scholarly journals Initial Mix-and-Match COVID-19 Vaccination Perceptions, Concerns, and Side Effects across Canadians

Vaccines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 93
Author(s):  
Adam Palanica ◽  
Jouhyun Jeon
Keyword(s):  
Side Effects ◽  
Immune Responses ◽  
Real World ◽  
Adenoviral Vector ◽  
Vaccine Dose ◽  
Demographic Characteristics ◽  
Vector Vaccine ◽  
Different Types ◽  
Psychological Perceptions ◽  
Mix And Match

Research indicates that mixing the first two doses of COVID-19 vaccine types (i.e., adenoviral vector and mRNA) produces potent immune responses against the coronavirus, but it is unclear how individuals may perceive these benefits, or whether there are different concerns compared to individuals who received two doses of the same vaccine. This research examines the demographic characteristics, psychological perceptions, and vaccination-related opinions and experiences of a large Canadian sample (N = 1002) who had received two initial doses of any COVID-19 vaccine combination. Participants included 791 (78.9%) who received two doses of the exact same brand and type of vaccine, 164 (16.4%) who received two doses of the same type of vaccine (i.e., either mRNA or adenoviral vector) but from different brands (e.g., Pfizer-BioNTech + Moderna), and 47 (4.7%) who received two doses from different types and brands of vaccine (e.g., Oxford-AstraZeneca + Pfizer-BioNTech). Results showed that, after the first vaccine dose, participants who received an adenoviral vector vaccine (e.g., Oxford-AstraZeneca) experienced the highest number of common side effects, and more severe levels of each side effect compared to those who received an mRNA vaccine (e.g., Pfizer-BioNTech or Moderna). After the second dose, participants who received Moderna as their second vaccine experienced the highest number of and most severe side effects, regardless of whether they received Moderna, Pfizer-BioNTech, or Oxford-AstraZeneca as their first dose. Real-world implications of these findings are discussed.

scholarly journals Real-World Effectiveness of Ad26.COV2.S Adenoviral Vector Vaccine for COVID-19

2021 ◽  
Author(s):  
Juan Corchado-Garcia ◽  
David Puyraimond-Zemmour‬ ◽  
Travis Hughes ◽  
Tudor Cristea-Platon ◽  
Patrick Lenehan ◽  
...  
Keyword(s):  
Real World ◽  
Adenoviral Vector ◽  
Vector Vaccine

Applications of Nanomaterials for Activation and Suppression of Immune Responses

2015 ◽  
pp. 205-220
Author(s):  
Akhilesh Kumar Shakya ◽  
Kutty Selva Nandakumar
Keyword(s):  
Side Effects ◽  
Immune Responses ◽  
Biomedical Applications ◽  
Inflammatory Diseases ◽  
Host Proteins ◽  
Different Types ◽  
Potential Therapeutics

Evaluation of immuno-modulating properties of nanomaterials is important to develop new potential therapeutics for inflammatory diseases and cancer. Activation and suppressive effects of nanomaterials on immune responses occur through various interactions with different host proteins. They can also be engineered as carriers and/or adjuvants for different proteins or antigens. Particles, emulsions, and tubes/rods are the major formats of nanomaterials currently used in biomedical applications. Sometimes, nanomaterials induce side effects like undesired immunosuppression and toxicities, which are major concerns at present in designing optimal nanotherapeutics. This chapter summarizes different types of nanomaterials and their effect on immune responses.

Applications of Nanomaterials for Activation and Suppression of Immune Responses

2017 ◽  
pp. 859-875
Author(s):  
Akhilesh Kumar Shakya ◽  
Kutty Selva Nandakumar
Keyword(s):  
Side Effects ◽  
Immune Responses ◽  
Biomedical Applications ◽  
Inflammatory Diseases ◽  
Host Proteins ◽  
Different Types ◽  
Potential Therapeutics

