Nhiễm trùng huyết cấy máu dương tính ở bệnh nhân mắc Covid-19

2022 ◽  
Author(s):  
Huu Hieu Dang-Tran
Keyword(s):  
Escherichia Coli ◽  
Blood Culture ◽  
Acinetobacter Baumannii ◽  
Positive Blood Culture ◽  
Burkholderia Cepacia ◽  
Treatment Time ◽  
Bacterial Strains ◽  
Cross Sectional ◽  
Risk Of Death ◽  
Antibiotic Response

TÓM TẮT Đặt vấn đề: Nhiễm Covid-19 đồng thời nhiễm trùng huyết là một bệnh nặng, nguy cơ tử vong cao. Nghiên cứu này nhằm mô tả đặc điểm bệnh nhân Covid-19 nhiễm trùng huyết cấy máu dương tính; đặc điểm vi khuẩn gây nhiễm trùng huyết và mức độ đáp ứng kháng sinh của vi khuẩn trên kháng sinh đồ. Phương pháp nghiên cứu: Mô tả cắt ngang, 26 bệnh nhân Covid-19 cấy máu dương tính từ 8/2021 - 10/2021. Kết quả: 26 bệnh nhân có độ tuổi trung bình 57,89 (nhỏ nhất 32; lớn nhất 78) tuổi, 57,7% bệnh nhân lớn hơn 60 tuổi, nữ nhiều hơn nam, 69,23% bệnh nhân có bệnh nền, thời gian nằm viện trung bình là 16,35 ngày, 84,62% bệnh nhân cấy máu dương tính sau 48 giờ nằm viện, 23,08% bệnh nhân hồi phục sau điều trị. 96,15% bệnh nhân tăng CRP, 100% bệnh nhân tăng Procalcitonin, 86,46% bệnh nhân tăng bạch cầu chung và bạch cầu trung tính. Vi khuẩn gây nhiễm trùng huyết nhiều nhất là Acinetobacter baumannii, Escherichia coli, Burkholderia cepacia với tỷ lệ 19,23% mỗi loại. Vi khuẩn Gram âm nhạy cảm nhiều nhất với nhóm kháng sinh Carbapenem, Aminoglycosid, vi khuẩn Gram dương nhạy cảm nhiều với kháng sinh Linezolid, Vancomycin. Kết luận: Nhiễm trùng huyết trên bệnh nhân Covid làm tăng tỷ lệ tử vong, xác định chủng vi khuẩn và điều trị kháng sinh tích cực phù hợp với từng chủng vi khuẩn là cần thiết. ABSTRACT POSITIVE BLOOD CULTURE SEPSIS IN COVID-19 PATIENTS Background: Infection with Covid 19 and sepsis is a severedisease that leads to a high risk of death. This study aims to describe the characteristics of Covid-19 patients with positive blood culture, elements of bacteria causing sepsis, and the level of antibiotic response of bacteria on the antibiotic chart. Methods: A cross - sectional descriptive study was conducted on 26 Covid-19 patients with positive blood culture 8/2021-10/2021. Result: Twenty - six Covid-19 patients had an average age of 57.89 years (range: 32 - 78). Of these, 57.7% of patients were older than 60 years; women were more than men. 69.23% of patients had a medical history of the disease. The average treatment time was 16.35 days; 84.62% of patients had positive blood cultures after 48 hours of treatment. 23.08% of patients were recovered after treatment. 96.15% of patients increased CRP, 100% of patientsincreased Procalcitonin, and 86.46% increased leukocytosis and neutrophils. The bacteria that caused the most sepsis are Acinetobacter baumannii, Escherichia coli, Burkholderia cepacia with 19.23%. Gram - negative bacteria were most sensitive to Carbapenem, Aminoglycoside antibiotics. Gram - positive bacteria were more susceptible to Linezolid and Vancomycin antibiotics. Conclusion: Sepsis with positive blood culture in covid patients increases the mortality rate. Identifying bacterial strains and appropriate aggressive antibiotic treatment for each bacterial is necessary. Keywords: Sepsis, bacteria, sensitive, Covid-19.

scholarly journals Sepsis Criteria and Revision in Toxicological Intensive Care Unit

