Evaluation of contrast enhancement ultrasound images of Sonazoid microbubbles in tissue-mimicking phantom obtained by optimal Golay pulse compression

Author(s):  
Shinnosuke Hirata ◽  
Yuki Hagihara ◽  
Kenji YOSHIDA ◽  
Tadashi YAMAGUCHI ◽  
Matthieu E. G. Toulemonde ◽  
...  

Abstract In contrast enhancement ultrasound (CEUS), the vasculature image can be formed from nonlinear echoes arising from microbubbles in a blood flow. The use of binary-coded pulse compression is promising for improving the contrast of CEUS images by suppressing background noise. However, the amplitudes of nonlinear echoes can be reduced, and sidelobes by nonlinear echoes can occur depending on the binary code. Optimal Golay codes with slight nonlinear-echo reduction and nonlinear sidelobe have been proposed. In this study, CEUS images obtained by optimal Golay pulse compression are evaluated through experiments using Sonazoid microbubbles flowing in a tissue-mimicking phantom.

2020 ◽  
Vol 100 (6) ◽  
pp. 363-371
Author(s):  
T. N. Trofimova ◽  
M. B. Sukhova

Objective – to assess the informativeness of multisclice computed tomography (MSCT) angiopulmonography in the assessment of peripheral blood flow and to determine the prognostic role of angiographic massiveness and volume of preserved peripheral blood flow as predictors of success of emergency surgical treatment of acute massive pulmonary embolism (PE). Material and methods. The article presents the results of 7-year work for the period from March 2012 to September 2019, which included a pilot retrospective stage (analysis of the results of 264 MSCT procedures with contrast enhancement for acute PE in patients aged 32 to 69 years for the period 2012–2013) and prognostic practical work (the second stage, analysis of the results of 974 MSCT procedures with contrast enhancement in patients aged 25 to 78 years for the period 2013–2019).Results. The obtained results and statistical dependences proved the influence of the saved volume of peripheral arterial pulmonary blood flow on the outcome of surgical treatment. The use of this indicator as an MSCT predictor reduced the hospital mortality rate from 7.2% to 3.5%. The analysis of the influence of the initial angiographic massiveness of PE on the outcome of surgical treatment has not been confirmed.Conclusion. According to the results of the study, we recommend the inclusion of segmental arterial pulmonary blood flow analysis by MSCT with contrast enhancement in the algorithm of preoperative examination of patients with acute massive pulmonary embolism in case of emergency surgical treatment. 


2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Xia Gao ◽  
Qiuying Li ◽  
Yanwen Qu ◽  
Jinzhi Zhang ◽  
Yougang Xing ◽  
...  

Objective. To study the clinical efficacy of integrated traditional Chinese medicine (TCM) and Western medicine (WM) in treating endometrial cancer and the influence on ultrasound, magnetic resonance imaging (MRI), tumor markers, human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125). Method. A total of 152 cases of patients with endometrial carcinoma were randomly divided into two groups: the TCM + WM group and the WM group. The WM group was treated with megestrol acetate tablets, and the TCM + WM group was treated with Radix Astragali injection on the basis of the control group. The levels of inflammatory factors, HE4 and CA125 in serum, were detected using enzyme-linked immunosorbent assay (ELISA) or radioimmunoassay. The characteristics of ultrasound images and MRI images were observed and recorded. Toxicity, side effects, and the 3-year cumulative survival rate after treatment were assessed. Results. After treatment, the levels of interleukin-4 (IL-4), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) in both groups decreased, and the decrease in the TCM + WM group was more obvious than that in the WM group. There were statistically significant differences between the two groups in lesion shape, boundary, blood flow signal, lesion diameter, resistance index (RI), echo, intima thickness, and muscle layer infiltration from transvaginal ultrasound images after treatment. The diameter, echo, boundary, shape, composition, and enhancement degree of lesions between the two groups have a significant difference. Moreover, the levels of serum HE4 and CA125 in both groups decreased after treatment, and the decrease in the TCM + WM group was more obvious than that in the WM group. There were statistically significant differences between the two groups in the occurrence of myelosuppression, abnormal liver function, decreased platelet number, gastrointestinal reactions, leukopenia, and cardiotoxicity. After three years of follow-up, the cumulative survival rate of the TCM + WM group was 76.32%, and the cumulative survival rate of the WM group was 57.89%. Conclusion. Radix Astragali injection combined with megestrol acetate tablets has obvious therapeutic effects against endometrial cancer. Through vaginal ultrasonography and MRI, it can significantly improve the size, shape, and blood flow signals of patients’ lesions, reduce the level of serum inflammatory factors and tumor markers HE4 and CA125, reduce the incidence of toxic and side reactions, improve the patient’s immunity, improve the patient’s condition significantly, and prolong the survival time of patients.


