Evaluation of the sensitizing effect of a disinfectant based on glutaraldehyde upon inhalation

2021 ◽  
pp. 19-24
Author(s):  
Galina Pavlovna Pankratova ◽  
◽  
Zukhra Kamilovna Shaikhutdinova ◽  
Tatyana Nikolaevna Potapova ◽  
Marina Vasilevna Bidevkina ◽  
...  
Keyword(s):  
Surface Treatment ◽  
Everyday Life ◽  
Guinea Pigs ◽  
The Body ◽  
Specific Lysis ◽  
Significant Release ◽  
Equipment State ◽  
State Registration ◽  
Sensitizing Effect

When investigating new disinfectants, it is necessary to assess the degree of their danger by modeling the conditions of use. As is known, the main danger of disinfectants, especially volatiles, is posed by the inhalation route of entry into the body, exerting an irritating effect on the respiratory organs, as well as a general toxic and sensitizing effect. Despite reasonable restrictions on the use of disinfectants from the aldehyde class for decontamination of the surfaces of premises and equipment, state registration receives disinfectants based on glutaraldehyde (GA), intended for wide use in various areas, including everyday life, which is unacceptable. Experiments were carried out to confirm the danger of using GA-based disinfectants. Sensitizing effect of GA-based disinfectant under conditions of surface treatment by rubbing method is studied. Significant release of GA into the air after surface treatment (27.7±4.1 mg/m3) was detected. The concentration of GA in the air decreased by 4.5 times after 6 hours of ventilation. The sensitizing effect of the GA-based agent was determined on guinea pigs by a provocative ear swelling test and a leukocyte specific lysis reaction. The results of the study indicate a pronounced sensitizing effect of the agent. Keywords: glutaraldehyde, toxicity, disinfectants, disinfection, sensitization, inhalation, guinea pigs.

Can’t wait to feel better: Facebook Live and the recalibration of downtime in tending to the body

2021 ◽  
pp. 016344372110034
Author(s):  
Dang Nguyen
Keyword(s):  
Everyday Life ◽  
Mobile Technology ◽  
Social Practices ◽  
The Body ◽  
Therapeutic Method ◽  
Temporal Space ◽  
The Everyday ◽  
Temporal Structures

This article explores the temporality of liveness on Facebook Live through the analytical lens of downtime. Downtime is conceptualized here as multiscale: downtime exists in between the micro action and inaction of everyday life, but also in larger episodes of personal and health crises that reorient the body toward technologies for instantaneous replenishment of meaning and activity. Living through downtime with mobile technology enables the experience of oscillation between liveness as simultaneity and liveness as instantaneity. By juxtaposing time-as-algorithmic against time-as-lived through the livestreaming practices of diện chẩn, an emergent unregulated therapeutic method, I show how different enactments of liveness on Facebook Live recalibrate downtime so that the body can reconfigure its being-in-time. The temporal reverberation of downtime and liveness creates an alternative temporal space wherein social practices that are shunned by the temporal structures of institution and society can retune and continue to thrive at the margin of these structures and at the central of the everyday.

Concluding remarks

1956 ◽  
Vol 146 (922) ◽  
pp. 90-92 ◽  
Keyword(s):  
Guinea Pigs ◽  
Current Trend ◽  
Distinct Type ◽  
Single Species ◽  
Immunological Tolerance ◽  
The Body ◽  
Immunological Reaction ◽  
Picryl Chloride ◽  
Purified Antigen ◽  
Circulating Antibody

In many ways immunological tolerance is an ideal subject for discussion at the present time. Experimental work has gone far enough to allow us to claim that the principle of immunological tolerance is soundly established and that we can see more or less clearly some of its implications. But obviously very much remains to be learnt of the part played by tolerance in the various fields that have been discussed. It is by no means certain that we are dealing with a single topic when we compare tolerance to homografts with inhibition of antibody production against soluble protein in a rabbit. Such a situation provides much for discussion but does not make it easy to condense or interpret that discussion. One might begin by reiterating that immunology is concerned with much more than the production and properties of typical circulating antibody. There are at least four different types of immunological reaction and there are hints of many minor differences within the main types. Pappenheimer’s recent work on the variety of responses given by a single species, man, to a single purified antigen, diphtheria toxoid, offers a characteristic example of the current trend. Chase’s experiments on the response of guinea pigs to simple allergens like picryl chloride, have been only incidentally mentioned in today’s discussion, but their importance is obvious. A form of tolerance very similar to that produced by prenatal treatment of mice can be produced by administering the allergen to adult guinea-pigs by mouth. The animals are resistant to sensitization by skin treatment and the inhibition is general and unrelated to any persistence of allergen in the body. The question immediately arises whether all forms of tolerance are basically similar or whether for each of the qualitatively distinct types of positive immunological reaction, a correspondingly distinct type of inhibition or tolerance must be sought.

