scholarly journals COMPARISON OF TREMOR RELATED ADVERSE DRUG REACTION BETWEEN INTRAVENOUS AMINOPHYLLINE AND NEBULIZED SALBUTAMOL FOR ASTHMA EXACERBATION TREATMENT

2021 ◽  
Vol 4 (1) ◽  
pp. 33-43
Author(s):  
Amelia Lorensia ◽  
◽  
Nur Annisa Yuliana
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Incidence Rate ◽  
Chronic Respiratory Disease ◽  
Department Of Health ◽  
Asthma Exacerbations ◽  
Nebulized Salbutamol ◽  
Asthma Drug ◽  
Quasi Experimental ◽  
The Difference

The Department of Health estimates that asthma including 10 major causes of morbidity and mortality in the hospital. Asthma is a chronic respiratory disease that is becoming a serious health problem in many countries around the world. Drugs used in the treatment of asthma exacerbations is salbutamol and aminophylline. Drugs such as salbutamol and aminophylline can cause ADR (Adverse Drug Reaction) in the form of tremor with a sign involuntary shaking part of the hand. This research was conducted at the RSAL Dr. Oepomo to sample Aminofilin and in hospitals Seowandi to sample Salbutamol. The method used was quasi experimental. This study was conducted to compare the incidence of tremor in both asthma drug that is often used for the treatment of asthma such as Salbutamol and Aminofilin. The results of this study indicate there are differences in the incidence rate of ADR-related tremor between salbutamol and Aminofilin. Knowing the difference in incidence rate of tremor between aminophylline and salbutamol can assist in the selection of treatment which safer to avoid the effects of tremors that can occur from the use of of drugs asthma exacerbations.

scholarly journals Creatinine Trends to Detect Ibuprofen-Related Maturational Adverse Drug Events in Neonatal Life: A Simulation Study for the ELBW Newborn

2021 ◽  
Vol 11 ◽  
Author(s):  
Tamara van Donge ◽  
Karel Allegaert ◽  
Marc Pfister ◽  
Anne Smits ◽  
John van den Anker
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Serum Creatinine ◽  
Adverse Drug Events ◽  
High Variability ◽  
Extremely Low Birth Weight ◽  
Neonatal Life ◽  
Elbw Neonates ◽  
The Difference ◽  
The Impact

Background: Recognizing a change in serum creatinine concentrations is useful to detect a renal adverse drug reaction signal. Assessing and characterizing the nephrotoxic side-effects of drugs in extremely low birth weight (ELBW, ≤1000 g) neonates remain challenging due to the high variability in creatinine in this population. This study aims to investigate and quantify the impact of ibuprofen treatment on kidney function, reflected by serum creatinine.Method: A recently developed dynamical model for serum creatinine was used to simulate creatinine profiles for typical, reference ELBW neonates with varying gestational and postnatal ages whilst being exposed to ibuprofen treatment.Results: The increase of serum creatinine concentrations due to ibuprofen treatment is most apparent during the first week of life. The difference in serum creatinine values between ibuprofen-exposed vs. non-exposed neonates decreases with increasing postnatal age, independent of gestational age.Conclusion: The difference in serum creatinine concentrations between ibuprofen-exposed vs. non-exposed neonates decreases with postnatal age, indicating an increased clearing capacity and resulting in a weak ibuprofen-related adverse drug reaction signal beyond early neonatal life.