Evaluation of immuno-modulating properties of nanomaterials is important to develop new potential therapeutics for inflammatory diseases and cancer. Activation and suppressive effects of nanomaterials on immune responses occur through various interactions with different host proteins. They can also be engineered as carriers and/or adjuvants for different proteins or antigens. Particles, emulsions, and tubes/rods are the major formats of nanomaterials currently used in biomedical applications. Sometimes, nanomaterials induce side effects like undesired immunosuppression and toxicities, which are major concerns at present in designing optimal nanotherapeutics. This chapter summarizes different types of nanomaterials and their effect on immune responses.

scholarly journals Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways

2021 ◽  
Vol 22 (19) ◽  
pp. 10791
Author(s):  
Ralf Kircheis
Keyword(s):  
Side Effects ◽  
Adenoviral Vector ◽  
Viral Vectors ◽  
Molecular Mechanisms ◽  
Herd Immunity ◽  
Current Data ◽  
Cellular Mechanisms ◽  
High Coverage ◽  
Vector Vaccine ◽  
Vaccine Type

Novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digit infection rates and thousands of death tolls daily. Enormous efforts are undertaken to achieve high coverage of immunization to reach herd immunity in order to stop the spread of SARS-CoV-2 infection. Several SARS-CoV-2 vaccines based on mRNA, viral vectors, or inactivated SARS-CoV-2 virus have been approved and are being applied worldwide. However, the recent increased numbers of normally very rare types of thromboses associated with thrombocytopenia have been reported, particularly in the context of the adenoviral vector vaccine ChAdOx1 nCoV-19 from Astra Zeneca. The statistical prevalence of these side effects seems to correlate with this particular vaccine type, i.e., adenoviral vector-based vaccines, but the exact molecular mechanisms are still not clear. The present review summarizes current data and hypotheses for molecular and cellular mechanisms into one integrated hypothesis indicating that coagulopathies, including thromboses, thrombocytopenia, and other related side effects, are correlated to an interplay of the two components in the vaccine, i.e., the spike antigen and the adenoviral vector, with the innate and immune systems, which under certain circumstances can imitate the picture of a limited COVID-19 pathological picture.

scholarly journals Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting

2021 ◽  
Vol 12 ◽  
Author(s):  
Ziwei Li ◽  
Tiandan Xiang ◽  
Boyun Liang ◽  
Hui Deng ◽  
Hua Wang ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Real World ◽  
Vaccine Dose ◽  
T Cell Responses ◽  
Neutralizing Antibody ◽  
Humoral Immune ◽  
Cell Responses ◽  
Effector Cytokines

While the immunogenicity of inactivated vaccines against coronavirus disease 2019 (COVID‐19) has been characterized in several well-conducted clinical trials, real-world evidence concerning immune responses against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) raised by such vaccines is currently missing. Here, we comprehensively characterized various parameters of SARS-CoV-2-specific cellular and humoral immune responses induced by inactivated COVID-19 vaccines in 126 individuals under real-world conditions. After two doses of vaccination, S-receptor binding domain IgG (S-RBD IgG) and neutralizing antibody (NAb) were detected in 87.06% (74/85) and 78.82% (67/85) of individuals, respectively. Female participants developed higher concentrations of S-RBD IgG and NAb compared to male vaccinees. Interestingly, a longer dosing interval between the first and second vaccination resulted in a better long-term SARS-CoV-2 S-RBD IgG response. The frequencies of CD4+ T cells that produce effector cytokines (IFN-γ, IL-2, and TNF-α) in response to stimulation with peptide pools corresponding to the SARS-CoV-2 spike (S), nucleocapsid (N) or membrane (M) protein were significantly higher in individuals received two doses of vaccine than those received one dose of vaccine and unvaccinated individuals. S, N, or M-specific CD4+ and CD8+ T cell responses were detectable in 95.83% (69/72) and 54.16% (39/72) of double-vaccinated individuals, respectively. The longitudinal analysis demonstrated that CD4+ T cell responses recognizing S, N, and M waned quickly after a single vaccine dose, but were boosted and became more sustained following a second dose. Overall, we provide a comprehensive characterization of immune responses induced by inactivated COVID-19 vaccines in real-world settings, suggesting that both humoral and cellular SARS-CoV-2-specific immunity are elicited in the majority of individuals after two doses of inactivated COVID-19 vaccines.