2020 ◽  
Vol 10 (4) ◽  
pp. 31452.1-31452.10
Author(s):  
Haleh Talaie ◽  
◽  
Maryam Nazari ◽  
Habib Emami ◽  
◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Blood Culture ◽  
Positive Blood Culture ◽  
Coagulase Negative Staphylococci ◽  
International Consensus ◽  
Suspected Sepsis ◽  
Cross Sectional ◽  
Arterial Blood ◽  
Study Results

Background: Sepsis is one of the significant causes of mortality in hospitalized patients. This cross-sectional study was performed to determine the frequency of positive blood culture and assess sepsis criteria based on Third International Consensus Definitions (related to Sequential Organ Failure Assessment score) and clinical and paraclinical findings (i.e., on-admission leukocytosis, increased lactate level, and fever) in poisoned patients admitted to the Toxicological Intensive Care Unit (TICU). Methods: Medical records of a total of 2000 poisoned patients admitted to the TICU of Loghman Hakim Hospital from 2016 to 2018 were assessed. Among them, 189 cases (9.45%) with suspected sepsis were considered eligible to be enrolled in the study. Results: Of 189 cases, 146 (77.24%) had possible signs and symptoms of sepsis as well as SOFA score higher than two with positive blood culture in 81 cases (55%). The Mean±SD serum level of lactate was 25.97±16.32 on admission. The most common pathogen detected in blood culture was coagulase-negative Staphylococci in 35 (24.0%) out of 146 cases. Glasgow Coma Scale (GCS) less than 12, age older than 50 years, and bilirubin more than 1.2 mg/dL were found as independent predictors of sepsis on multivariate analysis. Conclusion: Based on our findings, it is proposed that the sepsis definition should not be restricted to the guidelines. The patients’ poisoning background and presence of many confounding factors, including poisoning-induced on-admission increased lactate levels, leukocytosis, and disturbed arterial blood gas provide a critical decision-making situation to confirm sepsis according to guidelines.

Clinical Outcomes of Carbapenem-Resistant Acinetobacter baumannii Bloodstream Infections: Study of a 2-State Monoclonal Outbreak

2010 ◽  
Vol 31 (10) ◽  
pp. 1057-1062 ◽  
Author(s):  
L. Silvia Munoz-Price ◽  
Teresa Zembower ◽  
Sudhir Penugonda ◽  
Paul Schreckenberger ◽  
Mary Alice Lavin ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Blood Culture ◽  
Acinetobacter Baumannii ◽  
Bloodstream Infection ◽  
Positive Blood Culture ◽  
Culture Result ◽  
Blood Culture Result ◽  
Carbapenem Resistant ◽  
Single Positive

Objective.To characterize the clinical outcomes of patients with bloodstream infection caused by carbapenem-resistant Acinetobacter baumannii during a 2-state monoclonal outbreak.Design.Multicenter observational study.Setting.Four tertiary care hospitals and 1 long-term acute care hospital.Methods.A retrospective medical chart review was conducted for all consecutive patients during the period January 1, 2005, through April 30, 2006, for whom 1 or more blood cultures yielded carbapenem-resistant A. baumannii.Results.We identified 86 patients from the 16-month study period. Their mortality rate was 41%; of the 35 patients who died, one-third (13) had positive blood culture results for carbapenem-resistant A. baumannii at the time of death. Risk factors associated with mortality were intensive care unit stay, malignancy, and presence of fever and/or hypotension at the time blood sample for culture was obtained. Only 5 patients received adequate empirical antibiotic treatment, but the choice of treatment did not affect mortality.Fifty-seven patients (66.2%) had a single positive blood culture result for carbapenem-resistant A. baumannii; the only factor associated with a single positive blood culture result was the presence of decubitus ulcers. Interestingly, during the study period, a transition from single to multiple positive blood culture results was observed. Four patients, 3 of whom were in a burn intensive care unit, were bacteremic for more than 30 days (range, 36–86 days).Conclusions.To our knowledge, this is the first time a study has described 2 patterns of bloodstream infection with A. baumannii: single versus multiple positive blood culture results, as well as a subset of patients with prolonged bacteremia.

scholarly journals Study of procalcitonin in neonatal sepsis with blood culture in suspected sepsis in North India

