Review of Internet of Wearable Things and Healthcare based Computational Devices

Wearable computing have variety of applications in healthcare ranging from muscle disorders to neurocognitive disorders, Alzheimer’s disease, Parkinson’s disease, and psychological diseases, such as cardiovascular diseases, hypertension and so on. Different types of wearable computing devices are used, for example, bio fluidic-place on wearables, textile-place on wearables, and skin-place on wearables including tattoo place on wearables. In drug delivery systems, the wearable computing systems have shown promising developments, increasing its use in personalized healthcare. Wearable contain experiments, which need to be addressed before their consumerist as a fully customized healthcare system. Distinct types of wearable computing devices currently used in healthcare field are reviewed in this paper. Based on various factors, the paper provides an extensive classification of wearable computing devices. Additionally, limitations, current challenges and future perspective in health care is reviewed.

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Advances in healthcare wearable devices

npj Flexible Electronics ◽

10.1038/s41528-021-00107-x ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Sheikh M. A. Iqbal ◽

Imadeldin Mahgoub ◽

E Du ◽

Mary Ann Leavitt ◽

Waseem Asghar

Keyword(s):

Drug Delivery ◽

Cardiovascular Diseases ◽

Drug Delivery System ◽

Healthcare System ◽

Delivery System ◽

Wearable Devices ◽

Future Perspectives ◽

Muscle Disorders ◽

Personalized Healthcare ◽

Different Types

AbstractWearable devices have found numerous applications in healthcare ranging from physiological diseases, such as cardiovascular diseases, hypertension and muscle disorders to neurocognitive disorders, such as Parkinson’s disease, Alzheimer’s disease and other psychological diseases. Different types of wearables are used for this purpose, for example, skin-based wearables including tattoo-based wearables, textile-based wearables, and biofluidic-based wearables. Recently, wearables have also shown encouraging improvements as a drug delivery system; therefore, enhancing its utility towards personalized healthcare. These wearables contain inherent challenges, which need to be addressed before their commercialization as a fully personalized healthcare system. This paper reviews different types of wearable devices currently being used in the healthcare field. It also highlights their efficacy in monitoring different diseases and applications of healthcare wearable devices (HWDs) for diagnostic and treatment purposes. Additionally, current challenges and limitations of these wearables in the field of healthcare along with their future perspectives are also reviewed.

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Influence of different types of low substituted hydroxypropyl cellulose on tableting, disintegration, and floating behaviour of floating drug delivery systems

Saudi Pharmaceutical Journal ◽

10.1016/j.jsps.2014.09.001 ◽

2015 ◽

Vol 23 (6) ◽

pp. 658-666 ◽

Cited By ~ 6

Author(s):

Péter Diós ◽

Tivadar Pernecker ◽

Sándor Nagy ◽

Szilárd Pál ◽

Attila Dévay

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Hydroxypropyl Cellulose ◽

Delivery Systems ◽

Floating Drug Delivery ◽

Different Types ◽

Floating Drug Delivery Systems

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Recent advances in polymer shell-oily core nanocapsules for drug delivery applications

Nanomedicine ◽

10.2217/nnm-2021-0037 ◽

2021 ◽

Author(s):

Ahmed S AbdElhamid ◽

Dina G Zayed ◽

Lamia Heikal ◽

Sherine N Khattab ◽

Omar Y Mady ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Early Stage ◽

Controlled Drug Release ◽

Delivery Systems ◽

Polymeric Membranes ◽

Polymer Shell ◽

Recent Advances ◽

Target Sites ◽

Different Types

Polymeric nanocapsules are vesicular drug delivery systems composed of an inner oily reservoir surrounded by polymeric membranes. Nanocapsules have various advantages over other nanovesicular systems such as providing controlled drug release properties. We discuss the recent advances in polymeric shell-oily core nanocapsules, illustrating the different types of polymers used and their implementation. Nanocapsules can be utilized for many purposes, especially encapsulation of highly lipophilic drugs. They have been shown to have variable applications, especially in cancer therapy, due to the ability of the polymeric shell to direct the loaded drugs to their target sites, as well as their high internalization efficacy. Those productive applications guaranteed their high potential as drug delivery systems. However, their clinical development is still in an early stage.

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Classification of Drug Delivery Systems

A Review of Biomaterials and Their Applications in Drug Delivery - SpringerBriefs in Applied Sciences and Technology ◽

10.1007/978-981-10-0503-9_2 ◽

2018 ◽

pp. 9-25

Author(s):

Hamid Reza Rezaie ◽

Mohammadhossein Esnaashary ◽

Abolfazl Aref arjmand ◽

Andreas Öchsner

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems

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Delineation of Blood Vessels in Coronary Artery Region for Classification of Different Types of Plaques

Journal of Biomaterials and Tissue Engineering ◽

10.1166/jbt.2020.2307 ◽

2020 ◽

Vol 10 (7) ◽

pp. 901-914

Author(s):

D. Indumathy ◽

S. Sudha

Keyword(s):

Cardiovascular Diseases ◽

Blood Vessel ◽

Heart Defects ◽

Image Data ◽

Data Set ◽

Different Types ◽

Cardiac Muscles ◽

Pixel Analysis ◽

Effective Medication

Cardiac arrest in human arises owing to blood vessel diseases or heart defects. Blood vessel diseases result due to the blockage of blood in the heart vessels, which leads to pain in the heart. Heart defects occur because of damage in the cardiac muscles indicated by abnormal heart rhythms. Cardiovascular diseases cause mortality which could be avoided through the earlier detection of cardiovascular diseases. The major cause for cardiovascular diseases is cholesterol deposition inside the artery walls which later forms plaques that block the blood flow. Until now, plaques have been detected through medical imaging only after the heart attack. The plaques are blasted through angioplasty or reduced with medicine. Classification of the plaques before treatment, leads to effective medication based on the type of plaque. The sub classification of the plaque types such as rupture-prone plaque, ruptured plaque with sub occlusive thrombus, erosion-prone plaque, calcified nodule and non-plaque has been segmented and identified. In this paper, we propose a novel Spatial Fuzzy Propensity Score Matching (SFPSM) method to classify the plaques. The SFPSM method consists of clustering, ranking the cluster and region-based pixel wise analysis. Pixel analysis inspects specific regions of sub pixel points and calibrates the plaque. From the experimental results, the classification of plaque based on the 50-image data set has exhibited accuracy of 85% after validation. The plaque accuracy of classification provides the standard digital number values for the sub classification of plaques.

