Efficacy and safety of herbal medicines external application with Tuina in congenital muscular torticollis : A systematic review and meta-analysis protocol

Review question / Objective: By 3 to 4 months of age, infants can keep their necks upright and look into both eyes horizontally. But infants with CMT have a wry neck also known as a twisted neck. Complementary therapies have been commonly used to treat CMT, such as tuina, acupuncture, herbal medicine. Among them, external application of herbal medicine is non-surgical and non-invasive inventions so it can be used widely in East Asia. This review aims to evaluate any form of external application of herbal medicines in CMT, such as cream, oil, extract, form of patch, etc. Information sources: We will electronically search the following database 4 English databases(MEDLINE, PubMed, EMBASE, the Cochrane Central Register of Controlled Trials), 3 Chinese databases(China National Knowledge Infrastructure(CNKI), Chinese Scientific Journal Database(VIP), Wan Fang Database), 4 Korean medical databases(Oriental Medicine Advanced Searching Integrated System(OASIS), Korean Studies Information Service System(KISS), National Digital Science Links(NDSL), Research Information Sharing Service(RISS)) from their founding date to June 2022, without any language restrictions.

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External application of Ruyi Jinhuang powder for phlebitis: A systematic review and meta-analysis

Tropical Journal of Pharmaceutical Research ◽

10.4314/tjpr.v18i3.29 ◽

2021 ◽

Vol 18 (3) ◽

pp. 647-667

Author(s):

Qian Yang ◽

Chunyan Yang ◽

Yongqiong Deng ◽

Qunhua Ma

Keyword(s):

Meta Analysis ◽

Relevant Literature ◽

Onset Time ◽

Healing Time ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

External Application ◽

Search Terms ◽

Knowledge Infrastructure ◽

Central Register

Purpose: To systematically review the effectiveness of the external application, Ruyi Jinhuang powder, on phlebitis Methods: Relevant literature was retrieved from Medline, Embase, China National Knowledge Infrastructure database (CNKI), Cochrane Central Register, Chongqing Vip, Wanfang Data and SinoMed using the search terms “Ruyi Jinhuang San”, “Ruyi Jinhuang powder”, “Ruyi Jinhuang cream”, “Agreeable golden powder”, “satisfactory golden powder”, “Jinhuang cream”, “phlebitis”, “prevention and (or) treatment”, “randomized controlled trials” and “RCRs”. Two researchers independently arranged and analyzed the data. Results: Significant differences were observed in the total effectiveness rate of Ruyi Jinhuang powder [relative risk (RR) = 1.27, 95% confidence interval (CI) = 1.19 to 1.36, and p < 0.0001). Ruyi Jinhuang powder can reduce the incidence of phlebitis versus conventional therapy in preventing phlebitis (RR = 0.32, 95 % CI 0.24 to 0.42, and p < 0.0001). Shorten the average healing time [mean difference (MD) =- 32.17, 95 % CI= -48.39 to -15.94, and p = 0.0001). Reduced pain relief time for phlebitis (MD = -3.29, 95% CI -5.42 to -1.16, and p = 0.002). However, no statistical difference was observed with regard to the onset time of phlebitis (MD = -0.62, 95 % CI -1.76 to 0.52, and p = 0.29). Conclusion: Clinicians consider Ruyi Jinhuang powder a viable complementary and alternative medicine for phlebitis following the stronger evidence being offered.

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Add-on effect of Chinese herbal medicine in the treatment of mild to moderate COVID-19: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0256429 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0256429

Author(s):

Xuqin Du ◽

Lipeng Shi ◽

Wenfu Cao ◽

Biao Zuo ◽

Aimin Zhou

Keyword(s):

