scholarly journals Effectiveness of Insulin plant in Management of Diabetes Mellitus

2021 ◽  
Vol 3 (1) ◽  
pp. 135-139
Author(s):  
Yonis Ismed
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
Diabetes Management ◽  
Diabetes Mellitus Patient ◽  
Antioxidant Effect ◽  
Antidiabetic Agent ◽  
Significant Morbidity ◽  
Practical Action ◽  
Significant Health

Diabetes mellitus, to this day, is still one of significant health problems and created significant morbidity and mortalityamong world populations. Current diabetic drugs still have unpleasant side effects and costly price. Seeking new diabetic drugs from natural resources is one of the practical action for alternative management of the disease. Insulin plant, originated from Andes, has been cultivated in Indonesia. Insulin plant is rich in caffeic acid, clorgenic acid, flavonoid, fenolic compound and sesquiterpenic lactone has antihyperglycemic and antioxidant effect that possibly have a role in diabetes management. Several studies have reported potential of insulin plant as antidiabetic agent. This review aims to summarize and organize current literature on effectiveness and role of insulin plant on diabetes mellitus patient

scholarly journals Profil and Evaluation of Resistant Tuberculosis Drug’s Side Effect in Diabetes and Non Diabetes Mellitus Patient at RSUD Arifin Achmad

2020 ◽  
Vol 40 (3) ◽  
pp. 156-162
Author(s):  
Dani Rosdiana ◽  
Dewi Anggraini ◽  
Indra Yovi ◽  
Marlina Tasril
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Outcome ◽  
Side Effects ◽  
Side Effect ◽  
Diabetes Mellitus Patient ◽  
Cross Sectional ◽  
Resistant Tuberculosis ◽  
High Prevalence ◽  
Complete Treatment ◽  
Mdr Tb

Backgrounds: Diabetes mellitus (DM) increases the risk of reactivation of tuberculosis included multi-resistant drug tuberculosis (MDR-TB). This situation is threatening Riau province due to the high prevalence of DM. Since 2014 Arifin Achmad Hospital as a referral hospital of MDR-TB management. It’s treatment especially in DM patients, requires an evaluation of both outcome and side effects. This evaluation needs to be compared with non-DM MDR TB patients. The aim of this study was to evaluate and analyse patient’s characteristic, conversion of smear or culture, drugs side effect and treatment outcome. Methods: This is a cross sectional retrospective study in RSUD Arifin Achmad Pekanbaru on April-October 2018. Sample of this study were all patients from 2014 – 2017. This study was divided into 2 groups, namely the DM and non-DM groups, then analysed the differences between the two groups Results: There were 113 MDR TB patients had its treatment, which 61% of the patients were male. Baseline data show 26.5% of MDR TB patients have comorbid DM. The most common side effects were nausea and vomiting (100%) in all subjects. In the MDR TB DM group, we found included: well controlled plasma glucose level was 33.3%, severe side effects was16.7%, conversion in the second month 40% and cured or complete treatment was 30%. Conclusions: As many as 26,5% of MDR TB patients had DM comorbidity. There were no differences in the percentage of drugs side effects, smear conversion in the second month and treatment outcome between MDR TB DM and MDR TB non-DM group. (J Respir Indo. 2020; 40(3): 156-62)

scholarly journals New ways of diabetes management with smart data and genomic data

2017 ◽  
Vol 3 (2) ◽  
pp. 497-500
Author(s):  
Kurt Becker
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
Diabetes Management ◽  
Vascular System ◽  
The Body ◽  
Diabetic Patients ◽  
Model Parameters ◽  
Knowledge Based ◽  
Smart Data ◽  
Abstraction Levels

AbstractBy 2025, the number of diabetic patients worldwide could rise by more than 50 percent from now 250 million to about 380 million. With about 6 million patients, diabetes mellitus is one of the greatest national diseases in Germany.Type 1 diabetes is a mostly genetically induced autoimmune disease, type 2 diabetes is a civilization disease and arises due to lack of exercise and poor diet. Regardless of the type of diabetes, it is important for those affected to manage their own insulin production of the body and to harmonize these with appropriate possibilities. Because of the harmful side effects of exogenous insulin doses, the major focus should be on a sustainable behavioral change and low-threshold nutritional coaching.The most important side effects of diabetes are damage to the vascular system with possible consequences: myocardial infarction, stroke, kidney weakness, nasal damage and erectile dysfunction. A concept for a knowledge-based expert system for the therapy of diabetes mellitus is presented, in which genetic, anatomical and physiological parameters are recorded, evaluated and visualized by means of a model-based approach to specific therapeutic recommendations. The "user interface" is a digital avatar, which can display the model parameters in various "abstraction levels" as a metamodel.