2021 ◽  
Vol 8 (7) ◽  
pp. 1241
Author(s):  
Munna Lal Jaipal ◽  
Ajit Kumar Shrivastava ◽  
Prema Ram Choudhary
Keyword(s):  
Blood Culture ◽  
Positive Blood Culture ◽  
Tertiary Care ◽  
Clinical Signs ◽  
North India ◽  
Care Hospital ◽  
Negative Blood Culture ◽  
Suspected Sepsis ◽  
Cross Sectional ◽  
Number Of Patients

Background: Sepsis can occasionally be difficult to demonstrate, and its difference from non-infectious conditions in critically ill patients is often a challenge. Serum procalcitonin (PCT) assay is one of the biomarkers of sepsis. The aim of the study was to investigate the value of procalcitonin, in the early diagnosis of neonatal sepsis.Methods: A cross-sectional study was conducted at tertiary care hospital in New Delhi. It included all neonates with clinical signs of sepsis. The neonates were divided into two groups as sepsis, and healthy neonates. The PCT level was measured by using ELISA technique and compared between the two groups. Statistical analysis was performed using SPSS windows version 20.0 software.Results: In this study total number of patients included 350, out of which 175 were clinically suspected sepsis cases and 175 were healthy controls. 68 (39%) neonates were show positive blood culture and 107 (61%) neonates were representing negative blood culture report in study group. The mean serum value of PCT was significantly (p<0.001) higher in sepsis neonates. The serum PCT value was significantly increased in neonate’s sepsis with positive blood culture (p<0.001) and negative blood culture (p<0.001) as compared to healthy neonates.Conclusions: It is concluded from this study that the PCT assay was established to be a valuable biomarker of sepsis in this study. The assay might be performed and reported quickly and gave precious information before availability of culture results. This might assist in avoiding unnecessary antibiotic therapy.

scholarly journals Investigation of Antimicrobial Susceptibilities Among Bacteria Isolated from Blood Cultures in Hospitalized Patients, Tehran, Iran

2021 ◽  
Vol 16 (2) ◽  
Author(s):  
Shadi Aghamohammad ◽  
Maryam Nouri ◽  
Fatemeh Ashrafian ◽  
Mohtaram Sadat Kashi ◽  
Mehrdad Gholami ◽  
...  
Keyword(s):  
Blood Culture ◽  
Positive Blood Culture ◽  
Antimicrobial Agents ◽  
Clinical Laboratory ◽  
Blood Cultures ◽  
Multi Drug Resistance ◽  
National Committee ◽  
Coagulase Negative Staphylococci ◽  
Gram Positive ◽  
Cross Sectional

Background: Bacteremia is the status, which is detected via a positive blood culture test with no contamination. Centers for Disease Control and Prevention (CDC) indicates that direct medical procedures and total costs are significantly high. Antibiotic resistance can play a major role in the costs, which are related to the long duration of treatment. Objectives: The aim of this study was to investigate the rate and profiles of antimicrobial susceptibility of blood culture isolates from Tehran, Iran. Methods: In the current cross-sectional study, a total of 5,000 blood culture samples were collected from patients hospitalized in the Loghman General Hospital, Tehran, Iran, with positive blood culture results from 2012 to 2013. Susceptibility to antimicrobial agents was analyzed using National Committee for Clinical Laboratory Standards guidelines. Results: Coagulase-negative staphylococci (38.8%), Staphylococcus aureus (20.5%), Acinetobacter (11.9%), and Escherichia coli (11.7%) were the most frequent bacteria isolated from the blood cultures, collectively accounting for > 80% of the isolates. Of isolated microorganisms, 63.75% and 36.24% belonged to Gram-positive and Gram-negative bacteria, respectively. Moreover, 88% of the isolates were MRSA (oxacillin-/methicillin-resistant), and 7% were VRE (vancomycin-resistant). Conclusions: The most frequent isolated organisms were Gram-positive bacteria, and the rate of MDR (multi-drug resistance) was high. The results of the current study obviously indicate the misuse of antibiotic in society. National surveillance studies in Iran will be useful for clinicians to choose the right empirical treatment and will help control and prevent infections caused by resistant organisms.