scholarly journals TOXICOLOGICAL EVALUATION OF INDOMETHACIN AS A RISK FACTOR FOR WORKERS’ HEALTH

2019 ◽  
Vol 98 (5) ◽  
pp. 503-508
Author(s):  
N. A. Martynova ◽  
Larisa G. Gorokhova ◽  
V. A. Shtaiger
Keyword(s):  
Blood Serum ◽  
Guinea Pigs ◽  
Muscle Relaxation ◽  
Lethal Dose ◽  
The Body ◽  
Male Rats ◽  
Hazard Class ◽  
Toxicological Evaluation ◽  
Mucous Membranes ◽  
Ulcerogenic Effect

Introduction. The toxicity of indomethacin was studied for its hygienic regulation. Material and methods. The toxic properties of indomethacin in the experiments on out-bred and linear mice, rats, Guinea pigs and rabbits contained in standard vivarium conditions and quarantined have been studied. In the experiments, various modes (single, repeated, chronic) and ways of exposure (intragastric, inhalation, epicutaneous) were modeled. The average lethal dose (LD50) of Indomethacin and the threshold of a single acute action (Limac) were determined; irritant effect on the skin and mucous membranes, cumulative and allergenic activity were revealed. In subacute and chronic intake to the body, the main target organs were determined on the based of the results of biochemical and hematological studies. Results. DL50 for male rats, females and male mice, when introduced into the stomach, were have been established to be 20, 15 and 25.6 mg/kg respectively. It refers to the substances of hazard class 2. DL50 in the intraperitoneal introduction for the rats accounted for 13.8 mg/kg, for Guinea pigs - 500 mg/kg. The clinical picture of acute poisoning in mice and rats was characterized by low mobility, decreasing breathing, ataxia, muscle relaxation, anorexia, diarrhea, ulceration with the perforation of the intestines, and the death on the 2-4th days after the poisoning. In the experiments on Guinea pigs, the ulcerogenic effect was not detected. Local irritant effect on the skin and mucous membranes of the eyes was not revealed. It has a marked skin-resorptive action causing ulcerogenic effect and the death of the animals after 6 applications. The introduction of verospiron to the rats in a dose of 25 mg/kg simultaneously with the application of indomethacin ointment on the skin prevented the ulcer development in the gastrointestinal tract and the death of the animals. No sensitizing effect was detected. It has an average cumulative ability: the cumulation coefficient amounted to 2.6. In a subacute experiment, there was a decrease in the body temperature and summation-threshold index, an increase in the vertical motor activity and a threshold of pain sensitivity. During the study of blood serum an increase in AcAt activity, a rise of chlorides in the blood serum and their decrease in the urine, and an increase in the number of erythrocytes and hemoglobin in peripheral blood were revealed. In the pathomorphological study, there was an increase in the coefficients of liver mass and ulceration of the stomach and intestines. The threshold of acute inhalation action accounted for 0.52 mg/m3 (by the reduction of the summation-threshold index and the content of sodium and chlorides in the urine). Conclusion. The maximum permissible concentration of indomethacin in the air of the working area was of 0.05 mg/m3 with the mark “special protection of the skin and eyes”, hazard class 1, aerosol.

scholarly journals RESEARCH OF VIBRATION MACHINES DYNAMICS FOR PRODUCT SURFACES PROCESSING BY MATHEMATICAL MODELING

2020 ◽  
pp. 35-43
Author(s):  
Volodymyr Topilnytskyy ◽  
Yaroslav Kusyi ◽  
Dariya Rebot
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Surface Treatment ◽  
Lagrange Equation ◽  
The Body ◽  
Technological Problem ◽  
Surface Processing ◽  
Approximate Methods ◽  
Vibration Machine ◽  
Working Chamber