Herbal Medicine ◽

Symptom Score ◽

Chinese Herbal Medicine ◽

Conventional Therapy ◽

Meta Analysis ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

Chinese Herbal ◽

Wbc Count ◽

Meta Analyses

Introduction Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic since its outbreak in Wuhan, China. It is an urgent task to prevent and treat COVID-19 effectively early. In China’s experience combating the COVID-19 pandemic, Chinese herbal medicine (CHM) has played an indispensable role. A large number of epidemiological investigations have shown that mild to moderate COVID-19 accounts for the largest proportion of cases. It is of great importance to treat such COVID-19 cases, which can help control epidemic progression. Many trials have shown that CHM combined with conventional therapy in the treatment of mild to moderate COVID-19 was superior to conventional therapy alone. This review was designed to evaluate the add-on effect of CHM in the treatment of mild to moderate COVID-19. Methods Eight electronic databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, the Clinical Trials.gov website, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Database and China Biology Medicine (CBM) were searched from December 2019 to March 2021 without language restrictions. Two reviewers searched and selected studies, and extracted data according to inclusion and exclusion criteria independently. Cochrane Risk of Bias (ROB) tool was used to assess the methodological quality of the included RCTs. Review Manager 5.3.0 software was used for statistical analysis. Results Twelve eligible RCTs including 1393 participants were included in this meta-analysis. Our meta-analyses found that lung CT parameters [RR = 1.26, 95% CI (1.15, 1.38), P<0.00001] and the clinical cure rate [RR = 1.26, 95%CI (1.16, 1.38), P<0.00001] of CHM combined with conventional therapy in the treatment of mild to moderate COVID-19 were better than those of conventional therapy. The rate of conversion to severe cases [RR = 0.48, 95%CI (0.32, 0.73), P = 0.0005], TCM symptom score of fever [MD = -0.62, 95%CI (-0.79, -0.45), P<0.00001], cough cases [RR = 1.43, 95%CI (1.16, 1.75), P = 0.0006], TCM symptom score of cough[MD = -1.07, 95%CI (-1.29, -0.85), P<0.00001], TCM symptom score of fatigue[MD = -0.66, 95%CI (-1.05, -0.28), P = 0.0007], and CRP[MD = -5.46, 95%CI (-8.19, -2.72), P<0.0001] of combination therapy was significantly lower than that of conventional therapy. The WBC count was significantly higher than that of conventional therapy[MD = 0.38, 95%CI (0.31, 0.44), P<0.00001]. Our meta-analysis results were robust through sensitivity analysis. Conclusion Chinese herbal medicine combined with conventional therapy may be effective and safe in the treatment of mild to moderate COVID-19. More high-quality RCTs are needed in the future.

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The Effectiveness of Acupuncture and Moxibustion for Rheumatoid Arthritis: A Protocol of an Overview of Systematic Reviews and Meta-analysis

10.21203/rs.3.rs-70147/v1 ◽

2020 ◽

Author(s):

Genhua Tang ◽

Jun Xiong ◽

Siyuan Zhu ◽

Zhiying Zhong ◽

Jun Chen ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Reviews ◽

Meta Analysis ◽

Scientific Journal ◽

Joint Damage ◽

Biomedical Literature ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

Acupuncture And Moxibustion ◽

Meta Analyses

Abstract Background: Rheumatoid Arthritis(RA) is a common chronic disease with an annual incidence of 25 per 10000 of the population, which will result in severe joint damage,disability and death. It is strongly supported by systematic reviews (SRs) as part of the treatment of these patients. However, the evidence has not been methodically integrated. This overview aims to describe,synthesize,evaluate the reliability of evidence come from current systematic reviews of acupuncture and moxibustion therapy for RA.Methods: We will search for SRs and meta-analyses from Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, PubMed, MEDLINE, Wan-Fang Databases,China National Knowledge Infrastructure (CNKI), Citation Information by National Institute of Informatics, Chinese Biomedical Literature Database(CBM),Chinese Scientific Journal Database(VIP Database). Additionally, we will search for the ongoing, unpublished, or recently completed SRs on the PROSPERO database. Two reviewers will assess those SRs, select data independently. Any disagreement will be resolved through discussion or arbitrated by the third author if necessary. The overview of SRs and meta-analysis will be reportedaccording to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA)statement.Results: The results in this study will be published in a peer-reviewed journal.Conclusion: The conclusion of our study expects to provide extensive evidence from multiple meta-analysis and systematic reviews for patients with RA.INPLASY registration number:INPLASY202080031.

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Acupuncture for constipation in patients with stroke: protocol of a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2017-020400 ◽

2018 ◽

Vol 8 (3) ◽

pp. e020400 ◽

Cited By ~ 4

Author(s):

Jingbo Zhai ◽

Wei Mu ◽

Jinhua Si ◽

Yan Li ◽

Chen Zhao ◽

...