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Nanobiomaterials Used in Cancer Therapy: An Up-To-Date Overview

Molecules ◽

10.3390/molecules24193547 ◽

2019 ◽

Vol 24 (19) ◽

pp. 3547 ◽

Cited By ~ 21

Author(s):

Iulia Ioana Lungu ◽

Alexandru Mihai Grumezescu ◽

Adrian Volceanov ◽

Ecaterina Andronescu

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Reticuloendothelial System ◽

Stepping Stones ◽

Cancer Treatments ◽

Materials Development ◽

Different Types ◽

Effective System ◽

Healthy Body

The disadvantages that come with traditional cancer treatments, such as chemotherapy and radiotherapy, generated a research shift toward nanotechnology. However, even with the important advancements regarding cancer therapy, there are still serious stepping stones that need to be addressed. The use of both nanotechnology and nanomedicine has generated significant improvements in nano-sized materials development and their use as therapeutic, diagnosis, and imaging agents. The biological barriers that come from the healthy body, as well from the tumorous sites, are important parameters that need to be taken into consideration when designing drug delivery systems. There are several aspects of extreme importance such as the tumor microenvironment and vasculature, the reticuloendothelial system, the blood–brain barrier, the blood–tumor barrier, and the renal system. In order to achieve an effective system for cancer therapy, several characteristics of the nanoparticles have been outlined. Moreover, this review has also focused on the different types of nanoparticles that have been studied over the years as potential candidates for cancer therapy.

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Prospective of Natural Gum Nanoparticulate Against Cardiovascular Disorders

Current Chemical Biology ◽

10.2174/2212796813666190328194825 ◽

2019 ◽

Vol 13 (3) ◽

pp. 197-211

Author(s):

Aakash Deep ◽

Neeraj Rani ◽

Ashok Kumar ◽

Rimmy Nandal ◽

Prabodh C. Sharma ◽

...

Keyword(s):

Drug Delivery ◽

Cardiovascular Diseases ◽

Drug Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Natural Polymers ◽

Stabilizing Agents ◽

Synthetic Materials ◽

Materials Used ◽

Cellular Components

Background: Objective: Various natural gums can be synergistically used in nanoparticulate drug delivery systems to treat cardiovascular diseases. Nanotechnology has been integrated into healthcare in terms of theranostics. In this review, we consider various natural gums that can be used for the preparation of nanoparticles and their role to treat cardiovascular disease. Methods: Nanoparticles can carry drugs at nanoscales and deliver them to the targeted sites with the desired pattern of drug release. They have specialized uptake mechanisms (e.g. - absorptive endocytosis) which improve the bioavailability of drugs. Results: By considering cardiovascular diseases at the molecular level, it is possible to modify the materials with nanotechnology and apply nano-formulations efficiently as compared with conventional preparations, due to the fact that the extracellular matrix (ECM) comprises components at the nanoscale range. The interactions of ECM components with cellular components occur at the nanoscale, therefore the nanomaterials have the potential to maintain the nanoscale properties of cells. The synthetic materials used to develop the nanoparticulate drug delivery system may cause toxicity. Conclusion: This problem can be overcome by using natural polymers. Natural gums can be used in nanoparticulate drug delivery systems as reducing and stabilizing agents and in some cases; they may directly or indirectly influence the rate of drug release and absorption from the preparation.

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Investigational Hypoxia-Activated Prodrugs: Making Sense of Future Development

Current Drug Targets ◽

10.2174/1389450120666181123122406 ◽

2019 ◽

Vol 20 (6) ◽

pp. 668-678 ◽

Cited By ~ 2

Author(s):

Min-Xia Su ◽

Le-Le Zhang ◽

Zhang-Jian Huang ◽

Jia-Jie Shi ◽

Jin-Jian Lu

Keyword(s):

Drug Delivery ◽

Clinical Trials ◽

Patient Selection ◽

Drug Delivery Systems ◽

Drug Research ◽

Reductase Activity ◽

Research Progress ◽

Preclinical Models ◽

Making Sense ◽

Different Types

Hypoxia, which occurs in most cancer cases, disrupts the efficacy of anticarcinogens. Fortunately, hypoxia itself is a potential target for cancer treatment. Hypoxia-activated prodrugs (HAPs) can be selectively activated by reductase under hypoxia. Some promising HAPs have been already achieved, and many clinical trials of HAPs in different types of cancer are ongoing. However, none of them has been approved in clinic to date. From the studies on HAPs began, some achievements are obtained but more challenges are put forward. In this paper, we reviewed the research progress of HAPs to discuss the strategies for HAPs development. According to the research status and results of these studies, administration pattern, reductase activity, and patient selection need to be taken into consideration to further improve the efficacy of existing HAPs. As the requirement of new drug research and development, design of optimal preclinical models and clinical trials are quite important in HAPs development, while different drug delivery systems and anticancer drugs with different mechanisms can be sources of novel HAPs.

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