Distribution of the bulletin to young doctors and final-year students

1975 ◽  
Vol 13 (21) ◽  
pp. 84-84
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Medical Students ◽  
England And Wales ◽  
Department Of Health

Consumers’ Association and the Department of Health have jointly arranged for the Bulletin and the Adverse Drug Reaction Bulletin to be sent free to young doctors and senior medical students in England and Wales. The scheme is for an experimental two-year period and will include all doctors registered since 1 September 1971, those in their pre-registration year, and final-year medical students. We warmly welcome our new readers and look forward to having their suggestions and comments.

scholarly journals Differences of Respiratory Rate Between Salbutamol and Aminofilin in Exacerbation Asthma

2020 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Amelia Lorensia ◽  
Zullies Ikawati ◽  
Tri Murti Andayani ◽  
Daniel Maranatha
Keyword(s):  
Data Collection ◽  
Respiratory Rate ◽  
Experimental Method ◽  
Asthma Exacerbation ◽  
T Test ◽  
Purposive Sampling ◽  
Breath Rate ◽  
Asthma Exacerbations ◽  
Quasi Experimental ◽  
The Difference

Exacerbation of asthma is a progressive step in progressive breathing, coughing, wheezing, breathing. In Indonesia salbutamol nebulation is used for the therapy of the first exacerbation attack. In addition, intravenous aminophylline is also recommended as a therapy, even if the use of aminophylline abroad is reduced due to its smaller effectiveness and often leads to greater unwanted reaction events. The effectiveness of asthma exacerbation therapy needs to be monitored and one of the monitoring parameters that is easily seen is the rate of breath.The aim of this study was to investigate the difference in respiratory rate values using salbutamol nebulisation and intravenous aminophylline in patients with asthma exacerbations in hospitals in Surabaya. The research was conducted by using quasi experimental method and data collection by purposive sampling. Analysis of the data to be used is a independent t-test. The results showed that the salbutamol group decreased respiratory rate by 50.00%, there were also patients who experienced an increase of breath rate of 13.64%. In the aminophylline group experienced a decrease in respiratory rate of 43.75% with an increase of breath rate of 18.75%. From the results of the study, it is necessary to monitor the effectiveness and the need to monitor the unwanted reactions of both treatments so that the therapies produced in the treatment of asthma exacerbations are more effective.Key words: Aminophylline, exacerbation asthma, respiratory rate, salbutamol 

scholarly journals Role of Diabetes Mellitus on Adverse Drug Reaction to Anti-tuberculosis Drugs

2020 ◽  
pp. 34-39
Author(s):  
Daud M. Ishaq Aweis ◽  
Syed Azhar Syed Suleiman
Keyword(s):  
Diabetes Mellitus ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Teaching Hospitals ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
The Difference

Introduction: Tuberculosis (TB) is one of the leading cause of death among infectious diseases. The dual burden of TB and diabetes mellitus (DM) is a major economic and health concern. Anti-TB therapy may predispose patients to develop adverse drug reaction (ADR). The effect of DM on anti-TB ADR requires more studies. Methods: We performed a cross-sectional study and followed patients for at least two  years. Patients were selected from three Malaysian teaching hospitals. TB patients, and diabetic patients with TB were divided into two groups of 200 subjects each. Data were obtained from patients’ medical files at the beginning and end of the study  period. Prevalence of serious adverse drug reaction (ADR) requiring dose adjustment was assessed. Results: ADR in our subjects was documented in the medical records and confirmed by a system known as Challenge. The prevalence rates of ADR amongst DM-TB and TB only patients were 16.5% and 14.8%, respectively, but the difference was not significant (Fisher E.T: P > 0.05). ADR was more frequent with streptomycin treatment, partially because of its painful administration. Isoniazid treatment showed the least frequency of ADR. Conclusion: Although the frequency of ADR was high among DM-TB patients, it was not significantly different to that among TB only patients.

Difficulties in the detection of the culprit drug for an adverse drug reaction in a complicated case

2008 ◽  
Vol 149 (19) ◽  
pp. 883-887 ◽  
Author(s):  
Henriette Kopcsányi ◽  
Julianna Feldmann ◽  
Zsófia Péch ◽  
Ágnes Jurcsik
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Complicated Case ◽  
Erythema Exsudativum Multiforme ◽  
Culprit Drug

