scholarly journals Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

2021 ◽  
Vol 17 ◽  
pp. 2553-2569
Author(s):  
Luke O Jones ◽  
Leah Williams ◽  
Tasmin Boam ◽  
Martin Kalmet ◽  
Chidubem Oguike ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Freezing Temperature ◽  
Wound Dressings ◽  
3D Bioprinting ◽  
Surgical Incision ◽  
Comprehensive Review ◽  
Highly Effective ◽  
Polymeric Structures

Cryogels are macroporous polymeric structures formed from the cryogelation of monomers/polymers in a solvent below freezing temperature. Due to their inherent interconnected macroporosity, ease of preparation, and biocompatibility, they are increasingly being investigated for use in biomedical applications such as 3D-bioprinting, drug delivery, wound healing, and as injectable therapeutics. This review highlights the fundamentals of macroporous cryogel preparation, cryogel properties that can be useful in the highlighted biomedical applications, followed by a comprehensive review of recent studies in these areas. Research evaluated includes the use of cryogels to combat various types of cancer, for implantation without surgical incision, and use as highly effective wound dressings. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable macroporous cryogels.

Recent advances of self-assembling peptide-based hydrogels for biomedical applications

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1704-1715 ◽  
Author(s):  
Jieling Li ◽  
Ruirui Xing ◽  
Shuo Bai ◽  
Xuehai Yan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
3D Bioprinting ◽  
Biological Applications ◽  
Antitumor Therapy ◽  
Self Assembling ◽  
Recent Advances

The review introduces several methods for fabrication of robust peptide-based hydrogels and their biological applications in the fields of drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D bioprinting and tissue engineering.

scholarly journals Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Saurav Das ◽  
Debapratim Das
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Rational Design ◽  
Soft Materials ◽  
Biological Molecules ◽  
3D Bioprinting ◽  
Significant Progress ◽  
Mechanical Stiffness

Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.

Microfluidic Biomaterials

MRS Bulletin ◽  
2006 ◽  
Vol 31 (2) ◽  
pp. 114-119 ◽  
Author(s):  
Abraham D. Stroock ◽  
Mario Cabodi
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Mass Transfer ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Wound Dressings ◽  
Living Systems ◽  
Living Tissue ◽  
Hydrodynamic Stresses

Biomedical applications—prostheses, tissue engineering, drug delivery, and wound healing—demand increasingly sophisticated characteristics from the materials that come into contact with living systems in the laboratory and the clinic. With the development of microfluidics, there is an opportunity to create active biomaterials based on embedded microfluidic structures. These structures allow for control of the concentrations of soluble chemicals and hydrodynamic stresses within the material and at its interfaces, and thus allow one to tailor the environment experienced by the living tissue. In this article, we review initial efforts to develop these microfluidic biomaterials and present considerations regarding the required characteristics of the materials and of the microfluidic-mediated mass transfer. As specific examples, we present work toward microfluidic control of mass transfer in scaffolds for tissue engineering and in wound dressings.

Comprehensive Review on Hydrogels

2021 ◽  
Vol 18 ◽  
Author(s):  
Hitesh Chopra ◽  
Inderbir Singh ◽  
Sandeep Kumar ◽  
Tanima Bhattacharya ◽  
Md. Habibur Rahman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Bone Engineering ◽  
Comprehensive Review ◽  
Therapeutic Benefits ◽  
Conventional Drug ◽  
Repeated Dosing

: The conventional drug delivery systems have a long list of issues of repeated dosing and toxicity arising due to it. The hydrogels are the answer to them and offer a result that minimizes such activities and optimizes therapeutic benefits. The hydrogels proffer tunable properties that can withstand degradation, metabolism, and controlled release moieties. Some of the areas of applications of hydrogels involve wound healing, ocular systems, vaginal gels, scaffolds for tissue, bone engineering, etc. They consist of about 90% of the water that makes them suitable bio-mimic moiety. Here, we present a birds-eye view of various perspectives of hydrogels, along with their applications.

scholarly journals Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6123
Author(s):  
Fa-Wei Xu ◽  
Ying-Li Lv ◽  
Yu-Fan Zhong ◽  
Ya-Nan Xue ◽  
Yong Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Green Tea ◽  
Clinical Application ◽  
Epigallocatechin Gallate ◽  
Skin Wound ◽  
Wound Dressings ◽  
Skin Wound Healing ◽  
Comprehensive Review ◽  
Beneficial Effects ◽  
Underlying Mechanisms

Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

scholarly journals Antibacterial cellulose-based aerogels for wound healing application: A review

2020 ◽  
Vol 7 (10) ◽  
pp. 4032-4040
Author(s):  
Esam Bashir Yahya ◽  
Marwa Mohammed Alzalouk ◽  
Khalifa A. Alfallous ◽  
Abdullah F. Abogmaza
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Medical Applications ◽  
Tissue Engineering Scaffolds

Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.