Foundations of Blockchain Technology for Industrial and Societal Applications

2018 ◽  
Author(s):  
Shivika Narang ◽  
Praphul Chandra ◽  
Shweta Jain ◽  
Narahari Y
Keyword(s):  
Supply Chain ◽  
Data Structure ◽  
Real World ◽  
New Wave ◽  
Distributed Consensus ◽  
Wave Technology ◽  
Blockchain Technology ◽  
Different Types ◽  
Original Application

The blockchain concept forms the backbone of a new wave technology that promises to be deployed extensively in a wide variety of industrial and societal applications. In this article, we present the scientific foundations and technical strengths of this technology. Our emphasis is on blockchains that go beyond the original application to digital currencies such as bitcoin. We focus on the blockchain data structure and its characteristics; distributed consensus and mining; and different types of blockchain architectures. We conclude with a section on applications in industrial and societal settings, elaborating upon a few applications such as land registry ledger, tamper-proof academic transcripts, crowdfunding, and a supply chain B2B platform. We discuss what we believe are the important challenges in deploying the blockchain technology successfully in real-world settings.

scholarly journals Effects and Side Effects of Platelet Transfusion

2021 ◽  
Author(s):  
Fabrice Cognasse ◽  
Kathryn Hally ◽  
Sebastien Fauteux-Daniel ◽  
Marie-Ange Eyraud ◽  
Charles-Antoine Arthaud ◽  
...  
Keyword(s):  
Side Effects ◽  
Immune Responses ◽  
Platelet Transfusion ◽  
Biological Response ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Stress Injury ◽  
Processing And Storage ◽  
And Storage

AbstractAside from their canonical role in hemostasis, it is increasingly recognized that platelets have inflammatory functions and can regulate both adaptive and innate immune responses. The main topic this review aims to cover is the proinflammatory effects and side effects of platelet transfusion. Platelets prepared for transfusion are subject to stress injury upon collection, preparation, and storage. With these types of stress, they undergo morphologic, metabolic, and functional modulations which are likely to induce platelet activation and the release of biological response modifiers (BRMs). As a consequence, platelet concentrates (PCs) accumulate BRMs during processing and storage, and these BRMs are ultimately transfused alongside platelets. It has been shown that BRMs present in PCs can induce immune responses and posttransfusion reactions in the transfusion recipient. Several recent reports within the transfusion literature have investigated the concept of platelets as immune cells. Nevertheless, current and future investigations will face the challenge of encompassing the immunological role of platelets in the scope of transfusion.

An algebraic approach to N-soft sets with application in decision-making using TOPSIS

2021 ◽  
pp. 1-21
Author(s):  
Muhammad Shabir ◽  
Rimsha Mushtaq ◽  
Munazza Naz
Keyword(s):  
Decision Making ◽  
Mathematical Models ◽  
Real World ◽  
Algebraic Approach ◽  
Multi Criteria Decision Making ◽  
Commutative Monoids ◽  
Soft Sets ◽  
Algebraic Properties ◽  
Different Types ◽  
Selection Of

In this paper, we focus on two main objectives. Firstly, we define some binary and unary operations on N-soft sets and study their algebraic properties. In unary operations, three different types of complements are studied. We prove De Morgan’s laws concerning top complements and for bottom complements for N-soft sets where N is fixed and provide a counterexample to show that De Morgan’s laws do not hold if we take different N. Then, we study different collections of N-soft sets which become idempotent commutative monoids and consequently show, that, these monoids give rise to hemirings of N-soft sets. Some of these hemirings are turned out as lattices. Finally, we show that the collection of all N-soft sets with full parameter set E and collection of all N-soft sets with parameter subset A are Stone Algebras. The second objective is to integrate the well-known technique of TOPSIS and N-soft set-based mathematical models from the real world. We discuss a hybrid model of multi-criteria decision-making combining the TOPSIS and N-soft sets and present an algorithm with implementation on the selection of the best model of laptop.

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