Potential Health Benefits of Fenugreek With Multiple Pharmacological Properties

2022 ◽  
pp. 672-687
Author(s):  
Akanksha Srivastava ◽  
Zoomi Singh ◽  
Vandana Verma ◽  
Tashi Choedon
Keyword(s):  
Natural Food ◽  
Efficacy And Safety ◽  
Antidiabetic Agent ◽  
Potential Health ◽  
Toxicological Effects ◽  
Anticancer Properties ◽  
Food Texture ◽  
Fiber Protein ◽  
Emulsifying Agent ◽  
Gum Content

Fenugreek is one of the familiar spices found in human food and has been used extensively for curing numerous disorders. It provides natural food fibers and other nutrients required in the human body. It is used in functional foods, traditional foods, and nutraceuticals as well as in physiological uses such as antidiabetic agent, antibacterial, hypocholesterolemic, hypoglycemic, antioxidant, enzymatic pathway, and modifier gastric stimulant. It has a valuable influence on digestion and also has the capability to modify food texture. In modern food technology, it is used as a food stabilizer, adhesive, and emulsifying agent due its fiber, protein, and gum content. Recent pharmocological exploration of the seed extract of this plant discovered anticancer properties. Although it has many potential effects, there are some side effects as well; therefore, there is a greater need to study the pharmacological and toxicological effects of fenugreek to examine its clinical efficacy and safety.

Potential Health Benefits of Fenugreek With Multiple Pharmacological Properties

2020 ◽  
pp. 137-153 ◽  
Author(s):  
Akanksha Srivastava ◽  
Zoomi Singh ◽  
Vandana Verma ◽  
Tashi Choedon
Keyword(s):  
Natural Food ◽  
Efficacy And Safety ◽  
Antidiabetic Agent ◽  
Potential Health ◽  
Toxicological Effects ◽  
Anticancer Properties ◽  
Food Texture ◽  
Fiber Protein ◽  
Emulsifying Agent ◽  
Gum Content

Fenugreek is one of the familiar spices found in human food and has been used extensively for curing numerous disorders. It provides natural food fibers and other nutrients required in the human body. It is used in functional foods, traditional foods, and nutraceuticals as well as in physiological uses such as antidiabetic agent, antibacterial, hypocholesterolemic, hypoglycemic, antioxidant, enzymatic pathway, and modifier gastric stimulant. It has a valuable influence on digestion and also has the capability to modify food texture. In modern food technology, it is used as a food stabilizer, adhesive, and emulsifying agent due its fiber, protein, and gum content. Recent pharmocological exploration of the seed extract of this plant discovered anticancer properties. Although it has many potential effects, there are some side effects as well; therefore, there is a greater need to study the pharmacological and toxicological effects of fenugreek to examine its clinical efficacy and safety.

scholarly journals Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series

2016 ◽  
Vol 9 (1) ◽  
pp. e2017004 ◽  
Author(s):  
Shahrzad Zonoozi
Keyword(s):  
Diabetes Mellitus ◽  
Case Series ◽  
Close Monitoring ◽  
Thalassaemia Major ◽  
Efficacy And Safety ◽  
Antidiabetic Agent ◽  
Retrospective Case ◽  
Beta Thalassaemia ◽  
Equivalent Reduction

Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However there is paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM).This retrospective case series of five patients (mean age of 45 years) is the first study evaluating the use of sitagliptin in patients with β-TM and DM.Four patients responded well to sitagliptin, as evidenced by decrease in fructosamine by 77 and 96µmol/L (equivalent reduction in HbA1c of 1.5% and 1.9%) observed in two patients and reduction in the frequency of hypoglycaemia without worsening glycaemic control in two others. One patient did not respond to sitagliptin. No patients reported significant side effects.This study provides evidence that sitagliptin may be considered, with caution, for use in patients with β-TM and DM, under the close monitoring of a Diabetologist.

scholarly journals Black Tea Flavonoids: A Focus on Thearubigins and their Potential Roles in Diet & Health

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Bond JT ◽  
Derbyshire JE
Keyword(s):  
Health Outcomes ◽  
Observational Studies ◽  
Black Tea ◽  
Laboratory Studies ◽  
Mechanistic Studies ◽  
Potential Health ◽  
Anticancer Properties ◽  
Growing Body ◽  
The Uk ◽  
Specific Health