Porous bioactive glass micro- and nanospheres with controlled morphology: developments, properties and emerging biomedical applications

2021 ◽  
Author(s):  
Kai Zheng ◽  
Baiyan Sui ◽  
Kanwal Ilyas ◽  
Aldo R. Boccaccini
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Biomedical Applications ◽  
Controlled Morphology

Porous bioactive glass micro- and nanospheres are attractive biomaterials for biomedical applications: bone regeneration, wound healing, drug delivery and theranostics.

scholarly journals Hybrid Nanogels: Stealth and Biocompatible Structures for Drug Delivery Applications

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 71 ◽  
Author(s):  
Parisa Eslami ◽  
Filippo Rossi ◽  
Stefano Fedeli
Keyword(s):  
Drug Delivery ◽  
Immune Response ◽  
Immune System ◽  
Defense Mechanisms ◽  
Biomedical Applications ◽  
The Self ◽  
Host Organism ◽  
Zwitterionic Polymers ◽  
Self Defense ◽  
Polymeric Structures

Considering nanogels, we have focused our attention on hybrid nanosystems for drug delivery and biomedical purposes. The distinctive strength of these structures is the capability to join the properties of nanosystems with the polymeric structures, where versatility is strongly demanded for biomedical applications. Alongside with the therapeutic effect, a non-secondary requirement of the nanosystem is indeed its biocompatibility. The importance to fulfill this aim is not only driven by the priority to reduce, as much as possible, the inflammatory or the immune response of the organism, but also by the need to improve circulation lifetime, biodistribution, and bioavailability of the carried drugs. In this framework, we have therefore gathered the hybrid nanogels specifically designed to increase their biocompatibility, evade the recognition by the immune system, and overcome the self-defense mechanisms present in the bloodstream of the host organism. The works have been essentially organized according to the hybrid morphologies and to the strategies adopted to fulfill these aims: Nanogels combined with nanoparticles or with liposomes, and involving polyethylene glycol chains or zwitterionic polymers.

scholarly journals Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review

2020 ◽  
Vol 13 (05) ◽  
pp. 2030012 ◽  
Author(s):  
Zhimei Wei ◽  
Liqun Wang ◽  
Shouyu Zhang ◽  
Tonghai Chen ◽  
Jie Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biomedical Applications ◽  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Antimicrobial Agents ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Electrospun Fibers ◽  
Chronic Infections ◽  
Antibacterial Material

Bacterial infections are a major cause of chronic infections. Thus, antibacterial material is an urgent need in clinics. Antibacterial nanofibers, with expansive surface area, enable efficient incorporation of antibacterial agents. Meanwhile, structure similar to the extracellular matrix can accelerate cell growth. Electrospinning, the most widely used technique to fabricate nanofiber, is often used in many biomedical applications including drug delivery, regenerative medicine, wound healing and so on. Thus, this review provides an overview of all recently published studies on the development of electrospun antibacterial nanofibers in wound dressings and tissue medicinal fields. This reviewer begins with a brief introduction of electrospinning process and then discusses electrospun fibers by incorporating various types of antimicrobial agents used as in wound dressings and tissue. Finally, we finish with conclusions and further perspectives on electrospun antibacterial nanofibers as 2D biomedicine materials.

Nanomaterials for bioprinting: functionalization of tissue-specific bioinks

2021 ◽  
Author(s):  
Andrea S. Theus ◽  
Liqun Ning ◽  
Linqi Jin ◽  
Ryan K. Roeder ◽  
Jianyi Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Biomedical Applications ◽  
Disease Modeling ◽  
Three Dimensional ◽  
3D Bioprinting ◽  
Significant Step ◽  
Printing Processes

Abstract Three-dimensional (3D) bioprinting is rapidly evolving, offering great potential for manufacturing functional tissue analogs for use in diverse biomedical applications, including regenerative medicine, drug delivery, and disease modeling. Biomaterials used as bioinks in printing processes must meet strict physiochemical and biomechanical requirements to ensure adequate printing fidelity, while closely mimicking the characteristics of the native tissue. To achieve this goal, nanomaterials are increasingly being investigated as a robust tool to functionalize bioink materials. In this review, we discuss the growing role of different nano-biomaterials in engineering functional bioinks for a variety of tissue engineering applications. The development and commercialization of these nanomaterial solutions for 3D bioprinting would be a significant step towards clinical translation of biofabrication.

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