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Meta Analysis ◽

Scientific Journal ◽

Primary Outcome Measure ◽

Integrated System ◽

Primary Data ◽

Controlled Trials ◽

Cochrane Central Register ◽

Medical Database

IntroductionConstipation is one of the most common complications in patients with stroke. Acupuncture has gained increased popularity for the management of constipation. However, there is a lack of supportive evidence on the efficacy of acupuncture for poststroke constipation. This systematic review aims to collect and critically appraise all the available evidence about the efficacy and safety of the acupuncture for constipation in poststroke patients.Methods and analysisA comprehensive search of Pubmed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, four Chinese databases (National Knowledge Infrastructure (CNKI), Chinese Biomedical Literatures database (CBM), Wanfang Digital Periodicals (WANFANG) and Chinese Science and Technology Periodicals (VIP) database), one Japanese medical database (National Institute of Informatics, CiNii) and one Korean medical database (Oriental Medicine Advanced Searching Integrated System, OASIS) will be conducted to identify randomised controlled trials of acupuncture for constipation in poststroke patients. There is no restriction on language or publication status. The primary outcome measure will be frequency of bowel movement. The risk of bias will be assessed using the approach recommended by Cochrane Handbook for Systematic Reviews of Interventions. We will conduct the meta-analysis to synthesise the evidence for each outcome, if possible. The heterogeneity will be statistically assessed using a χ2test and I2statistic. This protocol is developed following the guideline of Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols 2015.Ethics and disseminationThe ethical approval is not required because no primary data are collected. The findings will be presented at scientific conferences or a peer-reviewed scientific journal.PROSPERO registration numberCRD42017076880.

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Acupuncture versus sham acupuncture for simple obesity: a systematic review and meta-analysis

Postgraduate Medical Journal ◽

10.1136/postgradmedj-2019-137221 ◽

2020 ◽

Vol 96 (1134) ◽

pp. 221-227 ◽

Cited By ~ 4

Author(s):

Yu-Mei Zhong ◽

Xiao-Chao Luo ◽

Yang Chen ◽

De-Li Lai ◽

Wen-Ting Lu ◽

...

Keyword(s):

Data Extraction ◽

Meta Analysis ◽

Scientific Journal ◽

Sham Acupuncture ◽

Obesity Treatment ◽

Risk Of Bias ◽

Controlled Trials ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

Simple Obesity

Obesity is a growing chronic health problem worldwide. Studies about acupuncture for obesity treatment are many. But there are some doubts about the effectiveness of acupuncture versus sham acupuncture in treating obesity due to its lack of medical evidence. Therefore, the aim of this study is to assess the efficacy of acupuncture for obesity treatment and provide clinic evidence. Four English databases (PubMed, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials) and four Chinese databases (China National Knowledge Infrastructure, Chinese BioMedical Database, Chinese Scientific Journal Database and Wan-Fang Data) were searched from their receptions to August 2019. Randomized controlled trials (RCTs) using the comparison between acupuncture and sham acupuncture to treat simple obesity were included. The primary outcome of body mass index (BMI) would be used to measure the effect of acupuncture on obesity. According to the trial data extraction form based on the Cochrane Handbook, two reviewers separately extracted the data. Risk of bias of the RCTs was assessed by the Cochrane Risk of Bias Tool. The study included 8 RCTs with 403 patients. When compared with sham acupuncture, acupuncture showed obviously effect in BMI reduction (MD=1.0kg/m2, 95% CI=0.6 to 1.4, P<0.001). There was also significant reduction in body weight (MD=1.85kg, 95%CI=0.82 to 2.88, p<0.001), WC (MD=0.97cm, 95%CI=0.24 to 1.71, p=0.01) and body fat mass percentage (MD=1.01, 95%CI=0.25 to 1.77, p<0.05). However, WHR (MD=0.01, 95%CI=0 to 0.03, p>0.05) was not statistically and significantly different between the acupuncture and control groups. Adverse effects were reported in 3 studies. The review suggests that acupuncture is an effective therapy for simple obesity rather than a placebo effect. This potential benefit needs to be further evaluated by longer-term and more rigorous RCTs.

