Faculty Opinions recommendation of Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors.

2013 ◽  
Author(s):  
Gordon Fain
Keyword(s):  
G Protein ◽  
Protein Assembly ◽  
Rod Photoreceptors ◽  
Retinal Rod

scholarly journals Phosducin-Like Protein 1 is Essential for G-Protein Assembly and Signaling in Retinal Rod Photoreceptors

2013 ◽  
Vol 33 (18) ◽  
pp. 7941-7951 ◽  
Author(s):  
C. W. J. Lai ◽  
A. V. Kolesnikov ◽  
J. M. Frederick ◽  
D. R. Blake ◽  
L. Jiang ◽  
...  
Keyword(s):  
G Protein ◽  
Protein Assembly ◽  
Rod Photoreceptors ◽  
Retinal Rod

scholarly journals A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease

2018 ◽  
Vol 29 (1) ◽  
pp. 45-52 ◽  
Author(s):  
W. Robert Bell ◽  
Alan K. Meeker ◽  
Anthony Rizzo ◽  
Sumit Rajpara ◽  
Ian M. Rosenthal ◽  
...  
Keyword(s):  
Rod Photoreceptors ◽  
Retinal Rod

scholarly journals Immunocytochemical localization of opsin in the cell membrane of developing rat retinal photoreceptors.

1984 ◽  
Vol 98 (5) ◽  
pp. 1788-1795 ◽  
Author(s):  
I Nir ◽  
D Cohen ◽  
D S Papermaster
Keyword(s):  
Plasma Membrane ◽  
Outer Segment ◽  
Plasma Membranes ◽  
Photoreceptor Cells ◽  
Rod Photoreceptor ◽  
Rod Photoreceptors ◽  
Retinal Photoreceptors ◽  
Retinal Rod ◽  
Ros Formation ◽  
Developing Rat

Mature retinal rod photoreceptors sequester opsin in the disk and plasma membranes of the rod outer segment (ROS). Opsin is synthesized in the inner segment and is transferred to the outer segment along the connecting cilium that joins the two compartments. We have investigated early stages of retinal development during which the polarized distribution of opsin is established in the rod photoreceptor cell. Retinas were isolated from newborn rats, 3-21 d old, and incubated with affinity purified biotinyl-sheep anti-bovine opsin followed by avidin-ferritin. At early postnatal ages prior to the development of the ROS, opsin is labeled by antiopsin on the inner segment plasma membrane. At the fifth postnatal day, as ROS formation begins opsin was detected on the connecting cilium plasma membrane. However, the labeling density of the ciliary plasma membrane was not uniform: the proximal cilium was relatively unlabeled in comparison with the distal cilium and the ROS plasma membrane. In nearly mature rat retinas, opsin was no longer detected on the inner segment plasma membrane. A similar polarized distribution of opsin was also observed in adult human rod photoreceptor cells labeled with the same antibodies. These results suggest that some component(s) of the connecting cilium and its plasma membrane may participate in establishing and maintaining the polarized distribution of opsin.

scholarly journals Reduced G Protein-coupled Signaling Efficiency in Retinal Rod Outer Segments in Response ton-3 Fatty Acid Deficiency

2004 ◽  
Vol 279 (30) ◽  
pp. 31098-31104 ◽  
Author(s):  
Shui-Lin Niu ◽  
Drake C. Mitchell ◽  
Sun-Young Lim ◽  
Zhi-Ming Wen ◽  
Hee-Yong Kim ◽  
...  
Keyword(s):  
Fatty Acid ◽  
G Protein ◽  
Rod Outer Segments ◽  
Outer Segments ◽  
Retinal Rod ◽  
Acid Deficiency ◽  
Fatty Acid Deficiency ◽  
G Protein Coupled ◽  
Signaling Efficiency ◽  
Retinal Rod Outer Segments

Calcium accumulation in intracellular compartments of frog retinal rod photoreceptors

1981 ◽  
Vol 205 (1) ◽  
pp. 200-206 ◽  
Author(s):  
Florette Ungar ◽  
Irene Piscopo ◽  
Eric Holtzman
Keyword(s):  
Rod Photoreceptors ◽  
Calcium Accumulation ◽  
Retinal Rod ◽  
Intracellular Compartments

scholarly journals Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors

eNeuro ◽  
2018 ◽  
Vol 5 (3) ◽  
pp. ENEURO.0144-18.2018 ◽  
Author(s):  
Paige M. Dexter ◽  
Ekaterina S. Lobanova ◽  
Stella Finkelstein ◽  
William J. Spencer ◽  
Nikolai P. Skiba ◽  
...  
Keyword(s):  
G Protein ◽  
Β Subunit ◽  
Light Detection ◽  
Rod Photoreceptors
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