Connecting the Bench with the Bedside

2011 ◽  
pp. 249-267
Author(s):  
Yue Wang Webster ◽  
Ernst R Dow ◽  
Mathew J Palakal
Keyword(s):  
Complex System ◽  
Colorectal Cancer ◽  
Conceptual Framework ◽  
Translational Research ◽  
Dynamic Process ◽  
Hybrid Approach ◽  
Disease Area ◽  
Cancer Disease ◽  
Clinical Observations ◽  
Hypotheses Generation

Even though numerous tools and technologies have been developed to meet this need with various degrees of success, a conceptual framework is needed to fully realize the value of those tools and technologies. The authors propose Complex System (CS) to be the logical foundation of such a framework. Since translational research is a spiral and dynamic process. With the CS mindset, they designed a multi-layer architecture called HyGen (Hypotheses Generation Framework) to address the challenges faced by translational researchers. In order to evaluate the framework, the authors carried out heuristic and quantitative tests in Colorectal Cancer disease area. The results demonstrate the potential of this hybrid approach to bridge silos and to identify hidden links among clinical observations, drugs, genes and diseases, which may eventually lead to the discovery of novel disease targets, biomarkers and therapies.

Determinants of dynamic process of emerging ICT adoption in SMEs – actor network theory perspective

2019 ◽  
Vol 10 (1) ◽  
pp. 2-34 ◽  
Author(s):  
Sunday C. Eze ◽  
Vera C. Chinedu-Eze ◽  
Adenike O. Bello
Keyword(s):  
Dynamic Process ◽  
Network Theory ◽  
Hybrid Approach ◽  
Actor Network Theory ◽  
Adoption Process ◽  
Actor Network ◽  
Content Type ◽  
One Stage ◽  
Factors Influencing ◽  
Ict Adoption

PurposeWhile traditional theories of information and communication technology (ICT) adoption have been deployed to study ICT adoption in the past, these theories considers ICT adoption as static and rely on conceptualising factors as variables and predicting their levels of outcome at a single decision stage. Although much has been credited to these theories, they have continuously ignored the fact that as decisions to adopt are made and challenged along the adoption process, such decision can be influenced by the same, different or combination of factors at different stages of the adoption process. This paper aims to examine ICT adoption from a dynamic process perspective and to explore the key determinants and how these differ from one stage of the adoption process to another.Design/methodology/approachQualitative method was adopted in this study. Both unstructured and semi-structured interviews were conducted in two separate stages using purposeful random sampling. Hybrid approach of thematic analysis was adopted in analysing the data.FindingsThis study develops a framework informed by actor network theory (ANT) concepts and finds that using ANT to examine the process of adoption helps to unveil the recursive nature of the process. The study reveals that the 14 determinants identified in this study influenced adoption at different stages. Factors such as ease of use, managerial time, customer focus and adoption influenced adoption at all the stages. This reveals that factors influencing ICT adoption are not static at one particular stage rather it may influence ICT adoption at different stages.Research limitations/implicationsQualitative research is often subjective and interpretive in nature, and one of the limitations is the sample used in this research. Considering the small number of interviews carried out in this study, the generalisation of finding and the framework remains to be established across a wider population. Therefore, the factors presented could be limited considering that a number of practitioners that are involved in establishing emerging ICT are numerous. Therefore, other factors are prevailing to other industries or sectors that may provide scholars another way of examining these factors. Also, the framework demonstrates that it is a valuable analytical tool for researchers to examine how and why different actors including small and medium enterprise (SME) managers act around emerging ICT.Originality/valueThis study develops a framework that revealed the interactive and recursive nature of ICT adoption and the determinants influencing the process of ICT adoption at different stages thereby advancing ICT adoption research. The study challenges researchers to always consider ICT adoption as dynamic and unpredictable instead of one-off action as factors influencing its adoption are not static rather; they vary from one stage to another.

scholarly journals Molecular and Translational Research on Colorectal Cancer

2020 ◽  
Vol 21 (11) ◽  
pp. 4105
Author(s):  
Alessandro Passardi ◽  
Emanuela Scarpi ◽  
Paola Ulivi
Keyword(s):  
Colorectal Cancer ◽  
Translational Research ◽  
The Third ◽  
The World

Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world [...]

