scholarly journals Features of the inflammatory process of the nasal mucous membrane and paranasal sinuses in patients with chronic rhinosinusitis with nasal polyps

2021 ◽  
Vol 6 (3) ◽  
pp. 13-16
Author(s):  
Rimma M. Pestova ◽  
Elena E. Saveleva ◽  
Liliya F. Aznabaeva
Keyword(s):  
Nasal Cavity ◽  
Mucous Membrane ◽  
Peroxidase Activity ◽  
Paranasal Sinuses ◽  
High Intensity ◽  
Nasal Polyps ◽  
Inflammatory Process ◽  
Nasal Mucous Membrane ◽  
Extracellular Peroxidase ◽  
Maxillary Sinuses

Objectives to assess the features of the inflammatory process of the nasal mucous membrane and sinuses in patients with сhronic rhinosinusitis with nasal polyps (CRSwNP). Material and methods. We analyzed the results of examination of 44 patients with CRSwNP. The objects of investigation were smears-reprints from the mucous membrane of the middle turbinate (rhinocytograms) and the intensity of the extracellular peroxidase activity of the lavage fluids of the maxillary sinuses. The data obtained were processed using the Statistica 8.0 software. Results. When analyzing rhinocytograms of the mucous membrane of the middle turbinates, the epithelial type of rhinocytogram was most often detected in 65.9% of cases (epithelial cells more than 50%); the eosinophilic type in 22.7% (eosinophils more than 1%) and smears with mast cells in 4.6% of cases; the neutrophilic type was less frequent (neutrophils more than 50%) 6.8% of cases. In 34.1% of patients, the cells of the columnar epithelium had pronounced changes in the cytoplasm (vacuolization and enzymatic activity); and in 38.6% of cases the gross pathology was recorded directly in the nucleus of the cells (nucleoli, granules, destruction of the nucleus). The revealed pathology of the cell nucleus suggests the viral etiology of the development of productive inflammation in the nasal cavity and sinuses In the lavage fluids of the maxillary sinuses, a high intensity of extracellular peroxidase activity was recorded (1777.9132.4 a.u. compared to 1225.0190.9 a.u. in patients with chronic purulent rhinosinusitis and 1245.0362.3 a.u. in patients with purulent-polypous rhinosinusitis). Conclusion. Chronic rhinosinusitis with nasal polyps is accompanied by a pronounced inflammatory process of the nasal mucous membrane and paranasal sinuses in the form of structural and functional changes in the cells of the columnar epithelium and a high intensity of extracellular peroxidase activity. The epithelial nucleus damage (the presence of nucleoli, granules, destruction of the nucleus) suggests a viral nature with the development of productive inflammation in the nasal cavity and sinuses.

scholarly journals COMPARISON OF THE STATE OF THE MAXILLARY SINUSES IN A NEW CORONAVIRUS INFECTION COVID-19 AND ACUTE RESPIRATORY VIRAL INFECTION

2021 ◽  
Vol 14 (5) ◽  
pp. 28-33
Author(s):  
ALEXANDER V. KOLSANOV ◽  
◽  
TATYANA JU. VLADIMIROVA ◽  
PAVEL V. ZELTER ◽  
OLESYA V. ZELYOVA ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Paranasal Sinuses ◽  
Chronic Sinusitis ◽  
Respiratory Infections ◽  
Control Group ◽  
Acute Respiratory Infections ◽  
Lower Wall ◽  
Study Results ◽  
Coronavirus Infection ◽  
Maxillary Sinuses

