Faculty Opinions recommendation of Autologous transplantation of peripheral blood-derived circulating endothelial progenitor cells attenuates endotoxin-induced acute lung injury in rabbits by direct endothelial repair and indirect immunomodulation.

2012 ◽  
Author(s):  
Randal Dull ◽  
Barbara Jericho
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Peripheral Blood ◽  
Autologous Transplantation ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells ◽  
Endothelial Repair

Increased Circulating Endothelial Progenitor Cells Are Associated with Survival in Acute Lung Injury

2005 ◽  
Vol 172 (7) ◽  
pp. 854-860 ◽  
Author(s):  
Ellen L. Burnham ◽  
W. Robert Taylor ◽  
Arshed A. Quyyumi ◽  
Mauricio Rojas ◽  
Kenneth L. Brigham ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells

scholarly journals Autologous Transplantation of Endothelial Progenitor Cells Attenuates Acute Lung Injury in Rabbits

2008 ◽  
Vol 108 (3) ◽  
pp. 392-401 ◽  
Author(s):  
Chen-Fuh Lam ◽  
Yen-Chin Liu ◽  
Jen-Kuo Hsu ◽  
Pei-An Yeh ◽  
Ting-Ya Su ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Pulmonary Artery ◽  
Endothelial Function ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Autologous Transplantation ◽  
Rabbit Model ◽  
Endothelial Progenitor ◽  
Vasomotor Function

Background Acute lung injury (ALI) and end-stage acute respiratory distress syndrome (ARDS) are among the most common causes of death in intensive care units. Activation and damage of pulmonary endothelium is the hallmark of ALI/ARDS. Recent studies have demonstrated the importance of circulating endothelial progenitor cells (EPCs) in maintaining normal endothelial function as well as endothelial repairing after vascular injury. Here, the authors present the first study demonstrating the therapeutic potential of EPCs in a rabbit model of ALI/ARDS. Methods Circulating EPCs were obtained from rabbits using Ficoll centrifugation. One week after culturing, ALI was induced in rabbits by oleic acid (75 mg/kg, intravenous), and autologous EPCs were transplanted intravenously. Vasomotor function of isolated pulmonary artery and degrees of lung injury were assessed 2 days later. Results Endothelial dysfunction in the pulmonary artery was significantly attenuated in rabbits treated with EPCs, whereas the endothelium-independent relaxation responses were not different. Expression of inducible nitric oxide synthase was suppressed in the pulmonary artery of EPC-treated animals. Infiltration of leukocytes in the lung parenchyma was significantly reduced after EPC transplantation. EPCs also decreased water content, hyaline membrane formation, and hemorrhage in lungs. Conclusion The authors demonstrated that autologous transplantation of EPCs preserves pulmonary endothelial function and maintains the integrity of pulmonary alveolar-capillary barrier. Transplantation of EPCs can be a novel cell-based, endothelium-targeted therapeutic strategy for prevention and treatment of ALI/ARDS.

scholarly journals Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury

2007 ◽  
Vol 8 (1) ◽  
Author(s):  
Christian M Kähler ◽  
Jutta Wechselberger ◽  
Wolfgang Hilbe ◽  
Andreas Gschwendtner ◽  
Daniela Colleselli ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Rat Bone

Endothelial progenitor cells: the promise of cell-based therapies for acute lung injury

2012 ◽  
Vol 62 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Mei Mao ◽  
Xilin Xu ◽  
Yong Zhang ◽  
Bo Zhang ◽  
Zu-hong Fu
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor

Endothelial Progenitor Cells in Regeneration after Acute Lung Injury

2013 ◽  
Vol 48 (4) ◽  
pp. 399-405 ◽  
Author(s):  
Neysan Rafat ◽  
Burkhard Tönshoff ◽  
Angelika Bierhaus ◽  
Grietje C. Beck
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor
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