Type 1 and Type 2 Diabetes and the Brain

2019 ◽  
pp. 116-136
Author(s):  
Olga Neyman ◽  
Tamara Hershey
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Side Effects ◽  
Current Knowledge ◽  
The World ◽  
The Brain

This chapter focuses on the neurocognitive effects of diabetes mellitus, particularly type 1 and type 2 diabetes. Although many of the side effects of diabetes—such as retinopathy, nephropathy, and peripheral neuropathy—are well known, the consequences on cognition have received comparatively little attention. These consequences will become more important as the rate of diabetes continues to rise at a staggering rate and millions of people are affected throughout the world. This chapter provides an overview of the current knowledge on how diabetes mellitus affects cognitive function, emphasizing the role of hypo- and hyperglycemia, while placing it in the context of diabetes as a whole.

Transient Neonatal Diabetes Mellitus: A Challenge and Opportunity for Specialized Nursing Care

2017 ◽  
Vol 36 (4) ◽  
pp. 196-205 ◽  
Author(s):  
Martha Anne Zammit ◽  
Stefanie Marie Agius ◽  
Jean Calleja-Agius
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Management ◽  
Neonatal Diabetes ◽  
Later Life ◽  
Neonatal Diabetes Mellitus ◽  
Transient Neonatal Diabetes Mellitus ◽  
Transient Neonatal Diabetes

AbstractTransient neonatal diabetes mellitus (TNDM) is a rare disorder, with a reported incidence of approximately 1 in 450,000 live births. It is characterized by insulin-requiring hyperglycemia in the neonatal period. The disease improves by early childhood, but the patient may relapse in later life. Diagnosis is made after genetic testing following presentation with hyperglycemia not conforming to Type 1 or Type 2 diabetes. Management is based on insulin and possible sulfonylurea administration. Three genetically distinct subtypes of TNDM are recognized. Type 1 TNDM is due to overexpression of genes at the 6q24 locus, whereas the 11p15 locus is involved in Type 2 and 3 TNDM. In this article the clinical presentation, management, and genetics of TNDM are discussed, particularly emphasizing the role of the neonatal nurse.

scholarly journals Biosynthesis of Copper Nanoparticles using Mucuna Pruriens and its Antioxidant and Antidiabetic Activity

2021 ◽  
pp. 621-629
Author(s):  
Shifa Jawahar Ali ◽  
R. V. Geetha ◽  
S. Rajeshkumar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Antioxidant Activity ◽  
Type 2 Diabetes Mellitus ◽  
Side Effects ◽  
Copper Nanoparticles ◽  
Mucuna Pruriens ◽  
Antidiabetic Activity ◽  
Antidiabetic Agent

Introduction: The field of Nanotechnology has gained importance since last century. Nanoparticles can be used in medicine due to its increased interaction with microbes and has less side effects than drugs. Antioxidant compounds scavenge free radicals and inhibit the oxidative mechanisms that lead to degenerative diseases. There is a growing number of diabetes patients all over the world. Wide varieties of synthetic drugs are being used for the treatment of Type 2 diabetes mellitus, most of them possess side effects in the long run such as hepatotoxicity, abdominal pain, flatulence and diarrhea. Therefore, there is a need for a search of an alternate antidiabetic agent Aim: The aim of the study is to synthesize Copper nanoparticles from Mucuna pruriens and to evaluate its antioxidant and antidiabetic activity. Materials and methods: Plant extract of Mucuna pruriens was prepared and filtered by Whatman No 1 filter paper. Copper sulphate was added to the plant extract and kept in a magnetic stirrer for nanoparticle synthesis. The synthesized nanoparticle was preliminarily analysed using UV visible spectroscopy. Finally the left over solution was taken to calculate antioxidant activity and antidiabetic activity. Results: Antioxidant activity was calculated by DPPH method and the percentage of inhibition of copper nanoparticles synthesised from Mucuna pruriens was 58.5% for 10µL, 59.6% for 20µL, 67.5% for 30µL, 71.4% for 40µL and 72.3% for 50µL. Antidiabetic activity was calculated by alpha-amylase inhibitory assay and the percentage of inhibition of copper nanoparticles synthesised from Mucuna pruriens was 66% for 10µL, 69% for 20µL, 73% for 30µL, 79% for 40µL and 80% for 50µL. Conclusion: We can conclude that copper nanoparticles synthesised from Mucuna pruriens are a potent antioxidant and antidiabetic agent. Since it shows a good activity in free radical scavenging, copper nanoparticles can be used in a clinical therapeutic application and also in the management of type 2 diabetes mellitus.

