Influence of polymer-organic solvent ratio on the physical and technological characteristics of gimantan nanoparticles

2020 ◽  
pp. 25-28
Author(s):  
V. Markeev ◽  
E. Blynskaya ◽  
A. Marakhova ◽  
K. Alekseev
Keyword(s):  
Organic Solvent ◽  
Targeted Delivery ◽  
Polymer Nanoparticles ◽  
Solvent Ratio ◽  
Pharmaceutical Substance ◽  
Technological Characteristics ◽  
Inflammatory Processes ◽  
The Creation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Ensuring targeted delivery of drugs is the most promising and studied direction in pharmacy. This task can be solved by creating nanostructures that can accumulate in the focus of inflammation in case of treatment of inflammatory processes. The results of studies on the creation of polymer nanoparticles with an encapsulated pharmaceutical substance of gimantan, which has a local anti-inflammatory effect, are described.

A PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis

2019 ◽  
Vol 7 (10) ◽  
pp. 4299-4309 ◽  
Author(s):  
Ya Wu ◽  
Minghui Sun ◽  
Dan Wang ◽  
Genyun Li ◽  
Jiangeng Huang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cyclosporine A ◽  
Targeted Delivery ◽  
Severe Ulcerative Colitis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

A novel nano-system (PKMCN) with medical value could accumulate in the inflamed colon tissues and exhibit a strong anti-inflammatory effect.

scholarly journals Serum Metabolic Profiling Reveals Potential Anti-Inflammatory Effects of the Intake of Black Ginseng Extracts in Beagle Dogs

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3759 ◽  
Author(s):  
Ye Jin Kim ◽  
Dae Young Lee ◽  
Ho-Eun Park ◽  
Dahye Yoon ◽  
Bumkyu Lee ◽  
...  
Keyword(s):  
Metabolic Profiling ◽  
Serum Biomarkers ◽  
Beagle Dogs ◽  
High Concentration ◽  
Experimental Diet ◽  
Inflammatory Processes ◽  
Black Ginseng ◽  
White Ginseng ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Black ginseng (BG) has better health benefits than white ginseng. The intake of BG changes the levels of metabolites, such as amino acids, fatty acids, and other metabolites. However, there is no research on the effect of BG extract intake on the metabolic profile of dog serum. In this study, serum metabolic profiling was conducted to investigate metabolic differences following the intake of BG extracts in beagle dogs. The beagle dogs were separated into three groups and fed either a regular diet (RD, control), RD with a medium concentration of BG extract (BG-M), or RD with a high concentration of BG extract (BG-H). Differences were observed among the three groups after the dogs ingested the experimental diet for eight weeks. The concentrations of alanine, leucine, isoleucine, and valine changed with the intake of BG extracts. Furthermore, levels of glycine and β-alanine increased in the BG-H group compared to the control and BG-M groups, indicating that BG extracts are associated with anti-inflammatory processes. Our study is the first to demonstrate the potential anti-inflammatory effect of BG extract in beagle dogs. Glycine and β-alanine are proposed as candidate serum biomarkers in dogs that can discriminate between the effects of ingesting BG-H.

scholarly journals Anti-Inflammatory Effect of Targeted Delivery of SOD to Endothelium: Mechanism, Synergism with NO Donors and Protective Effects In Vitro and In Vivo

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77002 ◽  
Author(s):  
Vladimir V. Shuvaev ◽  
Jingyan Han ◽  
Samira Tliba ◽  
Evguenia Arguiri ◽  
Melpo Christofidou-Solomidou ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Protective Effects ◽  
No Donors ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Inhibition of Neutrophil Secretion Upon Adhesion as a Basis for the Anti-Inflammatory Effect of the Tricyclic Antidepressant Imipramine

2021 ◽  
Vol 12 ◽  
Author(s):  
Svetlana I. Galkina ◽  
Ekaterina A. Golenkina ◽  
Natalia V. Fedorova ◽  
Alexander L. Ksenofontov ◽  
Marina V. Serebryakova ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Neutrophil Infiltration ◽  
Tricyclic Antidepressant ◽  
Basement Membranes ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Lysine Residues ◽  
Antidepressant Imipramine ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Recent studies demonstrate the involvement of inflammatory processes in the development of depression and the anti-inflammatory effects of antidepressants. Infiltration and adhesion of neutrophils to nerve tissues and their aggressive secretion are considered as possible causes of inflammatory processes in depression. We studied the effect of the antidepressant imipramine on the adhesion and accompanied secretion of neutrophils under control conditions and in the presence of lipopolysaccharides (LPS). As a model of integrin-dependent neutrophil infiltration into tissues, we used integrin-dependent adhesion of neutrophils to the fibronectin-coated substrate. Imipramine inhibited neutrophil adhesion and concomitant secretion of proteins, including matrix metalloproteinase 9 (MMP-9) and neutrophil gelatinase-associated lipocalin (NGAL), which modify the extracellular matrix and basement membranes required for cell migration. Imipramine also significantly and selectively blocked the release of the free amino acid hydroxylysine, a product of lysyl hydroxylase, an enzyme that affects the organization of the extracellular matrix by modifying collagen lysine residues. In contrast, imipramine enhanced the release of ROS by neutrophils during adhesion to fibronectin and stimulated apoptosis. The anti-inflammatory effect of imipramine may be associated with the suppression of neutrophil infiltration and their adhesion to nerve tissues by inhibiting the secretion of neutrophils, which provides these processes.