Az adverz gyógyszerreakciók különféle klinikai megjelenési formái alapján a kiváltó gyógyszerre nehéz következtetni. A gyanúba vett gyógyszerek elhagyása után fellépő javulás vagy az empirikus tapasztalat, esetleg irodalmi adatok alapján lehet a felelős gyógyszert feltételezni. A gyógyszerérzékenység bizonyítása bonyolult, jól átgondolt orvosi tevékenység útján lehetséges, és azokban az esetekben szükséges, amikor a gyanús gyógyszer más vegyületcsoportba tartozó szerrel nem helyettesíthető, és a betegnek feltétlenül szükséges szednie. A jelen közlemény célja egy eset kapcsán körvonalazni azokat a lehetőségeket és veszélyeket, melyek a kivizsgálás során alkalmazhatók, illetve megjelenhetnek. A kivizsgálás során használt módszerek a gyanúba vett gyógyszerekkel – lamotrigin, risperidon, sertralin – zopiclonum, atorvastatin elvégzett epicutan teszt során egyedül a sertralin adott a multiform tünetekkel azonos pozitív reakciót. A pozitív bőrteszt területéről készült hisztológiai vizsgálat eredménye visszautalt az eredetileg észlelt klinikai formára (erythema exsudativum multiforme Stevens–Johnson-szindróma). A beteg bipoláris affektív zavara miatt a negatív bőrtesztet adó készítményekkel per os provokáció történt, ez azonban a beteg számára kockázatos, de az egyetlen megbízható és biztos módszer. Az elvégzett per os expozíció során a törzsön a lamotrigintől már tört adag bevételét követően három órán belül diffúz erythema, 12 órán belül az alkalmazott szteroid- és antihisztamin-kezelés ellenére scarlatiniform exanthema jelent meg. Az eset érdekessége, hogy a gyanúba vett gyógyszerek során epicutan teszttel egy gyógyszer érzékenysége igazolódott, azonban a másik gyanúba vett készítménnyel végzett pozitív per os expozíciós próba is váratlanul tünetet provokált (scarlatiniform, azonnali reakciót). Megállapítható, hogy csupán egy bizonyos módszer még a klinikai képpel való egyező eredmény alapján sem elegendő adverz gyógyszerreakció provokáló tényezőjének bizonyítására.

1544-P: High Risk of Adverse Drug Reaction (ADR) in Older Adults with Type 1 Diabetes (T1D)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1544-P ◽  
Author(s):  
ELENA TOSCHI ◽  
CHRISTINE SLYNE ◽  
ASTRID ATAKOV-CASTILLO ◽  
KAYLA SIFRE ◽  
ALYSSA B. DUFOUR ◽  
...  
Keyword(s):  
Older Adults ◽  
Adverse Drug Reaction ◽  
Type 1 Diabetes ◽  
Drug Reaction ◽  
High Risk

PENINGKATAN KEMANDIRIAN BELAJAR SISWA SMP MELALUI PEMBELAJARAN BERBASIS MASALAH

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Tanti Jumaisyaroh Siregar
Keyword(s):  
Problem Based Learning ◽  
Mathematic Teacher ◽  
Self Regulated Learning ◽  
Regulated Learning ◽  
Quasi Experimental ◽  
Independent Variable ◽  
Direct Learning ◽  
The Difference ◽  
And Control ◽  
Learning Data

The purposes of this research were to know: the difference of improvement in self-regulated learning of students that given problem-based learning with students that given  direct learning. The type of this research is a quasi-experimental research by taking samples from the existing population. The variable of this research consist of independent variable that is problem based learning model while the dependent variable isself regulated learning of student.The population of this research is all students of SMP Swasta Ar-rahman Percut and the sample of this research is grade eight with taken sample two classes (experiment and control)  with total 60 students. The instrument of this research were: scale of self-regulated learning. Data that have been collected then analyzed and performed hypothesis testing by using T-test. Based of the results analysis, it showed that: improvment  of the students’ self-regulated learning that given problem-based learning was higher than the students’ ability that given direct learning His then, suggested that problem-based learning be used as an alternative for mathematic teacher to improved students’ ability in mathematical critical thinking and self-regulated learning.

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