Faculty Opinions recommendation of Six-Year Results From a Phase I/II Trial for Hypofractionated Accelerated Partial Breast Irradiation Using a 2-Day Dose Schedule.

2020 ◽  
Author(s):  
Lorenzo Livi ◽  
Isacco Desideri
Keyword(s):  
Phase I ◽  
Dose Schedule ◽  
Accelerated Partial Breast Irradiation ◽  
Partial Breast Irradiation ◽  
Breast Irradiation

Six-Year Results From a Phase I/II Trial for Hypofractionated Accelerated Partial Breast Irradiation Using a 2-Day Dose Schedule

2018 ◽  
Vol 41 (10) ◽  
pp. 986-991 ◽  
Author(s):  
John B. Wilkinson ◽  
Peter Y. Chen ◽  
Michelle F. Wallace ◽  
Chirag S. Shah ◽  
Pamela R. Benitez ◽  
...  
Keyword(s):  
Phase I ◽  
Dose Schedule ◽  
Accelerated Partial Breast Irradiation ◽  
Partial Breast Irradiation ◽  
Breast Irradiation

Very accelerated partial breast irradiation Phase I–II multicenter trial (VAPBI): Feasibility and early results

Brachytherapy ◽  
2020 ◽  
Author(s):  
Jose Luis Guinot ◽  
Victor Gonzalez-Perez ◽  
Norbert Meszaros ◽  
Tibor Major ◽  
Dina Najjari-Jamal ◽  
...  
Keyword(s):  
Phase I ◽  
Multicenter Trial ◽  
Accelerated Partial Breast Irradiation ◽  
Partial Breast Irradiation ◽  
Breast Irradiation ◽  
Early Results

scholarly journals A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 10-year results with critical evaluation

2020 ◽  
Vol 61 (4) ◽  
pp. 602-607
Author(s):  
Mariko Kawamura ◽  
Yoshiyuki Itoh ◽  
Takeshi Kamomae ◽  
Masataka Sawaki ◽  
Toyone Kikumori ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Phase I ◽  
Critical Evaluation ◽  
Intraoperative Radiotherapy ◽  
Phase Iii ◽  
Accelerated Partial Breast Irradiation ◽  
Partial Breast Irradiation ◽  
Breast Irradiation

Abstract Although phase III trials have been published comparing whole breast irradiation (WBI) with accelerated partial breast irradiation (APBI) using intraoperative radiotherapy (IORT), long-term follow-up results are lacking. We report the 10-year follow-up results of a prospective phase I/II clinical trial of IORT. The inclusion criteria were as follows: (i) tumor size <2.5 cm, (ii) desire for breast-conserving surgery, (iii) age >50 years, (iv) negative margins after resection and (v) sentinel lymph node-negative disease. A single dose of IORT (19–21 Gy) was delivered to the tumor bed in the operation room just after wide local excision of the primary breast cancer using a 6–12 MeV electron beam. Local recurrence was defined as recurrence or new disease within the treated breast and was evaluated annually using mammography and ultrasonography. A total of 32 patients were eligible for evaluation. The median patient age was 65 years and the median follow-up time was 10 years. Two patients experienced local recurrence just under the nipple, out of the irradiated field, after 8 years of follow-up. Three patients had contralateral breast cancer and one patient experienced bone metastasis after 10 years of follow-up. No patient experienced in-field recurrence nor breast cancer death. Eight patients had hypertrophic scarring at the last follow-up. There were no lung or heart adverse effects. This is the first report of 10-year follow-up results of IORT as APBI. The findings suggest that breast cancer with extended intraductal components should be treated with great caution.

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