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Benefits of Herbal Medicine on Bone Mineral Density in Osteoporosis: A Meta-Analysis of Randomized Controlled Trials

The American Journal of Chinese Medicine ◽

10.1142/s0192415x20500871 ◽

2020 ◽

Vol 48 (08) ◽

pp. 1749-1768

Author(s):

Wan-Ling Lin ◽

Pao-Yen Lin ◽

Yu-Chiang Hung ◽

Tun-Pin Hsueh

Keyword(s):

Bone Mineral Density ◽

Herbal Medicine ◽

Postmenopausal Women ◽

Bone Mineral ◽

Meta Analysis ◽

Herbal Medicines ◽

Control Group ◽

Mineral Density ◽

China National Knowledge Infrastructure ◽

Meta Regression Analysis

Bone mineral density (BMD) has been validated not only for the diagnosis of osteoporosis but also for prediction of the risk of osteoporosis-related fractures. The purpose of this paper was to investigate the overall benefits of herbal medicines on BMD using a meta-analytic method. Systematic searches in PubMed, Medline, Cochrane Central, and China National Knowledge Infrastructure were performed for eligible studies. A meta-analysis was conducted to evaluate the benefits of herbal medicine treatment and conventional treatment for BMD. Herbal medicines frequently used for interventions were pooled in the analysis and further investigated. Seventeen studies were pooled in the meta-analysis and showed that BMD was higher in the herbal medicine group than in the control group (standardized mean difference [SMD]: 0.857; 95% confidence interval [CI]: 0.412 to 1.301). Significant benefits of herbal medicine for BMD were found in the lumbar spine, femoral neck, and femoral trochanter and in postmenopausal women (SMD: 0.600, 95% CI: 0.068 to 1.131) by subgroup analysis. Moreover, through the meta-regression analysis, the age at menopause and the menopause duration were found to influence the herbal intervention effects on BMD. In addition, the most prescribed medicine among the effective herbs in the pooled studies was found to be Epimedium brevicornum Maxim. This paper provides evidence that herbal medicine interventions increase BMD more than conventional treatments in individuals with osteoporosis, especially postmenopausal women. The results of this study suggest that herbal medicines are effective for increasing BMD in individuals with osteoporosis.

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Protocol for Chinese Herbal Medicines Decoction Treatment of Angina Pectoris: a Systematic Review With Bayesian Network Meta-analysis

10.21203/rs.3.rs-592471/v1 ◽

2021 ◽

Author(s):

Nan Li ◽

Wentai Pang ◽

Fengwen Yang ◽

Bo Pang ◽

Xinyao Jin ◽

...

Keyword(s):

Systematic Review ◽

Angina Pectoris ◽

Herbal Medicine ◽

Bayesian Network ◽

Meta Analysis ◽

Herbal Medicines ◽

Cochrane Library ◽

China National Knowledge Infrastructure ◽

Chinese Herbal Medicines ◽

Chinese Herbal

Abstract Background Angina pectoris (AP) is the primary symptom of coronary heart disease. Evidence has shown Chinese herbal medicines can bring benefits to patients suffering from AP. There are many kinds of herbal medicines. However, the difference between them has not been systematically analysed. It is uncertain which one is better. For comparison and ranking, a systematic review and network meta-analysis is needed. Methods We will search for the following 6 electronic databases: China Biological Medicine DataBase(CBM), China National Knowledge Infrastructure(CNKI), WanFang Database, PubMed, Embase and the Cochrane Library, from inception to May 2021. Randomized controlled trials, which aim to assess the efficacy and safety of 5 kinds of Chinese herbal medicine for AP will be included. The outcomes include reduction of AP, improvement of the electrocardiogram and adverse events. The study screening and data extraction will be presented by 2 researchers. The risk of bias will be assessed according to the Cochrane handbook. A Bayesian network meta-analysis will be performed to compare the efficacy of 5 Chinese herbal medicines. Surface under the cumulative rank curve value will be calculated to rank the efficacy of each herbal medicine.DiscussionOur protocol will be expected that the results of this study will provide evidence for Clinical Practice Guideline, clinical decisions, and development of proprietary Chinese medicines.Systematic review registrationPROSPERO registration number: CRD42019146185.

