Faculty Opinions recommendation of Motions on the millisecond time scale and multiple conformations of HIV-1 capsid protein: implications for structural polymorphism of CA assemblies.

2012 ◽  
Author(s):  
David Cowburn
Keyword(s):  
Capsid Protein ◽  
Time Scale ◽  
Structural Polymorphism ◽  
Millisecond Time Scale ◽  
Multiple Conformations ◽  
Hiv 1

scholarly journals Motions on the Millisecond Time Scale and Multiple Conformations of HIV-1 Capsid Protein: Implications for Structural Polymorphism of CA Assemblies

2012 ◽  
Vol 134 (14) ◽  
pp. 6455-6466 ◽  
Author(s):  
In-Ja L. Byeon ◽  
Guangjin Hou ◽  
Yun Han ◽  
Christopher L. Suiter ◽  
Jinwoo Ahn ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Time Scale ◽  
Structural Polymorphism ◽  
Millisecond Time Scale ◽  
Multiple Conformations ◽  
Hiv 1

Using Amide1H and15N Transverse Relaxation To Detect Millisecond Time-Scale Motions in Perdeuterated Proteins:  Application to HIV-1 Protease

1998 ◽  
Vol 120 (40) ◽  
pp. 10534-10542 ◽  
Author(s):  
Rieko Ishima ◽  
Paul T. Wingfield ◽  
Stephen J. Stahl ◽  
Joshua D. Kaufman ◽  
Dennis A. Torchia
Keyword(s):  
Time Scale ◽  
Transverse Relaxation ◽  
Perdeuterated Proteins ◽  
Millisecond Time Scale ◽  
Hiv 1

scholarly journals An extensive thermodynamic characterization of the dimerization domain of the HIV-1 capsid protein

2005 ◽  
Vol 14 (9) ◽  
pp. 2387-2404 ◽  
Author(s):  
María C. Lidón-Moya ◽  
Francisco N. Barrera ◽  
Marta Bueno ◽  
Raúl Pérez-Jiménez ◽  
Javier Sancho ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Dimerization Domain ◽  
Thermodynamic Characterization ◽  
Hiv 1

scholarly journals Structure, Function, and Interactions of the HIV-1 Capsid Protein

Life ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 100
Author(s):  
Eric Rossi ◽  
Megan E. Meuser ◽  
Camille J. Cunanan ◽  
Simon Cocklin
Keyword(s):  
Life Cycle ◽  
Capsid Protein ◽  
Adaptor Proteins ◽  
Restriction Factors ◽  
Gag Polyprotein ◽  
Immunodeficiency Virus ◽  
Host Cell Factors ◽  
Hiv 1

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential structural component of a virion and facilitates many crucial life cycle steps through interactions with host cell factors. Capsid shields the reverse transcription complex from restriction factors while it enables trafficking to the nucleus by hijacking various adaptor proteins, such as FEZ1 and BICD2. In addition, the capsid facilitates the import and localization of the viral complex in the nucleus through interaction with NUP153, NUP358, TNPO3, and CPSF-6. In the later stages of the HIV-1 life cycle, CA plays an essential role in the maturation step as a constituent of the Gag polyprotein. In the final phase of maturation, Gag is cleaved, and CA is released, allowing for the assembly of CA into a fullerene cone, known as the capsid core. The fullerene cone consists of ~250 CA hexamers and 12 CA pentamers and encloses the viral genome and other essential viral proteins for the next round of infection. As research continues to elucidate the role of CA in the HIV-1 life cycle and the importance of the capsid protein becomes more apparent, CA displays potential as a therapeutic target for the development of HIV-1 inhibitors.

scholarly journals Solid-State NMR Studies of HIV-1 Capsid Protein Assemblies

2010 ◽  
Vol 132 (6) ◽  
pp. 1976-1987 ◽  
Author(s):  
Yun Han ◽  
Jinwoo Ahn ◽  
Jason Concel ◽  
In-Ja L. Byeon ◽  
Angela M. Gronenborn ◽  
...  
Keyword(s):  
Solid State ◽  
Capsid Protein ◽  
Solid State Nmr ◽  
Protein Assemblies ◽  
Nmr Studies ◽  
Hiv 1

scholarly journals Site-Specific Structural Variations Accompanying Tubular Assembly of the HIV-1 Capsid Protein

2014 ◽  
Vol 426 (5) ◽  
pp. 1109-1127 ◽  
Author(s):  
Marvin J. Bayro ◽  
Bo Chen ◽  
Wai-Ming Yau ◽  
Robert Tycko
Keyword(s):  
Capsid Protein ◽  
Structural Variations ◽  
Site Specific ◽  
Hiv 1

Sensing oxygen at the millisecond time-scale using an ultra-microelectrode array (UMEA)

2017 ◽  
Vol 238 ◽  
pp. 1008-1016 ◽  
Author(s):  
Fleur van Rossem ◽  
Johan G. Bomer ◽  
Hans L. de Boer ◽  
Yawar Abbas ◽  
Eddy de Weerd ◽  
...  
Keyword(s):  
Time Scale ◽  
Microelectrode Array ◽  
Millisecond Time Scale

scholarly journals Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein

2008 ◽  
Vol 6 (11) ◽  
pp. 2297-2307 ◽  
Author(s):  
Felix F. Vajdos ◽  
Sanghee Yoo ◽  
Megan Houseweart ◽  
Wesley I. Sundquist ◽  
Christopher P. Hill
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Capsid Protein ◽  
Cyclophilin A ◽  
Hiv 1
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