Emerging Pandemic COVID 19 versus SARS-COV-1

2022 ◽  
Vol 7 (1) ◽  
pp. 0-0
Keyword(s):  
Clinical Trials ◽  
Global Health ◽  
Disease Progression ◽  
Current Status ◽  
Normal Life ◽  
Global Pandemic ◽  
Similarities And Differences ◽  
Bioinformatic Approach ◽  
Potential Therapeutics

Rising threat of the global pandemic COVID 19 has become the major cause of concern among nations worldwide. The appalling pandemic has aggravated the global health of people making normal life come to a virtual standstill. The purpose of this study is to investigate and compare the similarities and differences between the previous global pandemic outbreak SARS-COV-1 with that of COVID 19. It makes use of a bioinformatic approach to analyze why COVID 19 has made situations uncontrollable as opposed to that of SARS-COV-1 although both belong to the same coronavirus family. Discusses about the recent clinical trials that are being conducted to evaluate potential therapeutics to combat the deadly pandemic. There is currently no available vaccine for COVID 19. E The current status of COVID 19 research stands progressive in various areas of knowledge. Further studies based on emerging evidences are required to produce drugs which can slow down disease progression and improve survival.

scholarly journals Male Contraceptives: Present and Future Approaches

2017 ◽  
pp. 1-12
Keyword(s):  
Clinical Trials ◽  
Global Health ◽  
Sexually Transmitted Diseases ◽  
Current Status ◽  
Sexually Transmitted ◽  
Full Control ◽  
Surgical Methods ◽  
Younger Men ◽  
Global Health Issue ◽  
Unwanted Pregnancies

There is general agreement that men, like women, must take full control of their fertility, an important global health issue. However, the contraceptives for preventing pregnancy that primarily involve male physiology have not changed in the last century. These options are still limited to the non-surgical methods of the use of a condom, abstinence, and a timely withdrawal (coitus interrupts) or the surgical approach of vas occlusion (vasectomy) that prevents sperm from being released during ejaculation. When not defective and used correctly, condoms are effective in preventing unwanted pregnancies as well as providing protection against sexually transmitted diseases. However, condoms, abstinence and timely withdrawal approaches have relatively higher typical-use failure rates whereas vasectomy is largely irreversible and not suitable for younger men. Thus, providing a safe, effective, reversible and affordable contraceptive for men has remained an elusive goal. In this article, we intend to discuss many details of currently available contraceptives for men, the current status of the research and development of non-surgical male contraceptives and also to describe experimental details of three intra-vas approaches that are undergoing advanced clinical trials and may soon be available for men to regulate their fertility. Finally, we will introduce the “sperm switch” approach. This is the latest invention that will allow men to decide if and when to ejaculate spermatozoa during coitus. The availability of several safe, effective, reversible and affordable contraceptives will allow men to take full control of their fertility.

scholarly journals Male Contraceptives: Present and Future Approaches

2017 ◽  
pp. 1-12
Keyword(s):  
Clinical Trials ◽  
Global Health ◽  
Sexually Transmitted Diseases ◽  
Current Status ◽  
Sexually Transmitted ◽  
Full Control ◽  
Surgical Methods ◽  
Younger Men ◽  
Global Health Issue ◽  
Unwanted Pregnancies

There is general agreement that men, like women, must take full control of their fertility, an important global health issue. However, the contraceptives for preventing pregnancy that primarily involve male physiology have not changed in the last century. These options are still limited to the non-surgical methods of the use of a condom, abstinence, and a timely withdrawal (coitus interrupts) or the surgical approach of vas occlusion (vasectomy) that prevents sperm from being released during ejaculation. When not defective and used correctly, condoms are effective in preventing unwanted pregnancies as well as providing protection against sexually transmitted diseases. However, condoms, abstinence and timely withdrawal approaches have relatively higher typical-use failure rates whereas vasectomy is largely irreversible and not suitable for younger men. Thus, providing a safe, effective, reversible and affordable contraceptive for men has remained an elusive goal. In this article, we intend to discuss many details of currently available contraceptives for men, the current status of the research and development of non-surgical male contraceptives and also to describe experimental details of three intra-vas approaches that are undergoing advanced clinical trials and may soon be available for men to regulate their fertility. Finally, we will introduce the “sperm switch” approach. This is the latest invention that will allow men to decide if and when to ejaculate spermatozoa during coitus. The availability of several safe, effective, reversible and affordable contraceptives will allow men to take full control of their fertility.