scholarly journals INTEGRATED APPROACH FOR DIABETES THROUGH LIFE STYLE MODIFICATIONS AND YOGA: A CRITICAL REVIEW

AYUSHDHARA ◽  
2021 ◽  
pp. 3028-3034
Author(s):  
Pooja Rani ◽  
Subash Sahu ◽  
Jai Singh Yadav
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Management ◽  
Integrated Approach ◽  
Hypoglycemic Agents ◽  
Sudden Increase ◽  
Oral Hypoglycemic Agents ◽  
Chronic Hyperglycemia ◽  
Contemporary Science ◽  
Characteristic Features

Diabetes mellitus is defined as multiple etiological disorder characterized by chronic hyperglycemia and disturbed of metabolism leads into defective insulin secretion, action or both. Research showed 150 million people have diabetes mellitus worldwide, which can be doubled by the year 2025. This tremendous sudden increase is due to population growth, ageing, unhealthy diets, obesity and sedentary lifestyles. In contemporary science diabetes management includes uses of oral hypoglycemic agents and insulin injections still blood sugar level remains uncontrolled and may leads to further complications. In Ayurveda characteristic features of diabetes has been described under Madhumeha in which treatment principles have been explained beautifully in detail which includes Shodhana therapy, Shamana therapy, diet and Yogic exercise. Through various studies we come across that there have been lots of research works done on role of Ayurveda and yoga in diabetes mellitus. In this article an attempt has been made to collect various data published by CCRAS, Ministry of AYUSH, ICMR and CSIR has. Along with data available on PubMed, Medline, Google Scholar, AYUSH research portal and various online journals based on some clinical studies. So, that a multidimensional approach can be made through these resources and apply to cure the patient and improve quality of life.

scholarly journals Influence of ambient temperature on the correlation between self-monitoring of blood glucose and plasma glucose values in diabetes management

2012 ◽  
Vol 4 (4) ◽  
pp. 294 ◽  
Author(s):  
Shigesumi Kinchiku ◽  
Kazuhiko Kotani ◽  
Shoko Kajiya ◽  
Kanoko Yodo ◽  
Yukiko Maruguchi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Ambient Temperature ◽  
Plasma Glucose ◽  
Diabetes Management ◽  
Self Care ◽  
Correlation Coefficients ◽  
Diabetes Mellitus Patient ◽  
Diabetic Patients ◽  
Self Monitoring

INTRODUCTION: Self-monitoring of blood glucose (SMBG) helps patients with diabetes mellitus maintain glycemic control. However, few reports exist on whether ambient temperature can influence SMBG values. AIM: To investigate the effect of ambient temperature on the association between SMBG and plasma glucose (PG) values. METHODS: The study was conducted between 2003 and 2010 in diabetic patients (n=2777, male/female = 1216/1561, mean age = 60.5 ±13.6 years) for whom the measurements of SMBG and PG were performed simultaneously (66 197 samples were measured). SMBG and PG were both measured by enzyme methods. Correlation coefficients were determined between SMBG and PG values, and the differences between their values were compared based on the temperature. RESULTS: SMBG and PG were closely correlated at each temperature. The PG–SMBG difference was smallest at an ambient temperature of 20°C, around which SMBG differed from PG with temperature; namely, the SMBG value decreased as the ambient temperature increased, while the SMBG value increased as the ambient temperature decreased. DISCUSSION: The present data indicate that the ambient temperature can minimally but significantly influence SMBG values. Further studies about the relevance of these findings on patient self-care are warranted. KEYWORDS: Blood glucose self-monitoring; diabetes mellitus; patient education; self care; skin temperature; temperature

scholarly journals Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1590
Author(s):  
Miriam Cabello-Olmo ◽  
Miriam Araña ◽  
Raquel Urtasun ◽  
Ignacio J Encio ◽  
Miguel Barajas
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Management ◽  
Current Knowledge ◽  
Biologically Active ◽  
Future Perspectives ◽  
Gastrointestinal Microbiota ◽  
Cell Structures ◽  
By Products ◽  
Novel Therapeutic

In the last decade, the gastrointestinal microbiota has been recognised as being essential for health. Indeed, several publications have documented the suitability of probiotics, prebiotics, and symbiotics in the management of different diseases such as diabetes mellitus (DM). Advances in laboratory techniques have allowed the identification and characterisation of new biologically active molecules, referred to as “postbiotics”. Postbiotics are defined as functional bioactive compounds obtained from food-grade microorganisms that confer health benefits when administered in adequate amounts. They include cell structures, secreted molecules or metabolic by-products, and inanimate microorganisms. This heterogeneous group of molecules presents a broad range of mechanisms and may exhibit some advantages over traditional “biotics” such as probiotics and prebiotics. Owing to the growing incidence of DM worldwide and the implications of the microbiota in the disease progression, postbiotics appear to be good candidates as novel therapeutic targets. In the present review, we summarise the current knowledge about postbiotic compounds and their potential application in diabetes management. Additionally, we envision future perspectives on this topic. In summary, the results indicate that postbiotics hold promise as a potential novel therapeutic strategy for DM.

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