The article describes the methodology for the study of the dynamics of vibrating machines for surface processing of products by mathematical modeling, which is presented in four main stages. The first stage: analysis of classes of vibrating machines for surface treatment of products, choice of basic for solving the technological problem, project of a unified calculation scheme of the machine. The second stage: development of a nonlinear mathematical model for describing the dynamics of the vibration machine working body and its filling, development of elements of automated calculations of the machine. The third stage: the study of the influence of the parameters of the vibrating machine, product sets and tools (with their various combinations) on the factors of the intensity of products surface processing. The fourth stage: recommendations for choosing vibrating machine parameters and machining bodies that will maximize the processing performance of products with the selected intensity criterion. A mathematical model for describing the motion of a vibrating machine for surface treatment of articles by a set of unrelated bodies of small size is created. It has two unbalance units that generate oscillations of its working body and a spring suspension-mounting of the working chamber (container). The model is parametric and nonlinear, incorporating key dynamic, kinematic and geometric parameters of the vibrating machine in symbolic format. It is constructed by: descriptions of the plane-parallel movement of the mechanical system, the rotational motion of the material point and the body; second-order Lagrange equation; asymptotic (approximate) methods of nonlinear mechanics. With the help of the model it is possible: to describe the oscillatory movement of the working chamber (container) of the vibrating machine; to study the influence of the machine parameters on the efficiency of performance of the set technological task, the conditions of occurrence of non-stationary modes of operation of the vibrating machine and the ways of their regulation.

scholarly journals Reproductive Characteristics, Serum Metabolites, and Oxidative Status in Female Guinea Pigs (Cavia porcellus) Fed with Ethanolic Extract of Dichrostachys glomerata Fruit

2021 ◽  
Vol 11 (1) ◽  
pp. 66-72
Author(s):  
Nadège Motchewo Djuissi ◽  
Ferdinand Ngoula ◽  
Justin Kouamo ◽  
Narcisse Bertin Vemo ◽  
Mathieu Fambo Stive Nono ◽  
...  
Keyword(s):  
Body Weight ◽  
Guinea Pigs ◽  
Ethanolic Extract ◽  
Oxidative Status ◽  
The Body ◽  
Control Group ◽  
Cavia Porcellus ◽  
Crown Rump Length ◽  
Serum Metabolites ◽  
Reproductive Characteristics

Dichrostachys glomerata (D. glomerata) is an aromatic plant which is used as a spice in cooking and Cameroonian traditional medicine to treat infertility in men. This work was designed to highlight the effects of the ethanolic extract of D. glomerata on oxidative status, serum metabolites and reproductive characteristics in female guinea pigs (Cavia porcellus). A total of 48 primiparous female guinea pigs, aged 4 months old with the body weight of 400 ± 10 g, were divided into four groups with two replications per group (6 guinea pigs each). During 90 days of trial, Group 1 (control group) orally received 1 ml/kg b.w. of distilled water daily, and groups 2, 3, and 4 received D. glomerata ethanolic extract once a day at doses of 50, 100, and 200 mg/kg b.w. using the same method of administration, respectively, for 90 days, including 60 days of gestation. After the first 30 days of treatment, mating was done by placing one non-treated male into cages containing six treated females. At the end of the treatment, data were collected on reproductive characteristics, serum metabolites, and oxidative stress markers. The results revealed that the ethanolic extract of D. glomerata induced a significant decrease in the number of post-implantation resorption and ovaries weight. Groups 3 and 4 showed a significant increase in the number of fetuses per dam and viable fetuses as well as placenta weight, compared to the control group. The serum level of progesterone significantly decreased in the group treated with 200 mg/kg D. Glomerata, compared to the other treated groups. The extract at 100 mg/kg body weight showed a significant increase in fetuses weight and fetuses crown-rump length, compared to the control group. Catalase activity significantly increased in the control group than D. glomerata treated groups. In conclusion, ethanolic extract of D. glomerata minimized reproductive stress and subsequently improved the reproductive performance of guinea pigs.