scholarly journals Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1646
Author(s):  
Abdelaziz Ghanemi ◽  
Mayumi Yoshioka ◽  
Jonny St-Amand
Keyword(s):  
Family Member ◽  
Tissue Repair ◽  
Trefoil Factor ◽  
Mucosal Repair ◽  
Inflammatory Processes ◽  
Trefoil Factor Family ◽  
Repair Factor ◽  
Anti Inflammatory ◽  
Inflammatory Effect ◽  
Inflammatory Tissue

Trefoil factor family member 2 (TFF2) is known for its involvement in mucosal repair. Whereas it is overexpressed during inflammatory processes, adding TFF2 leads to an anti-inflammatory effect that would contribute to create the microenvironment required for tissue repair. These properties present TFF2 with a homeostatic pattern during inflammatory processes as illustrated by selected examples.

Phytochemical Analysis and Antinociceptive Properties of Hydroalcoholic Extracts of Aleurites moluccanus Bark

Planta Medica ◽  
2021 ◽  
Author(s):  
Márcia Maria de Souza ◽  
Luiz G. R. D. Chagas ◽  
Ana Elisa Gonçalves ◽  
Marcelo Tomczak ◽  
Simone Reichert ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Bark Extract ◽  
Phytochemical Analysis ◽  
Solvent Ratio ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract ◽  
Extracting Solvent ◽  
Positive Results ◽  
Necrosis Factor

Abstract Aleurites moluccanus is used in folk medicine to treat many diseases including pain and inflammatory processes in general. Considering the potential of the leaf extract, evidenced in a previous study, the present study investigates the antinociceptive and anti-inflammatory properties of the hydroethanolic extract of A. moluccanus bark and isolated compounds in animal models of pain. The antinociceptive and anti-inflammatory activities of A. moluccanus bark were evaluated through hyperalgesia induced by carrageenan, PGE2, cytokines, bradykinin, epinephrine, Freundʼs complete adjuvant, and lipopolysaccharide. Five compounds were isolated from the dichloromethane bark extract: acetyl aleuritolic acid, atraric acid, spruceanol, (5β,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one and sonderianol. To optimize the extraction conditions, ethanol 50, 70, and 90°GL were used as extracting solvent, in a 1 : 20 (w/v) drug : solvent ratio, under stirring at room temperature for 4 h. The extracts were named AMC50, AMC70, and AMC90, respectively. These extracts were administered to mice (250 mg/kg, p. o.) with reduced mechanical hyperalgesia activity in the carrageenan test. Of these, AMC90 showed the best results. Pure (5β,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one showed a beneficial effect for up to 48 hours after the administration of carrageenan, while acetyl aleuritolic acid was effective only in the first hour. AMC90 was able to reverse the analgesia induced only by prostaglandin E2 and tumor necrosis factor. We also induced hyperalgesia using the lipopolysaccharide and Freundʼs complete adjuvant models, with positive results. These results support the antinociceptive and anti-inflammatory activity of A. moluccanus bark extract. The observed effects are partly due to the presence of acetyl aleuritolic acid, atraric acid, and (5β,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one.

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

2019 ◽  
pp. 1-9
Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Time Course ◽  
Acute Inflammation ◽  
Lichen Species ◽  
Paw Edema ◽  
Sod Activity ◽  
Edema Formation ◽  
Lobaria Pulmonaria ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

Anti-inflammatory effect of Curcuma longa (turmeric) rhizome when administered topically in gel form

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AH Mollik ◽  
W Mozammel Haq ◽  
S Chandra Bachar ◽  
R Jahan ◽  
M Rahmatullah
Keyword(s):  
Curcuma Longa ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory effect of Mitragyna speciosa crude methanol extract on the guinea pig ileum

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
WM Shaik Mossadeq ◽  
K Syamimi ◽  
MP Azyyati ◽  
ZA Zakaria ◽  
AK Arifah ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Methanol Extract ◽  
Guinea Pig Ileum ◽  
Mitragyna Speciosa ◽  
Anti Inflammatory ◽  
Crude Methanol Extract ◽  
Inflammatory Effect

Anti-inflammatory effect of Uncaria tomentosa in an experimental model of cyclophosphamide-induced hemorrhagic cystitis

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
IST Figueiredo ◽  
FT Benevides ◽  
NMS Queiroz ◽  
LM Marques ◽  
TFG Souza ◽  
...  
Keyword(s):  
Experimental Model ◽  
Hemorrhagic Cystitis ◽  
Uncaria Tomentosa ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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