scholarly journals COVID-19 clinical implications: the significance of nanomedicine

Bioimpacts ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 137-138
Author(s):  
Jaleh Barar
Keyword(s):  
Quality Of Life ◽  
De Novo ◽  
Virus Entry ◽  
Therapeutic Strategies ◽  
Clinical Implications ◽  
Molecular Signaling ◽  
Key Factor ◽  
To Come

COVID-19 pandemic has profoundly affected the lives of humans worldwide. We no longer experience the same quality of life and need to come up with effective solutions to combat the clinical implications. The vast knowledge about the pathways that regulate the virus entry and molecular signaling of the pathogenesis of coronavirus are the key factor for the development of de novo diagnostic/therapeutic strategies. Meanwhile, the emergence of nanotechnology, could offer enormous help in the battle against coronavirus. In this editorial, the role of molecular elements in the pathobiology of the disease and the significance of nanoscaled pharmaceuticals is highlighted.

scholarly journals The roles and mechanisms of hypoxia in liver fibrosis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingyao Cai ◽  
Min Hu ◽  
Zhiyang Chen ◽  
Zeng Ling
Keyword(s):  
Quality Of Life ◽  
Liver Fibrosis ◽  
Theoretical Basis ◽  
Liver Diseases ◽  
Molecular Mechanisms ◽  
Clinical Intervention ◽  
Chronic Liver Injury ◽  
Key Factor

AbstractLiver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the quality of life of patients, but the current clinical treatments of liver fibrosis have not been developed yet. Recent studies have shown that hypoxia is a key factor promoting the progression of liver fibrosis. Hypoxia can cause liver fibrosis. Liver fibrosis can, in turn, profoundly further deepen the degree of hypoxia. Therefore, exploring the role of hypoxia in liver fibrosis will help to further understand the process of liver fibrosis, and provide the theoretical basis for its diagnosis and treatment, which is of great significance to avoid further deterioration of liver diseases and protect the life and health of patients. This review highlights the recent advances in cellular and molecular mechanisms of hypoxia in developments of liver fibrosis.

Role of quality of life in therapeutic strategies in brain tumors

Health Policy ◽  
1988 ◽  
Vol 10 (3) ◽  
pp. 241-257 ◽  
Author(s):  
Pirjo Koivukangas ◽  
John Koivukangas
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Therapeutic Strategies

scholarly journals The role of nitric oxide in improving endothelial function andcardiovascular health: focus on nebivolol

2011 ◽  
Vol 10 (2) ◽  
pp. 116-121
Author(s):  
G. L. Bakris ◽  
J. N. Basile ◽  
T. D. Giles ◽  
A. A. Taylor
Keyword(s):  
Quality Of Life ◽  
Nitric Oxide ◽  
Antihypertensive Agents ◽  
Clinical Implications ◽  
Cvd Risk ◽  
Patients With Diabetes ◽  
Β Blocker ◽  
Β Blockers

Although β-blockers have been endorsed by guidelines committees for the treatment of patients with hypertension, particularly those with significant CVD and high CVD risk, there are concerns about conventional β-blockers related to poorer clinical outcomes compared with other classes of antihypertensive agents, as well as deleterious effects on quality of life and lipid and carbohydrate metabolism. β-blockers comprise a heterogeneous group of antihypertensive agents, including nonselective agents, cardioselective, nonvasodilating agents, and vasodilating agents that either combine β-nonselectivity with β-blockade or possess cardioselectivity without β-blockade. The pharmacologic, mechanistic, and hemodynamic differences between conventional, nonvasodilating β-blockers and vasodilating β-blockers are discussed in this review, with a focus on the cardioselective vasodilating β-blocker nebivolol. These differences may have important clinical implications, particularly in the treatment of complicated hypertension, such as that associated with patients with diabetes or cardiometabolic syndrome, elderly patients, and African American patients, suggesting that mechanism of action may be an important consideration when choosing a β-blocker.

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