The potential health benefits of black tea are well documented but the specific roles of thearubigins are less widely published. We undertook a review to identify human observational studies and laboratory studies investigating inter-relationships between thearubigin intakes and health. Twenty-two publications were identified-five observational studies and 17 laboratory/mechanistic studies. Evidence from observational studies demonstrates that black tea is a major dietary provider of thearubigins, with reported intakes of 327 mg/d in the UK, a nation of tea drinkers but lower in Europe (156 mg/d). A growing body of evidence (from laboratory/cell studies) signifies that thearubigins could have potential health roles, including antioxidant, antimutagenic and anticancer properties, along with the ability to reduce inflammation and improve gastrointestinal motility. Well-designed human trials are now needed to further investigate thearubigin intakes from dietary sources in relation to specific health outcomes.

scholarly journals Amygdalin laetrile-a nascent vitamin B17: a review

2021 ◽  
Vol 9 (7) ◽  
pp. 2160
Author(s):  
Aparajeeta Bora ◽  
Wilma Delphine Silvia C. R. ◽  
Shrabani Mohanty ◽  
Venkata Bharat Kumar Pinnelli
Keyword(s):  
Clinical Trials ◽  
Alternative Medicine ◽  
Cancer Prevention ◽  
Anticancer Activity ◽  
Low Cost ◽  
Food Sources ◽  
Natural Food ◽  
Toxicological Effects ◽  
Synthetic Product ◽  
Wide Availability

Amygdalin is also called Vitamin B17 and its semi synthetic product is laetrile. It is a natural glycoside nutrient which gained popularity due to wide availability and low cost in treating various diseases. Vitamin B17 is derived from natural food sources and can be used for cancer prevention in alternative medicine practices. This review illustrates the proposed anticancer activity and other effects of amygdalin on different body systems along with a variety of clinical trials on humans and animals with pharmacological, toxicological effects and provides a perspective for further investigation and research.

scholarly journals A Comprehensive Review on the Synthesis, Characterization, and Biomedical Application of Platinum Nanoparticles

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1719 ◽  
Author(s):  
Muniyandi Jeyaraj ◽  
Sangiliyandi Gurunathan ◽  
Muhammad Qasim ◽  
Min-Hee Kang ◽  
Jin-Hoi Kim
Keyword(s):  
Platinum Nanoparticles ◽  
Current Knowledge ◽  
Biomedical Application ◽  
Biological Synthesis ◽  
Stabilizing Agents ◽  
Toxicological Effects ◽  
Anticancer Properties ◽  
Automotive Catalytic Converters

Platinum nanoparticles (PtNPs) are noteworthy scientific tools that are being explored in various biotechnological, nanomedicinal, and pharmacological fields. They are unique because of their large surface area and their numerous catalytic applications such as their use in automotive catalytic converters and as petrochemical cracking catalysts. PtNPs have been widely utilized not only in the industry, but also in medicine and diagnostics. PtNPs are extensively studied because of their antimicrobial, antioxidant, and anticancer properties. So far, only one review has been dedicated to the application of PtNPs to nanomedicine. However, no studies describe the synthesis, characterization, and biomedical application of PtNPs. Therefore, the aim of this review is to provide a comprehensive assessment of the current knowledge regarding the synthesis, including physical, chemical, and biological and toxicological effects of PtNPs on human health, in terms of both in vivo and in vitro experimental analysis. Special attention has been focused on the biological synthesis of PtNPs using various templates as reducing and stabilizing agents. Finally, we discuss the biomedical and other applications of PtNPs.

scholarly journals Amaranth Sprouts: A Potential Health Promoting and Nutritive Natural Food

2015 ◽  
Vol 18 (12) ◽  
pp. 2688-2698 ◽  
Author(s):  
Paula Aphalo ◽  
E. Nora Martínez ◽  
María Cristina Añón
Keyword(s):  
Natural Food ◽  
Potential Health ◽  
Health Promoting

A review on chemistry, source and therapeutic potential of lambertianic acid

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Md Shahinozzaman ◽  
Moutushi Islam ◽  
Bristy Basak ◽  
Arifa Sultana ◽  
Rashiduzzaman Emran ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Bioactive Compound ◽  
Cancer Cell Proliferation ◽  
Neuroprotective Effects ◽  
Potential Health ◽  
Anticancer Properties ◽  
Toxicological Profile ◽  
Lambertianic Acid