The aim of the study was to identify possible changes in the maxillary sinuses during new coronavirus infection in comparison with the changes in the sinuses occurring during acute respiratory infections and to correlate the gender structure of the study groups. Material and methods. The study included 40 patients (18 women and 22 men) with a confirmed new coronavirus infection, hospitalized at the Covid Hospital Clinics of Samara State Medical University in 2020. All patients underwent multispiral computed tomography of the paranasal sinuses on a Ge revolution Evo 128 tomograph on the 10th day after the appearance of the first clinical symptoms. We also examined a control group of patients with acute respiratory infections with similar complaints of impaired sense of smell, rhinorrhea, and upper maxillary sinus discomfort. This group also included 40 people (24 women and 16 men). Statistical processing of the study results was performed using Microsoft Excel software package, the Mann – Whitney method of statistical significance calculation was used. Results and discussions. In 18 (45%) patients with a confirmed new coronavirus infection, a slight mucosal thickening along the lower wall of the maxillary sinuses was found symmetrically on both sides. Six (15%) of them were women and 12 (30%) were men. The age of the examined patients ranged from 31 to 83 years. Chronic sinusitis was noted in the history of 8 (20%) of the examined patients. In 6 (15%) patients with chronic sinusitis no abnormalities were detected in the maxillary sinuses at the time of examination. Two of them had parietal thickening of the mucous membrane along the lower wall of the maxillary sinuses. In the control group, there was significant symmetric parietal thickening of the mucous membrane of the paranasal sinuses in 24 (60%) examined patients (14 women and 10 men). There were no statistically significant differences in the prevalence of changes in the studied and control groups. Conclusion. According to the results of this study, there were no data on the pattern of occurrence of changes in the mucosa of the maxillary sinuses in new coronavirus infection with gender background or the presence of chronic inflammation of the maxillary sinuses in the history compared with the control group of examined patients after acute respiratory infections.

scholarly journals Morphofunctional State of the Maxillary Sinus Mucosa in Patients After Endoscopic Infundibulotomy

2021 ◽  
Vol 1 (3) ◽  
pp. 6-10
Author(s):  
Djuraev Jamolbek Abdukakharovich ◽  
◽  
Makhsitaliev Mukhammadbobur Ibrokhimovich, Ibrokhimovich ◽  
Keyword(s):  
Nasal Cavity ◽  
Maxillary Sinus ◽  
Chronic Rhinosinusitis ◽  
Mucous Membrane ◽  
Paranasal Sinuses ◽  
Pathological Process ◽  
Fundamental Factor ◽  
Sinus Mucosa ◽  
Morphological State

The work carried out made it possible to substantiate the need to apply a method for studying the frequency of beating of cilia of the mucous membrane of the nasal cavity and paranasal sinuses in patients with chronic rhinosinusitis when choosing treatment tactics in an ENT hospital. Analysis of the study of data on the functional and morphological state of the mucous membrane of the nasal cavity and maxillary sinus allows us to judge the severity of the pathological process before surgery, which is the fundamental factor in the algorithm for the treatment of chronic rhinosinusitis.

scholarly journals 5-HT7 receptorsare over-expressed in patients with nasal polyps

2017 ◽  
Vol 96 (12) ◽  
pp. E14-E18 ◽  
Author(s):  
Muhammed Yayla ◽  
Zekai Halici ◽  
Duygu Kose ◽  
Arzu Tatar ◽  
Mustafa SitkiGozeler
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Paranasal Sinuses ◽  
Nasal Polyps ◽  
Inferior Turbinate ◽  
Healthy Tissue ◽  
Receptor Expression ◽  
Pcr Analysis ◽  
And Control ◽  
First Time

Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT7 receptors in patients with NP and in inferior turbinate tissue (control).The study included 60 participants (40 with NP and 20 controls) aged 35 to 62 years. Nasal polyp samples were collected from all patients and relative 5-HT7 receptor expression analyses were performed. RT-PCR analysis of nasal polyps and control tissue identified 5-HT7 receptor expression in the nasal cavities of controls. This expression was approximately 67 times higher in nasal polyp tissue than in healthy tissue. Our study identifies the expression of 5-HT7 receptors in the nasal cavity for the first time. It is also the first demonstration of increased 5-HT7 receptor expression in tissue from nasal polyps, which occur in the paranasal sinuses and nasal cavity.

scholarly journals Structural reconstruction of the nasal mucosa and paranasal sinuses in patients with polypous rhinosinusitis according to cytological and histological studies