scholarly journals Current Status of HIV-1 Vaccines

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1026
Author(s):  
Anna Hargrave ◽  
Abu Salim Mustafa ◽  
Asma Hanif ◽  
Javed H. Tunio ◽  
Shumaila Nida M. Hanif
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Global Health ◽  
Low Income ◽  
Vaccine Development ◽  
Low Income Countries ◽  
Current Status ◽  
Health Challenge ◽  
Hiv 1 ◽  
Global Health Challenge

HIV-1 infection and its progression to AIDS remains a significant global health challenge, particularly for low-income countries. Developing a vaccine to prevent HIV-1 infections has proven to be immensely challenging with complex biological acquisition and infection, unforeseen clinical trial disappointments, and funding issues. This paper discusses important landmarks of progress in HIV-1 vaccine development, various vaccine strategies, and clinical trials.

scholarly journals Understanding COVID-19: From Origin to Potential Therapeutics

2020 ◽  
Vol 17 (16) ◽  
pp. 5904
Author(s):  
Muhammad Moazzam ◽  
Muhammad Imran Sajid ◽  
Hamza Shahid ◽  
Jahanzaib Butt ◽  
Irfan Bashir ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Infections ◽  
Middle Eastern ◽  
Clinical Manifestations ◽  
Current Status ◽  
The Public ◽  
Global Pandemic ◽  
First Case ◽  
Human Coronaviruses ◽  
Potential Therapeutics

Currently, a global pandemic era of public health concerns is going on with the Coronavirus Disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The first case of COVID-19 was reported from Wuhan’s Huanan seafood market in China late December 2019. Bats, pangolins, and snakes have been nominated as salient carriers of the virus. Thanks to its high pathogenicity, it can cause severe respiratory infections. Fever, dry cough, sore throat, pneumonia, septic shock, and ground-glass opacities are the foremost clinical manifestations of COVID-19. Immunocompromised patients are at high risk for COVID-19 infection and may lead to death. Scientist and government agencies around the globe are putting forward their best efforts and resources for the effective treatment of human coronavirus infections; however, neither vaccines nor antiviral drugs are available for the treatment of human coronaviruses (HCoV) infections such as SARS (severe acute respiratory syndrome), MERS (Middle Eastern respiratory syndrome), and COVID-19. Since the outbreak, a plethora of research and review articles have been published. Moreover, the mass media has bombarded the public with conflicting opinions about the pandemic. There is a dire need for accurate and reliable information concerning this pandemic. In this review, we have compiled the up to date information about the origins, evolution, epidemiology, and pathogenesis of this disease. Moreover, very few reports have addressed the clinical features and current status of treatment for COVID-19; we have adequately addressed these topics in detail in this review. Finally, a detailed account of clinical trials of vaccines and other therapeutics currently in progress has been delineated.

Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity and Pathogenesis?

2020 ◽  
Author(s):  
Angelo Spinello ◽  
Andrea Saltalamacchia ◽  
Alessandra Magistrato
Keyword(s):  
Health Economic ◽  
Global Health ◽  
Receptor Binding ◽  
Binding Motif ◽  
Spike Glycoprotein ◽  
High Affinity ◽  
Global Pandemic ◽  
Medical Countermeasures ◽  
High Infectivity ◽  
Human Receptor

<p>The latest outbreak of a new pathogenic coronavirus (SARS-CoV-2) is provoking a global health, economic and societal crisis. All-atom simulations enabled us to uncover the key molecular traits underlying the high affinity of SARS-CoV-2 spike glycoprotein towards its human receptor, providing a rationale to its high infectivity. Harnessing this knowledge can boost developing effective medical countermeasures to fight the current global pandemic.</p>

The Structural Landscape of SARS-CoV-2 Main Protease: Hints for Inhibitor Search.

