scholarly journals Nomimicins B–D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura

2021 ◽  
Vol 17 ◽  
pp. 2194-2202
Author(s):  
Zhiwei Zhang ◽  
Tao Zhou ◽  
Taehui Yang ◽  
Keisuke Fukaya ◽  
Enjuro Harunari ◽  
...  

Three new tetronate-class polyketides, nomimicins B, C, and D, along with nomimicin, hereafter named nomimicin A, were isolated from the culture extract of Actinomadura sp. AKA43 collected from floating particles in the deep-sea water of Sagami Bay, Japan. The structures of nomimicins B, C, and D were elucidated through the interpretation of NMR and MS analytical data, and the absolute configuration was determined by combination of NOESY/ROESY and ECD analyses. Nomimicins B, C, and D showed antimicrobial activity against Gram-positive bacteria, Kocuria rhizophila and Bacillus subtilis, with MIC values in the range of 6.5 to 12.5 μg/mL. Nomimicins B and C also displayed cytotoxicity against P388 murine leukemia cells with IC50 values of 33 and 89 μM, respectively.

2016 ◽  
Vol 16 (12) ◽  
pp. 1615-1621 ◽  
Author(s):  
Erik Andrade-Jorge ◽  
Marycarmen Godínez-Victoria ◽  
Luvia Enid Sánchez-Torres ◽  
Luis Humberto Fabila-Castillo ◽  
José G. Trujillo-Ferrara

2013 ◽  
Vol 842 ◽  
pp. 530-535 ◽  
Author(s):  
Zeng Meng Zhang ◽  
Yong Jun Gong ◽  
Jiao Yi Hou ◽  
Han Peng Wu

The water hydraulic reciprocating plunger pump driven by linear motor is suitable to deep sea application with high efficiency and variable control. Aiming to study the principle structure and working characteristics of the pump, two patterns of valve and piston distribution were designed. And the control method and the performance were analyzed by simulation based on the AMESim model. The results show that the pressure and flow pulsation of piston type pump are much smaller than the valve type, even though the piston type is large in scale and works at low flow rate. Compared with a valve distribution tri-linear-motor reciprocating plunger pump (VDTLMP), as the flow rate of the piston distribution double linear motor reciprocating plunger pump (PDDLMP) is decreased from 36.7 L/min to 21.2 L/min theoretically, the pressure pulsation amplitude is decreased from 46% to 2%, and the flow pulsation rate is also decreased from 0.266 to 0.007. These results contribute to the research on deep-sea water hydraulic power pack and direct drive pump with high efficiency and energy conservation.


2017 ◽  
Vol 32 (4) ◽  
pp. 336-343 ◽  
Author(s):  
Miho Hirai ◽  
Shinro Nishi ◽  
Miwako Tsuda ◽  
Michinari Sunamura ◽  
Yoshihiro Takaki ◽  
...  

2019 ◽  
Vol 69 (4) ◽  
pp. 932-936 ◽  
Author(s):  
Qiliang Lai ◽  
Xiupian Liu ◽  
Jun Yuan ◽  
Shuchen Xie ◽  
Zongze Shao

A taxonomic study was carried out on strain CIC4N-9T, which was isolated from deep-sea water of the Indian Ocean. The bacterium was Gram-stain-negative, catalase- and oxidase-positive, rod-shaped and non-motile. Growth was observed at salinities of 0–9% and at temperatures of 4–41 °C. The isolate was able to degrade gelatin but not aesculin. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain CIC4N-9T belonged to the genus Pararhodobacter , with the highest sequence similarity to the only recognized species, Pararhodobacter aggregans D1-19T (96.9 %). The average nucleotide identity and estimated DNA–DNA hybridization values between strain CIC4N-9T and P. aggregans D1-19T were 80.4 and 23.0 %, respectively. The principal fatty acids were summed feature 8 (C18 : 1 ω7c and/or C18 : 1 ω6c), C16 : 0, C18 : 1ω7c 11-methyl, C18 : 0 and C17 : 0. The G+C content of the chromosomal DNA was 66.8 mol%. The sole respiratory quinone was determined to be Q-10. Phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine, diphosphatidylglycerol, two unknown phospholipids, four unknown aminolipids and one unknown polar lipid were present. The combined genotypic and phenotypic data show that strain CIC4N-9T represents a novel species within the genus Pararhodobacter , for which the name Pararhodobacter marinus sp. nov. is proposed. The type strain is CIC4N-9T (=MCCC 1A01225T=KCTC 52336T).


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