2021 ◽  
Vol 5 (7) ◽  
pp. 479-485
Author(s):  
N.M. Zakharova ◽  
◽  
I.P. Shabalova ◽  
V.I. Egorov ◽  
E.Yu. Savushkina ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Mucous Membrane ◽  
Nasal Mucosa ◽  
Paranasal Sinuses ◽  
Pathological Process ◽  
Respiratory Epithelium ◽  
Epithelial Proliferation ◽  
Optical Level ◽  
Cut Surface ◽  
Morphological Patterns

Aim: to study the morphological patterns of polypous tissue according to cytology and histology. Pateints and methods: 78 patients with a confirmed diagnosis of polypoid rhinosinusitis (PRS) were selected for the study, including 50 men and 28 women aged 25 to 74 years. The material for cytology was scraped from the surface of nasal cavity and paranasal sinus (PNS) polyps, as well as touch smears from the cut surface of removed polyps, and the material for histology was pieces of removed polypous tissue. Results: in the course of the study, the following comparative analysis of the obtained results was made: a) with polyps with a fibrous component in touch smears, there are expressed signs of chronic inflammation along with signs of respiratory epithelial cells proliferation; b) edematous and myxoid polyps are commonly combined with an allergic condition; c) analysis of cytomorphological signs of the respiratory epithelium of the nasal cavity and PNS in PRS indicates a structural alteration of the mucous membrane in this disease. The epithelial proliferation is associated with the activation of stroma components — fibroblasts and leukocytes. At the light-optical level, the characteristics of compensatory and adaptive changes that contribute to the morphofunctional cell unity preservation of the mucous membrane that counteract the pathological process are revealed. Conclusions: according to the method of sampling material for cytology, the most informative are touch smears from the cut surface of the removed polyp, which help to identify more morphological patterns of the polypous tissue. The analysis of cytomorphological features of the respiratory epithelium of the nasal cavity and PNS in PRS indicates the remodeling of the mucous membrane in this disease. The epithelial proliferation is associated with the activation of stroma components — fibroblasts and leukocytes. At the light-optical level, the characteristics of compensatory and adaptive changes that contribute to the morphofunctional cell unity preservation of the mucous membrane that counteract the pathological process are revealed. The obtained results will help to understand the mechanisms of structural and functional alteration in the nasal mucosa and PNS in PRS. KEYWORDS: polypoid rhinosinusitis, cytology, histology, paranasal sinuses, smears, fibroblasts, eosinophils, leukocytes, respiratory epithelium. FOR CITATION: Zakharova N.M., Shabalova I.P., Egorov V.I. et al. Structural reconstruction of the nasal mucosa and paranasal sinuses in patients with polypous rhinosinusitis according to cytological and histological studies. Russian Medical Inquiry. 2021;5(7): 479–485 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-479-485.

scholarly journals Giant Primary Schwannoma of the Left Nasal Cavity and Ethmoid Sinus

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Eugene Wong ◽  
Justin Kong ◽  
Lawrence Oh ◽  
Daniel Cox ◽  
Martin Forer
Keyword(s):  
Nasal Cavity ◽  
Nasal Obstruction ◽  
Squamous Cell ◽  
Paranasal Sinuses ◽  
Ethmoid Sinus ◽  
Squamous Cell Carcinomas ◽  
Left Nasal Cavity ◽  
History Of ◽  
Maxillary Sinuses

A unilateral tumour in the nasal cavity or paranasal sinuses is commonly caused by polyps, cysts, and mucoceles, as well as invasive tumours such as papillomas and squamous cell carcinomas. Schwannomas, in contrast, are rare lesions in this area (Minhas et al., 2013). We present a case of a 52-year-old female who presented with a 4-year progressive history of mucous hypersecretion, nasal obstruction, pain, and fullness. Imaging of the paranasal sinuses showed complete opacification of the entire left nasal cavity and sinuses by a tumour causing subsequent obstruction of the frontal and maxillary sinuses. The tumour was completely excised endoscopically. Histopathology was consistent with that of a schwannoma.

scholarly journals Morphofunctional State of the Maxillary Sinus Mucosa in Patients After Endoscopic Infundibulotomy