2019 ◽  
Vol 28 (10) ◽  
pp. 1950176 ◽  
Author(s):  
P. Sreelatha ◽  
M. Ezhilarasi

Informative images endure from poor contrast and noise during image acquisition. Significant information retrieval necessitates image contrast enhancement and removal of noise as a prerequisite before any further processing can be done. Dominant applications with low contrast images affected by speckle noise are medical ultrasound images. The objective of this work is to improve the effectiveness of the preprocessing stage in medical ultrasound images by enhancing the image while retaining its structural characteristics. For image enhancement, this work proposes to develop an automatic contrast enhancement technique using cumulative histogram equalization and gamma correction based on the image. For noise removal, this work proposes an algorithm Gamma Correction with Exponentially Adaptive Threshold (GCEAT) which suggests the use of GC for contrast enhancement along with a new wavelet-based adaptive soft thresholding technique for noise removal. The proposed GCEAT-based image de-noising is validated with other enhancement and noise removal techniques. Experimental results with low contrast synthetic and actual ultrasound images show that the suggested proposed system performs better than existing contrast enhancement techniques. Encouraging results were obtained with medical ultrasound images in terms of Peak-Signal to Noise Ratio (PSNR), Mean Square Error (MSE), Structural Similarity Index Measure (SSIM) and Average Intensity (AI).


2020 ◽  
Vol 29 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Kelly A. Brock ◽  
Lindsey E. Eberman ◽  
Richard H. Laird ◽  
David J. Elmer ◽  
Kenneth E. Games

Context: Several interventions are available to reduce the intensity and duration of the unwanted effects (eg, muscle soreness) associated with physical activity, such as massage, compression garments, and sequential pulse compression (SPC). Such interventions aim to increase blood flow to alleviate symptoms. However, there is a lack of evidence to support the use of SPC to alter total hemoglobin concentration (THb) in active individuals. Objective: To examine the acute effects of a single session of SPC on hemoglobin concentration compared with a control condition. Design: Single cohort, crossover design. Participants: Thirty-four physically active and healthy participants (females = 12 and males = 22) completed the study. Interventions: The authors randomly assigned participants to first receive the experimental (SPC) or control condition. Measures were recorded precondition and postcondition. Participants returned to the laboratory to complete the second condition ≥24 hours after the first condition. Main Outcome Measures: Relative changes in THb, deoxygenated hemoglobin, and oxygenated hemoglobin measures were recorded using near-infrared spectroscopy placed on the muscle belly of the medial gastrocnemius of the dominant limb. Results: SPC significantly increased THb (P < .001, d = 0.505) and oxygenated hemoglobin (P < .001, d = 0.745) change scores compared with the control condition. No statistical difference in deoxygenated hemoglobin change scores was found between the SPC and control conditions, but a medium effect size suggests potential biological significance (P = .06, d = 0.339). Conclusions: Overall, SPC increases THb to the lower-extremity and may be a viable option in the management of muscle soreness related to physical activity.


2015 ◽  
Vol 41 (7) ◽  
pp. 1876-1883 ◽  
Author(s):  
Wing Keung Cheung ◽  
Dorothy M. Gujral ◽  
Benoy N. Shah ◽  
Navtej S. Chahal ◽  
Sanjeev Bhattacharyya ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Xing-xin Liang ◽  
Fan Li ◽  
Feng Gao ◽  
Chun-xiao Li ◽  
Xiao-hui Qiao ◽  
...  

This study was to explore the significance of ultrasound in determining whether the patients with secondary hyperparathyroidism (SHPT) are sensitive to calcitriol treatment. According to the decrease value of parathyroid hormone (PTH), 42 SHPT patients were divided into two groups: drug susceptible group and drug insusceptible group. These 42 SHPT patients’ ultrasound images were retrospectively analyzed. The morphology, size, number, blood flow, elastic modulus, and perfusion of the parathyroid glands were correlated with drug therapeutic outcome (oral calcitriol). Most SHPT patients with drug susceptible showed volume <438.50 mm3and number ≤2, with 0-1 structural and vascular patterns, associated with Relative Maximum Intensity (RIMAX) <1.59 and elastic modulus <18.8 kPa, whereas most SHPT patients with drug insusceptible showed volume ≥438.50 mm3and number ≥3, with 2-3 structural and vascular patterns, associated with Relative Maximum Intensity (RIMAX) ≥1.59 and elastic modulus ≥18.8 kPa. Therefore, ultrasonography in SHPT allows an accurate definition of the morphology, size, number, blood flow, elastic modulus, and perfusion of the parathyroid glands and is useful in determining whether SHPT patients are sensitive to calcitriol treatment.


2000 ◽  
Author(s):  
Guofang Xiao ◽  
J. Michael Brady ◽  
Alison J. Noble ◽  
Yongyue Zhang

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