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Musikalisasi Syi’ir Aqoid Kiai Zaini Mun’im dan Budidaya Tanaman Obat Keluarga (Toga) di Pesantren Nurul Jadid Probolinggo

GUYUB: Journal of Community Engagement ◽

10.33650/guyub.v1i1.1257 ◽

2020 ◽

Vol 1 (1) ◽

pp. 47-58

Author(s):

Khodijatul Qodriyah

Keyword(s):

Herbal Medicine ◽

Herbal Medicines ◽

Successful Implementation ◽

Short Term ◽

Middle Term

The lack of students’ knowledge of their teachers’ works and the less of their consciousness to the environment are crucial problems in some islamic boardingschool, especially in Nurul Jadid. These issues will be settled by implementation of religious preaching (dakwah) with poem (syi’ir) in Syu’abul Iman of Kiai Zaini Mun’im and prefentive action to the illness through herbal medicines of family crops medicine (tanaman obat keluarga). The program is undertaken with some phases, including planting family crops medicine, making herbal medicines, musicalisation of poem in book of Syu’abul Iman, socialization of the herbal medicine and musical poem of Syu’abul Iman. These phases have been structured with long-term, middle-term, and short-term programs which were finished during approximately 4 months (Augustus – November 2019). The involvement of many parties, such as activists of environment in Nurul Jadid, has strongly influenced on the successful implementation of these programs.Keywords: Family Crops Medicine, Nurul Jadid Islamic Boardingschool, Book of Syu’abul Iman

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Nano Phytomedicine Based Delivery System for CNS Disease

Current Drug Metabolism ◽

10.2174/1389200221666200523161003 ◽

2020 ◽

Vol 21 (9) ◽

pp. 661-673 ◽

Cited By ~ 1

Author(s):

Mohammed Asadullah Jahangir ◽

Chettupalli Anand ◽

Abdul Muheem ◽

Sadaf Jamal Gilani ◽

Mohamad Taleuzzaman ◽

...

Keyword(s):

Herbal Medicine ◽

Low Cost ◽

Herbal Medicines ◽

Herbal Drugs ◽

Widespread Acceptance ◽

The Central Nervous System ◽

Low Toxicity ◽

Ancient Times ◽

Plant Sources ◽

Herbal Formulations

Herbal medicines are being used since ancient times and are an important part of the alternative and traditional medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost, ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations. Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and reported nano-phytomedicines based delivery systems.

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Herbal Medicine: Clinical Perspective & Regulatory Status

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323999201110192942 ◽

2020 ◽

Vol 23 ◽

Author(s):

Md Abul Barkat ◽

Anjali Goyal ◽

Harshita Abul Barkat ◽

Mohammad Salauddin ◽

Faheem Hyder Pottoo ◽

...

Keyword(s):

Herbal Medicine ◽

Herbal Medicines ◽

New Drugs ◽

Herbal Drugs ◽

Clinical Perspective ◽

Regulatory Status ◽

Novel Drugs ◽

History Of ◽

Pros And Cons ◽

Health Complications

Abstract:: Herbal medicines pays an important in treating the vaious diseases mainly due to the their potentially high therapeutic values and also due to the better acceptance of vaioruspatient under different health complications. The herbal medicine practice involves use of part of plant, entire plant or the selectctive isolated phytomedicineand the use and practices based on these has its pros and cons and has been greatly affected during the dawn. The search of new drugs during scientific era revives the interest in discovery of herbal drugs from different natural resources during 20th century. The present modern healthcare system invovlves utilization drugs and 50% of them are of ofnaural origin. Herbal drug disocovery found to be highly costly affair with low success rate and it hinders the further progress in utilizting the phytomedicine in treating the various deseases. But in recent years there is an increase in the search interest of herbal drugs mainly by the pharmaceutical industry and those invoves in the search of novel drugs from the herbs. Discovery of such new novel phytomedicines has to overcomes various challenges in indentification of active extracts and their toxicity, advereffects, herb drug interaction and importantly their regulatory requirments. The present review mainly focused on the history of herbal medicine, current clinical perspective, pharmaceutical, and regulatory challenges as well as its clinical presentation. Moreover, problems encountered in drug discovery from herbal resources and its possible solutions are delineated.

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