2021 ◽  
pp. 6-10
Author(s):  
Djuraev Jamolbek Abdukakharovich ◽  
◽  
Makhsitaliev Mukhammadbobur Ibrokhimovich ◽  
Keyword(s):  
Nasal Cavity ◽  
Maxillary Sinus ◽  
Chronic Rhinosinusitis ◽  
Mucous Membrane ◽  
Paranasal Sinuses ◽  
Pathological Process ◽  
Fundamental Factor ◽  
Sinus Mucosa ◽  
Morphological State

The work carried out made it possible to substantiate the need to apply a method for studying the frequency of beating of cilia of the mucous membrane of the nasal cavity and paranasal sinuses in patients with chronic rhinosinusitis when choosing treatment tactics in an ENT hospital. Analysis of the study of data on the functional and morphological state of the mucous membrane of the nasal cavity and maxillary sinus allows us to judge the severity of the pathological process before surgery, which is the fundamental factor in the algorithm for the treatment of chronic rhinosinusitis.

The Nucleus in the Spores of Rhinosporangium seeberi

1972 ◽  
Vol 30 ◽  
pp. 216-217
Author(s):  
R. K. Mishra ◽  
K. Anand ◽  
S. K. Kacker ◽  
Wm. H. Falor
Keyword(s):  
Nucleic Acid ◽  
Mucous Membrane ◽  
Nasal Polyps ◽  
Amorphous Material ◽  
Taxonomic Position ◽  
Acid Complex ◽  
Nasal Mucous Membrane ◽  
Microscopic Studies ◽  
Membrane Bound ◽  
The Tropics

Rhinosporidiosis is a disease occurring usually in the tropics and is characterized by the production of nasal polyps supposedly caused by a fungus, Rhinosporangium seeberi, which was claimed after light microscopic studies to proliferate by “amitotic” division of the nucleus. The organism was studied electron microscopically and the spores were found to be bound by a non-collagenous wall enclosing a variety of vesicles, some containing smooth amorphous material, others coiled threads, and still others dark granules. Typically mitochondria, endoplasmic tubules, Golgi, and a membrane-bound nucleus were not seen although a few rudimentary membrane-bound spaces are present. These features as well as failure to culture the organism cast doubts about its taxonomic position, and it seemed the organism was essentially some nucleic acid complex organizing mucopolysaccharides in subepithelial zones in the nasal mucous membrane.

scholarly journals Data Set for the Reporting of Carcinomas of the Nasal Cavity and Paranasal Sinuses: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting

2018 ◽  
Vol 143 (4) ◽  
pp. 424-431 ◽  
Author(s):  
Alessandro Franchi ◽  
Justin A. Bishop ◽  
Hedley Coleman ◽  
Uta Flucke ◽  
Lisa F. Licitra ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
International Collaboration ◽  
Data Set ◽  
Close Proximity ◽  
Standardized Reporting ◽  
Collaborative Efforts ◽  
Anatomic Region ◽  
Maxillary Sinuses ◽  
Cancer Reporting

The International Collaboration on Cancer Reporting was established to internationally unify and standardize the pathologic reporting of cancers based on collected evidence, as well as to allow systematic multi-institutional intercountry data collection to guide cancer care in the future. This data set has been developed by the collaborative efforts of an international multidisciplinary panel of experts involved in the care of patients with carcinomas of the nasal cavity and paranasal sinuses (sinonasal tract). The nasal cavity and paranasal sinuses (including frontal, sphenoid, ethmoid, and maxillary sinuses) comprise a very complex anatomic area of the head and neck, affected by a sometimes bewildering array of neoplasms. Management of malignancies in this anatomic region involves complex surgery because of the anatomic confines and close proximity to many vital structures. Given a multidisciplinary approach, the standardized reporting of the carcinomas that develop in this anatomic region include both required (core) and recommended (noncore) elements in pathology reporting in order to be able to identify critical prognostic factors, often requiring clinical and radiologic correlation. A summary of the International Collaboration on Cancer Reporting guidelines and clinically relevant elements, along with additional explanatory notes, are provided, based on evidentiary support from the literature, set in the context of practical application.

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