A Dynamic Conceptual Framework of Generalized Adaptation to Stressful Stimuli

1976 ◽  
Vol 38 (1) ◽  
pp. 319-334 ◽  
Author(s):  
Bradford S. Wild ◽  
Carolyn Hanes
Keyword(s):  
Environmental Factors ◽  
Conceptual Framework ◽  
Adaptive Behavior ◽  
Dynamic Process ◽  
Empirical Investigation ◽  
The Other ◽  
Adaptation To Stress ◽  
Parallel Processes ◽  
Environmental Demands

This paper reviews the currently popular definitions and theoretical arguments of the so-called “stress” perspective with the purpose of integrating this material into one general paradigm. The literature has been concerned primarily with two parallel processes which purport to account for the individual's coping and adaptive behavior, one characterized by the interplay of internal, psychological forces, and the other by external, environmental factors. These two general processes have been integrated in this paper by expanding upon the general models presented by Dohrenwend (7) to include important feedback processes. It is argued that adaptation to stress is a dynamic process and that the failure to adapt is often the result of a continuing process of past failures by the organism effectively to cope with less severe stressful stimuli, each failure feeding back to affect future attempts to cope with new environmental demands. The implications of the approach presented in this paper for future empirical investigation are discussed.

Abstract 3166: Querying, viewing and analyzing colorectal cancer translational research studies in tranSMART

2016 ◽  
Author(s):  
Mariska Bierkens ◽  
Wim van der Linden ◽  
Ward Weistra ◽  
Kees van Bochove ◽  
Jeroen A.M. Beliën ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Translational Research ◽  
Research Studies

scholarly journals Potential contribution of the study nurse to colorectal cancer (CRC) translational research

2017 ◽  
Vol 28 ◽  
pp. vi110 ◽  
Author(s):  
I. Rigotto ◽  
M. Schirripa ◽  
D. Costardi ◽  
F. Loupakis ◽  
C. Magro ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Translational Research ◽  
Potential Contribution ◽  
Study Nurse

scholarly journals Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations

2017 ◽  
Vol 11 ◽  
pp. 117955491769076 ◽  
Author(s):  
Knut Magne Augestad ◽  
Marianne A Merok ◽  
Dejan Ignatovic
Keyword(s):  
Colorectal Cancer ◽  
Genetic Factors ◽  
Treatment Approach ◽  
Cancer Recurrence ◽  
Postoperative Phase ◽  
Cancer Disease ◽  
Tailored Treatment ◽  
Surgical Complexity ◽  
The Individual ◽  
Rectal Anatomy

Colorectal cancer (CRC) is a complex cancer disease, and approximately 40% of the surgically cured patients will experience cancer recurrence within 5 years. During recent years, research has shown that CRC treatment should be tailored to the individual patient due to the wide variety of risk factors, genetic factors, and surgical complexity. In this review, we provide an overview of the considerations that are needed to provide an individualized, patient-tailored treatment. We emphasize the need to assess the predictors of CRC, and we summarize the latest research on CRC genetics and immunotherapy. Finally, we provide a summary of the significant variations in the colon and rectal anatomy that is important to consider in an individualized surgical approach. For the individual patient with CRC, a tailored treatment approach is needed in the preoperative, operative, and postoperative phase.

An Advanced Automatic Electronic Diagnosis System

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Prabhakar Dubey ◽  
Mahendra Kumar
Keyword(s):  
Complex System ◽  
Personal Experience ◽  
Digital Circuits ◽  
Diagnostic Process ◽  
Diagnostic Equipment ◽  
Diagnosis System ◽  
Technical Diagnosis ◽  
Design Engineers ◽  
General Terms ◽  
Hypotheses Generation

Every complex system is liable to faults and failures. In the most general terms, a fault is any change in a system that prevents it from operating in the proper manner. Here, the diagnosis of catastrophic defects in complex digital circuits. In fact, today the technical diagnosis is great challenge for design engineers because diagnostic problems are generally under determinate. It is also a deductive process with one set of data creating, in general, unlimited number of hypotheses among which one should try to get the solution. So the diagnosis methods are based on proprietary knowledge and personal experience, although they were built into integrated diagnostic equipment. The approach proposed here is an alternative to existing solutions, and it is expected to encompass all phases of the diagnostic process: symptom detection, hypotheses generation, and hypotheses discrimination.

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