Faculty Opinions recommendation of Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

2020 ◽  
Author(s):  
Gwo-Tzer Ho ◽  
Rahul Kalla
Keyword(s):  
Inflammatory Bowel Disease ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Bowel Disease ◽  
Genetic Architecture ◽  
Whole Genome ◽  
Inflammatory Bowel

scholarly journals Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

2017 ◽  
Vol 49 (2) ◽  
pp. 186-192 ◽  
Author(s):  
Yang Luo ◽  
Katrina M de Lange ◽  
Luke Jostins ◽  
Loukas Moutsianas ◽  
Joshua Randall ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Bowel Disease ◽  
Genetic Architecture ◽  
Whole Genome ◽  
Inflammatory Bowel

scholarly journals Su1028 – Whole-Genome Sequencing of African Americans Identifies Novel Rare Variants Associated with Inflammatory Bowel Disease

2019 ◽  
Vol 156 (6) ◽  
pp. S-488-S-489
Author(s):  
Hari K. Somineni ◽  
Talin Haritunians ◽  
Claire L. Simpson ◽  
David J. Cutler ◽  
David Okou ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
African Americans ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Bowel Disease ◽  
Rare Variants ◽  
Whole Genome ◽  
Inflammatory Bowel

scholarly journals Inflammatory Bowel Disease–Associated Changes in the Gut: Focus on Kazan Patients

2020 ◽  
Author(s):  
Giuseppe Lo Sasso ◽  
Lusine Khachatryan ◽  
Athanasios Kondylis ◽  
James N D Battey ◽  
Nicolas Sierro ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Gut Microbiota ◽  
Bowel Disease ◽  
Redox Status ◽  
Fecal Microbiota ◽  
Whole Genome ◽  
Industrialized Countries ◽  
Newly Industrialized Countries ◽  
Inflammatory Bowel

Abstract Background Several studies have highlighted the role of host–microbiome interactions in the pathogenesis of inflammatory bowel disease (IBD), resulting in an increasing amount of data mainly focusing on Western patients. Because of the increasing prevalence of IBD in newly industrialized countries such as those in Asia, the Middle East, and South America, there is mounting interest in elucidating the gut microbiota of these populations. We present a comprehensive analysis of several IBD-related biomarkers and gut microbiota profiles and functions of a unique population of patients with IBD and healthy patients from Kazan (Republic of Tatarstan, Russia). Methods Blood and fecal IBD biomarkers, serum cytokines, and fecal short-chain fatty acid (SCFA) content were profiled. Finally, fecal microbiota composition was analyzed by 16S and whole-genome shotgun sequencing. Results Fecal microbiota whole-genome sequencing confirmed the presence of classic IBD dysbiotic features at the phylum level, with increased abundance of Proteobacteria, Actinobacteria, and Fusobacteria and decreased abundance of Firmicutes, Bacteroidetes, and Verrucomicrobia. At the genus level, the abundance of both fermentative (SCFA-producing and hydrogen (H2)-releasing) and hydrogenotrophic (H2-consuming) microbes was affected in patients with IBD. This imbalance was confirmed by the decreased abundance of SCFA species in the feces of patients with IBD and the change in anaerobic index, which mirrors the redox status of the intestine. Conclusions Our analyses highlighted how IBD-related dysbiotic microbiota—which are generally mainly linked to SCFA imbalance—may affect other important metabolic pathways, such as H2 metabolism, that are critical for host physiology and disease development.

Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

2018 ◽  
Vol 50 (12) ◽  
pp. 1696-1704 ◽  
Author(s):  
Haihua Bai ◽  
Xiaosen Guo ◽  
Narisu Narisu ◽  
Tianming Lan ◽  
Qizhu Wu ◽  
...  
Keyword(s):  
Gene Flow ◽  
East Asia ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Genetic Architecture ◽  
Whole Genome
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