Abstract Lambertianic acid (LA) is a diterpene bioactive compound mainly purified from different species of Pinus. It is an optical isomer of another natural compound daniellic acid and was firstly purified from Pinus lambertiana. LA can be synthesized in laboratory from podocarpic acid. It has been reported to have potential health benefits in attenuating obesity, allergies and different cancers including breast, liver, lung and prostate cancer. It exhibits anticancer properties through inhibiting cancer cell proliferation and survival, and inducing apoptosis, targeting major signalling components including AKT, AMPK, NFkB, COX-2, STAT3, etc. Most of the studies with LA were done using in vitro models, thus warranting future investigations with animal models to evaluate its pharmacological effects such as antidiabetic, anti-inflammatory and neuroprotective effects as well as to explore the underlying molecular mechanisms and toxicological profile. This review describes the chemistry, source, purification and therapeutic potentials of LA and it can therefore be a suitable guideline for any future study with LA.

scholarly journals Chemotherapeutic and Safety Profile of a Fraction from Mimosa caesalpiniifolia Stem Bark

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Paulo Michel Pinheiro Ferreira ◽  
Renata Rosado Drumond ◽  
Jurandy do Nascimento Silva ◽  
Ian Jhemes Oliveira Sousa ◽  
Marcus Vinicius Oliveira Barros de Alencar ◽  
...  
Keyword(s):  
Betulinic Acid ◽  
Primary Cultures ◽  
Stem Bark ◽  
Toxicological Effects ◽  
Anticancer Properties ◽  
Viable Cells ◽  
Antiproliferative Action ◽  
Loss Of Weight

Mimosa caesalpiniifolia (Fabaceae) is used by Brazilian people to treat hypertension, bronchitis, and skin infections. Herein, we evaluated the antiproliferative action of the dichloromethane fraction from M. caesalpiniifolia (DFMC) stem bark on murine tumor cells and the in vivo toxicogenetic profile. Initially, the cytotoxic activity of DFMC on primary cultures of Sarcoma 180 (S180) cells by Alamar Blue, trypan, and cytokinesis block micronucleus (CBMN) assays was assessed after 72 h of exposure, followed by the treatment of S180-bearing Swiss mice for 7 days, physiological investigations, and DNA/chromosomal damage. DFMC and betulinic acid revealed similar in vitro antiproliferative action on S180 cells and induced a reduction in viable cells, induced a reduction in viable cells and caused the emergence of bridges, buds, and morphological features of apoptosis and necrosis. S180-transplanted mice treated with DFMC (50 and 100 mg/kg/day), a betulinic acid-rich dichloromethane, showed for the first time in vivo tumor growth reduction (64.8 and 80.0%) and poorer peri- and intratumor quantities of vessels. Such antiproliferative action was associated with detectible side effects (loss of weight, reduction of spleen, lymphocytopenia, and neutrophilia and increasing of GOT and micronucleus in bone marrow), but preclinical general anticancer properties of the DFMC were not threatened by toxicological effects, and these biomedical discoveries validate the ethnopharmacological reputation of Mimosa species as emerging phytotherapy sources of lead molecules.

scholarly journals Health aspects of Spirulina (Arthrospira) microalga food supplement

2013 ◽  
Vol 78 (3) ◽  
pp. 395-405 ◽  
Author(s):  
Theodore Sotiroudis ◽  
Georgios Sotiroudis
Keyword(s):  
Side Effects ◽  
Essential Fatty Acids ◽  
Essential Amino Acids ◽  
Food Supplement ◽  
Sulfated Polysaccharides ◽  
Natural Food ◽  
Expert Committee ◽  
Filamentous Cyanobacterium ◽  
Potential Health ◽  
History Of Use

Spirulina, now named Arthrospira, is a microscopic and filamentous cyanobacterium that has a long history of use as a safe food lacking toxicity. It is commercially produced in large outdoor ponds under controlled conditions. The aim of this review article is to summarize available recent information concerning human clinical potential and applications of Spirulina, as well as clinical data related to the safety and side effects of Spirulina. Potential health benefits of Spirulina are mainly due to its chemical composition, which includes proteins (the highest protein content of any natural food, 55%-70%), carbohydrates, essential amino acids, minerals (especially iron), essential fatty acids, vitamins, and pigments. In this respect, three major bioactive components of Spirulina, the protein phycocyanin (a biliprotein pigment), sulfated polysaccharides and gamma linolenic acid seem to play significant role in imparting improved human body functions. Furthermore, new experimental evidence supports the immunomodulation and antiviral effects of Spirulina supplementation. According to the Dietary Supplements Information Expert Committee of United States Pharmacopeial Convention the available clinical evidence does not indicate a serious risk to health or other public health concerns for Spirulina. However, a few cases of severe side-effects have been reported.

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