed formulation and drug in plasma and brain distribution studies.

Sustainable extraction bioactive compounds procedures in medicinal Plants based on the principles of Green Analytical Chemistry: A review

2022 ◽  
pp. 107184
Author(s):  
Rodrigo F. da Silva ◽  
Candice N. Carneiro ◽  
Cheila B. do C. de Sousa ◽  
Federico J. V. Gomez ◽  
Magdalena Espino ◽  
...  
Keyword(s):  
Analytical Chemistry ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Green Analytical Chemistry ◽  
Sustainable Extraction

Water Depollution Control : A Gateway to Reaction Monitoring and Analytical Chemistry

2021 ◽  
Author(s):  
Martin Tiano ◽  
Max Roose
Keyword(s):  
Analytical Chemistry ◽  
Undergraduate Students ◽  
Environmental Chemistry ◽  
Organic Pollutant ◽  
Internal Standard ◽  
Experimental Session ◽  
Reaction Monitoring ◽  
Starting Point ◽  
Good Starting Point ◽  
Magnetite Particles

<div>We present here an experimental session for undergraduate students, based on the reaction monitoring of the degradation of an organic pollutant (para-nitrophenol) by a Fenton-like reaction, catalysed by magnetite particles. <br></div><div>During the session, students realized a follow-up of the reaction by Gas Chromatography with an internal standard, and by UV-Visible spectrophotometry. <br></div>This session was a good starting point to numerous discussions about analytical chemistry, environmental chemistry.

Green analytical chemistry metrics: A review

Talanta ◽  
2021 ◽  
pp. 123046
Author(s):  
Muhammad Sajid ◽  
Justyna Płotka-Wasylka
Keyword(s):  
Analytical Chemistry ◽  
Green Analytical Chemistry

scholarly journals NEW, GREEN AND MINIATURIZED ANALYTICAL METHOD FOR DETERMINATION OF CEFADROXIL MONOHYDRATE IN CAPSULES

2019 ◽  
Vol 3 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Bianca Marco ◽  
Ana Kogawa ◽  
Hérida Salgado
Keyword(s):  
Analytical Chemistry ◽  
Standard Sample ◽  
Low Cost ◽  
Visible Region ◽  
Hplc Method ◽  
Minimal Amount ◽  
Green Analytical Chemistry ◽  
Color Reagent ◽  
Routine Quality Control

Cefadroxil, an oral antimicrobial, presents few techniques optimized for the reduction of solvents and toxic residues and/or non-use of them. So, a quantitative, new and miniaturized method for determination of cefadroxil monohydrate in capsules has been developed and validated by spectrophotometric method in the visible region according to the international guidelines. The analyzes were performed using microplates containing 96 wells, 1 % of phenolphthalein and sodium hydroxide 0.1 M as reagent at 552 nm. The method was (i) linear in the range of 15-115 µg mL-1, (ii) selective when comparing standard, sample, adjuvants and color reagent, (iii) precise with deviations below 4 %, (iv) accurate when comparing the proposed method with the HPLC method, (v) robusts by making small and deliberate modifications to the method, (vi) besides being fast, low cost, eco-friendly and generates minimal amount of waste. The method can be applied to the routine quality control of cefadroxil monohydrate in capsules and an effective and accessible alternative that contemplates the concepts of current and sustainable green analytical chemistry.

scholarly journals ENERGY EFFICIENCY OF ENTERPRISES AS A KEY FACTOR IN THE DEVELOPMENT OF THE COUNTRY'S ECONOMY

10.23856/3304 ◽  
2019 ◽  
Vol 33 (2) ◽  
pp. 36-49
Author(s):  
Kateryna Andriushchenko ◽  
Lidiya Shergina ◽  
Vita Kovtun ◽  
Nataliia Revutska ◽  
Andrii Vashchyshyn
Keyword(s):  
Energy Efficiency ◽  
Alternative Energy ◽  
Fusion Energy ◽  
Primary Energy ◽  
State Regulation ◽  
Energy Sources ◽  
Alternative Energy Sources ◽  
Key Factor ◽  
Environmentally Safe ◽  
Energy Independence

The transition to alternative energy sources requires a long period, attracting significant investments in the process of creating and developing environmentally friendly fuels. Creating an environmentally safe, energy-efficient economy is a prerequisite for sustainable development of each country. The above-mentioned factors determine the relevance of the study of the problems of the functioning and development of energy, which is mainly due to the economic expediency of renewable energy and the requirements of the country's energy independence. The objective of the article is to determine the features of ensuring the energy efficiency of the Ukrainian economy using alternative energy sources. Research shows that the development of alternative energy will allow us to move away from the use of traditional fuels and create the prerequisites for the energy independence of countries. Taking into account the natural factors and the significant dependence of Ukraine on imported primary energy sources, it is determined that solving the problem of increasing energy efficiency of the economy is possible only with the stimulation of the use of alternative energy sources. The most promising sources of energy are identified, namely: biofuels, wind energy, geothermal energy, solar energy, solar thermal, controlled thermonuclear fusion, energy of tides and effluents. The recommendations for realization of such directions of the policy of the state regulation in the energy sphere as energy security, energy efficiency, energy saving are given.

Sign in / Sign up

Export Citation Format

Share Document