Faculty Opinions recommendation of Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease.

2009 ◽  
Author(s):  
Bruce Blazar ◽  
Christoph Bucher
Keyword(s):  
T Cell ◽  
Graft Versus Host Disease ◽  
Regulatory T Cell ◽  
Interleukin 6 ◽  
Host Disease ◽  
Graft Versus Host ◽  
T Cell Reconstitution

scholarly journals Mammalian Target of Rapamycin Inhibitors Permit Regulatory T Cell Reconstitution and Inhibit Experimental Chronic Graft-versus-Host Disease

2014 ◽  
Vol 20 (2) ◽  
pp. 183-191 ◽  
Author(s):  
Haruko Sugiyama ◽  
Yoshinobu Maeda ◽  
Hisakazu Nishimori ◽  
Yoshiko Yamasuji ◽  
Ken-ichi Matsuoka ◽  
...  
Keyword(s):  
T Cell ◽  
Graft Versus Host Disease ◽  
Regulatory T Cell ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Host Disease ◽  
Graft Versus Host ◽  
T Cell Reconstitution

scholarly journals A Crucial Role for Host APCs in the Induction of Donor CD4+CD25+ Regulatory T Cell-Mediated Suppression of Experimental Graft-versus-Host Disease

2010 ◽  
Vol 185 (7) ◽  
pp. 3866-3872 ◽  
Author(s):  
Isao Tawara ◽  
Warren D. Shlomchik ◽  
Angela Jones ◽  
Weiping Zou ◽  
Evelyn Nieves ◽  
...  
Keyword(s):  
T Cell ◽  
Graft Versus Host Disease ◽  
Regulatory T Cell ◽  
Crucial Role ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue

Immunology ◽  
2012 ◽  
Vol 137 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Christoph Dürr ◽  
Marie Follo ◽  
Marco Idzko ◽  
Wilfried Reichardt ◽  
Robert Zeiser
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
Graft Versus Host Disease ◽  
Regulatory T Cell ◽  
Tumour Tissue ◽  
Host Disease ◽  
Graft Versus Host ◽  
T Cell Migration

scholarly journals Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment

Blood ◽  
2007 ◽  
Vol 109 (12) ◽  
pp. 5502-5510 ◽  
Author(s):  
Jack Gorski ◽  
Xiao Chen ◽  
Mariya Gendelman ◽  
Maryam Yassai ◽  
Ashley Krueger ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Graft Versus Host Disease ◽  
Cell Expansion ◽  
Host Disease ◽  
Host Environment ◽  
Graft Versus Host ◽  
T Cell Reconstitution ◽  
T Cell Expansion ◽  
Cell Defect

Abstract Graft versus host disease (GVHD) typically results in impaired T-cell reconstitution characterized by lymphopenia and repertoire skewing. One of the major causes of inadequate T-cell reconstitution is that T-cell survival and expansion in the periphery are impaired. In this report, we have performed adoptive transfer studies to determine whether the quantitative reduction in T-cell numbers is due to an intrinsic T-cell defect or whether the environmental milieu deleteriously affects T-cell expansion. These studies demonstrate that T cells obtained from animals with graft-versus-host disease (GVHD) are capable of significant expansion and renormalization of an inverted CD4/CD8 ratio when they are removed from this environment. Moreover, these cells can generate complex T-cell repertoires early after transplantation and are functionally competent to respond to third-party alloantigens. Our data indicate that T cells from mice undergoing GVHD can respond to homeostatic signals in the periphery and are not intrinsically compromised once they are removed from the GVHD environment. We thereby conclude that the host environment and not an intrinsic T-cell defect is primarily responsible for the lack of effective T-cell expansion and diversification of complex T-cell repertoires that occurs during GVHD.

scholarly journals Granzyme A Is Required for Regulatory T-Cell Mediated Prevention of Gastrointestinal Graft-versus-Host Disease

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124927 ◽  
Author(s):  
Sarvari Velaga ◽  
Sya N. Ukena ◽  
Ulrike Dringenberg ◽  
Christina Alter ◽  
Julian Pardo ◽  
...  
Keyword(s):  
T Cell ◽  
Graft Versus Host Disease ◽  
Regulatory T Cell ◽  
Host Disease ◽  
Graft Versus Host ◽  
Granzyme A

scholarly journals The Effect of TNF-α on Regulatory T Cell Function in Graft-versus-Host Disease

2018 ◽  
Vol 9 ◽  
Author(s):  
Antonella Mancusi ◽  
Sara Piccinelli ◽  
Andrea Velardi ◽  
Antonio Pierini
Keyword(s):  
T Cell ◽  
Graft Versus Host Disease ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Host Disease ◽  
Graft Versus Host ◽  
T Cell Function ◽  
Tnf Α

Interleukin-22 Aggravates Murine Acute Graft-Versus-Host Disease by Expanding Effector T Cell and Reducing Regulatory T Cell

2014 ◽  
Vol 34 (9) ◽  
pp. 707-715 ◽  
Author(s):  
Kai Zhao ◽  
Dongmei Zhao ◽  
Dong Huang ◽  
Lingling Yin ◽  
Chong Chen ◽  
...  
Keyword(s):  
T Cell ◽  
Graft Versus Host Disease ◽  
Regulatory T Cell ◽  
Host Disease ◽  
Graft Versus Host ◽  
Effector T Cell ◽  
Interleukin 22 ◽  
Acute Graft
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