Antibiotic Susceptibility Patterns in the NICU of Ghaem Hospital of Mashhad

2021 ◽  
Author(s):  
Hassan Boskabadi ◽  
Elahe Heidari ◽  
Fatemeh Bagheri ◽  
Maryam Zakerihamidi
Keyword(s):  
Blood Culture ◽  
Positive Blood Culture ◽  
Neonatal Sepsis ◽  
Antibiotic Susceptibility ◽  
Clinical Signs ◽  
High Sensitivity ◽  
Signs And Symptoms ◽  
Clinical Syndrome ◽  
Cross Sectional ◽  
E Coli

Background and Aims: Neonatal sepsis is considered a clinical syndrome characterized by signs and symptoms of infection associated with positive blood culture. The present study investigates the rate of sensitivity and resistance to antibiotics in neonates with definite sepsis. Materials and Methods: This cross-sectional study was conducted on 268 neonates with definitive sepsis (positive blood culture with clinical signs of infection) hospitalized in the NICU of Ghaem Hospital of Mashhad, from 2008 to 2018. To investigate the antibiotic susceptibility pattern, identifying microorganism and antibiogram tests was performed according to the standard microbiological method. The data were collected through a questionnaire designed by the researchers. It included neonates’ characteristics, types of microorganisms in neonatal unite, and sensitivity and resistance to neonatal sepsis’s common microorganism. Results: Based on the results, Klebsiella showed sensitivity to norfloxacin (100%), ciprofloxacin (100%), meropenem (100%), imipenem (94%), cotrimoxazole (73%), and vancomycin (67%). Similarly, Enterobacter showed 100% sensitivity to ciprofloxacin, meropenem, norfloxacin, and high sensitivity to imipenem (94%) and co-trimoxazole (83%). Acinetobacter turned out to be sensitive to co-trimoxazole and norfloxacin (both of them were 67%) and to amikacin in 33% of the cases. E. coli was sensitive to imipenem (83.33%), ciprofloxacin (80%), and ceftazidime (71.43%). Finally, staphylococcus coagulase negative was sensitive to piperacillin in 100%, vancomycin in 96.67%, and imipenem in 71.43% of the cases. Conclusions: The findings of the present study suggest that high-sensitivity drugs for the treatment of definite neonatal sepsis are Meropenem(Klebsiella and E. coli), Enterobacter(Ampicilin), Acinetobacter(Imipenem) and Staphylococcus coagulase negative (vancomycin).

ANTIBIOTIC SUSCEPTIBILITY OF BACTERIAL STRAINS, WITH SPECIAL REFERENCE TO ESCHERICHIA COLI ISOLATED FROM URINARY TRACT INFECTIONS IN RURAL MAHARASHTRA

2016 ◽  
Vol 10 (1) ◽  
pp. 202
Author(s):  
Sunil Shivaputrayya Gidamudi ◽  
Gaurav V Salunke
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Multiple Antibiotic Resistance ◽  
Bacterial Strains ◽  
Cross Sectional ◽  
E Coli ◽  
Sensitivity Pattern ◽  
Tract Infections

ABSTRACTObjective: The objective of this study was to find out the etiology of urinary tract infections (UTIs) in patients attending B.K.L. Walawalkar Hospital,Dervan and to determine their antibiotic sensitivity pattern to currently used antimicrobial agents.Methods: A cross-sectional study was conducted in a rural hospital of Konkan Maharashtra, and urine samples were collected from368 clinically - suspected cases of UTIs using the mid-stream “clean catch” method and was tested and cultured using standard procedures. Antimicrobialsusceptibility test (AST) was performed for the isolated pathogens according to the Clinical and Laboratory Standards Institute guidelines.Results: Escherichia coli (54.84%) was the most prevalent uropathogen. 76.47% of the isolated E. coli were found to be extended spectrum betalactamase producers. A higher prevalence rate of resistance was seen among E. coli to the commonly prescribed antibiotic agents. 32 (94.11%) of34 E. coli isolates recovered had multiple antibiotic resistance (MAR), with 16 isolates (50%) possessing MAR indices of 0.6.Conclusion: The study indicates the isolated microorganisms in UTI showed very high resistance to the commonly prescribed antimicrobial drugs.This suggests the monitoring and rational use of the antimicrobial agents.Keywords: Mid-stream, Culture, Uropathogen, Resistance, Multiple antibiotic resistance.

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