Women’s Bodies and the Evolution of Anti-rape Technologies: From the Hoop Skirt to the Smart Frock

2021 ◽  
Vol 27 (4) ◽  
pp. 30-54
Author(s):  
Caroline Wilson-Barnao ◽  
Alex Bevan ◽  
Robyn Lincoln
Keyword(s):  
Sexual Abuse ◽  
Conceptual Framework ◽  
Everyday Life ◽  
Critical Analysis ◽  
Digital Technologies ◽  
Cultural Construction ◽  
The Body ◽  
Women's Bodies ◽  
Women And Girls ◽  
Online Searches

In this article, we explore smart deterrents and their historical precedents marketed to women and girls for the purpose of preventing harassment, sexual abuse and violence. Rape deterrents, as we define them, encompass customs, architectures, fashions, surveillant infrastructures, apps and devices conceived to manage and protect the body. Online searches reveal an array of technologies, and we engage with their prevention narratives and cultural construction discourses of the gendered body. Our critical analysis places recent rape deterrents in conversation with earlier technologies to untangle the persistent logics. These are articulated with reference to the ways that proto-digital technologies have been imported into the realm of ubiquitous computing and networks. Our conceptual framework offers novel pathways for discussing feminine bodies and their messy navigation of everyday life that include both threats to corporeal safety and collective imaginings of empowerment.

scholarly journals Problem-posing triggers or where do mathematics competition problems come from?

2020 ◽  
Vol 105 (3) ◽  
pp. 389-406 ◽  
Author(s):  
Igor’ Kontorovich
Keyword(s):  
Everyday Life ◽  
Elementary Mathematics ◽  
Mathematical Optimization ◽  
The Body ◽  
Problem Posing ◽  
School Students ◽  
Body Of Knowledge ◽  
Educational Literature ◽  
Life Tasks

AbstractSpurred by Kilpatrick’s (1987) “Where do good problems come from?”, this study explores problem-posing triggers of experienced problem posers for mathematics competitions. Triggers are conceived as instances of noticing, where an impulse draws a poser’s attention and “triggers off” a mathematical re-action, one of the outcomes of which is a creation of a problem that gets accepted to some mathematics competition. The data were collected from 26 problem posers residing in nine countries, and who had experience in creating problems for national, regional, and international competitions. Three types of triggers emerged from the analysis: (i) Instances where the participants extracted mathematical phenomena from activities that are replete with modern elementary mathematics. These triggers were described in emotionally loaded terms that resonated with appreciation, surprise, challenge, and feeling of innovation. (ii) Cases where the participants abstracted mathematical phenomena from common everyday-life tasks in which mathematical optimization was beneficial. These situations emphasized participants’ desire to compensate for self-disappointment with an initially made decision and the value of finding a better alternative. (iii) Situations where the participants were asked to pose a problem ‘here and now’. The posers were unanimous in their dislike of such situations. They elaborated on how difficult it is to pose ‘here and now’ and highlighted the low quality of the resulting problems. The findings are situated in the body of knowledge on expert problem posing and educational literature on school students and teachers.

Genes and organs

Vital Bodies ◽  
2018 ◽  
pp. 45-56
Author(s):  
Charlotte Bates
Keyword(s):  
Everyday Life ◽  
Emergency Services ◽  
The Body ◽  
Warning Signals ◽  
Daily Lives ◽  
Asthma Attack

The fourth chapter, Genes and organs examines how the interiors of our bodies structure and influence our exterior surfaces and identities and shape our daily lives, and how the inner workings of our bodies, the circulations of blood and the flows of air, affect and betray us. This chapter traces the transmission of conditions from their interior origins within the body to the outside world of everyday life and considers how the inner landscapes of the body are both visible and significant. Ami has asthma. She has learnt the warning signals of an asthma attack, from the wheezing sound originating from her chest, to the tight feeling in her shoulders, and the sudden pain in her teeth. She knows when to take her inhaler, and she also knows when to reach for the phone and call the emergency services. In moments like these, illness is transported from the safe and invisible interior of the body to the outside world.

Sign in / Sign up

Export Citation Format

Share Document