Diagnostic biomarkers for pancreatic cancer: An update

Abstract Background Pancreatic cancer (PC) is a devastating disease that has a poor prognosis and a total 5-year survival rate of around 5%. The poor prognosis of PC is due in part to a lack of suitable biomarkers that can allow early diagnosis. The lysophospholipase autotaxin (ATX) and its product lysophosphatidic acid (LPA) play an essential role in disease progression in PC patients and are associated with increased morbidity in several types of cancer. In this study, we evaluated both the potential role of serum LPA and ATX as diagnostic markers in PC and their prognostic value for PC either alone or in combination with CA19-9. Methods ATX, LPA and CA19-9 levels were evaluated using ELISA of serum obtained from PC patients (n = 114) healthy volunteers (HVs: n = 120) and patients with benign pancreatic diseases (BPDs: n = 94). Results Serum levels of ATX, LPA and CA19-9 in PC patients were substantially higher than that for BPD patients or HVs (p < 0.001). The sensitivity of LPA in early phase PC was 91.74% and the specificity of ATX was 80%. The levels of ATX, LPA and CA19-9 were all substantially higher for early stage PC patients compared to levels in serum from BPD patients and HVs. The diagnostic efficacy of CA19-9 for PC was significantly enhanced by the addition of ATX and LPA (p = 0.0012). Conclusion Measurement of LPA and ATX levels together with CA19-9 levels can be used for early detection of PC and diagnosis of PC in general.

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Serum Soluble PD-L1, PD-L2, and B7-H5 as Potential Diagnostic Biomarkers of Human Pancreatic Cancer

Clinical Laboratory ◽

10.7754/clin.lab.2021.210103 ◽

2021 ◽

Vol 67 (06/2021) ◽

Author(s):

Weigen Wu ◽

Xiaoping Xia ◽

Chen Cheng ◽

Lili Niu ◽

Jianguo Wu ◽

...

Keyword(s):

Pancreatic Cancer ◽

Human Pancreatic Cancer ◽

Diagnostic Biomarkers

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Serum miR-1290 and miR-1246 as Potential Diagnostic Biomarkers of Human Pancreatic Cancer

Journal of Cancer ◽

10.7150/jca.38048 ◽

2020 ◽

Vol 11 (6) ◽

pp. 1325-1333 ◽

Cited By ~ 4

Author(s):

Jia Wei ◽

Lu Yang ◽

Yi-ning Wu ◽

Jian Xu

Keyword(s):

Pancreatic Cancer ◽

Human Pancreatic Cancer ◽

Diagnostic Biomarkers

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Circulating microRNAs as promising diagnostic biomarkers for pancreatic cancer: a systematic review

OncoTargets and Therapy ◽

10.2147/ott.s207963 ◽

2019 ◽

Vol Volume 12 ◽

pp. 6665-6684 ◽

Cited By ~ 3

Author(s):

Jinru Xue ◽

Erna Jia ◽

Na Ren ◽

Andrew Lindsay ◽

Haixin Yu

Keyword(s):

Systematic Review ◽

Pancreatic Cancer ◽

Diagnostic Biomarkers ◽

Circulating Micrornas

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Exosomes: Ideal Diagnostic Biomarkers and Therapeutic Nanodevices of Pancreatic Cancer

Biomarkers Journal ◽

10.21767/2472-1646.100048 ◽

2018 ◽

Vol 01 (09) ◽

Author(s):

Hongpei Wu ◽

Bojun Bao ◽

Hui Cong ◽

Jinxia Liu ◽

Feng Jiang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Diagnostic Biomarkers

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Discovery of diagnostic biomarkers for pancreatic cancer in immunodepleted serum by SELDI-TOF MS

Pancreatology ◽

10.1016/j.pan.2012.02.009 ◽

2012 ◽

Vol 12 (2) ◽

pp. 124-129 ◽

Cited By ~ 9

Author(s):

Aiqun Xue ◽

Robert C. Gandy ◽

Liping Chung ◽

Robert C. Baxter ◽

Ross C. Smith

Keyword(s):

Pancreatic Cancer ◽

Diagnostic Biomarkers ◽

Tof Ms

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Review of Diagnostic Biomarkers in Autoimmune Pancreatitis: Where Are We Now?

Diagnostics ◽

10.3390/diagnostics11050770 ◽

2021 ◽

Vol 11 (5) ◽

pp. 770

Author(s):

Masataka Yokode ◽

Masahiro Shiokawa ◽

Yuzo Kodama

Keyword(s):

Pancreatic Cancer ◽

Autoimmune Pancreatitis ◽

Diagnostic Biomarkers ◽

Related Disease ◽

Igg4 Related Disease ◽

Disease Specific

Autoimmune pancreatitis (AIP) is a pancreatic manifestation of an IgG4-related disease (IgG4-RD). AIP lacks disease-specific biomarkers, and therefore, it is difficult to distinguish AIP from malignancies, especially pancreatic cancer. In this review, we have summarized the latest findings on potential diagnostic biomarkers for AIP. Many investigations have been conducted, but no specific biomarkers for AIP are identified. Therefore, further studies are required to identify accurate diagnostic biomarkers for AIP.

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Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer

Pancreatology ◽

10.1016/j.pan.2018.09.008 ◽

2018 ◽

Vol 18 (8) ◽

pp. 977-982 ◽

Cited By ~ 1

Author(s):

Milosz Wiktorowicz ◽

Damian Mlynarski ◽

Radoslaw Pach ◽

Romana Tomaszewska ◽

Jan Kulig ◽

...

Keyword(s):

Pancreatic Cancer ◽

Expression Profiling ◽

Diagnostic Biomarkers ◽

Qrt Pcr ◽

Mucin Expression

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Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications

Journal of Experimental & Clinical Cancer Research ◽

10.1186/s13046-020-01765-x ◽

2020 ◽

Vol 39 (1) ◽

Author(s):

Lidong Cao ◽

Jiacheng Wu ◽

Xianzhi Qu ◽

Jiyao Sheng ◽

Mengying Cui ◽

...

Keyword(s):

Pancreatic Cancer ◽

Pancreatic Ductal Adenocarcinoma ◽

Cancer Cells ◽

Biochemical Parameters ◽

Malignant Tumors ◽

Aerobic Glycolysis ◽

Clinical Applications ◽

Common Type ◽

Ductal Adenocarcinoma ◽

Diagnostic Biomarkers

AbstractPancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary way energy is produced to maintain the proliferation, invasion, migration, and metastasis of cancer cells, even under normoxia. However, the potential molecular mechanism is still unknown. From this perspective, this review mainly aimed to summarize the current reasonable interpretation of aerobic glycolysis in pancreatic cancer and some of the newest methods for the detection and treatment of pancreatic cancer. More specifically, we reported some biochemical parameters, such as newly developed enzymes and transporters, and further explored their potential as diagnostic biomarkers and therapeutic targets.

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