2020 ◽  
Author(s):  
Luigi Leonardo Palese
Keyword(s):  
Comparative Analysis ◽  
Global Health ◽  
Binding Site ◽  
Causative Agent ◽  
Data Set ◽  
Substrate Binding Site ◽  
Global Pandemic ◽  
Main Protease ◽  
Crystallographic Structures ◽  
Structural Aspects

In 2019, an outbreak occurred which resulted in a global pandemic. The causative agent of this serious global health threat was a coronavirus similar to the agent of SARS, referred to as SARS-CoV-2. In this work an analysis of the available structures of the SARS-CoV-2 main protease has been performed. From a data set of crystallographic structures the dynamics of the protease has been obtained. Furthermore, a comparative analysis of the structures of SARS-CoV-2 with those of the main protease of the coronavirus responsible of SARS (SARS-CoV) was carried out. The results of these studies suggest that, although main proteases of SARS-CoV and SARS-CoV-2 are similar at the backbone level, some plasticity at the substrate binding site can be observed. The consequences of these structural aspects on the search for effective inhibitors of these enzymes are discussed, with a focus on already known compounds. The results obtained show that compounds containing an oxirane ring could be considered as inhibitors of the main protease of SARS-CoV-2.

Clinical Epidemiology of Coronavirus Disease 2019:Defined on Current Research

2020 ◽  
pp. 54-72 ◽  
Author(s):  
Fengyu Zhang ◽  
Claude Hughes
Keyword(s):  
Clinical Presentation ◽  
Population Distribution ◽  
Clinical Epidemiology ◽  
Case Fatality ◽  
Immunological Response ◽  
Prevention Strategies ◽  
Clinical Type ◽  
Global Pandemic ◽  
Potential Therapeutics

Coronavirus disease 2019 (COVID-19) is a new infectious respiratory disease that has caused the ongoing global pandemic. The primary purpose of this article is to describe evolving clinical epidemiology of COVID-19, including 1) infection and testing, 2) clinical spectrum including classification of clinical type, asymptomatic cases, severe cases and comorbidity, and clinical and immunological response, 3) regional variation in clinical presentation, 4) population distribution by age, sex, and occupation, and finally, 5) case-fatality. This content may provide important information on detailed clinical type and presentation of the disease, in which appropriate clinical outcomes can be derived for developing prevention strategies and clinical studies or trials that aim to test potential therapeutics or products for different patient populations.

scholarly journals Experiences of Intimate Partner Violence during Lockdown and the COVID-19 Pandemic

2021 ◽  
Author(s):  
Minna Lyons ◽  
Gayle Brewer
Keyword(s):  
Intimate Partner Violence ◽  
Global Health ◽  
Thematic Analysis ◽  
Partner Violence ◽  
Intimate Partner ◽  
Substantial Impact ◽  
Female Victims ◽  
Global Pandemic ◽  
Qualitative Thematic Analysis ◽  
Service Disruption

AbstractPrevious studies have demonstrated that there is an increase in Intimate Partner Violence (IPV) during times of crisis (e.g., financial, environmental, or socio-political situations). The COVID-19 pandemic has triggered an unprecedented global health and financial tragedy, but research is yet to establish exactly how the situation may impact on IPV. The present study investigates victims’ experience of IPV during lockdown and the COVID-19 pandemic. We report a qualitative thematic analysis of 50 discussion forum posts written by victims of IPV. Of these, 48 forum posts were written by female victims of male perpetrated violence. All forum posts were obtained from the popular online platform, Reddit. We identified four themes associated with IPV victims’ experiences during lockdown and the global pandemic: (i) Use of COVID-19 by the Abuser, (ii) Service Disruption, (iii) Preparation to Leave, and (iv) Factors Increasing Abuse or Distress. The COVID-19 pandemic has had a substantial impact on those living with IPV, often increasing the severity of IPV experienced. The experiences of those affected by IPV during this period inform interventions and the guidance and support provided to IPV victims during times of crisis.

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