Synthesis and Characterization of Lipoic Acid–Peptide Conjugates and Their Effect on Collagen and Melanogenesis

2019 ◽  
Vol 50 (2) ◽  
pp. 11-21
Author(s):  
KHALIDAH KHALAF JABBAR
Keyword(s):  
Lipoic Acid ◽  
Synthesis And Characterization ◽  
Peptide Conjugates

Synthesis and characterization of a sulfur-containing phthalocyanine-gold nanoparticle hybrid

2015 ◽  
Vol 19 (01-03) ◽  
pp. 335-343 ◽  
Author(s):  
Vicente M. Blas-Ferrando ◽  
Javier Ortiz ◽  
Fernando Fernández-Lázaro ◽  
Ángela Sastre-Santos
Keyword(s):  
Gold Nanoparticle ◽  
Lipoic Acid ◽  
Zinc Phthalocyanine ◽  
Synthesis And Characterization ◽  
Ligand Exchange Reaction ◽  
H Nmr ◽  
Fluorescence Measurements ◽  
Transmission Electron ◽  
Yield Values

This work reports on the synthesis and characterization of a new gold nanoparticle-zinc phthalocyanine system, AuNP - S (t Bu )3 ZnPc , prepared by a ligand exchange reaction of tetraoctylammonium bromide with a novel unsymmetrically substituted zinc phthalocyanine which contains one thioester group in the peripheral position [ AcS (t Bu )3 ZnPc ]. The AuNP - S (t Bu )3 ZnPc hybrid was characterized using UV-vis and 1 H NMR spectroscopies. Transmission electron microscopy allowed the estimation of the size, which was calculated to be ~5 nm. AuNPs - S (t Bu )3 ZnPc conjugate showed much lower fluorescence quantum yield values than the AcS (t Bu )3 ZnPc demonstrating either an energy or electron transfer from the ZnPc to the AuNP . The AuNP - S (t Bu )3 ZnPc hybrid has been anchored to a TiO 2 semiconducting layer using lipoic acid. A solid configuration of TiO 2-lipoic acid- AuNP - S (t Bu )3 ZnPc has been prepared by anchoring lipoic acid to the TiO 2 ( TiO 2-LA) and introducing later the TiO 2-LA with free thiol groups in a toluene solution of AuNP - S (t Bu )3 ZnPc . We have also observed by UV-vis and fluorescence measurements the importance of the ZnPc in avoiding AuNP aggregation on the TiO 2 surface.

Targeting lipoic acid to mitochondria: Synthesis and characterization of a triphenylphosphonium-conjugated α-lipoyl derivative

2007 ◽  
Vol 42 (12) ◽  
pp. 1766-1780 ◽  
Author(s):  
Stephanie E. Brown ◽  
Meredith F. Ross ◽  
Alejandra Sanjuan-Pla ◽  
Abdul-Rahman B. Manas ◽  
Robin A.J. Smith ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Synthesis And Characterization

Synthesis and Characterization of Supported Bioactive Lipid Membranes

1997 ◽  
Vol 489 ◽  
Author(s):  
Theodore M. Winger ◽  
Elliot L. Chaikof
Keyword(s):  
Lipid Membranes ◽  
Room Temperature ◽  
Synthesis And Characterization ◽  
Peptide Conjugates ◽  
Force Microscopy ◽  
Atomic Force ◽  
Membrane Mimetic ◽  
Phosphate Buffered Saline ◽  
Mixed Systems

AbstractSingle and multicomponent membrane-mimetic surfaces of DPPC and synthetic lipid-peptide conjugates were formed on an alkylated glass surface by a process of vesicle fusion. Correlative atomic force microscopy and radiochemical titration techniques confirmed the generation of a single substrate supported monolayer and predictable deposition of defined concentrations of lipopeptide. Mixed systems were stable for periods exceeding 1 month if stored at room temperature in phosphate buffered saline.

Synthesis and characterization of new and potent α-lipoic acid derivatives

2004 ◽  
Vol 12 (5) ◽  
pp. 1183-1190 ◽  
Author(s):  
Arie Gruzman ◽  
Adel Hidmi ◽  
Jehoshua Katzhendler ◽  
Abdalla Haj-Yehie ◽  
Shlomo Sasson
Keyword(s):  
Lipoic Acid ◽  
Synthesis And Characterization

Synthesis and characterization of new ferrocene peptide conjugates

2009 ◽  
pp. 4370 ◽  
Author(s):  
Cailin Drexler ◽  
Mark Milne ◽  
Erin Morgan ◽  
Michael Jennings ◽  
H.-B. Kraatz
Keyword(s):  
Synthesis And Characterization ◽  
Peptide Conjugates
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